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Thyrotoxicosis after a massive levothyroxine ingestion: A case report

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World Journal of Clinical Cases 2022年第11期10卷 3624-3629页

作者： Fang Du Shi-Wei Liu Hua Yang Rui-Xue Duan wen-xia ren Department of Endocrinology Taiyuan Central Hospital of Shanxi Medical UniversityTaiyuan 030009Shanxi ProvinceChina Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology Shanxi Bethune HospitalShanxi Academy of Medical SciencesTaiyuan 030032Shanxi ProvinceChina

BACKGROUND The literature on thyrotoxicosis caused by excessive ingestion of exogenous thyroid hormone is limited,and most cases reported have involved pediatric clinical *** SUMMARY A 21-year-old woman initially presented with palpitation and chest tightness after an overdose of levothyroxine(10 mg).The patient transiently lost consciousness and developed atrial fibrillation during *** used propylthiouracil to decrease the peripheral conversion of T4 to T3 and inhibit the synthesis of endogenous thyroxine,propranolol to control heart rate,hydrocortisone to correct severe thyrotoxicosis,and hemoperfusion to increase levothyroxine *** patient recovered and was *** For patients with thyrotoxicosis after taking excess levothyroxine,it is critical to monitor vital signs and initiate effective treatment.

关键词： Levothyroxine Overdose Thyrotoxicosis Thyroid crisis Treatment Case report

Nicotine up-regulates SLC7A5 expression depending on TRIM29 in non-small cell lung cancer

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Genes & Diseases 2024年第2期11卷 582-584页

作者： Dahua Liu Haolin ren Guimin wen Pu xia Biological Anthropology Institute College of Basic Medical ScienceJinzhou Medical UniversityJinzhouLiaoning 121000China Department of Radiology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Community Nursing College of NursingJinzhou Medical UniversityJinzhouLiaoning 121000China

Non-small cell lung cancer(NSCLC)is a malignant tumor that poses a serious threat to human ***(LUAD)and squamous cell carcinoma(LUSC)are two common types of *** originate from glandular and squamous cells of the bronchial epithelium,*** gene changes during tumorigenesis is conducive to the selection of suitable treatment methods for ***98 is a heterodimeric transmembrane glycoprotein,which is composed of a heavy chain and a light chain.1 cD98 heavy chain(CD98hc),also known as 4F2hc or SLC3A2,is an 85kDa type ll transmembraneglycoprotein,which consists of a cytoplasmic region(NH2 terminal),a single chain transmembrane region,and a huge extracellular region(COOH terminal).1 CD98hc can combine with the CD98 light chain,LAT1(SLC7A5),to form CD98 protein through disulfide bonds.1 SLC7A5 is a 12 times transmembrane helix bundle protein composed of 501-535 amino acid residues1.

关键词： lung cancer NSCLC

A Study of 10 Rotating Radio Transients Using Parkes Radio Telescope

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Research in Astronomy and Astrophysics 2024年第4期24卷 114-123页

作者： Xinhui ren Jingbo Wang wenming Yan Jintao Xie Shuangqiang Wang Yirong wen Yong xia Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Institute of Optoelectronic Technology Lishui UniversityLishui 323000China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China

Rotating Radio Transients(RRATs)are a relatively new subclass of pulsars that emit detectable radio bursts *** analyzed 10 RRATs observed using the Parkes telescope,with eight of these observed via the ultra-wide-bandwidth low-frequency(UWL)*** measured the burst rate and produced integrated profiles spanning multiple frequency bands for three *** also conducted a spectral analysis on both integrated pulses and individual pulses of three *** of their integrated pulses follow a simple power law,consistent with the known range of pulsar spectral *** average spectral indices of single pulses are-0.9,-1.2,and-1.0 respectively,which are within the known range of pulsar spectral ***,we find that the spreads of single-pulse spectral indices for these RRATs(ranging from-3.5 to+0.5)are narrower compared to what has been observed in other ***,the average spectral index and scatter of single pulses are both relatively *** the remaining five RRATs observed at the UWL receiver,we also provide the upper limits on fluence and flux *** addition,we obtain the timing solution of PSR *** analysis shows that PSRs J1919+1745,J1709-43,and J1649-4653 are potentially nulling pulsars or weak pulsars with sparse strong pulses.

