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Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

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Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： Xiao-Wei Tang wen-Sen ren Shu Huang Kang Zou Huan Xu Xiao-Min Shi Wei Zhang Lei Shi Mu-Han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

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Pan-cancer analysis of ORAI family proteins and their genomic alterations

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Medical Data Mining 2024年第4期7卷 41-49页

作者： Zhan-Bo Wu wen-Shuai Zhang Dan-Yang ren Xin Li Department of Cancer Immunotherapy Tianjin Cancer Hospital Airport HospitalTianjin 300308China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Cancer Hospital Airport HospitalTianjin 300308China

Background:The ORAI family of proteins,comprising ORAI1,ORAI2,and ORAI3,plays a crucial role in the regulation of intracellular calcium signaling,which is essential for various cellular functions including proliferation,differentiation,and *** of calcium signaling has been implicated in cancer pathogenesis,influencing tumor progression,metastasis,and resistance to *** study aims to provide a comprehensive analysis of the ORAI family members across a broad spectrum of ***:Publicly available datasets from The Cancer Genome Atlas and the Gene Expression Omnibus were *** sequencing data,mutation profiles,copy number variation data,and methylation data across different cancer types were *** expression analysis,survival analysis,copy number variation analysis,mutation analysis,methylation analysis,immune cell infiltration analysis using the Cibersort algorithm,and gene set enrichment analysis were conducted using R ***:ORAI1 and ORAI3 were significantly upregulated in glioblastoma multiforme,whereas ORAI2 was notably downregulated in kidney chromophobe and pancreatic ***2 exhibited higher mutation rates and copy number gains in multiple cancers compared to ORAI1 and *** hypermethylation of ORAI2 in head and neck squamous cell carcinoma,esophageal carcinoma,and glioblastoma multiforme negatively correlated with its gene ***1 and ORAI3 expression positively correlated with regulatory T cells infiltration,whereas ORAI2 showed a negative correlation with CD8^(+)T cell *** set enrichment analysis revealed that ORAI1 and ORAI2 are associated with immune-related pathways,while ORAI3 is linked to MYC targets and oxidative ***:Our pan-cancer analysis reveals significant differential expression,genomic alterations,and epigenetic regulation of ORAI family members across various ***1 and ORAI3 appear to promote an immunosuppr

关键词： ORAI family calcium signaling cancer progression immune cell infiltration gene expression

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Effects of Silicon Formulations on Cold Tolerance of Rice Seedlings

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Journal of Northeast Agricultural University(English Edition) 2024年第2期31卷 43-52页

作者： ren Hongyu Wang wenbo Li Xuecong Li Shuai wen Yahuan Zhang Xingwen College of Resources and Environmental Sciences Northeast Agricultural UniversityHarbin 150030China College of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China

To investigate the effects of silicon formulations on the cold tolerance of rice seedlings,Song Japonica 16(not cold tolerant)and Dongnong 427(cold tolerant)rice varieties were used as test materials and four different types of silicon formulations,Si-50-G,Si-60-G,Si-T-G,and Si-E-G,were applied as foliar sprays at the seedling stage,and a control group CK(equal amount of distilled water)was set *** week after the first silicon spray,two types of rice were subjected to low-temperature stress treatments at day/night temperatures of 12℃/10℃for 2,4,6,and 8 *** effects of different silicon formulations on the chlorophyll,proline(Pro)and soluble sugar contents as well as superoxide dismutase(SOD),peroxidase(POD)and catalase(CAT)activities of rice seedlings under low-temperature stress were compared to find out the effects of silicon formulations on the cold tolerance of rice *** results showed that silicon formulations could significantly increase the chlorophyll content of rice seedling leaves,with Si-50-G being the most effective,with a significant increment of 40.17%compared to the CK at 2 days of low *** silicon formulations significantly increased the proline content and soluble sugar content of rice leaves at low temperature for 4-8 *** Song Japonica 16,the most significant increment in leaf POD activity was observed in Si-E-G treatment at 2,4 and 8 days of temperature stress,with 73.58%,20.95%and 217.24%increases compared to the CK,*** 4 and 6 days of temperature stress,the most significant increase in CAT activity was observed in Si-E-G treatment,with 25.70%and 75.78%increases compared to the CK,*** Dongnong 427,the Si-60-G treatment showed the highest increase in leaf SOD activity for 4 and 8 days of temperature stress,with significant increases of 58.15%and 82.76%compared to the CK,respectively,and the Si-E-G treatment showed the highest increase in leaf POD activity for 2 and 8 days of temperature st

