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Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 374-379页

作者： Jie Cai wen-wen fan Yun-Hui Zhong Cai-Lan wen Xiao-Dan Wei Wan-Chen Wei Wan-Yan Xiang Jin-Mao Chen Department of Ophthalmology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Digital and Intelligent Technology Transformation and Application Research Institute of Visual Function Tianjin 300000China Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university ***:Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical *** data were used to identify the different types of accommodation and nonstrabismic binocular vision dysfunction and to determine their *** analysis and logistic regression were used to examine the factors associated with these ***:The results showed that 36.71%of the subjects had accommodation and non-strabismic binocular vision issues,with 8.86%being attributed to accommodation dysfunction and 27.85%to binocular *** insufficiency(CI)was the most common abnormality,accounting for 13.29%.Those with these abnormalities experienced higher levels of eyestrain(χ2=69.518,P<0.001).The linear correlations were observed between the difference of binocular spherical equivalent(SE)and the index of horizontal esotropia at a distance(r=0.231,P=0.004)and the asthenopia survey scale(ASS)score(r=0.346,P<0.001).Furthermore,the right eye's SE was inversely correlated with the convergence of positive and negative fusion images at close range(r=-0.321,P<0.001),the convergence of negative fusion images at close range(r=-0.294,P<0.001),the vergence facility(VF;r=-0.234,P=0.003),and the set of negative fusion images at far range(r=-0.237,P=0.003).Logistic regression analysis indicated that gender,age,and the difference in right and binocular SE did not influence the emergence of these ***:Binocular vision abnormalities are more prevalent than accommodation dysfunction,with CI being the most frequent *** binocular refractive disparity leads to more severe eyestrain symptoms.

关键词： optometry clinic non-strabismic binocular vision dysfunction college students convergence insufficiency

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui Wei Shu-Hui fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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南堡凹陷西斜坡中深层高精度层序地层及沉积体系研究

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中国石油勘探 2017年第5期22卷 72-81页

作者：夏景生刘晓李文华张博明文雯李赫樊蓉薛林中国石油冀东油田公司勘探开发研究院中国石油集团东方地球物理勘探有限责任公司

应用高精度层序地层学理论和方法,通过对地震资料新一轮处理和精细解释,结合岩—电响应特征,共识别出南堡凹陷西斜坡中深层4个三级层序界面,划分了3个三级层序(SQ7、SQ8、SQ9)。以三级层序内部相对稳定的水进面和岩性突变面为界进行高... 详细信息

应用高精度层序地层学理论和方法,通过对地震资料新一轮处理和精细解释,结合岩—电响应特征,共识别出南堡凹陷西斜坡中深层4个三级层序界面,划分了3个三级层序(SQ7、SQ8、SQ9)。以三级层序内部相对稳定的水进面和岩性突变面为界进行高精度层序地层划分,进一步划分出12个四级层序或体系域的地层单元。在对研究区物源研究的基础上,开展系统的岩心相、测井相精细研究,共识别出扇三角洲和湖泊两种沉积体系。并在高精度层序地层格架内研究了各沉积体系平面展布特征,其中扇三角洲平原分布范围相对较小,主要集中在研究区北部靠近物源口附近;而扇三角洲前缘分布范围较广,主要发育于研究区的中心部位。

关键词：体系域高精度层序地层格架扇三角洲沉积体系湖泊沉积体系南堡凹陷西斜坡

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Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期 268-282页

作者： ZHENG Weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao XIE fan ZENG wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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Urban stormwater disinfection, quality variability during storage and influence on the freshwater algae: Implications for reuse safety

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Journal of Environmental Sciences 2023年第2期124卷 655-666页

作者： Shanshan fan Gang wen An Liu College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Water Science and Environmental Engineering Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

Stormwater reuse is one of the most important ways to mitigate water resource ***,urban stormwater contains many bacteria species,which threaten the reuse ***,stormwater disinfection is highly *** disinfection has been widely conducted in the drinking water and reclaimed water,it is rarely carried out for *** study collected the roof stormwater and undertook chlorination *** typical bacteria,Escherichia coli(***)and Staphylococcus aureus(***)were selected in this study to investigate the disinfection *** is found that bacteria species present in the stormwater had an important influence on disinfection efficiency while the original stormwater quality did not show an obvious ***,when the disinfected stormwater was stored,the stormwater quality was highly variable during its storage process and the variability was affected by bacteria *** *** containing stormwater showed a high variability of quality and *** significantly ***,the *** containing stormwater quality had a relatively low variability and *** did not significantly ***,it is noted that after storage,the dissolved form of stormwater was more positive to the freshwater algae’s growth while the particulate form(including bacteria and other particulate matters)was *** implies that a further treatment such as filtration is needed before the stored stormwater is recharged into receiving waters in order to remove particulate *** research outcomes can provide useful insight to effective stormwater disinfection and ensure reuse safety.

关键词： Stormwater quality Stormwater disinfection Stormwater storage Stormwater reuse Escherichia coli Staphylococcus aureus

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Wide area measurements based fault detection and location method for transmission lines

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Protection and Control of Modern Power Systems 2019年第1期4卷 53-64页

作者： wen fan Yuan Liao Department of Electrical and Computer Engineering University of KentuckyLexingtonKY40506USA

Electric power grids are critical infrastructure for delivering energy from generation stations to load centers. To maximize utilization of assets, it is desirable to increase the power transferred over transmission systems. Reliable protection of transmission systems is essential for safeguarding the integrity and reliability of the power grid. Distance protection is the most widely used scheme for protecting transmission lines. Most existing protection systems use local measurements to make a decision while pilot protection is used in some circumstances. Distance protection may fail under stressed operating conditions, which could lead to cascading faults. This paper proposes a system integrity protection scheme by utilizing wide area measurements. The scheme partitions the system into subnetworks or protection zones and employs current measurements to derive a fault identification vector indicating the faulted zone. Then the fault location is pinpointed based on wide area measurements and network data. The proposed method is able to deal with multiple, simultaneous faults, and is applicable to both transposed and untransposed lines. Evaluation studies based on simulation studies are presented.

关键词： System integrity protection scheme Fault location Transmission systems

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