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Rare manifestation of familial vitreous amyloidosis caused by Gly103Arg transthyretin

International Journal of Ophthalmology(English edition) 2023年第7期16卷 1093-1099页

作者： Yan-Bing Feng Yan-Bo Shi Yan-Yan He Zhen-Yi Ma Yi-Xing Zhu wen-qing weng Department of Ophthalmology Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical UniversityJiaxing 314001Zhejiang ProvinceChina Jiaxing Key Laboratory of Diabetic Angiopathy Jiaxing 314001Zhejiang ProvinceChina Central Laboratory of Molecular Medicine Research Center Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical UniversityJiaxing 314001Zhejiang ProvinceChina Department of Pathology Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical UniversityJiaxing 314001Zhejiang ProvinceChina The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005Zhejiang ProvinceChina

AIM:To identify and analyze the genotype of the patients with special ocular manifestations of familial vitreous amyloidosis(FVA)in a Chinese Han ***:Pars plana vitrectomy(PPV)surgery was performed on a 52-year-old Chinese woman presented with vitreous amyloidosis and progressive visual impairment,without evidence of cardiac,renal,gastrointestinal,central nervous system or peripheral nervous system *** the surgery,the patient presented with a gray-white dense and thick cotton woollike change in the vitreous body,accompanied by complete retinal ***,hard,free and movable yellow-white deposits were observed in the posterior pole and surrounding retina,the vitreous and subretinal deposits were examined by Congo red staining and immunohistochemical pathological examination,and whole exome sequencing was performed on blood samples from the patient and her ***:During the operation,it was discovered that there was a complete detachment of the retina and a significant amount of hard,free-floating yellow-white deposits were observed beneath the posterior pole and surrounding *** is an exceedingly rare ocular *** examination of the vitreous and subretinal deposit specimens revealed positive Congo red staining,as well as elevated vascular endothelial growth factor(VEGF)expression in vascular endothelial cells within the sediment specimens upon immunohistochemical *** patient and her cousin both exhibited a heterozygous mutation in Glyl03Arg within the transthyretin(TTR)gene,resulting in a substitution of glycine(Gly)at position 103 with arginine(Arg).CONCLUSION:FVA may present with various ocular manifestations,but panretinal detachment is a rare *** cases where retinal detachment persists for an extended period of time,amyloid deposits may form under the retina through retinal tears,leading to subretinal deposits that can impede retinal reattachment and negatively impa

关键词： familial vitreous amyloidosis transthyretin gene Gly103Arg vascular endothelial growth factor

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显微镜下行孔源性视网膜脱离复位术的临床观察

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国际眼科杂志 2015年第2期15卷 339-341页

作者：沈志新高恩芳翁文庆中国浙江省嘉兴市中医医院眼科 314000

目的:评价显微镜直视下行孔源性视网膜脱离复位手术与直接检眼镜下行孔源性视网膜脱离复位手术的疗效。方法:对93例93眼孔源性视网膜脱离随机分为两组,A组47例采用显微镜直视下行孔源性视网膜脱离复位手术;B组46例采用直接检眼镜下行孔... 详细信息

目的:评价显微镜直视下行孔源性视网膜脱离复位手术与直接检眼镜下行孔源性视网膜脱离复位手术的疗效。方法:对93例93眼孔源性视网膜脱离随机分为两组,A组47例采用显微镜直视下行孔源性视网膜脱离复位手术;B组46例采用直接检眼镜下行孔源性视网膜脱离复位手术。观察术后2wk手术成功率及视力提升率。结果:A组视网膜复位率为95.74%,B组为80.43%。A组术后视力提升率为82.98%,B组67.39%。A组手术时间明显短于B组。结论:显微镜直视下手术较直接检眼镜下行孔源性视网膜脱离复位手术成功率更高,且更简便、精确、易操作,能有效延长主刀医师的手术年限。

关键词：手术显微镜孔源性视网膜脱离手术

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Multiaxial fatigue life prediction of composite laminates

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Chinese Journal of Aeronautics 2021年第12期34卷 227-237页

