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Value of the controlling nutritional status score and psoas muscle thickness per height in predicting prognosis in liver transplantation

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World Journal of Clinical Cases 2021年第35期9卷 10871-10883页

作者： Xing Dai Ben Gao Xin-Xin Zhang jiang Li wen-tao jiang Department of Liver Transplant The First Central College of Tianjin Medical UniversityTianjin 300110China Department of Endocrinology Tianjin Medical University Chu Hsien-I Memorial HospitalTianjin 300134China Department of Liver Transplant Tianjin First Central HospitalTianjin 300110China

BACKGROUND Patients with end-stage liver disease usually have varying degrees of malnutrition,and severe malnutrition may affect the prognosis of patients after liver transplantation(LT).However,there is no recommended standard for the nutrition assessment of patients waiting for LT,and it is unknown whether malnutrition has an impact on the occurrence of postoperative *** The study aim was to investigate the value of the controlling nutritional status(CONUT)score and psoas muscle thickness per height(PMTH)in predicting prognosis in *** We retrospectively analyzed the clinical data of 313 patients who underwent classic orthotopic LT from January 2016 to December 2018 in Tianjin First Central Hospital affiliated with Tianjin Medical *** CONUT score is derived from the preoperative serum albumin and total cholesterol levels,and total lymphocyte *** were divided into low(≤4),medium(5–8),and high(9–12)CONUT score groups perioperative characteristics,Clavien-Dindo grade III/IV/V postoperative complications,graft loss and infection,and cumulative postoperative survival in the three groups were compared 3 mo after *** was calculated as the ratio of the transverse thickness of the psoas muscle in the umbilical plane to the height of the *** cutoff values of receiver operating characteristic curves were determined separately for men and *** values were 14.1 cm/m2 for women and 17.9 cm/m2 for *** patients were then divided into low and high PMTH groups by the cutoff *** comparison of data between the two groups was the same as *** Patients with medium and high CONUT scores had lower preoperative serum hemoglobin,more intraoperative red blood cell(RBC)transfusions,longer postoperative intensive care unit stay and hospital stays,higher 7 and 14 preoperative-day serum bilirubin levels,and a higher incidence of postoperative grade III/IV complications and infections than patients with low CONUT scor

关键词： Liver transplantation Controlling nutritional status score Psoas muscle thickness per height Nutrition assessment Complications Prognosis

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Complex liver retransplantation to treat graft loss due to long-term biliary tract complication after liver transplantation: A case report

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World Journal of Clinical Cases 2020年第3期8卷 568-576页

作者： jiang Li Qing-Jun Guo wen-tao jiang Hong Zheng Zhong-Yang Shen Department of Liver Transplant Tianjin First Central Hospital

BACKGROUND Loss of graft function after liver transplantation(LT) inevitably requires liver retransplant. Retransplantation of the liver(Re LT) remains controversial because of inferior outcomes compared with the primary orthotopic LT(OLT).Meanwhile, if accompanied by vascular complications such as arterial and portal vein(PV) stenosis or thrombosis, it will increase difficulties of surgery. We hereby introduce our center’s experience in Re LT through a complicated case of *** SUMMARY We report a patient who suffered from hepatitis B-associated cirrhosis and underwent LT in December 2012. Early postoperative recovery was *** months after LT, the patient’s bilirubin increased significantly and he was diagnosed with an ischemic-type biliary lesion caused by hepatic artery occlusion. The patient underwent percutaneous transhepatic cholangial drainage and repeatedly replaced intrahepatic biliary drainage tube regularly for 5 *** patient developed progressive deterioration of liver function and underwent liver re-transplant in January 2019. The operation was performed in a classic OLT manner without venous bypass. Both the hepatic artery and PV were occluded and could not be used for anastomosis. The donor PV was anastomosed with the recipient’s left renal vein. The donor hepatic artery was connected to the recipient’s abdominal aorta. The bile duct reconstruction was performed in an end-to-end manner. The postoperative process was very uneventful and the patient was discharged 1 mo after *** With the development of surgical techniques, portal thrombosis and arterial occlusion are no longer contraindications for ReLT.

