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Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

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World Journal of Pediatrics 2024年第1期20卷 92-96页

作者： Wei Li Bing-Han Wang Bao-Hai Chen Yi Sun Lin Li wen-qing xiang Ahmed Faisal Ali Lin-Xuan Su Hai-Yan Mao Hong-Qiang Shen Qiang Shu Department of Clinical Laboratory Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Department of Information Center Children's HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouChina Department of Thoracic&Cardiovascular Surgery Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina

Since the outbreak of coronavirus disease 2019(COVID-19),the entire world has been affected by the epidemic[1,2].On November 9,2021,a variant of the novel coronavirus B.1.1.529 was detected for the first time from case samples in South *** Omicron strain spread and mutated significantly *** variant has the characteristics of escape immunity,which can induce relatively extreme disease and reduce the neutralization of antibodies in vaccinators,and is more likely to be reinfected[3,4].The clinical presentation of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)in children has mild symptoms and a lower risk of hospitalization and death.

关键词： respiratory immunity acute

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

解决道路拥堵问题创造优良交通环境——南海区道路交通拥堵现状、原因及解决对策

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广东交通职业技术学院学报 2005年第1期4卷 65-71页

作者：温庆祥廖成忠佛山市公安局南海分局广东佛山528200 中共广东省委党校广东广州510053

佛山市南海区交通拥堵严重,危害明显。文中分析了交通拥堵的主要原因:车辆增长过快,道路供给不足;公路的规划设计不合理,交通安全设施不配套;人们的交通安全意识较差,违章行为突出,管理有待进一步加强;混合交通层次多,客运运输效率低;... 详细信息

佛山市南海区交通拥堵严重,危害明显。文中分析了交通拥堵的主要原因:车辆增长过快,道路供给不足;公路的规划设计不合理,交通安全设施不配套;人们的交通安全意识较差,违章行为突出,管理有待进一步加强;混合交通层次多,客运运输效率低;停车设施不足,占道停车严重。为解决交通拥堵问题,论文提出了相应的对策:加强交通设施建设;大力提高交通管理水平;减少道路交通层次;大力培养群众的文明交通素质;加强停车场建设。

关键词：南海区道路拥堵交通环境解决对策原因现状交通安全设施交通安全意识交通拥堵问题交通设施建设停车场建设规划设计违章行为混合交通运输效率停车设施占道停车管理水平道路交通文明交通佛山市车辆公路

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai xiang wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Polarization-encoded neural networks with simplified grating patch

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Science China Technological Sciences 2025年

作者： Chengyan ZHONG xiang WANG Lingfei LI Yuanchi CUI Lei XIAO Dawei SONG Junxiong GUO wen HUANG Yufeng GUO Yu LIU College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Nanjing Mumusili Technology Co. LTD School of Integrated Circuits Tsinghua University Institute of Advanced Study School of Electronic Information and Electrical Engineering Chengdu University State Key Laboratory of Electronic Thin Films and Integrated Devices School of Integrated Circuit Science and EngineeringUniversity of Electronic Science and Technology of China

Optical neural networks (ONNs) offer a promising solution for high-performance, energy-efficient artificial intelligence hardware by leveraging the parallelism and speed of light. However, the large-scale implementation of ONNs remains challenging due to the bulky footprint and complex control of optical synapses. In this work, we propose and simulate a plasmonic polarized synaptic architecture that overcomes the diffraction limit and enables ultra-compact ONNs. By tuning the polarization state of incident light, the optical transmittance through each plasmonic unit can be dynamically adjusted to represent a synaptic weight. Our plasmonic structures, with features as small as 40 nm, operate well below this limit in the visible spectrum (400–750 nm). Compared with diffraction and interference-based circuit designs, our proposed method achieves a substantial reduction in synaptic density by factors of 150000-fold and 1500-fold, respectively. Furthermore, we successfully demonstrate a proof-of-concept plasmonic ONN applied to the Canadian Institute for Advanced Research—10classes (CIFAR-10) dataset using a Visual Geometry Group network with 16 layers (VGG16) model. After training for 80epochs, the network achieves an accuracy of 93%. The polarization-tunable plasmonics paves the way towards scalable ONNs for next-generation artificial intelligence (AI) accelerators and smart sensors.

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尿β_2-微球蛋白联合检测在H型高血压早期肾损害中的应用

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标记免疫分析与临床 2013年第2期20卷 69-70页

作者：石瑾荣蓉温庆祥首都医科大学附属北京中医医院北京100010

目的探讨尿β2-微球蛋白(β2-MG)对H型高血压早期肾损害诊断的意义。方法对67例H型高血压患者(男36例,女31例),用循环酶法和放射免疫法检测血清Hcy、尿β2-MG的含量。结果 H型高血压患者β2-MG明显升高(P<0.01)。结论检测尿β2-MG对H型... 详细信息

目的探讨尿β2-微球蛋白(β2-MG)对H型高血压早期肾损害诊断的意义。方法对67例H型高血压患者(男36例,女31例),用循环酶法和放射免疫法检测血清Hcy、尿β2-MG的含量。结果 H型高血压患者β2-MG明显升高(P<0.01)。结论检测尿β2-MG对H型高血压早期肾损害的诊断及治疗有重要意义。

关键词： H型高血压同型半胱氨酸 β2-微球蛋白放射免疫肾损害

The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 1-26页

作者： Wei Zhou Xiaogang Zhu qing-Long Han Lin Li Xiao Chen Sheng wen Yang xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao wen-Bo Deng Ji Xiong Kai Guo Ya-qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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两种采集体位对核素胃排空显像结果的影响

标记免疫分析与临床 2018年第12期25卷 1812-1813页

作者：温庆祥李蔷崔璨石瑾首都医科大学附属北京中医医院核医学科北京100010

目的探讨两种体位采集对核素胃排空显像结果的影响研究。方法选取2014年6月至2017年12月,本院门诊及住院患者36例,随机分为两组,站立组18例,男9例,女9例;仰卧组18例,男8例,女10例,分别行胃排空放射性核素显像,得到两组患者的半排时间和... 详细信息

目的探讨两种体位采集对核素胃排空显像结果的影响研究。方法选取2014年6月至2017年12月,本院门诊及住院患者36例,随机分为两组,站立组18例,男9例,女9例;仰卧组18例,男8例,女10例,分别行胃排空放射性核素显像,得到两组患者的半排时间和胃排空率。结果站立组、仰卧组显像结果在15min时差异无统计学意义,30min至60min站立组胃排空速率大于仰卧组,差异具有统计学意义(P<0.05)。结论不同体位对胃排空显像的结果影响极显著,因此建立自己的参考值非常重要。

关键词：体位胃排空放射性核素脂餐显像