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Body mass index and outcomes of patients with cardiogenic shock:A systematic review and meta-analysis

World Journal of Clinical Cases 2022年第30期10卷 10956-10966页

作者： wen-xia tao Guo-Ying Qian Hong-Dan Li Feng Su Zhou Wang Department of Cardiovascular Medicine Huzhou Cent HospitalAffiliated Cent Hospital Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Cardiogenic shock continues to be a highly morbid complication that affects around 7%-10% of patients with acute myocardial infarction or heart ***,obesity has become a worldwide *** To analyze the impact of higher body mass index(BMI) on outcomes of patients with cardiogenic *** A systematic and comprehensive search was undertaken on the electronic databases of PubMed,Embase,ScienceDirect,CENTRAL,and Google Scholar for all types of studies comparing mortality outcomes of patients with cardiogenic shock based on *** studies defined overweight or obese patients based on the World Health Organization BMI *** data were then extracted and assessed on the basis of the Reference Citation Analysis(https://***/).RESULTS Five studies were *** pooled analysis of multivariable-adjusted ratios,we noted a statistically significantly reduced risk of mortality in overweight/obese vs normal patients(three studies;odds ratio [OR] = 0.92,95% confidence interval [CI]:0.85-0.98,I~2 = 85%).On meta-analysis,we noted that crude mortality rates did not significantly differ between overweight/obese and normal patients after cardiogenic shock(OR = 0.95,95%CI:0.79-1.15,I~2 = 99%).The results were not stable on sensitivity analysis and were associated with substantial *** Current evidence on the association between overweight/obesity and mortality after cardiogenic shock is scarce and *** obesity paradox might exist in patients with cardiogenic shock but could be confounded by the use of mechanical circulatory *** is a need for further studies to clarify this relationship.

关键词： Obese Overweight Myocardial infarction Shock Mortality

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Predicting visual acuity with machine learning in treated ocular trauma patients

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1005-1014页

作者： Zhi-Lu Zhou Yi-Fei Yan Jie-Min Chen Rui-Jue Liu xiao-Ying Yu Meng Wang Hong-xia Hao Dong-Mei Liu Qi Zhang Jie Wang wen-tao xia Department of Forensic Medicine Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformInstitute of Forensic ScienceMinistry of JusticeShanghai 200063China The SMART(Smart Medicine and AI-based Radiology Technology)Lab Shanghai Institute for Advanced Communication and Data ScienceShanghai UniversityShanghai 200444China School of Communication and Information Engineering Shanghai UniversityShanghai 200444China Basic Medical College Jiamusi UniversityJiamusi 154007Heilongjiang ProvinceChina

AIM:To predict best-corrected visual acuity(BCVA)by machine learning in patients with ocular trauma who were treated for at least ***:The internal dataset consisted of 850 patients with 1589 eyes and an average age of *** initial visual acuity was 0.99 log *** test dataset consisted of 60 patients with 100 eyes collected while the model was *** different machine-learning algorithms(Extreme Gradient Boosting,support vector regression,Bayesian ridge,and random forest regressor)were used to predict BCVA,and four algorithms(Extreme Gradient Boosting,support vector machine,logistic regression,and random forest classifier)were used to classify BCVA in patients with ocular trauma after treatment for 6mo or *** features were obtained from outpatient records,and ocular parameters were extracted from optical coherence tomography images and fundus *** features were put into different machine-learning models,and the obtained predicted values were compared with the actual BCVA *** best-performing model and the best variable selected were further evaluated in the test ***:There was a significant correlation between the predicted and actual values[all Pearson correlation coefficient(PCC)>0.6].Considering only the data from the traumatic group(group A)into account,the lowest mean absolute error(MAE)and root mean square error(RMSE)were 0.30 and 0.40 log MAR,*** the traumatic and healthy groups(group B),the lowest MAE and RMSE were 0.20 and 0.33 log MAR,*** sensitivity was always higher than the specificity in group A,in contrast to the results in group *** classification accuracy and precision were above 0.80 in both *** MAE,RMSE,and PCC of the test dataset were 0.20,0.29,and 0.96,*** sensitivity,precision,specificity,and accuracy of the test dataset were 0.83,0.92,0.95,and 0.90,***:Predicting BCVA using machine-learning models in patients wit