关键词： Liver retransplantation Biliary tract complication Ischemic type biliary lesion Portal vein thrombosis Arterial occlusion Graft liver failure Case report

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Effect of donor age on graft function and longterm survival of recipients undergoing living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 50-55页

作者： Kai Wang wen-tao jiang Yong-Lin Deng Cheng Pan Zhong-Yang Shen Department of Transplant Surgery Tianjin First Center Hospital Key Laboratory of Organ Transplantation of Tianjin

BACKGROUND： Donor shortage is the biggest obstacle in organ transplantation. Living donor liver transplantation（LDLT） has been considered as a valuable approach to shortening waiting time. The objectives of this study were to investigate the feasibility of utilizing donors older than 50 years in LDLT and to evaluate the graft function and recipient ***： All LDLT cases（n=159） were divided into the older（donor age ≥50 years, n=10） and younger（donor age 〈50 years,n=149） donor groups. Donor graft and recipient condition pre-,intra- and post-operation were compared between the two *** particular, graft functions and recipient survivals were ***： The median donor age was 58.5（52.5-60.0） years in the older donor group and 25.0（23.0-32.0） in the younger donor group. There was no significant difference in cold ischemic time, anhepatic phase and operation time between the older and younger donor groups（P〉0.05）. However, the volume of red blood cell transfused in operation was greater in the older donor group than in the younger donor group（1900 vs 1200 m L, P=0.023）. The 1-, 3- and 5-year graft survival rates were 90%, 80% and 80% for the older donor group, and 92%, 87% and 87% for the younger donor group, respectively（P=0.459）.The 1-, 3- and 5-year survival rates were 100%, 90% and 90% for recipients with older grafts, and 93%, 87% and 87% for those with younger grafts, respectively（P=0.811）.CONCLUSION： It is safe for a LDLT recipient to receive liver from donors older than 50 years, and there is no significant adverse effect on graft function and long-term patients’ survival.

关键词： living donor liver transplantation donor age graft liver function long-term survival

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Simultaneous liver, pancreas-duodenum and kidney transplantation in a patient with hepatitis B cirrhosis, uremia and insulin dependent diabetes mellitus

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World Journal of Gastroenterology 2017年第45期23卷 8104-8108页

作者： jiang Li Qing-Jun Guo Jin-Zhen Cai Cheng Pan Zhong-Yang Shen wen-tao jiang Department of Liver Transplant Tianjin First Central Hospital Department of Transplant Surgery Tianjin First Central Hospital

Simultaneous liver,pancreas-duodenum,and kidney transplantation has been rarely reported in the literature. Here we present a new and more efficient en bloc technique that combines classic orthotopic liver and pancreas-duodenum transplantation and heterotopic kidney transplantation for a male patient aged 44 years who had hepatitis B related cirrhosis,renal failure,and insulin dependent diabetes mellitus(IDDM). A quadruple immunosuppressive regimen including induction with basiliximab and maintenance therapy with tacrolimus,mycophenolate mofetil,and steroids was used in the early stage post-transplant. Postoperative recovery was uneventful and the patient was discharged on the 15 th postoperative day with normal liver and kidney function. The insulin treatment was completely withdrawn 3 wk after operation,and the blood glucose level remained normal. The case findings support that abdominal organ cluster and kidney transplantation is an effective method for the treatment of end-stage liver disease combined with uremia and IDDM.

关键词： Insulin dependent diabetes mellitus Cirrhosis Chronic renal failure Transplantation En bloc Liver-pancreas

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Simultaneous partial splenectomy during liver transplantation for advanced cirrhosis patients combined with severe splenomegaly and hypersplenism

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World Journal of Gastroenterology 2021年第7期27卷 654-665页

作者： wen-tao jiang Jian Yang Yan Xie Qing-Jun Guo Da-Zhi Tian Jun-Jie Li Zhong-Yang Shen Department of Liver Transplantation Tianjin First Center HospitalFirst Clinical Institute of Tianjin Medical UniversityTianjin 300192China Organ Transplantation Center Tianjin First Center HospitalTianjin 300192China Department of Hepatological Surgery Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKGROUND The most effective treatment for advanced cirrhosis and portal hypertension is liver transplantation(LT).However,splenomegaly and hypersplenism can persist even after LT in patients with massive *** To examine the feasibility of performing partial splenectomy during LT in patients with advanced cirrhosis combined with severe splenomegaly and *** Between October 2015 and February 2019,762 orthotopic LTs were performed for patients with end-stage liver diseases in Tianjin First Center ***-four cases had advanced cirrhosis combined with severe splenomegaly and *** these patients,41 received partial splenectomy during LT(PSLT group),and 43 received only LT(LT group).Patient characteristics,intraoperative parameters,and postoperative outcomes were retrospectively analyzed and compared between the two *** The incidence of postoperative hypersplenism(2/41,4.8%)and recurrent ascites(1/41,2.4%)in the PSLT group was significantly lower than that in the LT group(22/43,51.2%;8/43,18.6%,respectively).Seventeen patients(17/43,39.5%)in the LT group required two-stage splenic embolization,and further splenectomy was required in 6 of *** operation time and intraoperative blood loss in the PSLT group(8.6±1.3 h;640.8±347.3 mL)were relatively increased compared with the LT group(6.8±0.9 h;349.4±116.1 mL).The incidence of postoperative bleeding,pulmonary infection,thrombosis and splenic arterial steal syndrome in the PSLT group was not different to that in the LT group,*** Simultaneous PSLT is an effective treatment and should be performed in patients with advanced cirrhosis combined with severe splenomegaly and hypersplenism to prevent postoperative persistent hypersplenism.