作者： Jingmeng weng Tong MENG Weidong wen Shaodong weng Xi'an Aerospace Propulsion Institute Xi'an 710100China Academy of Space Electronic Information Technology Xi'an 710100China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Mechcmo-Electronic Engineering Xidian UniversityXi'an 710071China

A study of composite laminates under tension–torsion biaxial loading is *** focus is placed on fatigue lives of composite laminates under different tension–torsion biaxial fatigue loading paths.A macro-meso model used to predict multiaxial fatigue life of composite laminates is also presented in this ***,a macro-scale 3 D RVE corresponding to composite laminates is established to determine strain components in the material principal direction of each layer for each biaxial stress ***,a meso-scale 3 D RVE corresponding to each layer with fibers distributed randomly is established,with progressive damage prediction method,biaxial strength of composite laminates can be predicted,and the final failure layer can be ***,select any one of fatigue loading path at which the final failure of composite laminates is fiber failure(matrix failure)to establish the reference curve for fiber(matrix).Finally,with reference curve,fatigue life of composite laminates under any biaxial loading path can be *** numerical results show good agreements with experimental data.

关键词： Composite laminates Fatigue damage parameter Life prediction Multiaxial fatigue Multiaxial strength

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Multiaxial fatigue life prediction of composite materials

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Chinese Journal of Aeronautics 2017年第3期30卷 1012-1020页

作者： Jingmeng weng Weidong wen Hongjian ZHANG Jiangsu Province Key Laboratory of Aerospace Power System Nanjing 210016 China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing 210016 China College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In order to analyze the stress and strain fields in the fibers and the matrix in composite materials,a fiber-scale unit cell model is established and the corresponding periodical boundary conditions are *** matrix cracking as the failure mode of composite materials,an energy-based fatigue damage parameter and a multiaxial fatigue life prediction method are *** method only needs the material properties of the fibers and the matrix to be *** the relationship between the fatigue damage parameter and the fatigue life under any arbitrary test condition is established,the multiaxial fatigue life under any other load condition can be *** proposed method has been verified using two different kinds of load *** is unidirectional laminates subjected to cyclic off-axis loading,and the other is filament wound composites subjected to cyclic tension-torsion *** fatigue lives predicted using the proposed model are in good agreements with the experimental results for both kinds of load forms.

关键词： Fatigue damage parameter Finite element analysis Life prediction Multiaxial fatigue Periodical boundary condition

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Preparation of cauliflower-like bismuth sulfide and its application in electrochemical sensor

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Chinese Chemical Letters 2008年第5期19卷 585-588页

作者： qing Xiang Wang Feng Gao Shun Xing Li wen weng Zheng Shui Hu Department of Chemistry Zhangzhou Normal University Zhangzhou 363000 China College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China

A solvothermal process was developed for the preparation of cauliflower-like Bi2S3 from N,N-dimethylformamide （DMF） solution of bismuth nitrate [Bi（NO3）3.5H2O] and thioacetamide （TAA） with 2-undecyl-1-dithioureido-ethyl-imidazoline （SUDEI） as the morphology-controlling agent. The obtained Bi2S3 products were characterized by transmission electron microscopy （TEM）, scanning electron microscopy （SEM）, and X-ray diffraction （XRD）, etc. The sensing properties of Bi2S3 with different morphologies were evaluated by the electrochemical analysis of dopamine （DA） and ascorbic acid （AA） coexisting solution. The results showed that cauliflower-like Bi2S3 showed a better resolving ability than rod-like Bi2S3 for the simultaneous determination of DA and AA,

关键词： Bismuth sulfide Solvothermal synthesis Electrochemical sensor

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Electrochemical Synthesis and Research of Two Polymers Composed of Alternate Carbazole and Thiophene Units

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Chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： qing Cheng qing-zhen wen College of Science Naval University of Engineering Wuhan 430033 china

Two organic conjugated molecules composed of central carbazole and bithiophene groups were prepared via the Stille coupling reaction, conductive polymers were prepared by electrochemical method. Structure and photoelectric research of polymers were investigated. 1H NMR and 13C NMR of molecules were consistent with the theorical results, FT-IR showed electrochemical polymeric site were β-position of thiophene units. The smooth morphology and distributed holes were beneficial to improve the electrical conductivity by SEM. When applied voltage was from ?0.1 V to 1.2 V, both of the polymer films P1 and P2 showed good electrochromic performances. Compared with P1, P2 had better electrochemical stability and thermal stability due to the better coplanarity by repeated cyclic voltammograms and TGA. The P2 was a promising material in the electrochemical field, meanwhile, it showed that the monomer structure had greatly impact on the performance of polymer.