关键词： (stars:)pulsars:general stars:neutron stars:individual(PSRs J1919+1745.1909+0641,0628+0909)

Path signature-based XAI-enabled network time series classification

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Science China(Information Sciences) 2024年第7期67卷 91-106页

作者： Le SUN Yueyuan WANG Yongjun ren Feng xia Department of Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science and Technology School of Computing Technologies Royal Melbourne Institute of Technology

Classifying network time series(NTS) is crucial for automating network administration and ensuring cyberspace security. It enables the detection of anomalies, the identification of network attacks,and the monitoring of performance issues, thereby providing valuable support for network protection and optimization. However, modern communication networks pose challenges for NTS classification *** include handling large-scale and complex NTS data, extracting features from intricate datasets, and addressing explainability requirements. These challenges are particularly pronounced for complex 5G networks. Notably, explainability has become crucial for the widespread deployment of network automation for 5G networks and beyond. To tackle these challenges, we propose a path-signature-based NTS classification model called recurrent signature(Recur Sig). This innovative model is designed to overcome the time-consuming feature selection problem by utilizing deep-learning(DL) techniques. Additionally, it provides a solution for addressing the black-box issue associated with DL models in network automation systems(NAS) by incorporating an explainable classification approach. Extensive experimentation on various public datasets demonstrates that Recur Sig outperforms existing models in accuracy and explainability. The results indicate its potential for application in cyberspace security and automated network management, offering an explainable solution for network protection and optimization.

关键词： network time series classification explainable artificial intelligence path signature automated network management recurrent neural network

A Cyclic Constitutive Model Based on Crystal Plasticity for Body-Centered Cubic Cyclic Softening Metals

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Acta Mechanica Solida Sinica 2024年第1期37卷 33-42页

作者： Xuehong ren wenjie Zhao Shaopu Yang Guilin wen State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China School of Mechanical Engineering Tianjin Sino-German University of Applied SciencesTianjin 300350China State Key Laboratory of Mechanical Behavior in Traffic Engineering Structure and System Safety Shijiazhuang Tiedao UniversityShijiazhuang 050043China

Under the framework of the small deformation crystal plasticity theory,a crystal plastic cyclic constitutive model for body-centered cubic(BCC)cyclic softening polycrystalline metals is *** constitutive model introduces the isotropic softening rule that includes two different mechanisms:namely softening under monotonic deformation and softening under cyclic deformation on each slip ***,a modified Armstrong-Frederick nonlinear kinematic hardening rule is *** appropriate explicit scale transition rule is selected to extend the single crystal constitutive model to the polycrystalline constitutive *** the model is used to predict the uniaxial and multiaxial ratcheting deformation of BCC axle steel EA4T to verify the rationality of the proposed *** simulation results indicate that the newly established crystal plasticity model can not only describe the cyclic softening characteristics of BCC axle steel EA4T well,but also reasonably describe the evolution laws of uniaxial ratcheting and nonproportional multiaxial ratcheting ***,the established crystal plastic cyclic constitutive model can reasonably predict the ratcheting behavior of BCC single crystal as well.

关键词： Crystal plasticity Constitutive model Softening Ratcheting

Enhancing action discrimination via category-specific frame clustering for weakly-supervised temporal action localization

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 809-823页

作者： Huifen xia Yongzhao ZHAN Honglin LIU xiaopeng ren School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang 212013China Jiangsu Engineering Research Center of Big Data Ubiquitous Perception and Intelligent Agricultural Applications Zhenjiang 212013China Changzhou Vocational Institute of Mechatronic Technology Changzhou 213164China

Temporal action localization (TAL) is a task of detecting the start and end timestamps of action instances and classifying them in an untrimmed video. As the number of action categories per video increases, existing weakly-supervised TAL (W-TAL) methods with only video-level labels cannot provide sufficient supervision. Single-frame supervision has attracted the interest of researchers. Existing paradigms model single-frame annotations from the perspective of video snippet sequences, neglect action discrimination of annotated frames, and do not pay sufficient attention to their correlations in the same category. Considering a category, the annotated frames exhibit distinctive appearance characteristics or clear action ***, a novel method to enhance action discrimination via category-specific frame clustering for W-TAL is proposed. Specifically,the K-means clustering algorithm is employed to aggregate the annotated discriminative frames of the same category, which are regarded as exemplars to exhibit the characteristics of the action category. Then, the class activation scores are obtained by calculating the similarities between a frame and exemplars of various categories. Category-specific representation modeling can provide complimentary guidance to snippet sequence modeling in the mainline. As a result, a convex combination fusion mechanism is presented for annotated frames and snippet sequences to enhance the consistency properties of action discrimination,which can generate a robust class activation sequence for precise action classification and localization. Due to the supplementary guidance of action discriminative enhancement for video snippet sequences, our method outperforms existing single-frame annotation based methods. Experiments conducted on three datasets (THUMOS14, GTEA, and BEOID) show that our method achieves high localization performance compared with state-of-the-art methods.

