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Protein phosphatase 2A,a key player in Alzheimer’s disease

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Frontiers of Medicine 2009年第1期3卷 8-12页

作者： rong LIU qing TIAN Department of Pathophysiology Hubei Provincial Key Laboratory of Neurological DiseasesTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Protein phosphatase 2A(PP2A)is the pre-dominant serine/threonine phosphatase in eukaryotic *** the brains of patients with Alzheimer’s disease(AD),decreased PP2A activities were observed,which is suggested to be involved in neuroﬁbrillary tangle(NFT)formation,disturbed amyloid precursor protein(APP)secretion and neurodegeneration in AD *** on our research and other previousﬁndings,decreased PP2Ac level,decreased PP2A holoenzyme composition,increased level of PP2A inhibitors,increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation underlie PP2A inactivation in AD.β-amyloid(Aβ)over-production,estrogen deﬁciency and impaired homocys-teine metabolism are the possible up-stream factors that inactivate PP2A in AD *** studies are required to disclose the role of PP2A in Alzheimer’s disease.

关键词： protein phosphatase 2A Alzheimer’s disease holoenzyme composition protein phosphatase 2A inhibi-tors Leu309 demethylation Tyr307 phosphorylation

Spectral Characteristics of White Organic Light-emitting Diodes Based on Novel Phosphorescent Sensitizer

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Chinese Journal of Chemical Physics 2008年第6期21卷 510-514页

作者： Xiao-qing Tang Jun-sheng Yu Lu Li wen wen Ya-dong Jiang State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 China

White organic light-emitting diodes were fabricated by using a novel phosphorescence bis（1,2-diphenyl-1H-benzoimidazole）iridium（acetylacetonate）[（pbi）2Ir（acac）] as sensitizer and a fluorescent dye of 4- （dicyanomethylene）-2-t-butyl-6-（1,1,7,7-tetramethyljulolidyl-9-enyl）-4H-pyran （DCJTB） codoped into a carbazole polymer of poly（N-vinylcarbazole）（PVK）. Through characterizing the UV-Vis absorption spectra, the photoluminescence spectra of （pbi）2Ir（acac） and DCJTB, and the electroluminescence spectral properties of the WOLEDs, the energy transfer mechanisms of the codoped polymer system were deduced. The results demonstrate that the luminescent spectra with different intensity of （pbi）2Ir（acac） and DCJTB were co-existent in the EL spectra of the blended system, which is ascribed to an incomplete energy transfer process in the EL process. The efficient Forster and Dexter energy transfer between the host and the guests enabled a strong yellow emission from （pbi）2Ir（acac） and DCJTB, where （pbi）2Ir（acac） plays an important role as a phosphorescent sensitizer for DCJTB. With the blue emitting-layer of N,N＇-diphenyl-N,N＇-bis（1- naphthyl）（1,1＇-biphenyl）-4,4＇-diamine, the codoped system device achieved white emission. The codoped system showed that its Commissions Internationale de 1＇Eclairage coordinates were more independent of the variation of bias voltage than those of phosphorescent doped PVK systems.

关键词： White organic light-emitting diode Phosphorescent sensitizer Spectrum analysis

Effect of thermal oxidation on microstructures and mechanical properties of nanoporous coppers

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Science China(Technological Sciences) 2018年第12期61卷 1839-1844页

作者： ZHOU wen YANG qing SUN ShaoDong LIANG ShuHua Faculty of Materials Science and Engineering Xi'an University of Technology Shaanxi Province Key Laboratory for Electrical Materials and Infiltration Technology Xi'an University of Technology

Nanoporous copper oxides were formed by thermal oxidation of nanoporous copper at 150°C–270°C. The oxidation process of nanoporous copper was investigated by using XRD, SEM, nitrogen adsorption, HRTEM and nanoindentation. The variation of microstructures and mechanical properties was analyzed. The results showed that the content of copper oxides increased, the ligament gradually coarsened, and the mechanical properties of nanoporous structure were improved with the increase of oxidation temperature. When the oxidation temperature was below 210°C, the ligament surface was oxidized to Cu_2O, and the composite structure of Cu_2O@Cu was formed. The formation of CuO occurred since 220°C, and the composite structure of CuO/Cu_2 O@Cu was formed. CuO nanowires were grown on the ligament surface at 250°C; the specific surface area, elastic modulus and hardness of nanoporous structure are 1.37, 3.31 and 7.58 times that of the nanoporous copper, respectively.

