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Achieving further refinement of grain structure and improvement of mechanical properties in Al-12Si-4Cu-2Ni-1Mg alloy by Al-Ti-C-B master alloy addition and deep cryogenic treatment

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China Foundry 2025年第1期22卷 75-82页

作者： lin-fei Xia wen-bo Li Zuo-shan Wei Yu-ying Wu Xiang-fa Liu China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China Shandong Key Laboratory of Advanced Aluminum Materials and Technology Binzhou Institute of TechnologyBinzhou 256600ShandongChina

Near-eutectic Al-Si alloys are widely used in automotive manufacturing due to their superior wear resistance and high temperature *** of high Si content,the grain refinement of near-eutectic Al-Si alloy has been a problem for many *** this study,the effect of deep cryogenic treatment(DCT)on the microstructure and mechanical properties of Al-12Si-4Cu-2Ni-Mg alloy with addition of Al-Ti-C-B master alloy was fully *** show that the average grain size of the alloy is greatly reduced from 0.92 mm to 0.50 mm,and the eutectic Si and Al7Cu4Ni precipitates are spheroidized and refined in Al-12Si-4Cu-2Ni-Mg after DCT for 24 h and aging *** these changes of microstructures result in a significant increment of about 22.5%in elongation and a slight enhancement of about 6.8%in tensile ***,the refinement of microstructure also significantly improves the fatigue life of the alloy.

关键词： deep cryogenic treatment near-eutectic Al-Si master alloy microstructure mechanical properties

Thermal distribution and response in Q-switched ruby laser treatment for oculodermal melanosis (Nevus of Ota)

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Plastic and Aesthetic Research 2017年第1期4卷 1-8页

作者： David Cheong Chon Fok Cheng-Jen Chang Yun-Liang Su Shu-Ying Chang Yen-Chang Hsiao Kuen Ting wen-shiung lin Kuen-Tasnn Chen Shih-Feng Chen Department of Plastic Surgery Chang Gung Memorial HospitalChang Gung UniversityTaoyuan 333TaipeiChina Department of Plastic Surgery Taipei Medical University HospitalTaipei 110TaipeiChina Department of Applied Mathematics National Chung Hsing UniversityTaichung 402TaipeiChina Department of Mechanical Engineering Lunghwa University of Science and TechnologyTaoyuan 333TaipeiChina.

Aim: A clinically useful treatment laser must generate stable and precise energy of low diffusivity. This study assessed the photothermal response of a Q-switched ruby laser (QSRL) in the treatment of oculodermal melanosis (Nevus of Ota).Methods: A two-year retrospective review of 40 patients with oculodermal melanosis treated with a QSRL (λ = 694 nm, pulse duration = 25 ns, 3 mm spot size, energy density 6-10 J/cm2) was performed. Demographics included an age range of 18-54 years (mean 28) and a gender distribution of 25 females and 15 males. The values recorded from real-time infrared thermal imaging of the lasered skin were inserted into standard thermal wave equations. This permitted analysis of the resultant temperature distributions related to the energy ***: Skin temperature was unchanged during the initial heating stage. This was followed by a very rapid temperature rise. A thermal burn injury manifested by dermal-epidermal disruption, resulted when the energy density of the QSRL exceeded 8 J/cm2 (> 44℃).Conclusion: The use of infrared thermal imaging with a standard thermal wave equation allows prediction of skin temperature distribution when QSRL is used for the treatment of oculodermal melanosis. With the use of appropriate settings, complications may be minimized.

关键词： Infrared thermal imaging thermal wave equation Q-switched ruby laser Nevus of Ota

A special core-shell material(Mxene@Ag@Phytate)to improve EVA composite fire safety,radiation cross-linking effect,and electromagnetic shielding

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Nuclear Science and Techniques 2025年第2期36卷 27-39页

作者： Si-Yi Xu Dan-Yi Li wen-Rui Wang lin lin Ying Sun Ji-Hao Li lin-Fan Li Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

High-performance MXene-based polymer nanocomposites are well-suited for various industrial applications owing to their excellent mechanical,thermal,and other ***,the fabrication of flame-retardant polymer/MXene nanocom-posites remains challenging owing to the limited flame-retardant properties of MXene *** study prepared a novel MXene@Ag@PA hybrid material via radiation modification and complexation *** material was used to further enhance the key properties of ethylene-vinyl acetate(EVA),such as its mechanical properties,thermal conductivity,flame retardancy,and electromagnetic *** addition of two parts of this hybrid material increased the thermal conduc-tivity of EVA by 44.2%and reduced its peak exothermic rate during combustion by 30.1%compared with pure *** material also significantly reduced smoke production and increased the residue *** the X-band,the electromagnetic shielding effectiveness of the EVA composites reached 20 ***,the MXene@Ag@PA hybrid material could be used to further enhance the mechanical properties of EVA composites under electron-beam ***,this study contributes to the development of MXene-based EVA advanced materials that are fire-safe,have high strength,and exhibit good electromagnetic shielding performance for various applications.