关键词： Weakly supervised Temporal action localization Single-frame annotation Category-specific Action discrimination

NAD+associated genes as potential biomarkers for predicting the prognosis of gastric cancer

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Oncology Research 2024年第2期32卷 283-296页

作者： xiaNGDONG SUN HUIJUAN wen FAZHAN LI IHTISHAM BUKHARI FEIFEI ren xia XUE PENGYUAN ZHENG YANG MI Henan Key Laboratory for Helicobacter Pylori&Microbiota and GI Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Nicotinamide adenine dinucleotide(NAD+)plays an essential role in cellular metabolism,mitochondrial homeostasis,inflammation,and ***,the role of NAD+-regulated genes,including coding and long non-coding genes in cancer development is poorly *** constructed a prediction model based on the expression level of NAD+metabolism-related genes(NMRGs).Furthermore,we validated the expression of NMRGs in gastric cancer(GC)tissues and cell lines;additionally,β-nicotinamide mononucleotide(NMN),a precursor of NAD+,was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation,cell cycle,apoptosis,and senescence-associated secretory phenotype(SASP).A total of 13 NMRGs-related lncRNAs were selected to construct prognostic risk signatures,and patients with high-risk scores had a poor *** immune checkpoint genes were upregulated in the high-risk *** addition,cell cycle,epigenetics,and senescence were significantly downregulated in the high-risk ***,we found that the levels of immune cell infiltration,including CD8 T cells,CD4 naïve T cells,CD4 memory-activated T cells,B memory cells,and naïve B cells,were significantly associated with risk ***,the treatment of NMN showed increased proliferation of AGS and MKN45 *** addition,the expression of SASP factors(IL6,IL8,IL10,TGF-β,and TNF-α)was significantly decreased after NMN *** conclude that the lncRNAs associated with NAD+metabolism can potentially be used as biomarkers for predicting clinical outcomes of GC patients.

关键词： NAD+ LncRNAs Cancer Cell infiltration Prognosis Tumor microenvironment

Spontaneous Infection and Periodic Evolving of Domain in a Diffusive SIS Epidemic Model

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 164-191页

作者： Qiang wen Guo-qiang ren Bin Liu School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan430074China

In this paper, we consider a susceptible-infective-susceptible(SIS) reaction-diffusion epidemic model with spontaneous infection and logistic source in a periodically evolving domain. Using the iterative technique,the uniform boundedness of solution is established. In addition, the spatial-temporal risk index R0(ρ) depending on the domain evolution rate ρ(t) as well as its analytical properties are discussed. The monotonicity of R0(ρ)with respect to the diffusion coefficients of the infected dI, the spontaneous infection rate η(ρ(t)y) and interval length L is investigated under appropriate conditions. Further, the existence and asymptotic behavior of periodic endemic equilibria are explored by upper and lower solution method. Finally, some numerical simulations are presented to illustrate our analytical results. Our results provide valuable information for disease control and prevention.

关键词： diffusive SIS model spontaneous infection periodically evolving domain periodic endemic equilibrium

Effect of BaO and MgO on structure and properties of aluminate slag with various CaO/Al_(2)0_(3)ratios

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Journal of Iron and Steel Research International 2024年第1期31卷 204-214页

作者： Yu-qi Kong Ting Wu wen-zhi xia wen Yang Hai-chuan Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resource Recycling(Ministry of Education) Anhui University of TechnologyMa’anshan243002AnhuiChina

To provide theoretical guidance for performance stability control of low-reactive mold fluxes,the effects of BaO and MgO on the structure and properties of aluminate slag with various CaO/Al_(2)0_(3)(C/A)ratios were investigated using the Fourier transform infrared spectrometer,Raman spectroscope,hemispherical melting point instrument,rotational viscometer and X-ray *** results indicated that with BaO and MgO addition,the structure polymerization was first weakened and then enhanced at C/A of 1.1,and the transition contents corresponded to 8 wt.%BaO and 2 wt.%MgO,respectively,while the structure polymerization decreased continuously at C/A of *** the viscosity change was well consistent with the structure evolution,the polymerization degree played a more prominent role in the slag viscosity than superheat degree when the melting temperature difference was within 40℃.The break temperature decreased initially and then increased with augment of BaO and MgO at C/A of 1.1,while it manifested a decrease trend with BaO addition,and it decreased obviously but then turned to increase with MgO increment at C/A of *** crystallization phase and crystallization ratio kept stable with BaO increment,while the crystallization ratio rose greatly with MgO promoting LiAlO_(2)precipitation at C/A of *** crystal types of all experimental slags were mainly Ca_(12)Al_(14)O_(33)and CaF_(2)at C/A of 1.3,and the precipitation of crystalline phase BaAl2O4 demonstrated a rising trend,while that of Ca_(12)Al_(14)O_(33)gradually declined with BaO augment.

关键词： Aluminate slag Structure MgO BaO Viscosity Property