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Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity

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Cellular & Molecular Immunology 2021年第2期18卷 472-483页

作者： Pei-Chi Chen Yu-Ting Shao Miao-Hsi Hsieh Hui-Fang Kao Wen-Shuo Kuo Shih-Min Wang Shun-Hua Chen Lawrence Shih Hsin Wu Hui-Ju Tsai Jiu-Yao Wang Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Microbiology and Immunology College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Center for Allergy and Clinical Immunology Research College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Nursing National Tainan Junior College of NursingTainanTaiwanChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjingChina Department of Pediatrics National Cheng Kung University HospitalTainanTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Division of Biostatistics and Bioinformatics Institute of Population Health SciencesNational Health Research InstitutesZhunanTaiwanChina Department of Pediatrics National Cheng Kung University HospitalNo139Sheng-Li RoadTainan 70428 TaiwanChina

Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonetheless,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is unknown.Early-life enterovirus infection was correlated with higher risks of allergic diseases in children.Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period.Bone marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.

关键词： trained immunity allergy asthma

Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease

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Cellular & Molecular Immunology 2023年第1期20卷 38-50页

作者： Miao-Hsi Hsieh Pei-Chi Chen Han-Yin Hsu Jui-Chang Liu Yu-Sheng Ho Yuh Jyh Lin Chin-Wei kuo Wen-Shuo Kuo Hui-Fang Kao Shulhn-Der Wang Zhi-Gang Liu Lawrence Shih-Hsin Wu Jiu-Yao Wang Center for Allergy Immunologyand Microbiome(A.I.M.)China Medical University HospitalTaichungTaiwanChina Graduate Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Nursing National Tainan Junior College of NursingTainanTaiwanChina Graduate Institute of Biochemistry and Molecular Biology College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Pediatrics National Cheng Kung University HospitalTainanTaiwanChina Division of Pulmonary Medicine Department of Internal MedicineNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainanTaiwanChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjingChina School of Post-Baccalaureate Chinese Medicine China Medical UniversityTaichungTaiwanChina Department of Respirology and Allergy Third Affiliated Hospital of Shenzhen UniversityShenzhenChina Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Allergy Immunologyand Rheumatology(AIR)China Medical University Children’s HospitalTaichungTaiwanChina

Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to cigarette smoke (CS). However, the roles and molecular mechanisms of SP-D and FMs in COPD have not yet been determined. In this study, increased levels of SP-D were found in the bronchoalveolar lavage fluid (BALF) and sera of ozone- and CS-exposed mice. Furthermore, SP-D-knockout mice showed increased lipid-laden FMs and airway inflammation caused by ozone and CS exposure, similar to that exhibited by our study cohort of chronic smokers and COPD patients. We also showed that an exogenous recombinant fragment of human SP-D (rfhSP-D) prevented the formation of oxidized low-density lipoprotein (oxLDL)-induced FMs in vitro and reversed the airway inflammation and emphysematous changes caused by oxidative stress and CS exposure in vivo. SP-D upregulated bone marrow-derived macrophage (BMDM) expression of genes involved in countering the oxidative stress and lipid metabolism perturbations induced by CS and oxLDL. Our study demonstrates the crucial roles of SP-D in the lipid homeostasis of dysfunctional alveolar macrophages caused by ozone and CS exposure in experimental mouse emphysema, which may provide a novel opportunity for the clinical application of SP-D in patients with COPD.