关键词： ocular trauma predicting visiual acuity best-corrected visual acuity visual dysfunction machine learning

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang xia Ning Xu wen Sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

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聚氨酯涂层性能与织物梯形撕裂强力的相关性

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印染 2007年第18期33卷 28-30页

作者：黄时建高琮陶文霞上海工程技术大学服装学院上海201620 上海纺发产业用品有限公司上海200050

研究了聚氨酯涂层织物的模量、断裂强力及断裂伸长率与其梯形撕裂强力之间的关系。试验所得数据经SPSS软件处理,分析结果表明:涂层剂树脂型号和焙烘温度等涂层工艺参数会改变织物的模量、拉伸强力及断裂伸长率,进而对撕裂强力产生影响... 详细信息

研究了聚氨酯涂层织物的模量、断裂强力及断裂伸长率与其梯形撕裂强力之间的关系。试验所得数据经SPSS软件处理,分析结果表明:涂层剂树脂型号和焙烘温度等涂层工艺参数会改变织物的模量、拉伸强力及断裂伸长率,进而对撕裂强力产生影响。因此,涂层织物的梯形撕裂强度是可以控制的,梯形撕裂强力下降并不是织物涂层整理后的必然结果。

关键词：涂层整理聚氨酯撕裂强力弹性模量织物

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不同测试体位对屈腕、屈指肌群定量肌力的影响及其标准化

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法医学杂志 2024年第3期40卷 237-244,253页

作者：杨泽人高东夏晴冉聃盛延良夏文涛佳木斯大学基础医学院微生态-免疫调节网络与相关疾病重点实验室黑龙江佳木斯154000 司法鉴定科学研究院上海市法医学重点实验室司法部司法鉴定重点实验室上海市司法鉴定专业技术服务平台上海200063

目的探究不同测试体位对手、腕屈曲肌群定量肌力的影响,建立各肌群的标准化肌力检测方案。方法征集40例健康受试者(男性12例,女性28例),使用MicroFET2TM便携式数字肌力测试仪,分别于腕关节背伸30°位、中立0°位和掌屈30°位测量各手... 详细信息

目的探究不同测试体位对手、腕屈曲肌群定量肌力的影响,建立各肌群的标准化肌力检测方案。方法征集40例健康受试者(男性12例,女性28例),使用MicroFET2TM便携式数字肌力测试仪,分别于腕关节背伸30°位、中立0°位和掌屈30°位测量各手指屈曲及腕关节掌屈肌力,分别于拇指掌侧外展30°位和60°位测量拇指掌侧外展肌力。从40例受试者中随机抽取10例,间隔10~15 d后由同一操作者再次测试各肌群定量肌力。结果除男性腕关节背伸30°位和中立0°位之间的拇指屈曲肌力、腕关节掌屈肌力差异无统计学意义(P>0.05),各指屈曲及腕掌屈肌力值主要呈现以下特点:腕关节背伸30°位>腕关节中立0°位>腕关节掌屈30°位,拇指掌侧外展30°位>60°位;所有受试者手指屈曲肌力均为拇指>示指>中指>环指>小指;男性各项肌力值均大于女性(P0.05)。10例受试者不同时期测量肌力值的可靠性良好。结论手、腕各肌群定量肌力均受体位影响,鉴定过程中应采取规范、统一的测试体位。MicroFET2TM用于手、腕关节定量肌力测试具有良好的可靠性。腕关节背伸30°位可作为各手指屈曲肌力及腕关节掌屈肌力的最佳标准化检测条件。拇指掌侧外展30°位可作为拇指掌侧外展肌力的最佳标准化检测条件。

