检索结果-南通市图书馆

Transcriptomic analysis reveals the effects of maternal exposure to bisphenol AF on hypothalamic development in male neonatal mice

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第7期141卷 304-313页

作者： Lin lv Yuanyuan Li Xuanyue Chen Zhanfen Qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Fragmented data suggest that bisphenol AF(BPAF),a chemical widely used in a variety of products,might have potential impacts on the ***,we employed male neonatal mice following maternal exposure to explore the effects of low-dose BPAF on hypothalamic development by *** found that maternal exposure to approximately 50μg/(kg·day)BPAF from postanal day(PND)0 to PND 15 altered the hypothalamic transcriptome,primarily involving the pathways and genes associated with extracellular matrix(ECM)and intercellular adhesion,neuroendocrine regulation,and neurological *** RNA analysis confirmed the changes in the expression levels of concerned ***,we further revealed that low-dose BPAF posed a stimulatory impact on pro-opiomelanocortin(POMC)neurons in the arcuate nucleus of the hypothalamus and induced the browning of inguinal white adipose *** findings indicate that developmental exposure to low-dose BPAF could interfere with hypothalamic development and thereby lead to alterations in the ***,5000μg/(kg·day)BPAF caused slighter,non-significant or even inverse alterations than the low dose of 50μg/(kg·day),displaying a dose-independent *** observations suggest that the the dose-independent effects of BPAF might be associated with oxidative stress and inflammatory responses caused by the high ***,our study highlights a risk of low-dose BPAF to human neuroendocrine regulation and metabolism.

关键词： Bisphenol AF Hypothalamus Transcriptomic alteration Pro-opiomelanocortin(POMC)neurons White adipose tissue browning

Finite Groups with Some Bounded Codegrees

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第7期40卷 1778-1784页

作者： Dong Fang YANG Yu ZENG Heng lv School of Mathematics and Statistics Southwest UniversityChongqing400715P.R.China Department of Mathematics Changshu Institute of TechnologyChangshu215500P.R.China

For a characterχof a finite group G,the number cod(χ) := ∣G:ker(χ)∣/χ(1)is called the codegree ofχ.In this paper,we give a solvability criterion for a finite group G depending on the minimum of the ratioχ(1)^(... 详细信息

关键词： Finite group codegree degree simple group

Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第3期15卷 391-410页

作者： Jin-Yu Shi Xin Che Rui wen Si-Jia Hou Yu-Jia Xi Yi-Qian Feng Ling-Xiao Wang Shi-Jia Liu wen-Hao lv Ya-Fen Zhang Department of Breast Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Colorectal Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Urology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Breast Surgery The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Ferroptosis has recently been associated with multiple degenerative *** induction in cancer cells is a feasible method for treating neoplastic ***,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is *** To identify and evaluate fresh ferroptosis-related biomarkers for HER2+*** First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC *** were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk ***,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk ***,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial *** We found that the higher the risk score was,the worse the prognosis was(P<0.05).We also found that the immune cell infiltration,mutation,and drug sensitivity were different between the different risk *** highrisk subgroup was associated with lower immune scores and high ***,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct ***-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(P<0.0001).Analysis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer pa

关键词： HER2+breast cancer Ferroptosis Tumor mutation burden Single-cell RNA sequencing Prognosis

Management of non-alcoholic fatty liver disease:Lifestyle changes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第22期30卷 2829-2833页

作者： Hao lv Yang Liu Department of General Surgery Xi'an Jiaotong University Second Affiliated HospitalXi'an 710004Shaanxi ProvinceChina

In this editorial,we commented on a recently released manuscript by Zeng et al in the World Journal of *** focused specifically on lifestyle changes in patients with non-alcoholic fatty liver disease(NAFLD).NAFLD is a hepatic manifestation of the metabolic syndrome,which ultimately leads to advanced hepatic fibrosis,cirrhosis,and hepatocellular carcinoma and affects more than 25%of the population *** therapeutic strategies against NAFLD such as pharmacologic therapies focus on liver protection,anti-inflammation,and regulating disease-related metabolic disorder *** several drugs are in late-stage development,potent drugs against the diseases are ***,existing surgical approaches such as bariatric surgery are not routinely used to treat *** in patients’unhealthy lifestyles,such as weight loss through dietary changes and exercises to ameliorate patientassociated metabolic disorders and metabolic syndrome,is the first-line treatment for patients with *** sufficient intrinsic motivation and adherence,the management of unhealthy lifestyles can reduce the severity of the disease,improve the quality of life,and increase the survival expectancy of patients with NAFLD.

关键词： Non-alcoholic fatty liver disease Lifestyle physical activity Physical exercise Low-calorie diet Mediterranean diet

Global outreach and networking promotion to accelerate tropical diseases elimination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贫困所致传染病(英文) 2024年第3期13卷 1-5页

作者： lv Shan Zhou Xiao-Nong National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases Shanghai People’s Republic of China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Hainan Center for Tropical Diseases Research (Hainan Subcenter of Chinese Center for Tropical Diseases Research) Haikou People’s Republic of China

Cooperation and networking are powerful tools in the combating against tropical diseases. Cooperation on a global scale is essential due to the transboundary nature of tropical diseases. Networking plays a pivotal role in facilitating such cooperation. Both cooperation and networking can foster innovation in disease control programmes. Collaborative research can lead to the development of new drugs and vaccines, while shared surveillance data can enable the early detection and control of disease epidemics. Therefore, consensus of cooperation and networking has been reached during the 7th Symposium on Surveillance-Response Systems Leading to Tropical Diseases Elimination, which reflected in the two documents, i.e.,Consensus for Transboundary Tropical Diseases Control, andAction Consensus of the Network of WHO Collaborating Centres Related to NTDs. These documents will improve the efforts in the fighting against tropical diseases through collective actions to achieve the United Nations’ Sustainable Development Goals (SDGs).