关键词： silicon formulation rice seedling stage cold tolerance physiological indicator

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge wen-Ying Zhuang Gang Hu ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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“新舞蹈”的话语流变与时空逻辑

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北京舞蹈学院学报 2024年第3期 1-8页

作者：任文惠北京舞蹈学院人文学院北京100081

“新舞蹈”是中国舞蹈在20世纪的新现象与新发展,从“新舞蹈艺术”“社会主义民族新舞蹈”“中国特色社会主义新舞蹈”到“当代舞”,“新舞蹈”在20世纪中国的政治文化场域中历经启蒙、救亡与民族主义话语,民族国家与阶级话语,改革、人... 详细信息

“新舞蹈”是中国舞蹈在20世纪的新现象与新发展,从“新舞蹈艺术”“社会主义民族新舞蹈”“中国特色社会主义新舞蹈”到“当代舞”,“新舞蹈”在20世纪中国的政治文化场域中历经启蒙、救亡与民族主义话语,民族国家与阶级话语,改革、人道主义与现代主义话语,艺术体制话语,呈现出历史语境对“新舞蹈”进行话语赋权的动态演进过程,形成社会主义文化时间和空间的建构逻辑。“新舞蹈”在“新”的语义之下始终保持中国舞蹈的现实主义品格,勾勒出中国社会主义舞蹈艺术的历史连续性,体现出中国舞蹈现代性的诗意建构。

关键词：新舞蹈话语流变社会历史时间空间意识形态

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新时代社会主义意识形态建设的创新发展及其经验析论

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南通大学学报（社会科学版） 2024年第1期40卷 1-10,159页

作者：孙绍勇任雯陕西(高校)哲学社会科学重点研究基地“马克思主义创新发展研究中心” 西北工业大学马克思主义学院

意识形态作为观念上层建筑,对经济社会发展具有巨大的反作用。高度重视意识形态建设,牢牢掌握意识形态工作的领导权,是中国共产党的优良传统。新时代以来,面对纷繁复杂的意识形态领域的风险和挑战,中国共产党审时度势、深谋远虑,不断推... 详细信息

意识形态作为观念上层建筑,对经济社会发展具有巨大的反作用。高度重视意识形态建设,牢牢掌握意识形态工作的领导权,是中国共产党的优良传统。新时代以来,面对纷繁复杂的意识形态领域的风险和挑战,中国共产党审时度势、深谋远虑,不断推进社会主义意识形态建设的创新发展。洞察时代大势科学研判社会主义意识形态建设的坐标定位、聚焦本质规律辩证认识社会主义意识形态建设的原则导向、把握历史主动系统优化社会主义意识形态建设的战略举措,深入总结党的十八大以来中国共产党推进社会主义意识形态建设创新发展,以及所积累创造的经验,对于党在新征程上不断提升社会主义意识形态的引领力和凝聚力,进而统一全党全国各族人民的意志和思想,推进全面建设社会主义现代化强国,具有深刻的理论价值和现实意义。

关键词：新时代社会主义意识形态创新发展宝贵经验

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Down-regulation of 67LR reduce the migratory activity of Human Glioma Cell

Down-regulation of 67LR reduce the migratory activity of Hum...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： wen-wen ren,Yan-Hong DUAN,Yan-Rong QIAN,Yong-Hua JI,Fu-Xue CHEN~* Laboratory of Neural Molecular Biology,School of Life Sciences,Shanghai University,Shanghai,China