关键词： MXene@Ag@PA Ethylene-vinyl acetate(EVA) Flame retardancy Electromagnetic shielding performance

Corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 143-156页

作者： Meng-zhen ZHU Jing-lei MIAO Xiong-wen ZHOU Er-lin ZHANG Zhi-lin LIU Hai-lin YANG State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China The Third Xiangya Hospital Central South UniversityChangsha 410013China Department of Prosthodontics Centre of StomatologyXiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Light Alloy Research Institute College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China

The corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting were evaluated using electrochemical experiments and a variety of antibacterial *** is found that the charge transfer resistance of Ti−3Cu alloy was 4.89×10^(5)Ω∙cm^(2),which was doubled the data obtained by CP-Ti *** antibacterial rates of Ti−3Cu alloy against *** and *** were 45.0%and 54.5%.And the antibacterial rates increased with the prolongation of cultivation time,reaching up to 62.8%and 68.6%,*** in-situ nano Ti_(2)Cu precipitates were homogeneously distributed in the matrix of the Ti−3Cu alloy,which was the key reason of increasing the corrosion ***,the microscale electric fields between theα-Ti matrix and the Ti_(2)Cu was responsible for the enhancement of the antibacterial properties.

关键词： selective laser melting Ti−3Cu alloy microstructure corrosion resistance antibacterial properties

The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 1-26页

作者： Wei Zhou Xiaogang Zhu Qing-Long Han lin Li Xiao Chen Sheng wen Yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

关键词： Artificial intelligence (AI) ChatGPT large language models (LLMs) security

Construction and application of multicomponent fluorescent droplets

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Chinese Chemical Letters 2025年第1期36卷 137-146页

作者： Wei-Tao Dou Qing-wen Zeng Yan Kang Haidong Jia Yulian Niu Jinglong Wang lin Xu Shanghai Key Laboratory of Green Chemistry and Chemical Processes Shanghai Frontiers Science Center of Molecule Intelligent SynthesesSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Shanghai Jahwa United Co. Ltd.Shanghai 200082China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401120China

The rapid development of microfluidic technology has led to the evolution of microdroplets from simple emulsion structures to complex multilayered and multicompartmental *** advancements have endowed microdroplets with the capability to contain multiple compartments that remain isolated from one another,enabling them to carry different molecules of ***,researchers can now investigate intricate spatially confined chemical reactions and signal transduction pathways within subcellular ***,modern microdroplets often possess excellent optical transparency,allowing fluorescently labelled,multi-layered,and compartmental droplets to provide detailed insights through real-time,in situ,and dynamic fluorescence ***,this review systematically summarizes current methodologies for preparing multicomponent microdroplets and their applications,particularly focusing on fluorescent ***,it discusses existing critical challenges and outlines future research *** offering a comprehensive overview of the preparation methods and applications of fluorescent microdroplets,this review aims to stimulate the interest of researchers and foster their utilization in more complex and biomimetic environments.

关键词： Fluorescent Microfluidic Fluorescent droplets Multilayered droplets Multicompartmental droplets

An association analysis of lipidome and transcriptome highlights the involvement of MmGDPD1 in regulating low phosphorus tolerance in Malus mandshurica

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Horticultural Plant Journal 2025年第1期11卷 85-104页

作者： Hong Zhao Yawei Wu Luonan Shen Zhengchun Li lin Deng Xiaopeng wen Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) Institute of Agro-bioengineering/College of Life SciencesGuizhou UniversityGuiyangGuizhou 550025China Institute of Pomology Science Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006China College of Forestry/Institute for Forest Resources&Environment of Guizhou Guizhou UniversityGuiyangGuizhou 550025China

