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Cuproptosis: copper-induced regulated cell death

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Science China(Life Sciences) 2022年第8期65卷 1680-1682页

作者： wen-Jun Duan rong-rong He Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China

“Life is pleasant. Death is peaceful. It's the transition that's troublesome.”——Isaac Asimov Copper is an essential trace element central to cardiovascular, neuronal, and immune functions. While copper deficiency ... 详细信息

关键词： functions copper peace

Analysis method and algorithm design of biological sequence problem based on generalized k-mer vector

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Applied Mathematics(A Journal of Chinese Universities) 2021年第1期36卷 114-127页

作者： LIU wen-li WU qing-biao Department of Mathematics Zhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhou 310012China

K-mer can be used for the description of biological sequences and k-mer distribution is a tool for solving sequences analysis problems in *** can use k-mer vector as a representation method of the k-mer distribution of the biological ***,such as similarity calculations or sequence assembly,can be described in the k-mer vector *** helps us to identify new features of an old sequence-based problem in bioinformatics and develop new algorithms using the concepts and methods from linear space *** this study,we defined the k-mer vector space for the generalized biological *** meaning of corresponding vector operations is explained in the biological *** presented the vector/matrix form of several widely seen sequence-based problems,including read quantification,sequence assembly,and pattern detection *** advantages and disadvantages are ***,we implement a tool for the sequence assembly problem based on the concepts of k-mer vector *** shows the practicability and convenience of this algorithm design strategy.

关键词： vector space biological sequence k-mer algorithm design analysis method.

Precise Deviations for Discrete Ensembles

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Acta Mathematica Sinica,English Series 2023年第8期39卷 1580-1596页

作者： wen Xuan CHEN Fu qing GAO School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

We consider precise deviations for discrete ***β=2 case,we first establish an asymptotic formula of the Christoffel–Darboux kernel of the discrete orthogonal polynomials on an infinite regular lattice with weight e^(−NV(x)).Then we use the asymptotic formula to get the precise deviations of the extreme value for corresponding ensemble.

关键词： Discrete ensemble precise deviation random growth model Riemann-Hilbert problem

Strange quark star and the parameter space of the quasi-particle model

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Communications in Theoretical Physics 2021年第10期73卷 125-131页

作者： wen-Hua Cai qing-Wu Wang College of physics Sichuan UniversityChengdu 610064China

The properties of strange quark stars are studied within the quasi-particle model. Taking into account chemical equilibrium and charge neutrality, the equation of state(EOS) of(2+ 1)-flavor quark matter is obtained. We illustrate the parameter spaces with constraints from two aspects: one is based on the astronomical results of PSR J0740+ 6620 and GW 170 817,and the other is based on the constraints proposed from the theoretical study of a compact star that the EOS must ensure the tidal deformability Λ_(1.4)=190_(-120)^(+390) and support a maximum mass above 1.97M⊙. It is found that neither type of constraints can restrict the parameter space of the quasi-particle model in a reliable region and thus we conclude that the low mass compact star cannot be a strange quark star.

关键词： strange quark compact star tidal deformability quasi-particle model neutron star

喹啉羧酸共价有机框架微球在线固相萃取4种黄曲霉毒素

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分析测试学报 2025年第1期44卷 163-171页

作者：王荣雨刘杰周静李涛王晓纪文华齐鲁工业大学(山东省科学院)山东省分析测试中心天然产物分离提取共性技术创新与应用山东省工程研究中心山东济南250014 山东明仁福瑞达制药股份有限公司山东济南250014 山东蓝城分析测试有限公司山东济南250100

以1,3,5-三(4-氨基苯基)苯、联苯二甲醛、丙酮酸为合成反应单体,氨基磺酸为催化剂,利用Doebner串联反应成功制备了具有喹啉羧酸骨架的共价有机框架(QCA-COF)微球。通过优化反应条件发现,采用1,4-二氧六环-乙腈溶液(1∶4,体积比)作为反... 详细信息

