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Clinical classification and treatment of leukokeratosis of the vocal cords

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Chinese Medical Journal 2013年第18期126卷 3523-3527页

作者： MA Li-jing WANG Jun XIAOyang YE Jing-ying XU wen yang qing-wen Department of Otorhinolaryngology-Head and Neck Surgery and Beijing Institute of Otorhinolaryngology Beijing Tongren Hospital Affiliated to Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery Ministry of Education Beijing 100730 China

Background Leukokeratosis of the vocal cords is a clinical descriptive diagnosis, which includes a group of squamous intraepithelial lesions of the vocal cord mucosa. We investigated the clinical classification and treatment efficacy of leukokeratosis of the vocal cords. Methods We conducted a retrospective analysis of the medical history, laryngoscopic examinations, morphological features under a surgical microscope, and pathology results of 360 cases of leukokeratosis of the vocal cords to examine correlations among treatment modalities, therapeutic effects, and clinical features. Results All cases were divided into four types based on symptoms, examination results, and treatment efficacies as follows： 21 patients had type I inflammatory leukoplakia and their vocal cord morphology and voice quality recovered after conservative therapies; 76 patients had type II frictional polyps and received CO2 laser submucosal cordectomy; 68 patients had type III sulcus vocalis and received mucosal slicing with dredging; and 195 cases had type IV simple leukokeratosis and received partial subligamental cordectomy with CO2 lasers or transmuscular cordectomy. Our treatment achieved a surgical cure rate of 90.9% （308/339）, with a recurrence rate of 9.1% （31/339） and malignant transformation rate of 6.5% （22/339）. All cancerous transformations occurred in type IV patients. Conclusion Choosing conservative or C02 laser surgery based on the morphological characteristics of squamous epithelial lesions of keratinized vocal cord mucosa can maximally protect voice quality, reduce complications, and improve the cure rate.

关键词： vocal cords leukokeratosis inflammation malignant CO2 lasers

A large area ^(3)He tube array detector with vacuum operation capacity for the SANS instrument at the CSNS

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Nuclear Science and Techniques 2022年第7期33卷 83-92页

作者： Xing-Fen Jiang Jian-Rong Zhou Hong Luo Liang Xiao Xiao-Juan Zhou Hong Xu Yuan-Guang Xia Xiao-Guang Wu Lin Zhu wen-qing yang Gui-An yang Bei-Ju Guan Hong-Yu Zhang Yu-Bin Zhao Zhi-Jia Sun Yuan-Bo Chen State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803China University of Chinese Academy of Sciences Beijing100049China

The small-angle neutron scattering(SANS)instrument,one of the first three instruments of the China Spallation Neutron Source(CSNS),is designed to probe the microscopic and mesoscopic structures of materials in the scale range 1–100 nm.A large-area ^(3)He tube array detector has been constructed and operates at the CSNS SANS instrument since August *** consists of 120 linear position-sensitive detector tubes,each 1 m in length and 8 mm in diameter,and filled with ^(3)He gas at 20 bar to obtain a high detection *** ^(3)He tubes were divided into ten modules,providing an overall area of 1000 mm×1020 mm with a high count rate *** each tube is installed independently,the detector can be quickly repaired in situ by replacing damaged *** reduce air scattering,the SANS detector must operate in a vacuum environment(0.1 mbar).An all-metal sealing technique was adopted to avoid high-voltage breakdown by ensuring a high-voltage connection and an electronic system working in an atmospheric environment.A position resolution of 7.8±0.1 mm(full width at maximum)is measured along the length of the tubes,with a high detection efficiency of 81±2% at *** over the past four years,the detector appears to perform well and with a high stability,which supports the SANS instrument to finish approximately 200 user scientific programs.