关键词： Alveolar macrophages Chronic obstructive pulmonary diseases Surfactant protein D Lipid metabolism Ozone Cigarettes

Medium-Mn steels for hot forming application in the automotive industry

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 741-753页

作者： shuo-shuo Li Hai-wen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Advanced high-strength steels have been widely used to improve the crashworthiness and lightweight of vehicles.Different from the popular cold stamping,hot forming of boron-alloyed manganese steels,such as 22MnB5,could produce ultra-high-strength steel parts without springback and with accurate control of dimensions.Moreover,hot-formed medium-Mn steels could have many advantages,including better mechanical properties and lower production cost,over hot-formed 22MnB5.This paper reviews the hot forming process in the automotive industry,hot-formed steel grades,and medium-Mn steel grades and their application in hot forming in depth.In particular,the adaptabilities of medium-Mn steels and the presently popular 22MnB5 into hot forming were compared thoroughly.Future research should focus on the technological issues encountered in hot forming of medium-Mn steels to promote their commercialization.

关键词： medium-Mn transformation-induced plasticity steel hot forming mechanical properties retained austenite baking

Vacancies-rich CoAl monolayer layered double hydroxide as efficient superoxide dismutase-like nanozyme

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Nano Research 2022年第9期15卷 7940-7950页

作者： shuo Zhang Jun Chen wen-Sheng Yang Xu Chen State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

With the extensive development of nanozymes in recent years,catalytic efficiency has been considered as the Gordian knot that restricts the further applications of nanozyme.Moreover,the usage of layered double hydroxides(LDHs)as antioxidant nanozymes for scavenging reactive oxygen species(ROS)has not been studied.Herein,we report a vacancies-rich monolayer cobalt-alumina LDH nanosheet(m-CoAl-LDH)through a facile direct synthesis method as an efficient nanozyme with superoxide dismutase(SOD)-like activity.The m-CoAl-LDH exhibits a record-breaking catalytic efficiency with the catalytic constant(Kcat)as high as 4.33×10^(11)M^(−1)·s−1.Elucidated by the experimental and theoretical studies,the abundant oxygen and metal vacancies were existed in the single layer for the outstanding performance owing to the increased active sites.In addition,density functional theory(DFT)calculations further reveal the significant role of synergistic effect of oxygen and metal vacancies in reducing the adsorption energy of superoxide(O_(2)^(•−)),which improves the catalytic performance.The m-CoAl-LDH nanosheets were applied in cells to relieving the oxidative damage caused by O_(2)^(•−)in mitochondria.Such vacancy-rich monolayer CoAl-LDH nanosheets represent the first example of LDH nanozyme with specific SOD-like activity as well as record high catalytic efficiency,which may provide deeper insight into efficient nanozyme design by defect-engineering.

关键词： nanozymes superoxide dismutase layered double hydroxides defect catalytic efficiency

Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing Ma Bo Wang Xiaodi Li shuo Wang wen Wang Yongzhen Peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen removal.However,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater treatment.In this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of bio-carriers.By using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 days.The long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,respectively.By eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase V.Both in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and anammox.Moreover,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial denitrification.Overall,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass Bio-carriers Partial denitrification Mainstream wastewater

Optimal Technology Investment under Emission Trading Policy

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Journal of Systems Science and Systems Engineering 2020年第2期29卷 143-162页

作者： shuo Huang Zhong wen Jian Chen Ning Cui School of Economics and Management Tsinghua UniversityBeijing 100084China Beijing Foreign Studies University China Southern Asset Management Co. Ltd.

Low-carbon economy is gaining growing attention nowadays as global warming intensifies.As a market-based policy,emission trading policy is widely considered an effective means to achieve the doublewin of economic development and environmental protection.Under such circumstances,carbon trading markets are developing rapidly in many countries and regions,demanding more attention to compliance strategy issues for emission-intensive companies.In this study,we build a dynamic programming model in search of the optimal emission trading and technology investment decisions for a make-to-order company faced with a stochastic demand under emission trading policy.After a comprehensive analysis of the proposed model,we find that an optimal emission permit level,which increases in carbon penalty and decreases in carbon price,exists in each period.As for the abatement technology investment decision,the firm should invest only ff the investment cost per unit of abatement effort is less than a certain threshold,which increases in carbon penalty and carbon price.On the basis of a two-period dynamic programming model,we further explore the problem of investment timing.Results show how optimal investment decisions are influenced by the speed of technology progress under different parameters.These findings are important for firms to choose the time of investment depending on specific situations.