关键词： Liver transplantation Partial splenectomy Hypersplenism Splenomegaly Liver cirrhotic Megalosplenia

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Liver retransplantation:report of 80 cases and review of literature

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 180-184页

作者： Zhong-Yang Shen Zhi-Jun Zhu Yong-Lin Deng Hong Zheng Cheng Pan Ya-Ming Zhang Rui Shi wen-tao jiang Jian-Jun Zhang Orient Organ Transplant Center First Central Hospital Tianjin 300192 China. shenzy@***.

BACKGROUND: Because the orthotopic liver transplantation (OLT) was performed widely in recent 5 years throughout China, the proportion of recipients whose graft function deteriorated to be retransplantation candidates increased gradually. This study was undertaken to analyze clinical experience of orthotopic liver retransplantation (re-OLT) at our center. METHODS: The medical records of 80 patients who had undergone liver retransplantation at our center from January 1999 to July 2005 were analyzed retrospectively, including indications and timing of retransplantation, surgical techniques, and the causes of death. RESULTS: The commonest cause leading to hepatic graft loss and subsequent retransplantation was biliary complications in 36 patients (45%). The patients underwent retransplantation more than 30 days after their primary transplant recovered better than those who underwent retransplantation within 8-30 days after primary transplantation (peri-operative mortality 19.6% versus 70%). Sepsis (12 of 22 patients, 54.5%) and multiple organ failure (4 of 22 patients, 18.2%) were leading causes of re-OLT recipient deaths. CONCLUSIONS: Proper indications and optimal operative time, surgical procedures, perioperative monitoring and appropriate postoperative treatment contribute to the improvement of the survival rate of patients after liver retransplantation.

关键词： liver retransplantation

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Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： tao Zou Yanwu Dong Zhouhua jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

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基于EMD的高压燃气管道泄漏信号欠定盲分离方法

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振动与冲击 2013年第18期32卷 81-86页

作者：孙洁娣郝雅立温江涛李香文燕山大学信息科学与工程学院河北秦皇岛066004 燕山大学河北省测试计量技术及仪器重点实验室河北秦皇岛066004 中国石油天然气管道通信电力工程总公司河北廊坊065000

为能将城市高压燃气管道泄漏产生的应力波信号中混有多种干扰振动及噪声的有效泄漏信号与多源混合振动信号分离,提出基于EMD的泄漏信号欠定盲分离方法。对传感器采集的混合信号进行经验模态分解;对各固有模态函数归一化峭度特征进行分析... 详细信息

为能将城市高压燃气管道泄漏产生的应力波信号中混有多种干扰振动及噪声的有效泄漏信号与多源混合振动信号分离,提出基于EMD的泄漏信号欠定盲分离方法。对传感器采集的混合信号进行经验模态分解;对各固有模态函数归一化峭度特征进行分析,选取含主要泄漏信息的固有模态函数进行重构;构造由重构信号及观测信号组成的矩阵,用扩展联合对角化算法实现信号分离,以解决欠定情况下的盲分离问题。实验结果表明该方法能较好实现有效泄漏信号的提取。

关键词：管道泄漏检测经验模态分解(EMD) 欠定盲源分离

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基于HHT的地面活动目标定位方法的研究

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振动与冲击 2009年第5期28卷 169-171,187,198页

作者：孙洁娣温江涛靳世久天津大学精密测试技术与仪器国家重点实验室天津300072 燕山大学信息科学与工程学院河北秦皇岛066004 燕山大学电气工程学院河北秦皇岛066004

针对广泛存在的油气管道周边安全问题,研究了管道周围地面活动目标产生的震动信号的特性,阐述了采用不同传感器测量信号到达时间差来进行定位的方法。地面震动信号是非平稳信号,采用希尔伯特黄变换(HHT)处理信号获得其特征频率、幅值与... 详细信息

针对广泛存在的油气管道周边安全问题,研究了管道周围地面活动目标产生的震动信号的特性,阐述了采用不同传感器测量信号到达时间差来进行定位的方法。地面震动信号是非平稳信号,采用希尔伯特黄变换(HHT)处理信号获得其特征频率、幅值与发生的时间,进行目标定位。设计了数据采集系统,通过多个传感器采集目标产生的震动信号,经HHT方法处理得到不同测量信号中目标特征频率出现的时间,结合时间差异和传感器阵列与目标的相对位置实现定位。通过对实验采集数据的分析验证了文中提出的方法。

关键词：目标定位希尔伯特黄变换经验模态分解时频分析地震动信号

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