关键词： Neutron detectors ^(3)He tubes Gaseous detectors Small-angle neutron scattering

Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species(Oryza rufipogon and O. nivara)

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Science China(Life Sciences) 2020年第11期63卷 1714-1724页

作者： Xun Xu qing-Lin Meng Mu-Fan Geng Ning-Ning Ren Lian Zhou Yu-Su Du Zhe Cai Mei-Xia Wang Xin Wang Xiu-Hua Wang Jing-Dan Han Shuai Jiang Chun-Yan Jing Rong Liu Xiao-Ming Zheng qing-wen yang Fu-Min Zhang Song Ge State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

It is of critical importance for our understanding of speciation process to determine the forms of reproductive isolation and their relative importance in species divergence. Oryza nivara and O. rufipogon are direct ancestors of Asian cultivated rice and a progenitor-daughter species pair. Investigating the reproductive isolation between them provides insights into plant speciation and helps understanding of the rice domestication. Here, we quantitatively measured the major components of reproductive isolation between the two species based on common garden and crossing experiments for three pairs of sympatric populations in Nepal, Cambodia and *** revealed significant differences in the flowering times between species pairs, with O. nivara flowering much earlier than O. rufipogon. A very weak reduction in seed set but no reduction in F1 viability and fertility were detected for the crosses between species relative to those within species. Moreover, we detected asymmetrical compatibility between species and found that emasculation significantly decreased pollination success in O. nivara but not in O. *** study demonstrates that the divergence between O. nivara and O. rufipogon is maintained almost entirely by the difference in flowering times and suggests that differential flowering times contribute to both habitat preferences and reproductive isolation between species.

关键词： reproductive isolation flowering time speciation adaptation Oryza species

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MUSIC算法在相干探海雷达中的应用

武汉大学学报（理学版） 2001年第5期47卷 649-652页

作者：赵汉青文必洋吴敏武汉大学电子信息学院湖北武汉430072

根据海杂波的频谱特性 ,运用对称阵列方法中提到的思想对传统的 MU ltiple SIgnal Classification(MU SIC)算法进行了两个方面的改进 .一是对要进行特征值分解的矩阵进行重构 ,以解决有相干信号存在的问题 ;二是把算法推广到频域中执行 ... 详细信息

根据海杂波的频谱特性 ,运用对称阵列方法中提到的思想对传统的 MU ltiple SIgnal Classification(MU SIC)算法进行了两个方面的改进 .一是对要进行特征值分解的矩阵进行重构 ,以解决有相干信号存在的问题 ;二是把算法推广到频域中执行 ,以满足目标信号的背景噪声是海杂波的特性 .

关键词：多重信号分类算法相干信号海杂波相干雷达海洋回波高分辨率空间谱分析 MUSIC算法

高分辨率太阳吸收光谱二氧化碳反演中参数的敏感性分析

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光谱学与光谱分析 2017年第7期37卷 1997-2003页

作者：单昌功刘诚王薇孙友文刘文清田园杨维中国科学技术大学环境科学与光电技术学院安徽合肥230031 中国科学技术大学地球与空间科学学院安徽合肥230031 中国科学院安徽光学精密机械研究所环境光学与技术重点实验室安徽合肥230031

基于高分辨率傅里叶变换红外太阳吸收光谱可以准确测量大气中二氧化碳的柱总量。基于光谱反演算法中的前向模型,分析了改变前向模型中不同参数和不同天顶角情况下对反演结果的影响及其原因。选取具有代表性的两天的测量光谱,改变前向模... 详细信息

基于高分辨率傅里叶变换红外太阳吸收光谱可以准确测量大气中二氧化碳的柱总量。基于光谱反演算法中的前向模型,分析了改变前向模型中不同参数和不同天顶角情况下对反演结果的影响及其原因。选取具有代表性的两天的测量光谱,改变前向模型中连续体倾斜量值、内部视场角、零偏置和多普勒效应四个模型参数,观察不同先验模型参数的扰动对二氧化碳测量结果的影响。结果表明,不同模型参数的扰动引起反演的二氧化碳柱平均干空气混合比(XCO_2)相对偏差并不一样;不同的测量时间,相同参数扰动引起的二氧化碳含量相对偏差也不同。其中连续体倾斜量值的变化对反演结果的影响最大,其变化引起的相对偏差波动范围在0.1%~0.2%之间;内部视场角、零偏置和多普勒效应的变化对反演结果影响较小,引起的二氧化碳的相对偏差分别在-0.045%~0.02%,-0.045%~0.015%和-0.03%~0.04%之间。最后用二氧化碳反演平均核解释了反演误差来源。研究结果对光谱反演算法中模型参数的设定和提高测量的准确度提供了理论依据。

