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Synthesis and luminescence properties of Eu^(3+),Sm^(3+) doped(Y_xGd_(1-x))_2O_3:Si^(4+),Mg^(2+) long-lasting phosphor

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International Journal of Minerals,Metallurgy and Materials 2010年第3期17卷 347-352页

作者： Yan Liu Shi-xiang Liu Ming-wen wang wen-jun Li Ting Zhang Xia Zhang School of Applied Science University of Science and Technology Beijing Beijing 100083 China

A novel red long-lasting phosphor, （YxGd1-x）2O3：Eu3＋, Sm3＋, Si4＋, Mg2＋, was synthesized by the co-precipitation method using oxalate precipitation as the precursor. X-ray diffraction （XRD）, scanning electronic microscopy （SEM）, integrated thermal analyzer （TG）, and photoluminescence spectra （PL） as well as the ST-900PM weak light photometer were used to study the synthesis conditions, morphology, luminescence properties, and the decay time of the phosphor. The XRD results show that the products synthesized at 1400~C for 4 h have good crystallization without any detectable impurity phases. Based on the PL spectra, the optimal conditions are as the following. The molar ratios of Y3＋ to Gd3＋ and Eu3＋ to Sm3＋ are 2：8 and 3：1, respectively, and the contents of Mg2＋ and SiO2 are 5mol% and 3mol%, respectively. The decay time monitored by the ST-900PM weak light photometer is 7200 s, increasing 44% and 100%, respectively, compared with the Eu3＋ and Sm3＋ single-doped phosphors. The results indicate that the energy transfer is from Sm3＋ to Eu3＋ ion, and Sm3＋ is a good sensitizer to Eu3＋.

关键词： long lasting phosphor luminescence energy transfer

Finite element analysis of stress corrosion cracking for copper in an ammoniacal solution

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Rare Metals 2015年第6期34卷 426-430页

作者： wen-wen wang Ji Luo Lei-Chen Guo Zhi-Meng Guo Yan-Jing Su Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Engineering Rensselaer Polytechnic Institute

Finite element analyses including a cohesive zone model （CZM） were conducted to investigate the role of corrosion product films （CPFs） in stress corrosion cracking （SCC） for copper in an ammoniacal solution. It is found that a tensile CPF-induced stress generates near the interface between the CPF and the copper substrate at the substrate side in front of the notch tip for a U-shaped edgenotched specimens. The CPF-induced stress is superimposed on the applied stress to enhance emission and motion of dislocations. The peak opening stress （S11） increases with an increase in CPF thickness and a decrease in CPF Young＇s modulus. Damage mechanics based on the CZM was applied to study the stress corrosion crack initiation and propagation by analyzing the stress redistributions and load-displacement curves. The results show that the crack initiates first in the CPF and then propagates to the copper substrate. The fracture strain of the specimen covered a CPF is lower than that without a CPF. Based on the simulation results, the mechanism of the CPF-induced SCC, which promoted the initiation and propagation of the stress corrosion cracks, was discussed.

关键词： Stress corrosion cracking Finite elementanalysis Corrosion product film-induced stress Corrosionproduct films

Steroid hormone 20-hydroxyecdysone promotes CTL1-mediated cellular immunity in Helicoverpa armigera

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Insect Science 2021年第5期28卷 1399-1413页

作者： Gui-Jie wang wen-wen wang Yu Liu Lian-Qin Chai Guo-Xiu wang Xu-Sheng Liu Yu-Feng wang Jia-Lin wang Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079China School of Life Sciences Henan UniversityKaifengHenan475004China

Mermithid nematodes,such as Ovomermis sinensis,are used as biological control agents against many insect pests,including cotton bollworm(Helicoverpa armigera).However,given the host's robust immune system,the infection rate of *** is low,thus restricting its widespread *** understand the host defense mechanisms against mermithid nematodes,we identified and characterized a protein involved in the recognition of ***,the potential ***-binding protein C-type lectin 1(HaCTLla and/or HaCTLIb),which was eluted from the surface of *** after incubation with *** *** is homologous to the previously reported HaCTLla *** was predominantly expressed in hemocytes and was induced by the steroid hormone 20-hydroxyecdysone through ecdysone receptor(HaEcR)or ultraspiracle(HaUSP),or *** assays confirmed the interactions of the HaCTLI proteins with *** but not with Romanomermis wuchangensis,a parasitic nematode of ***,the HaCTL1 proteins were secreted into the hemocoel and promoted hemocyte-mediated encapsulation and phagocytosis.A knockdown of HaEcR and/or HaUSP resulted in compromised encapsulation and ***,HaCTLI appears to modulate cellular immunity in the defense against parasitic nematodes,and the 20-hydroxyecdysone-HaEcR-HaUSP complex is involved in regulating the process.

关键词： C-type lectin encapsulation phagocytosis 20-hydroxyecdysone

Primary Treatment for Clinically Early Cervical Cancer with Lymph Node Metastasis:Radical Surgery or Radiation?

