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Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching

World Journal of Gastrointestinal Surgery 2024年第1期16卷 124-133页

作者： Yang Liu Xian-Xue Wang Yu-Lin Li wen-tao he Hong Li Hua Chen Department of General Surgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Anesthesiology Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)is increasing *** radical resection of CRC is a minimally invasive procedure preferred in clinical *** To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed *** control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 *** in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were *** Thirty patients from both groups were successfully *** PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than ***-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before *** 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation gro

关键词： Colorectal cancer Laparoscopic Open surgery Inflammatory reaction Immune function Propensity score

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Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2826-2841页

作者： Gang Wang tao Liu wen-Ting he School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Translational Medicine Engineering Research Center of Gansu Province Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Hospital&Clinical Medical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical *** over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is *** To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this *** The literature was collected from Web of Science ***-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst *** 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation ***‘online platform for bibliometric analysis(https://***/app)’was used to assess the total number of publications and the cooperation relationships between ***,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the *** Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor *** United States(n=393)and helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing *** most influential journal in this field is *** most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge *** focal points were further detailed based on the *** This bibl

关键词： Gastrointestinal tumor organoids Bibliometric analysis Drug development and screening Model CiteSpace

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Sensitivity of seismic attenuation and dispersion to dynamic elastic interactions of connected fractures: Quasi-static finite element modeling study

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Petroleum Science 2023年第1期20卷 177-198页

作者： Yan-Xiao he wen-tao he Meng-Fan Zhang Jia-Liang Zhang Wei-Hua Liu Xiao-Yi Ma Gen-Yang Tang Shang-Xu Wang Guo-Fa Li Jun-Zhou Liu Xiang-Long Song State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing100083China Sinopec Key Laboratory of Seismic Elastic Wave Technology Beijing100083China State Key Laboratory of Petroleum Resources and Prospecting CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)Beijing102249China CNOOC(China)Co. Ltd.Hainan BranchHaikouHainan570311China PetroChina Dagang Oilfield Tianjin300280China Sinopec Geophysical Research Institute NanjingJiangsu211103China Sinopec Petroleum Exploration and Production Research Institute Beijing100083China Chinese Academy of Geological Sciences Beijing100037 China

Prediction of seismic attenuation and dispersion that are inherently sensitive to hydraulic and elastic properties of the medium of interest in the presence of mesoscopic fractures and pores,is of great interest in the characterization of fractured *** has been very difficult,however,considering that stress interactions between fractures and pores,related to their spatial distributions,tend to play a crucial role on affecting overall dynamic elastic properties that are largely *** thus choose to quantitatively investigate frequency-dependent P-wave characteristics in fractured porous rocks at the scale of a representative sample using a numerical scale-up procedure via performing finite element *** on 2-D numerical quasi-static experiments,effects of fracture and fluid properties on energy dissipation in response to wave-induced fluid flow at the mesoscopic scale are quantified via solving Biot's equations of *** show that numerical results are sensitive to some key characteristics of probed synthetic rocks containing unconnected and connected fractures,demonstrating that connectivity,aperture and inclination of fractures as well as fracture infills exhibit strong impacts on the two manifestations of WIFF mechanisms in the connected scenario,and on resulting total wave attenuation and phase ***,in turn,illustrates the importance of these two WIFF mechanisms in fractured rocks and thus,a deeper understanding of them may eventually allow for a better characterization of fracture systems using seismic ***,this presented work combines rock physics predictions with seismic numerical simulations in frequency domain to illustrate the sensitivity of seismic signatures on the monitoring of an idealized geologic CO_(2) sequestration in fractured *** simulation demonstrates that these two WIFF mechanisms can strongly modify seismic records and hence,indicating that incorporating the two energy dis

关键词： Attenuation and dispersion Rock physics Fractured media Frequency dependence Numerical study

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New recessive compound heterozygous variants of RP1L1 in RP1L1 maculopathy

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 107-112页

作者： wen-Chao Cao Qing-Shan Chen Run Gan tao Huang Xiao-he Yan The Second Clinical Medical College Jinan UniversityShenzhen 518040Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChin

AIM:To identify a maculopathy patient caused by new recessive compound heterozygous variants in ***:Comprehensive retinal morphological and functional examinations were evaluated for the patient with RP1L1 *** sequence capture array technique was used to screen potential pathologic *** chain reaction and Sanger sequencing were used to confirm the screening ***:Fundus examination showed round macular lesions appeared in both *** coherence tomography showed that the inner segment/outer segment continuity was disorganized and disruptive in the left eye,but it was uneven and slightly elevated in the right *** autofluorescence showed patchy hyper-autofluorescence in the *** field examination indicates central defects in both ***(ERG)and multifocal ERG showed no obvious *** fluorescein angiography in the macula showed obviously irregular hyper-fluorescence in the right eye and slightly hyper-fluorescence in the left *** found that the proband carried a missense variant(c.1972C>T)and a deletion variant(c.4717_4718del)of RP1L1,which were originated from the parents and formed compound heterozygous *** variants are likely pathogenic according to the ACMG *** imaging,ERG and detailed medical history are important diagnostic tools for differentiating between acquired and inherited retinal ***:A maculopathy case with detailed retinal phenotype and new recessive compound heterozygous variants of RP1L1 is identified in a Chinese family,which expands the understanding of phenotype and genotype in RP1L1 maculopathy.

关键词： maculopathy recessive compound heterozygous variants RP1L1

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Corrugated Graphene Paper Reinforced Silicone Resin Composite for Efficient Interface Thermal Management

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Chinese Journal of Polymer Science 2024年第7期42卷 1002-1014,I0010页

作者： Bo-wen Wang heng Zhang Qing-Xia he Hui-tao Yu Meng-Meng Qin Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China International Engineering Institute Tianjin UniversityTianjin300350China

With the rapid development of high-power-density electronic devices,interface thermal resistance has become a critical barrier for effective heat management in high-performance electronic ***,there is an urgent demand for advanced thermal interface materials(TIMs)with high cross-plane thermal conductivity and excellent compressibility to withstand increasingly complex operating *** achieve this aim,a promising strategy involves vertically arranging highly thermoconductive graphene on ***,with the currently available methods,achieving a balance between low interfacial thermal resistance,bidirectional high thermal conductivity,and large-scale production is ***,we prepared a graphene framework with continuous filler structures in in-plane and cross-plane directions by bonding corrugated graphene to planar graphene *** interface interaction between the graphene paper framework and polymer matrix was enhanced via surface functionalization to reduce the interface thermal *** resulting three-dimensional thermal framework endows the polymer composite material with a cross-plane thermal conductivity of 14.4 W·m^(-1)·K^(-1)and in-plane thermal conductivity of 130W·m^(-1)·K^(-1)when the thermal filler loading is 10.1 wt%,with a thermal conductivity enhancement per 1 wt%filler loading of 831%,outperforming various graphene structures as *** its high thermal conductivity,low contact thermal resistance,and low compressive modulus,the developed highly thermoconductive composite material demonstrates superior performance in TIM testing compared with TFLEX-700,an advanced commercial TIM,effectively solving the interfacial heat transfer issues in electronic *** novel filler structure framework also provides a solution for achieving a balance between efficient thermal management and ease of processing.

关键词： Graphene paper Vertically aligned structure Cross-plane thermal conductivity Low compressive modulus Thermal interface material

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Low profile cavity-embedded ultra-wideband UHF array antenna with end-fire beams

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Journal of Electronic Science and Technology 2024年第2期22卷 24-35页

作者： Huan he wen-Song Wang Southwest China Institute of Electronic Technology Chengdu610036China School of Electrical and Electronic Engineering Department Nanyang Technological UniversitySingapore639798Singapore

A low-profile,vertically polarized,ultra-wideband array antenna with end-fire beams operating in an ultra-high frequency(UHF)band is developed in this *** array antenna consists of 1×16 log-periodic top-hat loaded monopole antenna arrays and is feasible to embed into a shallow cavity to further reduce the array *** is introduced in the proposed antenna element to reduce profile height and the rectangular top hats are carefully designed to minimize the transverse *** results show that when the antenna array operates in a frequency range of 300 MHz-900 MHz,the end-fire radiation pattern achieves±45°scanning range in the horizontal *** prototypes of the proposed end-fire antenna element and a uniformly spaced linear array(1×2)are fabricated and *** end-fire antenna array should be suitable for airborne applications where low-profile and conformal scanning phased antenna arrays with end-fire radiations are *** design is attractive for airborne platform applications that are used to search,discover,identify,and scout the aerial target with vertically polarized beams.