关键词： nanoporous copper thermal oxidation microstructure mechanical property

In situ synthesis and hardness of TiC/Ti_5Si_3 composites on Ti-5Al-2.5Sn substrates by gas tungsten arc welding

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International Journal of Minerals,Metallurgy and Materials 2013年第3期20卷 284-289页

作者： wen-qing Yan Le Dai Chi-bin Gui School of Mechanical and Automotive Engineering South China University of Technology School of Materials and Metallurgy Wuhan University of Science and Technology Military Representative Office of Navy 407 Factory College of Materials Science and Engineering Huazhong University of Science and Technology

TiC/TisSi3 composites were fabricated on Ti-5A1-2.5Sn substrates by gas tungsten arc welding （GTAW）. Identification of the phases was performed using X-ray diffraction （XRD）. The microstructures were analyzed using scanning electron microscopy （SEM） combined with energy-dispersive X-ray spectrometry （EDS） and optical microscopy （OM）. The Vickers hardness was measured with a micro-hardness tester. The TiC/TisSi3 composites were obtained in a double-layer track, and the Vickers hardness of the track increased by two to three times compared with the Ti-5A1-2.5Sn substrate.

关键词： titanium alloys surface modification gas tungsten arc welding (GTAW) microstructure hardness

Study on Inertial Response Performance of A Micro Electrical Switch for Fuze

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Defence Technology（防务技术） 2013年第4期9卷 187-192页

作者： Wei-rong NIE Zhan-wen XI Wei-qing XUE Zhi-jian ZHOU School of Mechanical Engineering Nanjing University of Science and Technology

The design,modeling,and simulation of a micro electrical switch for fuze are *** consists of springemass system with zigzag slot in mass,latching and electrical connection mechanism and movement-limit *** switch keeps off-state until it is subjected to an acceleration when fuze is launched *** acceleration is simulated as half-sine pulse with specific amplitude and *** dynamics model of the switch is *** on zigzag slot in mass,the methods used for recognizing acceleration load are established and analyzed according to the dynamics *** typical half-sine accelerations are loaded on the switch in *** simulation results are in accordance with those of theoretical *** inertial response characteristics of the switch can ensure that the fuze power supply and circuit are connected safely and reliably.

关键词：引信电源响应性能电开关惯性弹簧质量系统模拟交换机微机动力学模型

Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue Sun wen Li Hai-qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

Spatial and Temporal Variability of Water Vapor Content during 1961-2011 in Tianshan Mountains,China

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Journal of Mountain Science 2015年第3期12卷 571-581页

作者： HU wen-feng YAO Jun-qiang HE qing YANG qing Center for Climate Change and Hydrologic Cycle in Arid Region College of Earth and Environmental ScienceLanzhou University College of Resources and Environment Xinjiang University Institute of Desert Meteorology China Meteorological Administration

Based on the climate factors data and surface vapor pressure （SVP） data of 44 weather stations in Tianshan Mountains during the years 1961-2011, this paper establishes a water vapor content （WVC） estimation model according to the relationship between monthly WVC of radiosonde and corresponding SVP and analyzes the spatial and temporal variability of WVC and their causes. The results show that the WVC is linearly and negatively related to the elevation and longitude （Vertical zonality and Longitude zonality）, while it was not linearly related to the latitude. The westerly wind, geographical situation and sea level elevation composed complex surface conditions to influence the spatial distribution of WVC in the Tianshan Mountains. The Mann-Kendall （M-K） statistical test shows a significant increasing trend in the mean annual WVC in Tianshan Mountains during 1961- 2011（P 〈 0.001）, with a rate of 0.23 mm/decade, and indicates an abrupt turning point in 1985 （P.〈0.001）. Correlation analysis shows that the WVC are significantly correlated to the temperature, especially during the winter, but the summer WVC are significantly correlated to the precipitation. In addition, the North Atlantic Oscillation Index （NAOI） and the Arctic Oscillation Index （AOI） are significantly correlated to the winter WVC in the Tianshan Mountains. As a new Microwave radiometric profilers （MWRPs） instrument, the MP- 3000A provides continuous, real-time and high temporal resolution atmospheric profiles up to 10 km. In order to monitor water vapor and atmosphere profiles in Tianshan Mountains, an MP-3000A was established in Urumqi （43.8°N, 87.58°N） in May 2008. The results indicated that the MP-3oooA was applicable to this area, and the evolutionary process of water vapor and the WVC peak values of MP- 3000A were a strong signal for rainstorm and flood forecasts for Urumqi and the Tianshan Mountains.