关键词： Low-carbon emission trading compliance strategy investment-timing

A long and winding road to understand latent autoimmune diabetes in adults

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Chinese Medical Journal 2021年第1期134卷 1-4页

作者： shuo-Ming Luo Bing-wen Liu wen-Feng Yin Xia Li Zhi-Guang Zhou Department of Metabolism and Endocrinology The Second Xiangya HospitalCentral South UniversityKey Laboratory of Diabetes Immunology(Central South University)Ministry of EducationNational Clinical Research Center for Metabolic DiseasesChangshaHunan 410011China

Latent autoimmune diabetes in adults(LADA)describes a subgroup of patients who develop phenotypic type 2 diabetes(T2D)but with markers of islet autoimmunity.It is under debate whether LADA is a subtype of type 1 diabetes(T1D)or a unique disease.LADA comprises about 1.5%to 14.2%in phenotypic T2D depending on ethnicity.It is the most common form of autoimmune diabetes diagnosed in adults,with 3.3-to 12.2-fold higher prevalence than that of adult-onset T1D.

关键词： autoimmune diabetes islet

Dynamic response characteristics of a circular lined tunnel under anisotropy frost heave of overlying soil at the tunnel portal section in cold regions

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Journal of Mountain Science 2023年第5期20卷 1424-1440页

作者： ZHANG shuo-cheng CHEN wen-hua School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China

The rapid development of traffic engineering in cold regions and its consequent problems need to be considered.In this paper,the dynamic response characteristics of the tunnel portal section in cold regions with harmonic load acting on the lining were studied in the frequency domain.The lining is in close contact with the frozen soil,and there is relative movement between the frozen and unfrozen soil due to the phase change.The analytical solution of the vibration of tunnel portal section caused by the harmonic load acting on the lining was derived under the consideration of the anisotropy frost heave of overlying soil.Based on the continuity conditions and boundary conditions,the undetermined coefficients were obtained,and the analytical solutions for different medium displacements and stresses of the cold-region tunnel system were acquired.The vertical pressure coefficient was equivalently simplified as a variable that could be used to replace the thickness of the overlying soil above the tunnel.The analysis of the parameter model shows that the change of the medium parameters(lining,frozen,and unfrozen soil)affects the circumferential stresses,the radial displacements and their peak frequencies of the soil.For example,the increase of density ratio of tunnel lining to frozen soil decreases the radial stresses of the frozen and unfrozen soil;the increase of volumetric frost heaving strain of the frozen soil increases the radial displacements of the frozen surface and decreases the stability of the frozen surface;the increasing of thickness of the frozen soil significantly reduces the radial displacement of unfrozen soil at dimensionless radius η=4.5 compared with that of frozen soil at η=1.5.

关键词： Frost heave Tunnel portal section Relative movement Dynamic response characteristics Cold region

Robust Assignment of Airport Gates with Operational Safety Constraints

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International Journal of Automation and computing 2016年第1期13卷 31-41页

作者： shuo Liu wen-Hua Chen Jiyin Liu Department of Aeronautical and Automotive Engineering Loughborough University School of Business and Economics Loughborough University

This paper reviews existing approaches to the airport gate assignment problem （AGAP） and presents an optimization model for the problem considering operational safety constraints. The main objective is to minimize the dispersion of gate idle time periods （to get robust optimization） while ensuring appropriate matching between the size of each aircraft and its assigned gate type and avoiding the potential hazard caused by gate apron operational conflict. Genetic algorithm is adopted to solve the problem, An illustrative example is given to show the effectiveness and efficiency of the algorithm. The algorithm performance is further demonstrated using data of a terminal from Beijing Capital International Airport （PEK）.

关键词： Gate assignment problem operational safety constraints robust optimization conflict avoidance genetic algorithm.