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Current Medical Science 2023年第3期43卷 551-559页

作者： Xin-yi LI Jia-yi wen Yu-hui HUANG wen-wen wang Zheng WEI Yu-jia MA Xiang KANG Ze-hua wang Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Gynecology the Sixth Afiliated HospitalSun Yat-sen UniversityGuangzhou 510655China

Objective To compare survival outcomes between primary radical surgery and primary radiation in early cervical *** Patient information was extracted from the Surveillance,Epidemiology,and Results *** diagnosed with early cervical cancer of stage T1a,T1b,and T2a(American Joint Committee on Cancer,7th edition)from 1998 to 2015 were included in this study after propensity score *** survival(OS)was analyzed using the Kaplan-Meier *** Among the 4964 patients included in the study,1080 patients were identified as having positive lymph nodes(N1),and 3884 patients were identified as having negative lymph nodes(N0).Patients with primary surgery had significantly longer 5-year OS than those with primary radiotherapy in both the N1 group(P<0.001)and N0 group(P<0.001).In the subgroup analysis,similar results were found in patients with positive lymph nodes of stage T1a(100.0%vs.61.1%),T1b(84.1%vs.64.3%),and T2a(74.4%vs.63.8%).In patients with T1b1 and T2a1,primary surgery resulted in longer OS than primary radiation,but not in patients with T1b2 and *** multivariate analysis,the primary treatment was identified as an independent prognostic factor in both N1 and N0 patients(HR_(N1)=2.522,95%CI=1.919–3.054,PN1<0.001;HR_(N0)=1.895,95%CI=1.689–2.126,PN0<0.001).Conclusion In early cervical cancer stage T1a,T1b1,and T2a1,primary surgery may result in longer OS than primary radiation for patients with and without lymph node metastasis.

关键词： early cervical cancer overall survival primary treatment lymph node status radical surgery radiation

Helicobacter pylori intragastric colonization and migration:Endoscopic manifestations and potential mechanisms

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World Journal of Gastroenterology 2023年第30期29卷 4616-4627页

作者： Tong Mu Zhi-Ming Lu wen-wen wang Hua Feng Yan Jin Qian Ding Li-Fen wang Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Clinical Laboratory Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

After being ingested and entering the human stomach,Helicobacter pylori(***)adopts several effective strategies to adhere to and colonize the gastric mucosa and move to different regions of the stomach to obtain more nutrients and escape from the harsher environments of the stomach,leading to acute infection and chronic gastritis,which is the basis of malignant gastric *** endoscopic manifestations and pathological features of *** infection are diverse and vary with the duration of *** this review,we describe the endoscopic manifestations of each stage of *** gastritis and then reveal the potential mechanisms of bacterial intragastric colonization and migration from the perspective of endoscopists to provide direction for future research on the effective therapy and management of *** infection.

关键词： Helicobacter pylori Colonization Endoscopy Gastritis Infection

Clinical efficacy of intravitreal corticoid as an adjunctive therapy to anti-VEGF treatment of neovascular age-related macular degeneration:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1092-1099页

作者： Bo-Hao Cui Wei Zhou wen-wen wang Hao Yang Ya-Lan Dong Yuan-Yuan Liu Hua Yan Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China Laboratory of Molecular Ophthalmology Tianjin Medical UniversityTianjin 300070China Graduate School Tianjin Medical UniversityTianjin 300070China Department of Obstetrics and Gynecology Tianjin Medical University General HospitalTianjin 300052China

AIM:To evaluate the efficacy and safety of intravitreal cor ticoid as an adjunctive therapy to anti-vascular endothelial growth factor(VEGF)treatment of neovascular age-related macular degeneration(nvAMD).METHODS:Four databases including Pub Med,Embase,Cochrane Library,and the *** were comprehensively searched for studies comparing intravitreal corticoid plus anti-VEGF(IVC/IVA)vs anti-VEGF monotherapy(IVA)in patients with *** profiler was used to assess the quality of ***-corrected visual acuity(BCVA),central macular thickness(CMT)and adverse events including the occurrence of severe elevation of intraocular pressure(IOP)and the progress of cataract were extracted from the eligible *** Manager(Rev Man)5.3 was used to analyze the ***:There was no statistic difference of mean change in BCVA at 6 and 12 mo between IVC/IVA and IVA group[95%confidence interval(CI):-2.28 to 4.24,P=0.55;95%CI:-3.01 to 8.70,P=0.34].No statistic difference was found in the change of CMT between two groups at 6 mo time point(95%CI:-17.98 to 16.42,P=0.93)while the CMT reduction in IVC/IVA group was significantly more obvious than IVA group at 12 mo time point[mean difference(MD)=-44.08,95%CI:-80.52 to-7.63,P=0.02].The risk of occurrence of severe elevation of IOP in the IVC/IVA group was higher than that in the IVA group(95%CI:1.92 to 9.48;P=0.0004).Cataract progression risk was calculated no statistic difference between two groups(95%CI:0.74 to 4.66;P=0.18).CONCLUSION:No visual or anatomical benefits are observed in IVC/IVA group at 6 *** 12 mo,the CMT of the IVC/IVA group is significantly lower than that of the IVA *** of severe elevation of IOP is significantly higher when treated by IVC/IVA.

