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Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer

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World Journal of Gastroenterology 2018年第20期24卷 2181-2190页

作者： wen-Juan Ma Xing Wang wen-ting yan Zhong-Guo Zhou Zhi-Zhong Pan Gong Chen Rong-Xin Zhang State Key Laboratory of Oncology in South China Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Collaborative Innovation Center of Cancer Medicine Guangzhou 510060Guangdong ProvinceChina Tongji Medical College Huazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Hepatobiliary Surgery Cancer CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Department of Colorectal Surgery Cancer CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM To evaluate indoleamine-2,3-dioxygenase 1/cyclooxygenase 2(IDO1/COX2) expression as an independent prognostic biomarker for colorectal cancer(CRC) *** We retrospectively studied the medical records of 95 patients who received surgical resection from August 2008 to January 2010. All patients were randomly assigned to adjuvant treatment with or without celecoxib groups after surgery. We performed standard immunohistochemistry to assess the expression levels of IDO1/COX2 and evaluated the correlation of IDO1/COX2 with clinicopathological factors and overall survival(OS) *** The expression of nuclear IDO1 was significantly correlated with body mass index(P ting lymphocytes, and COX2. In univariate analysis, we found that nuclear IDO1(P = 0.039), nuclear/cytoplasmic IDO1 [hazard ratio(HR) = 2.044, 95% confidence interval(CI): 0.871-4.798, P = 0.039], nuclear IDO1/COX2(HR = 3.048, 95%CI: 0.868-10.7, P = 0.0049) and cytoplasmic IDO1/COX2(HR = 2.109, 95%CI: 0.976-4.558, P = 0.022) all yielded significantly poor OS outcomes. Nuclear IDO1(P = 0.041), nuclear/cytoplasmic IDO1(HR = 3.023, 95%CI: 0.585-15.61, P = 0.041) and cytoplasmic IDO1/COX2(HR = 2.740, 95%CI: 0.764-9.831, P = 0.038) have significantly poor OS outcomes for the CRC celecoxib subgroup. In our multivariate Cox model, high coexpression of cytoplasmic IDO1/COX2 was found to be an independent predictor of poor outcome in CRC(HR = 2.218, 95%CI: 1.011-4.48, P = 0.047) and celecoxib subgroup patients(HR = 3.210, 95%CI: 1.074-9.590, P = 0.037).CONCLUSION Our results showed that cytoplasmic IDO1/COX2 coexpression could be used as an independent poor predictor for OS in CRC.

关键词： Prognosis Indoleamine-2,3-dioxygenase 1 Cyclooxygenase 2 Colorectal cancer

乳腺浸润性小叶癌组织Ki-67表达与临床病理特征相关性分析

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中华肿瘤防治杂志 2017年第14期24卷 989-995页

作者：徐文婷杨艳芳刘君天津医科大学肿瘤医院乳腺二科.国家肿瘤临床医学研究中心.天津市"肿瘤防治"重点实验室.天津市恶性肿瘤临床医学研究中心.乳腺癌防治教育部重点实验室天津300060

目的浸润性小叶癌(invasive lobular carcinoma,ILC)组织中Ki-67表达的研究较少,对其预后预测价值尚需进一步文献支持。本研究探讨ILC组织不同临床病理特征下Ki-67表达差异及其与预后的关系。方法收集天津医科大学肿瘤医院2003-01-10-20... 详细信息

目的浸润性小叶癌(invasive lobular carcinoma,ILC)组织中Ki-67表达的研究较少,对其预后预测价值尚需进一步文献支持。本研究探讨ILC组织不同临床病理特征下Ki-67表达差异及其与预后的关系。方法收集天津医科大学肿瘤医院2003-01-10-2012-12-15收治的381例乳腺ILC患者的临床病理资料,分析Ki-67与其临床病理特征的相关性。分析不同年龄、月经状态、体质量指数、家族史、肿瘤大小、淋巴结状态、病理学分期、组织学分型、ER状态、PR状态、HER-2状态和p53状态下,Ki-67表达与预后的关系。结果 381例ILC组织中Ki-67低表达76例(19.9%),中表达91例(23.9%),高表达214例(56.2%)。在不同肿物大小(χ~2=12.524,P=0.014)、腋窝淋巴结情况(χ~2=6.114,P=0.047)、临床分期(χ~2=10.434,P=0.034)、ER表达(χ~2=6.339,P=0.041)和组织学类型(χ~2=78.288,P0.05。Cox多因素分析显示,有无淋巴结转移(P=0.000)是ILC总生存的独立预后因素,而肿瘤大小、临床分期和Ki-67表达水平不是影响ILC总生存的独立预后因素,P>0.05。结论乳腺ILC组织中Ki-67高表达。就诊时肿物越大、有腋窝淋巴结转移和临床分期越高,Ki-67表达水平越高,而ER表达水平越高,Ki-67表达水平越低,肿物大小2~5cm、有腋窝淋巴结转移及临床Ⅱ期,即中低度恶性ILC组织中Ki-67表达对患者预后有一定的预测价值,但不是独立预后因素,Ki-67对ILC预后预测作用尚需进一步研究。