关键词： End-fire radiation Low-profile Vertical polarization Log-periodic array

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The Influence of the Sun and Moon on the Observation of Very High Energy Gamma-ray Sources Using EAS Arrays

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Research in Astronomy and Astrophysics 2024年第6期24卷 245-252页

作者： tao wen Songzhan Chen Benzhong Dai School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China

With great advance of ground-based extensive air shower arrays,such as LHAASO and HAWC,many very high energy(Vhe)gamma-ray sources have been discovered and are being monitored regardless of the day and the ***,the Sun and Moon would have some impacts on the observation of gamma-ray sources,which have not been taken into account in previous *** this paper,the influence of the Sun and Moon on the observation of very high energy gamma-ray sources when they are near the line of sight of the Sun or Moon is *** tracks of all the known Vhe sources are scanned and several Vhe sources are found to be very close to the line of sight of the Sun or Moon during some *** absorption of very high energy gamma rays by sunlight is estimated with detailed method and some useful conclusions are *** main influence is the block of the Sun and Moon on gamma rays and the shadow on the cosmic ray *** influence is investigated considering the detector angular resolution and some strategies on data analysis are proposed to avoid the underestimation of the gamma-ray emission.

关键词： astroparticle physics Sun:general methods:observational Sun:UV radiation

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Study on a conical bearing for acceleration-sensitive equipment

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 103-128页

作者： Pang Hui Xu wen Dai Junwu Jiang tao Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China School of Civil Engineering and Transportation Beihua UniversityJilin 132013China

Seismic isolation effectively reduces seismic demands on building structures by isolating the superstructure from ground vibrations during ***,isolation strategies give less attention to acceleration-sensitive systems or ***,as the isolation layer’s displacement grows,the stiffness and frequency of traditional rolling and sliding isolation bearings increases,potentially causing self-centering and resonance *** a result,a new conical pendulum bearing has been selected for acceleration-sensitive equipment to increase self-centering capacity,and additional viscous dampers are incorporated to enhance system ***,the theoretical formula for conical pendulum bearings is supplied to analyze the device’s dynamic parameters,and shake table experiments are used to determine the proposed device’s isolation efficiency under various *** to the test results,the newly proposed devices have remarkable isolation performance in terms of minimizing both acceleration and displacement ***,a numerical model of the isolation system is provided for further research,and the accuracy is demonstrated by the aforementioned experiments.

关键词： seismic isolation acceleration-sensitive equipment the conical pendulum bearing shake table tests isolation performance,numerical model

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In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： Wei-Jian Guo Ao Zhou wen-wen Cai Jin-tao Zhang Key Laboratory for Colloid and Interface Chemistry (Ministry of Education) School of Chemistry and Chemical EngineeringShandong University

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO2) into high-value chemicals, thereby presenting a promising avenue toward achieve carbon neutrality. However, addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting task. In this study, the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ pyrolysis. The porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer, thus enhancing their electrocatalytic activity and stability. Additionally, nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions, thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical calculation. Consequently, Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential windows. Notably, its faradaic efficiency(FE) of formate reaches 92.7% in H-cell and94.9% in flow cell, respectively, with good electrocatalytic stability. The in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Carbon dioxide reduction Electron delocalization N-doping Porous carbon nanofiber

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Interaction of yttrium barrier and calcium-rich phase on production and properties of WC precursor powders and alloys

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Journal of Rare Earths 2024年第1期42卷 228-236,I0008页

作者： wen he Dunqiang Tan Zhiqiang Yi Zhiqiang Liu School of Materials Science and Engineering Nanchang UniversityNanchang330031China Instrumental Analysis Center of Nanchang Hangkong University Nanchang330063China

In order to reduce or eliminate the adverse effects of calcium impurity,the interaction of Ca and rare earth Y co-doping on the preparation of WC-Co cemented carbides was investigated.X-ray diffraction,scanning electron microscopy and transmission electron microscopy were employed to analyze the phase compositions,particle sizes and morphologies of them,*** results show that the second type of"yttrium barrier effect"is observed and the adverse influence of Ca-rich phase on tungsten powder can be eliminated by *** flexural strength and fracture toughness of YG6-0.01%Ca+0.09%Y alloy are 2199.5 MPa and 11.49 MPa·m^(1/2),showing improvement of 6.5% and 2.7% compared to YG6 alloy,*** evolutions of Ca-rich phase and Y-rich phase at the every alloy preparation stage of WO_(3),W,WC and cemented carbides are ***,the strengthening mechanism of WC-Co cemented carbide with co-addition of Ca and Y is proposed.

关键词： Yttrium barrier effect Ca-rich phase WC-Co cemented Carbide Microstructures Mechanisms Rare earths

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