关键词：模型参数傅里叶变换红外光谱敏感性分析二氧化碳

塔中人工绿地与自然沙面感热通量和潜热通量差异性研究

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干旱区资源与环境 2017年第1期31卷 115-120页

作者：慕文玲霍文何清杨兴华杨帆新疆师范大学地理科学与旅游学院乌鲁木齐830054 中国气象局乌鲁木齐沙漠气象研究所乌鲁木齐830002 塔克拉玛干沙漠大气环境观测试验站塔中841000

文中利用新疆塔中站2013年5月、6月的三维风速、温度和水汽脉动资料,运用涡旋相关计算法得出了塔中人工绿地与自然沙面感热通量、潜热通量。结果表明,塔中地区人工绿地与自然沙面地表热量输送主要是以感热输送为主,人工绿地最大感热通... 详细信息

文中利用新疆塔中站2013年5月、6月的三维风速、温度和水汽脉动资料,运用涡旋相关计算法得出了塔中人工绿地与自然沙面感热通量、潜热通量。结果表明,塔中地区人工绿地与自然沙面地表热量输送主要是以感热输送为主,人工绿地最大感热通量变化范围160-220W·m^(-2),自然沙面变化范围170-270W·m^(-2),自然沙面感热通量高于人工绿地,并且变化幅度较大,6时之前感热通量为负值,之后出现正值,19时左右变为负值,即它的符号改变出现在日出、日落前后。人工绿地与自然沙面潜热通量相比,人工绿地潜热通量高于自然沙面,自然沙面潜热通量最大值变化范围10-80W·m^(-2),人工绿地变化范围30-80W·m^(-2),并且自然沙面潜热通量的变化幅度较大。

关键词：人工绿地自然沙面感热通量潜热通量

Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis： A Preliminary Report

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Chinese Medical Journal 2015年第21期128卷 2913-2918页

作者： Xiao-Peng Qu Zhen-Xiao Huang Yan Sun Ting Ye Shun-Jiu Cui Qian Huang Li-Jing Ma qing-wen yang Hong Wang Er-Zhong Fan Ying Li Liang Zhang Bing Zhou Department of Otolaryngology-Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Key Laboratory of Otolaryngology-Head and Neck Surgery Ministry of Education Beijing Institute of Otolaryngology Beijing 100005 China

Background： Adenoid hypertrophy （AH） is associated with pediatric chronic rhinosinusitis （pCRS）, but its role in the inflammatory process of pCRS is unclear. It is thought that innate immunity gene expression is disrupted in the epithelium of patients with chronic rhinosinusitis （CRS）, including antimicrobial peptides and pattern recognition receptors （PRRs）. The aim of this preliminary study was to detect the expression of innate immunity genes in epithelial cells of hypertrophic adenoids with and without pCRS to better understand their role in pCRS. Methods： Nine pCRS patients and nine simple AH patients undergoing adenoidectomy were recruited for the study. Adenoidal epithelium was isolated, and real-time quantitative polymerase chain reaction （RT-qPCR） was employed to measure relative expression levels of the following messenger RNAs in hypertrophic adenoid epithelial cells of pediatric patients with and without CRS： Human β-defensin （HBD） 2 and 3, surfactant protein （SP）-A and D, toll-like receptors 1-10, nucleotide-binding oligomerization domain （NOD）-like receptors NOD 1, NOD 2, and NACHT, LRR and PYD domains-containing protein 3, retinoic acid-induced gene 1, melanoma differentiation-associated gene 5, and nuclear factor-riB （NF-KB）. RT-qPCR data from two groups were analyzed by independent sample t-tests and Mann-Whitney U-tests. Results： The relative expression of SP-D in adenoidal epithelium ofpCRS group was significantly lower than that in AH group （pCRS 0.73 ± 0.10 vs. AH 1.21 ±0.15; P = 0.0173, t = 2.654）. The relative expression levels of all tested PRRs and NF-κB, as well as HBD-2, HBD-3, and SP-A, showed no statistically significant differences in isolated adenoidal epithelium between pCRS group and AH group. Conclusions： Down-regulated SP-D levels in adenoidal epithelium may contribute to the development of pCRS. PRRs, however, are unlikely to play a significant role in the inflammatory process ofpCRS.