Phosphorus(Pi)plays a crucial role in the growth and development of *** lipid regulation is one of the main mechanisms underlying plant adaptation to Pi ***,the high tolerance to low-Pi stress was justified in an elite line,MSDZ 109,which was obtained from Malus *** better understand the mechanism underlying high adaptation to low-Pi stress,currently,lipidomic and transcriptomic analysis,as well as CRISPR/Cas9 and MmGDPD1-overexpressing methodologies were comprehensively integrated into a strategy for elucidating the high tolerance to low-Pi ***,770 differential metabolites were identified from the roots between the low-Pi and stress-free,belonging to 21 sub-classes of lipid *** acids(FA)constituted the predominant lipid component,accounting for approximately 50%-60%of the total lipids,and triglycerides(TAG)ranked the second,comprising around 12%of the total,consecutively followed by phosphatidylcholine(PC)and diacylglycerol(DAG)with approximately 10%and 8%of the total,*** synchronous transcriptomic analysis revealed a significant up-regulation of genes related to glycerophospholipid and glycerolipid metabolism,specifically those(e.g.,MmGDPD1,MmDGDG1,MmMGDG1,MmSQDG,etc.)involved in phospholipid and galactosyl synthesis in response to low-Pi *** fusing reporter assay showed that MmGDPD1 promoter induced GUS gene expression and demonstrated initiation *** on expression analysis,a dual-luciferase reporter assay,as well as yeast one-hybrid(Y1H)identification,MmPHR1 was justified to bind with the MmGDPD1 promoter and positively regulate plant tolerance to low-Pi *** further elucidate the role of MmGDPD1,CRISPR/Cas9 and MmGDPD1-overexpressing vectors were successfully introduced into apple(‘Royal Gala')***,the MmGDPD1-KO line calli exhibited the remarkable decreases in the contents of phosphodiesterase(PDE),activity,as well as the contents of total Pi,and P

关键词： Malus mandshurica Lipidome profiling Transcription profiles Low phosphorus stress MmGDPD1

Integrated Medicine Treatment of Rare Bone Marrow Tuberculosis in Systemic Lupus Erythematosus and Potentiating and Detoxifying Effects of Chinese Medicine:A Case Report

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Chinese Journal of Integrative Medicine 2025年第2期31卷 153-156页

作者： CHEN Wu HUANG lin SHI Wei-man MA Ke wen Cheng-ping DAI Qiao-ding School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou(310000)China The Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Hangzhou(310000)China Department of Rheumatology and Immunology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou(310000)China

Systemic lupus erythematosus(SLE)is an autoimmune disease that affects multiple organ systems.(1,2)Patients with SLE who undergo long-term immunosuppressive and glucocorticoids therapy are at an elevated risk of devel... 详细信息

关键词： Systemic tuberculosis erythematosus

Advanced pancreatic cancer treated with camrelizumab combined with apatinib:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 284-290页

作者： Yun-Hao Luo Ting He Lu lin Rong-Qiu Wang Hong-Xia Cai wen Hu Department of Critical Care Medicine Chengdu First People's HospitalChengdu 610000Sichuan ProvinceChina Department of Radiology Sichuan Second Hospital of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Department of Oncology Chengdu Seventh People's HospitalChengdu 610000Sichuan ProvinceChina Department of Oncology West China Tianfu HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND The 5-year survival rate for patients with pancreatic cancer(PC)is 4%-12%.Surgery is the only treatment that offers curative potential,but only 15%-20%of patients are eligible for *** is prone to recurrence and metastasis,and the antitumor effect of chemotherapy is notably *** SUMMARY Histopathological analysis of a 53-year-old female PC patient who underwent Whipple surgery revealed poorly differentiated tumor cells infiltrating nerves,lymphatics,and blood *** patient received two different first-line chemotherapy regimens consecutively;however,both regimens struggled to control disease *** this period,the patient underwent liver metastasis ablation surgery,Candida albicans liver abscess,and stereotactic body *** the addition of camrelizumab to the modified FOLFIRINOX regimen,tumor control was *** patient subsequently refused to continue chemotherapy,and the antitumor regimen was changed to a combination of camrelizumab and *** patients received a combination of immunotherapy and targeted therapy,the length of hospital stay was significantly ***,all side effects were within acceptable limits,leading to an improved quality of life and prolonged progression-free ***,the pain associated with cancer,coupled with the side effects of opioid analgesics,has led the patient to reject all available anticancer treatment *** one month after camrelizumab and apatinib were discontinued without medical authorization,the PC recurred and rapidly progressed to widespread metastasis,ultimately leading to the patient's death approximately one month *** overall survival was 2 *** Immunotherapy and targeted therapy have the potential to increase both the quality of life and survival time of PC patients,particularly those whose tumor progression is not effectively controlled by chemotherapy ***,further clinical trials a

关键词： Advanced pancreatic cancer Immunotherapy Camrelizumab Targeted therapy Apatinib Case report