以1,3,5-三(4-氨基苯基)苯、联苯二甲醛、丙酮酸为合成反应单体,氨基磺酸为催化剂,利用Doebner串联反应成功制备了具有喹啉羧酸骨架的共价有机框架(QCA-COF)微球。通过优化反应条件发现,采用1,4-二氧六环-乙腈溶液(1∶4,体积比)作为反应溶剂时,可获得具有微米级粒径的微球。采用扫描电子显微镜、红外光谱、X射线粉末衍射、N_(2)吸脱附实验对QCA-COF微球的结构进行表征。由于QCA-COF微球具有芳环、喹啉基团、羧基等官能团,可通过氢键、π-π等多重相互作用与黄曲霉毒素进行吸附,其吸附能力优于C_(18)、PSA以及GCB等商用材料。将QCA-COF材料作为在线固相萃取柱的填料,详细优化了在线固相萃取条件。将在线固相萃取柱与高效液相色谱联用,建立了4种黄曲霉毒素的检测方法,检出限为0.024~0.030 ng·g^(-1)。经方法学验证,该方法具有较好的回收率(82.5%~105%)和精密度(4.3%~10%,n=6),适用于花生、小麦、陈皮、杏仁、决明子等食品与中药材中4种黄曲霉毒素的测定。

关键词：黄曲霉毒素在线固相萃取共价有机框架高效液相色谱

Bending Solutions of FGM Reddy-Bickford Beams in Terms of Those of the Homogenous Euler-Bernoulli Beams

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Acta Mechanica Solida Sinica 2019年第4期32卷 499-516页

作者： You-Ming Xia Shi-rong Li Ze-qing Wan School of Civil Science and Engineering Yangzhou UniversityYangzhou 225127 China

In this paper, correspondence relations between the solutions of the static bending of functionally graded material (FGM) Reddy-Bickford beams (RBBs) and those of the corresponding homogenous Euler-Bernoulli beams are presented. The effective material properties of the FGM beams are assumed to vary continuously in the thickness direction. Governing equations for the titled problem are formulated via the principle of virtual displacements based on the third-order shear deformation beam theory, in which the higher-order shear force and bending moment are included. General solutions of the displacements and the stress resultants of the FGM RBBs are derived analytically in terms of the deflection of the reference homogenous Euler- Bernoulli beam with the same geometry, loadings and end conditions, which realize a classical and homogenized expression of the bending response of the shear deformable non-homogeneous FGM beams. Particular solutions for the FGM RBBs under specified end constraints and load conditions are given to validate the theory and methodology. The key merit of this work is to be capable of obtaining the high-accuracy solutions of thick FGM beams in terms of the classical beam theory solutions without dealing with the solution of the complicated coupling differential equations with boundary conditions of the problem.

关键词： Functionally graded material beams Reddy-Bickford beam theory Euler- Bernoulli beam theory Bending solution Shear deformation

Combined effect of repetitive transcranial magnetic stimulation and physical exercise on cortical plasticity

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Neural Regeneration Research 2020年第11期15卷 1986-1994页

作者： Ya-wen Yang wen-Xiu Pan qing Xie Department of Rehabilitation Medicine Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Rehabilitation Medicine Shanghai Ruijin Rehabilitation HospitalShanghaiChina

Physical exercise can minimize dysfunction and optimize functional motor recovery after stroke by modulating cortical ***,the limitation of physical exercise is that large amounts of time and effort are necessary to significantly improve motor function,and even then,substantial exercise may not be sufficient to normalize the observed ***,interventions that could be used to strengthen physical exercise-induced neuroplasticity may be valuable in treating hemiplegia after *** transcranial magnetic stimulation seems to be a viable strategy for enhancing such *** a non-invasive cortical stimulation technique,repetitive transcranial magnetic stimulation is able to induce longterm plastic changes in the motor ***,repetitive transcranial magnetic stimulation was found to optimize the plastic changes caused by motor training,thereby enhancing the long-term effects of physical exercise in stroke ***,it is believed that the combination of repetitive transcranial magnetic stimulation and physical exercise may represent a superior method for restoring motor function after stroke.