关键词： Adenoids: Epithelial Cell Innate Immunity: Pattern Recognition Receptors Pediatric Chronic Rhinosinusitis

集束化护理在重症急性胰腺患者胃肠功能恢复中的应用

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世界华人消化杂志 2017年第23期25卷 2071-2079页

作者：李雪杨文晴周谊霞贵州医科大学附属医院护理学院贵州省贵阳市550004

重症急性胰腺炎(severe acute pancreatitis,SAP)是临床中常见的发病率高、并发症多、死亡率较高的疾病,其死亡的主要原因是并发了不同程度的多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS),全身炎症反应综合征(syste... 详细信息

重症急性胰腺炎(severe acute pancreatitis,SAP)是临床中常见的发病率高、并发症多、死亡率较高的疾病,其死亡的主要原因是并发了不同程度的多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS),全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)是导致MODS的重要基础,而胃肠功能障碍又是激发SIRS的源头.因此,胃肠功能障碍在该病的发生发展过程中起重要作用,早期胃肠功能恢复有助于疾病的恢复和并发症的预防.集束化护理的运用,可以使每一位患者在有限的时间内,得到最有效的治疗,这是集束化护理最突出的特点.文章就集束化护理在SAP患者的胃肠功能恢复中的应用进行简要综述,为临床工作提供循证参考.

关键词：集束化护理重症急性胰腺炎胃肠功能连续性血液净化

贵州松桃腊山河洞洞穴动物群落结构与环境因子的关系研究

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四川动物 2017年第4期36卷 404-411页

作者：温清杨卫诚陶红梅贵州师范大学生命科学学院贵阳550001 贵州师范大学喀斯特洞穴研究中心贵阳550001

通过对贵州省松桃县腊山河洞洞穴动物进行采集和调查,共获标本472号,隶属于3门9纲19目33科38种。按个体组成和环境差异,将腊山河洞洞穴动物划分为4个群落,群落多样性分析结果显示,群落A的物种数最多(23)、丰富度最大(4.571 7),群落多样... 详细信息

通过对贵州省松桃县腊山河洞洞穴动物进行采集和调查,共获标本472号,隶属于3门9纲19目33科38种。按个体组成和环境差异,将腊山河洞洞穴动物划分为4个群落,群落多样性分析结果显示,群落A的物种数最多(23)、丰富度最大(4.571 7),群落多样性指数依次为群落A(2.637 9)>B(2.475 7)>C(1.442 3)>D(1.311 5)。群落D均匀度指数最高(0.946 1),虽然群落C物种数较少但形成了较大的类群,所以优势度最高(0.378 8)。群落多样性与环境因子的Pearson相关性分析显示,温度与物种丰富度呈极显著正相关(r=1.000),土壤中汞(Hg)与物种数呈显著正相关(r=0.997),土壤中砷(As)与多样性指数、丰富度、优势度之间呈显著相关,相关系数分别为-1.000、-0.999、0.998。重金属污染评价结果表明,3个光带内土壤重金属Hg、As的综合污染指数均达到重污染等级,而水体中重金属Hg、As的含量均达到国家Ⅲ类地下水质标准,与相关性分析结果相吻合。由此可见,环境中重金属的含量与洞穴动物群落结构密切相关,影响着洞穴动物群落的组成及分布。

关键词：洞穴动物汞砷群落结构腊山河洞贵州