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胡适《尝试集》:白话新诗的实地试验

湖南大学学报（社会科学版） 2015年第6期29卷 83-90页

作者：文贵良华东师范大学中文系上海200241

胡适的《尝试集》是他"实地试验白话"之作,以证明白话可以创作出好的诗歌。胡适的诗来自于他的生活,他对现实的感知,追求"自然"的白话新诗音节;胡适青睐虚词以调和文言和白话,多用"了"字,甚至用"了"字押韵,又常用"也"字;《尝试集》第二... 详细信息

胡适的《尝试集》是他"实地试验白话"之作,以证明白话可以创作出好的诗歌。胡适的诗来自于他的生活,他对现实的感知,追求"自然"的白话新诗音节;胡适青睐虚词以调和文言和白话,多用"了"字,甚至用"了"字押韵,又常用"也"字;《尝试集》第二篇、第三篇大多数诗运用了"对语体"结构,因为这种形式容易造成诗歌的说话语调,形成比较自然的节奏;《尝试集》还开拓出一些新的意象,如《老鸦》中"乌鸦"的全新意象。这四个方面构成了《尝试集》白话新诗的现代特质。

关键词：胡适《尝试集》白话新诗实地试验

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2363-2383页

作者： Lei Chen wenjing Zhang Dan Chen quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei liang Chaoqun Chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui Zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi Institute of Cancer Stem Cells and the Second Affiliated Hospital of Dalian Medical University Dalian Medical UniversityDalian116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Department of Oncology the Second Affiliated Hospital of Dalian Medical UniversityDalian116023China Department of Thoracic Surgery the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Research Center the Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China

Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct ***,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely *** we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer *** level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant ***4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR ***,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in ***,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine ***,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high *** RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics.

关键词： LKB1 ESCC protective

Hif-1α/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker(Larimichthys crocea)under environmental hypoxia

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Zoological Research 2021年第6期42卷 746-760页

作者： Sheng-Yu Luo Jing-Qian Wang Cheng Liu Xin-Ming Gao Yi-Bo Zhang Jie Ding Cong-Cong Hou Jun-quan Zhu Bao Lou Wei-liang Shen Xiong-Fei Wu Chun-Dan Zhang Dao-Jun Tang Key Laboratory of Applied Marine Biotechnology by the Ministry of Education School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Zhejiang Academy of Agricultural Sciences HangzhouZhejiang 310021China State Key Laboratory of Large Yellow Croaker Breeding Ningbo Academy of Oceanology and FisheryNingboZhejiang 315012China

Oxygen is an essential molecule for animal respiration,growth,and *** in terrestrial environments,contamination and climate change have led to the frequent occurrence of hypoxia in aquatic environments,thus impacting aquatic animal ***,the adaptative mechanisms underlying fish responses to environmental hypoxia remain largely ***,we used large yellow croaker(Larimichthys crocea)and large yellow croaker fry(LYCF)cells to investigate the roles of the Hif-1α/Hsf1/Hsp70 signaling pathway in the regulation of cellular redox homeostasis,and *** confirmed that hypoxia induced the expression of Hif-1α,Hsf1,and Hsp70 in vivo and in *** Hsp70 knockdown/overexpression indicated that Hsp70 was required for maintaining redox homeostasis and resisting oxidative stress in LYCF cells under hypoxic ***70 inhibited caspase-dependent intrinsic apoptosis by maintaining normal mitochondrial membrane potential,enhancing Bcl-2 mRNA and protein expression,inhibiting Bax and caspase3 mRNA expression,and suppressing caspase-3 and caspase-9 ***70 suppressed caspaseindependent intrinsic apoptosis by inhibiting nuclear translocation of apoptosis-inducing factor(AIF)and disturbed extrinsic apoptosis by inactivating *** knockdown/overexpression of Hif-1αand dual-luciferase reporter assay indicated that Hif-1αactivated the Hsf1 DNA promoter and enhanced Hsf1 mRNA ***1 enhanced Hsp70 mRNA transcription in a similar *** summary,the Hif-1α/Hsf1/Hsp70 signaling pathway plays an important role in regulating redox homeostasis and anti-apoptosis in *** under hypoxic stress.