＜正＞Glioma is the most common brain tumor in central nervous *** therapies are not effective to cure this *** evidence indicates that the 67 kDa elastin-laminin receptor（67LR） subunit is a high-affinity non-integrin laminin-binding protein that is over-expressed on the tumor cell surface in a variety of cancers and plays an important role in several physiological as well as pathological processes,including cell differentiation,growth,migration and cancer *** this study,we testified whether 67LR was constitutively over-expressed in high-grade astrocytomas, and then investigated the role of a low level of 67LR expression in glioma cells by constructing an interfering RNA expression *** results showed that the 67LR was constitutively overexpressed in high-grade astrocytomas and glioma cells reduced their migratory activity after interference of the 67LR expression by *** hypothesized a low level of 67LR expression could reduced migtratoty activity of glioma cell,which further proved that 67LR played an important role in tumor invasion by mediating essential tumor cell functions leading to *** study provides a new alternative to gene therapy for glioma treatment.

关键词： Glioma 67LR RNAi migratory

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Doping-reinforced interfacial electric field for charge oriented accumulation in Ohm junction boosting photocatalytic Nfixation

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Science China Chemistry 2024年

作者： Hua wen Ruqi Li Jingyu ren Razium Ali Soomro Shoujian Fu Li Guo Feng Fu Bin Xu Chunming Yang Danjun Wang College of Chemistry and Chemical Engineering Yan'an University Shaanxi Key Laboratory of Chemical Reaction Engineering

The interfacial electric field （IEF） determines the charge carriers transport and the reactivity of heterostructure ***,the restricted IEF lead to inefficient interfacial charge transport and oriented accumulation,resulting in low photocatalytic ***,a interfacial chemical-bonded Ti-BiOBr/1T-MoS1.85Ohm junction is fabricated via electrostatic self-assembly strategy,in which Ti doping precisely regulates the local electrical structure and work function of BiOBr,thus boosting the IEF to efficiently drive charge transfer and oriented accumulation to active *** femtosecond transient absorption spectroscopy verified that the Ti0.1Bi0.9OBr/1T-MoS1.85-6%increased the shallow electron trapping （τ1=0.57 ps）while the depressed recombination of photoinduced electrons with trapped holes （τ2=71.88 ps） compared to the BiOBr/1T-MoS1.85-6%（τ1=0.78 ps,τ2=54.61 ps）.More Importantly,the interfacial charge carriers transfer from Ti0.1Bi0.9OBr to 1T-MoS1.85（τ3=86.53 ps） was significantly accelerated by the reinforced IEF compared to BiOBr/1T-MoS1.85-6%（τ3=221.51 ps）.The N2-to-NH3conversion rate of Ti0.1Bi0.9OBr/1T-MoS1.85-6%Ohm junction (36.8μmol g-1cath-1) was 1.9 and 6.9-fold higher than that of BiOBr/1T-MoS1.85-6%and 1T-MoS1.85,*** work provides a new insight into the design of Ohm junction with reinforced IEF for efficient interfacial charge carrier transfer and oriented accumulation towards efficient N2fixation.

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A FAS approach for stabilization of generalized chained forms: part 1. Discontinuous control laws

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Science China(Information Sciences) 2024年第2期67卷 118-143页

作者： Guang-ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology Center for Control Science and Technology Southern University of Science and Technology

In this paper, a type of general nonholonomic systems is proposed, which contains both the Brockett’s two example systems, and their extended n-dimensional chained forms, as special cases. For the stabilization of such systems, a stabilizing controller is proposed based on the fully actuated system(FAS)approach, which is discontinuous at the origin but time-invariant when the open-loop system is time-invariant,and drives the feasible trajectories of the system to the origin exponentially. Furthermore, the proposed FAS approach is also extended to the sub-normal system case and the time-delay system case.

关键词： nonholonomic systems feedback stabilization exponential convergence sub-fully actuated systems time-delay systems

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