关键词：浸润性小叶癌临床病理特征 Ki-67 相关性预后

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一种提高乳腺扩散光学层析成像分辨率的方式

生物化学与生物物理进展 2022年第12期49卷 2440-2449页

作者：李伦吴丹温艳婷陈艺迟子惠田银蒋华北重庆邮电大学计算机科学与技术学院重庆400065 重庆邮电大学光电工程学院重庆400065 成都市第五人民医院超声医学科成都611130 Department of Medical Engineering University of South FloridaTampa 33620USA

目的扩散光学层析成像(diffuse optical tomography,DOT)在女性大尺寸乳腺检测时因信噪比低,导致其成像分辨率较低。本文基于计算机断层扫描激光乳腺成像系统(computed tomography laser mammography,CTLM),提出一种提高乳腺扩散光学... 详细信息

目的扩散光学层析成像(diffuse optical tomography,DOT)在女性大尺寸乳腺检测时因信噪比低,导致其成像分辨率较低。本文基于计算机断层扫描激光乳腺成像系统(computed tomography laser mammography,CTLM),提出一种提高乳腺扩散光学层析成像分辨率的方式。方法本文首先通过仿体实验探讨仿体直径和目标深度对扩散光学层析成像分辨率的影响;其次,本文使用高透性的光敏树脂通过3D打印制作外壳定位件,在验证其对扩散光学层析成像分辨率无显著影响后,利用外壳定位件对被测物进行约束压缩,以减小被测物直径来提高信噪比,优化扩散光学层析成像分辨率。结果本文通过仿体实验验证了仿体直径的增加和目标深度的变化均会在一定程度上影响成像分辨率,随着仿体直径的增加,其感兴趣区(region of interests,ROIs)宽轴和长轴半高宽基本属于上升趋势;随着目标深度的增加,也会对ROIs宽轴和长轴半高宽产生影响。同时发现仿体直径对ROIs长轴半高宽有显著影响,目标深度对ROIs宽轴半高宽有显著影响。另外通过仿体实验结果验证了外壳定位件对扩散光学层析成像分辨率无显著影响,利用外壳定位件约束压缩后ROIs长轴半高宽降幅明显,降幅达到30%以上,远大于宽轴半高宽的降幅,达到了提高成像分辨率的作用。结论本文所提出的方式能够达到提高乳腺扩散光学层析成像分辨率的作用,且所使用的材料和方法简单,具有较强的可实施性,为提高乳腺扩散光层析成像分辨率提供了新思路。

关键词：扩散光学层析成像(DOT) 乳腺定量分析计算机断层扫描激光乳腺成像系统外壳定位件

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多波长光声层析成像技术用于人体气管探测

生物化学与生物物理进展 2022年第3期49卷 600-606页

作者：温艳婷吴丹张静郭丹熊春燕迟子惠陈艺李伦蒋华北重庆邮电大学计算机科学与技术学院重庆400065 成都市第五人民医院超声医学科成都611130 Department of Medical Engineering University of South FloridaTampa 33620USA

目的通过多波长光声层析成像技术对气管结构进行重建成像。方法基于阵列换能器的光声成像技术对7名志愿者的气管进行了多波长光声层析成像实验,研究光声层析成像技术对气管不同呼吸相、不同层面的高分辨率(高达150μm)图像特征,并对该... 详细信息