关键词： Hypoxia Larimichthys crocea Apoptosis Redox homeostasis Hif-1α/Hsf1/Hsp70

Discovery of Fractionalized Neutral Spin-1/2 Excitation of Topological Order

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Chinese Physics Letters 2017年第9期34卷 1-2页

作者： Xiao-Gang wen Department of Physics Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA

After the discovery of fraction quantum Hall states in the 1980s, it became more and more clear that Landau symmetry breaking theory does not describe all possible quantum phases of matter. The new quan- tum phases of matter were called topologically ordered phases（for gapped cases） or quantum ordered phases （for gapless cases）, which correspond to pat- terns of many-body entanglement. One may won- der： besides quantum Hall systems, are there other systems that realize the new topological/quantum order？

关键词： Discovery of Fractionalized Neutral Spin-1/2 Excitation of Topological Order

Structural abnormalities of trigeminal root with neurovascular compression revealed by high resolution diffusion tensor imaging

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 749-752页

作者： Jing Chen Zi-Yi Guo Qi-Zhou liang Hai-Yan Liao wen-Rui Su Cai-Xiang Chen Shui-Xi Fu Xiang-Jun Han Radiology Department Municipal Hospital of Haikou

Objective:To detect neurovascular compression-induced structural abnormalities of trigeminal nerves(TGN) by diffusion tensor imaging(DTI).Methods:The affected ipsilateral TGN(iTGN) and unaffected contralateral TGN(cTGN) of 20 trifacial neuralgia(TIM) patients as well as the bilateral TGN of 10 normal controls(nTGN) were examined by DTI and 3D high resolution MR] using a 3.0 T MRI *** fractional anisotropy and apparent diffusion coefficieiil(ADC) were ***:Compared with the cTGN and nTGN,the *** significantly lower fraction of anisotropy(FA),significantly higher *** significantly smaller volume and crosssectional area(P<0.05).Conclusions:The increase in ADC and decrease in FA has a close relationship with morphological changes of TGN,and the DTI could provide valuable diagnostic information on TGN structure forTN patients.

关键词： Trigeminal nerves Diffusion tensor imaging Trifacial neuralgia Apparent diffusion coefficient Fraction of anisotropy

Depression and myocardial injury in ST-segment elevation myocardial infarction:A cardiac magnetic resonance imaging study

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World Journal of Clinical Cases 2020年第7期8卷 1232-1240页

作者： Zhao-Qing Sun Tong-Tong Yu Yue Ma quan-Mei Ma Yun-Di Jiao Dong-Xu He Jia-KeWu Zong-Yu wen Xiao-Nan Wang Yang Hou Zhi-Jun Sun Department of Cardiology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Radiology Shenyang 110004Liaoning ProvinceChina

BACKGROUND Depression is common in patients with myocardial infarction and has been independently associated with adverse ***,the association between depression and myocardial injury on cardiac magnetic resonance(CMR)in patients with ST-segment elevation myocardial infarction(STEMI)has still not been *** To assess the association between depression and myocardial injury on CMR in patients with *** A total of 107 STEMI patients undergoing primary percutaneous coronary intervention(P-PCI)were analyzed in this prospectivecohort *** subject completed the Patient Health Questionnaire-9(PHQ-9)to assess the presence and severity of depressive *** was performed at a median of 3 d after PPCI for quantifying post-MI myocardial *** between depression identified by the PHQ-9 and myocardial injury measured on CMR were *** In this study,19 patients(17.8%)were diagnosed with major depression identified by the PHQ-9≥***-9 was analyzed both as a continuous variable and dichotomous *** multivariable adjustment,the proportion of patients with large infarction size was significantly higher in the major depression group(PHQ-9≥10)(OR:4.840,95%CI:1.122–20.868,P=0.034).When the PHQ-9 was evaluated as a continuous variable,after multivariable adjustment,an increased PHQ-9 score was associated with an increased risk of large infarction size(OR:1.226,95%CI:1.073–1.401,P=0.003).CONCLUSION In patients with STEMI undergoing PCI,depression was independently associated with a large infarction size.