关键词： Stille reaction Cyclic voltammetry Electrochemistry polymerization Spectroelectrochemistry

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Lithium cobaltate:a novel host material enables high-rate and stable lithium-sulfur batteries

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Rare Metals 2018年第11期37卷 929-935页

作者： wen Ma qing Xu GRINM Bohan (Beijing) Publisher Co. Ltd.GRINM Group Co.Ltd. Subinstitute of Standardization Theory and Strategy China National Institute of Standardization

Element sulfur is highly attractive due to their potentially low cost and environmental ***, polysulfides dissolution hinders the lithiumsulfur(Li-S) batteries toward commercialization. To overcome these issues, in this work, lithium cobaltate as a commercial material, for the first time, was devoted to engineering the electrode structure and composition to improve the performance. When incorporated with 80% sulfur powder, the synergetic effects of cobalt atoms and interlayer spaces effectively enable the production of Li-S batteries with a relatively high discharge capacity of 1420 mAh·g-1at the low surface current density of 1 mA·cm-2and stable capacity retention of 650 mAh·g-1at high surface current density of 6 mA·cm-2. The introduction of lithium cobaltate is a viable approach for successfully developing practical Li-S batteries.

关键词： Lithium cobaltate Polysulfides dissolution Electrochemical properties Lithium-sulfur batteries

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Strength Prediction of Cruciform Specimen Under Biaxial Loading

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第3期34卷 286-295页

作者： weng Jingmeng wen Weidong Xu Ying Jiangsu Province Key Laboratory of Aerospace Power System State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and Astronautics

In order to achieve a better understanding of failure behavior of cruciform specimen under different biaxial loading conditions,a three-dimensional finite element model is established with solid and interface *** stress criterion,two Hashin-type criteria and the new proposed criteria are used to predict the strength of plain woven textile composites when biaxial loading ratio equals *** with experimental data,only the new proposed criteria can reach reasonable *** applicability of the new proposed criteria is also verified by predicting the tensile and compressive strength of cruciform specimen under different biaxial loading ***,the introduction of interface element makes it more intuitive to recognize delamination *** shape of the predicted delamination failure region in the interface layer is similar to that of the failure region in neighboring entity layers,but the area of delamination failure region is a little larger.

关键词： woven compressive tensile intuitive verified recognize specimen Prediction neighboring loaded

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The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 1-26页

作者： Wei Zhou Xiaogang Zhu qing-Long Han Lin Li Xiao Chen Sheng wen Yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

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The Heisenberg double of the quantum Euclidean group and its representations

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Science China Mathematics 2023年第8期66卷 1713-1736页

作者： wen-qing Tao School of Mathematical Science Yangzhou UniversityYangzhou 225002China

The Heisenberg double D_(q)(E_(2))of the quantum Euclidean group O_(q)(E_(2))is the smash product of O_(q)(E_(2))with its Hopf dual U_(q)(e_(2)).For the algebra D_(q)(E_(2)),explicit descriptions of its prime,primitive and maximal spectra are *** the prime factors of D_(q)(E_(2))are presented as generalized Weyl *** a result,we obtain that the algebra D_(q)(E_(2))has no finite-dimensional representations,and D_(q)(E_(2))cannot have a Hopf algebra *** automorphism groups of the quantum Euclidean group and its Heisenberg double are *** centralizers are explicitly described via generators and defining *** enables us to give a classification of simple weight modules and the so-called a-weight modules over the algebra D_(q)(E_(2)).

关键词： Heisenberg double quantum Euclidean group automorphism group prime ideal weight module

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