关键词： Tropical diseases Cooperation Networking Elimination Sustainable development goals

Design of double protograph LDPC codes based JSCC systems via the ACE-PEG algorithm

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第7期67卷 339-340页

作者： Yijie lv Jiguang HE Shaohua HONG Department of Information and Communication Engineering Xiamen University Technology Innovation Institute Centre for Wireless Communications Oulu University

In this study, we present a state-of-the-art design of double protograph low-density parity-check (DP-LDPC) codes based on progressive edge-growth (PEG) algorithm with approximated cycle extrinsic message degree (ACE)... 详细信息

关键词： Benchmarking

同方期刊数据库

Genomic surveillance of emerging SARS-CoV-2 Omicron variations in Tianjin Municipality, China 2022

在线全文

学校读者我要写书评

暂无评论

Biosafety and Health 2024年第2期6卷 61-69页

作者： Xin Gao Ming Zou Yue Lei Zhaolin Tan Zhichao Zhuang Baolu Zheng Aiping Yu Yanzhen Han Xiaohui Lu Xiaochang Liu Ying Wang Yuan Wang Liru Guo Guangwen Liu wen Li Yang Liu Likun lv Peiyong Ning Xiaoyan Li Tianjin Centers for Disease Control and Prevention Tianjin 300011China Tianjin Key Laboratory of Pathogenic Microbiologyof Infectious Disease Tianjin Centers for Disease Controland PreventionTianjin 300011China

The coronavirus disease 2019(COvID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has severely impacted public *** 2022,the Omicron variant of SARS-CoV-2 rapidly became the dominant circulating variant in the local COVID-19 outbreaks in Tianjin Municipality,*** gain a deeper understanding of the genetic variations of the Omicron variant in Tianjin,specimens from indi-viduals who tested positive for SARS-CoV-2 between December 2021 and November 2022 were used for virus whole genome sequencing and phylogenetic analysis.A total of 1,674 high-quality Omicron sequences were obtained,consisting of 1,339 sequences from local cases belonging to 20 Phylogenetic Assignment of Named Global Outbreak(PANGO)lineages and 335 sequences from imported cases belonging to 70 *** experienced five waves of local outbreaks,accompanied by multiple substitutions among subvariants,ranging from the initial BA.1.1 lineage to the subsequent BA.2,BF.7,and BA.5.2 *** evolutionary rate of local strains,estimated to be 28.999 substitutions per year,and the evolutionary rate of imported strains,estimated to be 24.946 substitutions per year,were lower than that of the strains circulating *** addi-tional substitutions and deletions of local strains have been used to identify and disrupt the virus transmission *** subvariants such as BA.5.2.48,BA.5.2.49,BF.7.14,and XBB.1 circulating in the fifth epidemic wave presented criterial immune escape mutations including S:R346T,S:L452R and S:*** is essential to implement genomic surveillance strategies to investigate further the development of genomic mutation char-acteristics in the SARS-CoV-2 *** ongoing monitoring will contribute to a better understanding of the virus's genetic changes and aid in effective control measures.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Omicron variant Whole genome sequencing(WGS)

Deposition of thin TiO_(2)films on fluorophlogopite particle surface by CVD in fluidized bed reactor to prepare silver pearlescent pigments

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第6期89卷 88-98页

作者： Ming Liu Guoqiang Shao Pengpeng lv Jun Li Qingshan Zhu State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Two critical parameters:Glossiness and chromaticity space of pearlescent pigments were evaluated based on crystallinity and grain *** the roughness and the vertical distance evolution along the surface of deposited TiO_(2)film are affected by the *** optimal crystallinity of TiO_(2)was deposited at the temperature of 350℃.The TiCl4 concentration effectively changed the grain ***,the high flow rate of fluidizing gas and optimal gas–solid ratio(lver pearlescent pigment with high glossiness was prepared by chemical vapor deposition method in a fluidized bed reactor.

关键词： Fluidized bed chemical vapor deposition TiO_(2)film deposition Pearlescent pigment Free powder restrain Crystal growth

Numerical simulation of granular silicon growth and silicon fines formation process in polysilicon fluidized bed

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第4期87卷 74-86页

作者： Guangkai Gu Guoqiang lv wenhui Ma Shanlin Du Boqiang Fu Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Complex Nonferrous Metal Resources Cleaning Utilization in Yunnan Province Kunming 650093China

Operating conditions strongly affect the yield and quality of polysilicon in a polysilicon fluidized *** this study,a new model of polysilicon fluidized bed was established using the Euler-Euler model coupled with population balance model(PBM),which was combined with fluid flow,heat,and mass transfer models,while considering the scavenging effect of silicon *** effects of different operating conditions on the deposition and formation rates of silicon fines were *** show that the model can correctly describe the particle growth process in the fluidized bed of *** silicon fines and the interphase velocity difference show"N"-and"M"-shaped distributions along the axial direction,*** particle temperature and concentration near the wall are higher than those in the central *** decomposition of silane in the bottom region of the bed is dominated by het-erogeneous *** scavenging of silicon fines occurs in the dilute-phase *** effects of operating conditions,*** gas temperature,silane composition,and gas velocity,on the reactor performance were also explored *** the inlet gas composition and velocity enhances the formation rates of solid silicon and *** the inlet gas temperature promotes the growth of solid silicon and inhibits the formation of silicon *** fluidization ratio,low inlet silane concentration,and high inlet gas temperature enhance the selectivity of silicon growth.

关键词： Polysilicon fluidized bed Particle growth Fines CFD Population balance model(PBM)