关键词： Depression Patient Health Questionnaire-9 Myocardial injury ST-segment elevation myocardial infarction Cardiac magnetic resonance

A Nomogram Model for Prediction of Mortality Risk of Patients with Dangerous Upper Gastrointestinal Bleeding:A Two-center Retrospective Study

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当代医学科学(英文) 2023年第4期43卷 723-732页

作者： Zhou LIU liang ZHANG Guang LI wen-hui BAI Pei-xue WANG Gui-jun JIANG Ji-xiang ZHANG Li-ying ZHAN Li CHENG Wei-guo DONG Department of Intensive Care Unit Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Radiology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Hepatobiliary Surgery Renmin Hospital of Wuhan UniversityEastern CampusWuhan 430200China Department of Gastroenterology The First People's Hospital of JingzhouJingzhou 434000China Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Intensive Care Unit Renmin Hospital of Wuhan UniversityEastern CampusWuhan 430200China

Objective:This study aimed to establish a nomogram model to predict the mortality risk of patients with dangerous upper gastrointestinal bleeding(DUGIB),and identify high-risk patients who require emergent ***:From January 2020 to April 2022,the clinical data of 256 DUGIB patients who received treatments in the intensive care unit(ICU)were retrospectively collected from Renmin Hospital of Wuhan University(n=179)and the Eastern Campus of Renmin Hospital of Wuhan University(n=77).The 179 patients were treated as the training cohort,and 77 patients as the validation *** regression analysis was used to calculate the independent risk factors,and R packages were used to construct the nomogram *** prediction accuracy and identification ability were evaluated by the receiver operating characteristic(ROC)curve,C index and calibration *** nomogram model was also simultaneously externally *** curve analysis(DCA)was then used to demonstrate the clinical value of the ***:Logistic regression analysis showed that hematemesis,urea nitrogen level,emergency endoscopy,AIMS65,Glasgow Blatchford score and Rockall score were all independent risk factors for *** ROC curve analysis indicated the area under curve(AUC)of the training cohort was 0.980(95%CI:0.962-0.997),while the AUC of the validation cohort was 0.790(95%CI:0.685-0.895).The calibration curves were tested for Hosmer-Lemeshow goodness of fit for both training and validation cohorts(P=0.778,P=0.516).Conclusion:The developed nomogram is an effective tool for risk stratification,early identification and intervention for DUGIB patients.

关键词： acute upper gastrointestinal bleeding mortality risk factors nomogram model prognosis

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改进SA-PSO在系统误差配准中的应用

光电工程 2010年第9期37卷 27-31,38页

作者：周林潘泉梁彦西北工业大学自动化学院西安710129

针对融合系统中系统误差未固定的情况,将模拟退火算法SA(Simulated Annealing)引入到改进的粒子群优化算法PSO(Particle Swarm Optimization)中来解决系统误差配准问题。该方法结合了改进PSO的全面、快速寻优能力和SA的概率突跳特性,解... 详细信息

针对融合系统中系统误差未固定的情况,将模拟退火算法SA(Simulated Annealing)引入到改进的粒子群优化算法PSO(Particle Swarm Optimization)中来解决系统误差配准问题。该方法结合了改进PSO的全面、快速寻优能力和SA的概率突跳特性,解决了PSO容易陷入局部最优的缺点,也保证了群体的多样性,避免了种群的退化。仿真结果表明,改进的SA-PSO方法较PSO、GA方法在系统误差配准精度上得到了提高。

关键词：系统误差误差配准粒子群优化(PSO) 模拟退火(SA)

基于多块格子Boltzmann方法模拟接触热阻

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工程热物理学报 2017年第3期38卷 595-599页

作者：方文振任兴杰陶文铨西安交通大学热流科学与工程教育部重点实验室能源与动力工程学院西安710049

本文基于OpenMP并行语言,采用拼接式的多块格子Boltzmann方法研究了接触压力、粗糙度、间隙介质导热系数对接触热阻的影响规律。结果表明:铝之间的接触热阻随着接触压力的增加而降低,随着粗糙度的增加而增加;当块体气凝胶之间的间隙填... 详细信息

本文基于OpenMP并行语言,采用拼接式的多块格子Boltzmann方法研究了接触压力、粗糙度、间隙介质导热系数对接触热阻的影响规律。结果表明:铝之间的接触热阻随着接触压力的增加而降低,随着粗糙度的增加而增加;当块体气凝胶之间的间隙填充空气时,气凝胶之间的接触热阻随压力的增加变化不大;而当气凝胶间隙趋于真空时,接触热阻随压力的增大而降低;间隙介质的气体导热对于接触热阻起着关键的作用,在低接触压力时。气凝胶间隙趋于真空时的接触热阻是填充空气的大约50倍。

关键词：多块格子 Boltzmann 方法接触热阻间隙介质