关键词：法医学肌力定量肌力体位手指屈曲腕关节

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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眼外伤评分与眼球结构参数在眼外伤愈后视力评估中的价值

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国际眼科杂志 2023年第2期23卷 261-266页

作者：周智露王杰夏文涛陈捷敏郝虹霞贵州医科大学法医学院贵州省贵阳市550009 司法鉴定科学研究院司法部司法鉴定重点实验室上海市法医学重点实验室上海市司法鉴定专业技术服务平台上海市200063 佳木斯大学基础医学院黑龙江省佳木斯市154007

目的:探讨眼外伤评分(OTS)、初诊视力与眼球结构参数在眼外伤愈后视力评估中的价值。方法:选取司法鉴定科学研究院2015-06/2021-06受理并出具明确鉴定意见的眼外伤者302例302眼,根据眼外伤愈后最佳矫正视力(BCVA)进行分组,Ⅰ组63例63眼,... 详细信息

目的:探讨眼外伤评分(OTS)、初诊视力与眼球结构参数在眼外伤愈后视力评估中的价值。方法:选取司法鉴定科学研究院2015-06/2021-06受理并出具明确鉴定意见的眼外伤者302例302眼,根据眼外伤愈后最佳矫正视力(BCVA)进行分组,Ⅰ组63例63眼,BCVA<3.7;Ⅱ组70例70眼3.7≤BCVA<4.5;Ⅲ组78例78眼,4.5≤BCVA<4.9;Ⅳ组91例91眼,BCVA≥4.9。另选取纳入的眼外伤者健眼77例77眼作为对照组即Ⅴ组。分析纳入研究对象的眼外伤愈后BCVA和眼球结构参数及其相关性,并使用IBM SPSS Modeler 18.0软件建立预测眼外伤愈后视力的随机森林(RF)和支持向量机(SVM)模型。结果:纳入眼外伤者初诊视力、OTS评分、眼外伤愈后角膜分级、晶状体分级、眼底分级、视神经周围神经纤维层厚度与眼外伤愈后BCVA均存在相关性(P<0.01)。除中央视网膜厚度外,各组眼球结构参数均有差异(P<0.001)。SVM模型较RF模型预测眼外伤愈后视力的准确率高,误差在0.15以内者准确率达80%以上。结论:OTS评分与眼球结构检查可为眼外伤后视觉功能障碍的法医临床鉴定提供有效信息,在鉴别伪装视觉功能障碍中具有价值。

关键词：眼损伤眼外伤评分眼球结构参数视力预测法医临床学

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伊马替尼在胃肠道间质瘤治疗中的应用

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中国新药与临床杂志 2004年第11期23卷 806-810页

作者：尚雯陶霞刘皋林中国人民解放军第二军医大学附属长征医院药学部上海200003

伊马替尼为苯胺嘧啶的衍生物 ,是一特异性的酪氨酸激酶抑制剂 ,合成于 1992年 ,2 0 0 1年 5月被FDA批准用于治疗慢性粒细胞白血病。最近 ,伊马替尼又被FDA批准用于治疗胃肠道间质瘤(GIST) ,本文主要综述该药的药效学、药动学以及在GIST... 详细信息

伊马替尼为苯胺嘧啶的衍生物 ,是一特异性的酪氨酸激酶抑制剂 ,合成于 1992年 ,2 0 0 1年 5月被FDA批准用于治疗慢性粒细胞白血病。最近 ,伊马替尼又被FDA批准用于治疗胃肠道间质瘤(GIST) ,本文主要综述该药的药效学、药动学以及在GIST治疗中的疗效、不良反应和耐受性。

关键词：胃肠肿瘤药物疗法药动学伊马替尼真肠遭间质瘤

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu xia wenting Ye Yan Sun Jing Cai Fubing Yu Haiping wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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