关键词： functional recovery motor cortex neuroplasticity physical exercise primary motor cortex repetitive transcranial magnetic stimulation stroke

Differences in expression of retinal proteins between diabetic and normal rats

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World Journal of Gastroenterology 2007年第14期13卷 2118-2124页

作者： Shang-qing Liu Jian Kang Cheng-Jun Li En-Jie Tang Bin wen rong Cai Hui-Jun Yang Department of Anatomy School of Preclinical and Forensic Medicine Sichuan University Chengdu 610041 Sichuan Province China North Sichuan Medical College Nanchong 637007 Sichuan Province China Chengdu Medical College Chengdu 610083 Sichuan Province China

AIM： To compare and identify the differences in expression of retinal proteins between normal and diabetic rats, and to analyze the molecular pathogenetic mechanisms of retinal diseases caused by diabetes.METHODS： Changes in protein expression of retinal tissues from diabetic and normal rats were observed using 2-dimensional polyacrylamide gel electrophoresis （2-DE）. Some protein spots exhibiting statistically significant variations （P 〈 0.05） were selected randomly and identified by tandem mass spectrometry and analyzed by bioinformatics.RESULTS： 2-DE showed that the expression was upregulated in 5 retinal proteins, down-regulated in 23retinal proteins, and disappeared in 8 retinal *** spots were identified from the 36 spots by tandem mass spectrometry （MS/MS） and analyzed by bioinformatics. Guanylate kinase 1, triosephosphate isomerase 1, ATP synthase subunit d, albumin and dimethylarginine dimethylaminohydrolase 2 played an important role in signal transduction. Triosephosphate isomerase 1, crystallin alpha B, ATP synthase subunit d and peroxiredoxin 6 were involved in energy metabolism of retinal tissues. Guanylate kinase 1 played an important role in photoexcitation of retinal rod photoreceptor *** crystallin beta A1 plays a role in diabetic retinas is unknown so far.CONCLUSION： There are differences in expression of retinal proteins between diabetic and normal *** proteins may be involved in the mechanisms and prognosis of retinal diseases caused by diabetes.

关键词： Diabetes Rat Retina Proteomics Two-dimensional electrophoresis Tandem mass spectrometry Bioinformatics

Effect of Rotational Tillage on Soil Aggregates, Organic Carbon and Nitrogen in the Loess Plateau Area of China

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Pedosphere 2013年第4期23卷 542-548页

作者： HOU Xian-qing LI rong JIA Zhi-Kuan HAN qing-Fang Chinese Institute of Water-Saving Agriculture Northwest A&F University Key Laboratory of Crop Physi-Ecology and Tillage Science in Northwestern Loess Plateau Ministry of Agriculture Northwest A&F University School of Agriculture Ningxia University

In rain-fed semi-arid agroecosystems, continuous conventional tillage can cause serious problems in soil quality and crop production, whereas rotational tillage （no-tillage and subsoiling） could decrease soil bulk density, and increase soil aggregates and organic carbon in the 0-40 cm soil layer. A 3-year field study was conducted to determine the effect of tillage practices on soil organic carbon （SOC）, total nitrogen （TN）, water-stable aggregate size distribution and aggregate C and N sequestration from 0 to 40 cm soil in semi-arid areas of southern Ningxia. Three tillage treatments were tested： no-tillage in year 1, subsoiling in year 2, and no-tillage in year 3 （NT-ST-NT）; subsoiling in year 1, no-tillage in year 2, and subsoiling in year 3 （ST-NT-ST）; and conventional tillage over years 1-3 （CT）. Mean values of soil bulk density in 0-40 cm under NT-ST-NT and ST-NT-ST were significantly decreased by 3.3% and 6.5%, respectively, compared with CT, while soil total porosity was greatly improved. Rotational tillage increased SOC, TN, and water-stable aggregates in the 0-40 cm soil, with the greatest effect under ST-NT-ST. In 0-20 and 2（}-40 cm soils, the tillage effect was confined to the 2-0.25 mm size fraction of soil aggregates, and rotational tillage treatments obtained significantly higher SOC and TN contents than conventional tillage. No significant differences were detected in SOC and TN contents in the 〉 2 mm and 〈 0.25 mm aggregates among all treatments. In conclusion, rotational tillage practices could significantly increase SOC and TN levels, due to a fundamental change in soil structure, and maintain agroecosystem sustainability in the Loess Plateau area of China.

关键词： semi-arid region SOC sorage soil bulk density tillage practice water-stable aggregates