关键词： Water vapor content Spatial variability Temporal variability Microwave radiometers Tianshan Mountains

New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma:a retrospective study

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Chinese Journal of Cancer 2016年第12期35卷 713-724页

作者： qing-qing Cai Li-Yang Hu Qi-rong Geng Jie Chen Zhen-Hai Lu Hui-Lan Rao qing Liu wen-Qi Jiang Hui-Qiang Huang Tong-Yu Lin Zhong-Jun Xia State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China. Department of Medical Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuang-zhou 510060GuangdongP.R.China. Department of Hematology Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Guangdong Province Key Laboratory of Arrhythmia and Elec-trophysiology Guangzhou 510120GuangdongP.R.China. Department of Radiotherapy Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhou 510120GuangdongP.R.China. Department of Colorectal Carci-noma Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Department of Cancer Preven-tion Research Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China.

Background: In patients with difuse large B?cell lymphoma(DLBCL), central nervous system(CNS) relapse is uncom?mon but is nearly always fatal. This study aimed to determine the risk factors for CNS relapse in DLBCL patients and to evaluate the eicacy of rituximab and intrathecal chemotherapy prophylaxis for CNS relapse ***: A total of 511 patients with newly diagnosed DLBCL treated at the Sun Yat?sen University Cancer Center between January 2003 and December 2012 were included in the study. Among these patients, 376 received R?CHOP regimen(rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) as primary treatment, and 135 received CHOP regimen(cyclophosphamide, doxorubicin, vincristine, and prednisone) as primary treatment. Intrathe?cal chemotherapy prophylaxis(methotrexate plus cytarabine) was administered to those who were deemed at high risk for CNS relapse. In the entire cohort and in the R?CHOP set in particular, the Kaplan–Meier method coupled with the log?rank test was used for univariate analysis, and the Cox proportional hazards model was used for multivariate analysis. Diferences were evaluated using a two?tailed test, and P 110 U/L(HR = 3.59, 95% CI 1.25–10.34), serum albumin(ALB) <35 g/L(HR = 3.63, 95% CI 1.25–10.51), treatment with rituxi?mab(HR = 0.34, 95% CI 0.12–0.96), and a time to complete remission ≤ 108 days(HR = 0.22, 95% CI 0.06–0.78) were independent p

关键词： Diffuse large B?cell lymphoma Central nervous system relapse Risk factor Rituximab Intrathecal chemotherapy prophylaxis

MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4

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Current Medical Science 2023年第2期43卷 223-231页

作者： qing ZHANG rong-rong PAN Yu-tao WU Yu-miao WEI Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Cardiology Affiliated Cixi HospitalWenzhou Medical UniversityNingbo 315300China Department of Cardiology First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Objective Vascular smooth muscle cell(VSMC)differentiation from stem cells is one source of the increasing number of VSMCs that are involved in vascular remodeling-related diseases such as hypertension,atherosclerosis,and ***-146a(miR-146a)has been proven to be involved in cell proliferation,migration,and tumor ***,little is known about the functional role of miR-146a in VSMC differentiation from embryonic stem cells(ESCs).This study aimed to determine the role of miR-146a in VSMC differentiation from *** Mouse ESCs were differentiated into VSMCs,and the cell extracts were analyzed by Western blotting and *** addition,luciferase reporter assays using ESCs transfected with miR-146a/mimic and plasmids were ***,C57BL/6J female mice were injected with mimic or miR-146a-overexpressing ESCs,and immunohistochemistry,Western blotting,and RT-qPCR assays were carried out on tissue samples from these *** miR-146a was significantly upregulated during VSMC differentiation,accompanied with the VSMC-specific marker genes smooth muscle-alpha-actin(SMαA),smooth muscle 22(SM22),smooth muscle myosin heavy chain(SMMHC),and ***,overexpression of miR-146a enhanced the differentiation process in vitro and in ***,the expression of Kruppel-like factor 4(KLF4),predicted as one of the top targets of miR-146a,was sharply decreased in miR-146a-overexpressing ***,inhibiting KLF4 expression enhanced the VSMC-specific gene expression induced by miR-146a overexpression in differentiating *** addition,miR-146a upregulated the mRNA expression levels and transcriptional activity of VSMC differentiation-related transcription factors,including serum response factor(SRF)and myocyte enhancer factor 2c(MEF-2c).Conclusion Our data support that miR-146a promotes ESC-VSMC differentiation through regulating KLF4 and modulating the transcription factor activity of VSMCs.

关键词： microRNA-146a embryonic stem cells differentiation vascular smooth muscle cells Kruppel-like factor 4