关键词： age-related macular degeneration dexamethasone triamcinolone anti-vascular endothelial growth factor Meta-analysis

EZH2 Contributes to Anoikis Resistance and Promotes Epithelial Ovarian Cancer Peritoneal Metastasis by Regulating m6A

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Current Medical Science 2023年第4期43卷 794-802页

作者： Shao-hai wang Lin LIU Ke-yong BAO Yi-fan ZHANG wen-wen wang Shi DU Na-er JIA Suo SUO Jing CAI Jian-feng GUO Gang LV Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Obstetrics and Gynecology Affiliated Hospital of Inner Mongolia University for The NationalitiesTongliao 028000China Department of Obstetrics and Gynecology Bozhou Branch of Union HospitalBozhou 833400China Department of Obstetrics and Gynecology Bozhou People's HospitalBozhou 833400China

Objective:Histone modification has a significant effect on gene *** of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltransferase *** development of anoikis resistance in tumor cells is considered to be a critical step in the metastatic process of primary malignant *** purpose of this study was to investigate the effect and mechanism of anoikis resistance in ovarian adenocarcinoma peritoneal ***:In addition to examining EZH2 protein expression in ovarian cancer omental metastatic tissues,we established a model of ovarian cancer cell anoikis and a xenograft tumor model in nude *** resistance and ovarian cancer progression were tested after EZH2 and N6-methyladenosine(m6A)levels were ***:EZH2 expression was significantly higher in ovarian cancer omental metastatic tissues than in normal ovarian *** the level of EZH2 decreased the level of m6A and ovarian cancer cell anoikis resistance in vitro and inhibited ovarian cancer progression in vivo.M6a regulation altered the effect of EZH2 on anoikis ***:Our results indicate that EZH2 contributes to anoikis resistance and promotes ovarian adenocarcinoma abdominal metastasis by m6A *** findings imply the potential of the clinical application of m6A and EZH2 for patients with ovarian cancer.

关键词： anoikis heterografts N6-methyladenosine enhancer of zeste homolog 2 ovarian neoplasms

Management of venous stenosis in living donor liver transplant recipients

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World Journal of Gastroenterology 2009年第39期15卷 4969-4973页

作者： Jie Yang Ming-Qing Xu Lu-Nan Yan Wu-Sheng Lu Xiao Li Zheng-Rong Shi Bo Li Tian-Fu wen wen-Tao wang Jia-Ying Yang Department of Liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To retrospectively evaluate the management and outcome of venous obstruction after living donor liver transplantation(LDLT).METHODS:From February 1999 to May 2009,1 intraoperative hepatic vein(HV) tension induced HV obstruction and 5 postoperative HV anastomotic stenosis occurred in 6 adult male LDLT *** portal vein(PV) anastomotic stenosis occurred in 1 pediatric left lobe *** ranged in age from 9 to 56 years(median,44 years).An air balloon was used to correct the intraoperative HV *** surgical reoperation,transjugular HV balloon dilatation with stent placement and transfemoral venous HV balloon dilatation was performed for HV stenosis on days 3,15,50,55,and 270 after LDLT,*** dilatation followed with stent placement via superior mesenteric vein was performed for the pediatric PV stenosis 168 d after ***:The intraoperative HV tension was corrected with an air *** recipient who underwent emergent reoperation for hepatic stenosis died of hemorrhagic shock and renal failure 2 d *** balloon dilatation via the transjugular and transfemoral venous approach was technically successful in all *** patient with early-onset HV stenosis receiving transjugular balloon dilatation and stent placement on the 15th postoperative day left hospital 1 wk later and disappeared,while the patient receiving the same interventional procedures on the 50th postoperative day died of graft failure and renal failure 2 wk *** patients with late-onset HV stenosis receiving balloon dilatation have survived for 8 and 4 mo without recurrent stenosis and ascites,*** dilatation and stent placement via the superior mesenteric venous approach was technically successful in the pediatric left lobe LDLT,and this patient has survived for 9 mo without recurrent PV stenosis and ***:Intraoperative balloon placement,emergent reoperation,proper interventional balloon dilatation and

关键词： Living donor liver transplantation Venous obstruction Anastomotic stenosis Venoplasty Stent

Mullite Refractory Made from Andalusite and α-Al_2O_3

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Journal of Wuhan University of Technology(Materials Science) 2001年第2期16卷 44-46页

作者：李博文 Sch. of Materials Sci. and Eng. China University of Geosciences Beijing 100083 China

Mullite refractory was made from micropowder of andalusite and α-M2O3 by an ' one-step sintering process' . This refractory has a lower linear expansion coefficient, more simple process and the sintering tem-parature can be decreased 200 - 25017 . But the cool strength of the material is near to that of fused casting mullite brick. For this material, the test sum of α-Al2 O3 added is 20% , the favorable sintering temperature is 1400℃.

关键词： andalusite mullile α - A12 O3 refractory micropawder