目的通过多波长光声层析成像技术对气管结构进行重建成像。方法基于阵列换能器的光声成像技术对7名志愿者的气管进行了多波长光声层析成像实验,研究光声层析成像技术对气管不同呼吸相、不同层面的高分辨率(高达150μm)图像特征,并对该技术的成像优劣性进行评价。结果光声层析成像技术能对人体气管进行清晰成像,能够真实反映气管及气管周围组织的结构特征。结论光声层析成像技术可作为一种无创便捷、无电离辐射的成像方式,对气管解剖和功能状态进行实时评估。

关键词：光声层析成像图像重建气管诊断

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基于微波热声层析成像定量重建生物组织电导率的改进方法

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生物化学与生物物理进展 2023年第2期50卷 405-416页

作者：陈艺迟子惠吴丹刘悦温艳婷李伦蒋华北重庆邮电大学计算机科学与技术学院重庆400065 重庆邮电大学光电工程学院重庆400065 成都市第五人民医院超声医学科成都611130 Department of Medical Engineering University of South FloridaTampa 33620USA

目的生物电磁学参数中的电导率与组织的功能性信息直接相关,精准重建生物组织电导率在医学成像技术和医学诊断领域中有着重要意义。本文改进定量微波热声层析成像(microwave-induced thermoacoustic tomography,MTAT)算法,使组织电导率... 详细信息

目的生物电磁学参数中的电导率与组织的功能性信息直接相关,精准重建生物组织电导率在医学成像技术和医学诊断领域中有着重要意义。本文改进定量微波热声层析成像(microwave-induced thermoacoustic tomography,MTAT)算法,使组织电导率的重建精度提高。方法本文在利用有限元离散法求解热声波动方程和亥姆霍兹方程的基础之上,提出了一种基于正则化牛顿迭代法(regularized Newton iteration method,RNIM)定量重建组织电导率的改进方法。结果通过数值模拟实验和含不同浓度NaCl溶液的仿体实验,验证了算法改进的有效性。组织仿体实验结果表明,目标在不同位置、不同大小、不同对比度情况下,相比于定量微波热声层析成像采用拟合(fitting)的方法,采用正则化牛顿法定量重建的仿体电导率相对误差明显降低,重建目标精度提高。在仿体实验中采用RNIM方法重建相同浓度的单目标在不同位置的电导率变化幅度更小,以及重建多目标电导率的相对比值与实际更接近,实验结果验证了改进方法的稳定性。结论研究结果表明优化算法能更加准确地定量重建组织仿体的电导率,这对于肿瘤的定位和分期的早期筛查及精准诊疗,预防疾病恶化具有重要意义。

关键词：生物组织电导率定量微波热声层析成像(MTAT) 正则化牛顿迭代法(RNIM)

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-Li Li Xiao-ting Sun Li-ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

基于数据挖掘分析近20年针刺治疗突发性耳聋的选穴规律

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广州中医药大学学报 2021年第10期38卷 2192-2196页

作者：温燕婷陈劼广州中医药大学针灸康复临床医学院广东广州510006

【目的】运用数据挖掘技术探析针刺治疗突发性耳聋的腧穴配伍规律,为临床治疗提供参考方案及新思路。【方法】通过计算机检索中国知网(CNKI)、万方数据库(Wanfang)近20年收录的针刺治疗突发性耳聋的临床研究文献,应用Excel建立数据库,运... 详细信息

【目的】运用数据挖掘技术探析针刺治疗突发性耳聋的腧穴配伍规律,为临床治疗提供参考方案及新思路。【方法】通过计算机检索中国知网(CNKI)、万方数据库(Wanfang)近20年收录的针刺治疗突发性耳聋的临床研究文献,应用Excel建立数据库,运用SPSS统计软件分析及数据挖掘,分析腧穴配伍的规律。【结果】共收集到139首处方,腧穴总频次由高到低依次为翳风、听会、听宫、耳门、中渚等;腧穴出现频次最高的归经为手少阳三焦经,其次是足少阳胆经;关联度较高的腧穴组合有“翳风-听宫,翳风-听会,听会-听宫”等。通过聚类分析,以23为标度,得到8个聚类群。【结论】针刺治疗突发性耳聋,具有重视耳部穴位的运用,并与远端配穴相结合的特点。

关键词：突发性耳聋暴聋针刺选穴规律数据挖掘翳风听宫听会

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong yan ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway