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Signal Transduction and Targeted Therapy 2021年第3期6卷 596-598页

作者： An-Guo Wu Rong Pan Betty Yuen-Kwan Law wen-qiao qiu Jian-Ming Wu Chang-Long He Vincent Kam-Wai Wong Chong-Lin Yu Xiao-Gang Zhou Da-Lian Qin Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSchool of PharmacyDepartment of Human AnatomySchool of Preclinical MedicineEducation Ministry Key Laboratory of Medical ElectrophysiologySouthwest Medical UniversityLuzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina

Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins.

关键词： nude dopamine therapeutic

新疆杏果实发育过程中香气物质的变化及其特征成分的确定

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园艺学报 2016年第10期43卷 1878-1890页

作者：卢娟芳郑惠文郑巧张秋云李文慧席万鹏西南大学园艺园林学院重庆400716 新疆农科院轮台国家果树资源圃新疆轮台841600 南方山地园艺学教育部重点实验室重庆400715

以5个新疆主栽杏品种不同发育阶段的果皮和果肉为试验材料,使用GC–MS法检测分析其香气物质,共检测到154种香气物质,其中58种含量较为丰富。成熟期对果实香气物质的组成与含量有显著影响。随果实发育,芳樟醇、α–萜品醇、香叶醇、β–... 详细信息

以5个新疆主栽杏品种不同发育阶段的果皮和果肉为试验材料,使用GC–MS法检测分析其香气物质,共检测到154种香气物质,其中58种含量较为丰富。成熟期对果实香气物质的组成与含量有显著影响。随果实发育,芳樟醇、α–萜品醇、香叶醇、β–月桂烯、罗勒烯、2–己烯醇、苯乙醛和己醛的含量均迅速下降,而β–紫罗兰酮、香叶基丙酮、γ–癸内酯、δ–癸内酯和γ–十二内酯的含量迅速增加。果实发育前期以积累醇类、醛类、萜类和萜烯类为主,果实成熟过程中以积累酮类和内酯为主。果皮中萜类、萜烯类、醇、醛和内酯的含量均显著高于果肉中,而酮类物质的含量却显著低于果肉中。基于风味阈值法,共鉴别出新疆杏果实特征香气成分22种,其中芳樟醇、γ–癸内酯、δ–十二内酯、β–大马酮、顺,反–2,6–壬烯醛、苯乙醛、己醛、α–萜品醇、乙酸己酯、香叶醇和β–月桂烯等的贡献最大。

关键词：杏果实发育成熟香气物质风味

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Electronic structure and optical properties of plutonium dioxide from first-principles calculations

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Rare Metals 2016年第8期35卷 643-648页

作者： Jun Chen Da-qiao Meng qiu-Yun Chen wen-Hua Luo Science and Technology on Surface Physics and Chemistry Laboratory Mianyang 621907China

The electronic structure and optical properties of plutonium dioxide were calculated using the generalized gradient approximation with a Hubbard parameter U （GGA ＋ U） for considering the strong coulomb correlation between localized Pu of electrons based on the first-principles density functional theory. The calculated results show that PuO2 is a semiconductor material with the band gap of 1.8 eV, which is in good agreement with the corresponding experimental data. Furthermore, the dielectric function, reflectivity, refractive index, and extinction coefficient were calculated and analyzed using the Kramers-Kronig relationship for PuO2. The calculated results were compared with the experimental data from the published literature.

关键词： PuO2 Generalized gradientapproximation + U Electronic structure Optical properties

Refined mathematical model for the breaching of concrete-face sand-gravel dams due to overtopping failure

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Journal of Mountain Science 2023年第3期20卷 670-687页

作者： qiu wen LI Yan-long wen Li-feng WANG Jing YIN qiao-gang State Key Laboratory of Eco-hydraulics in Northwest Arid Region Xi'an University of TechnologyXi'an 710048China

Overtopping is one of the main reasons for the breaching of concrete-face sand-gravel dams(CFSGDs).In this study,a refined mathematical model was established based on the characteristics of the overtopping breaching of *** model characteristics were as follows:(1)Based on the Renormailzation Group(RNG)k-εturbulence theory and volume of fluid(VOF)method,the turbulent characteristics of the dam-break flow were simulated,and the erosion surface of the water and soil was tracked;(2)In consideration of the influence of the change in the sediment content on the dam-break flow,the dam material transport equation,which could reflect the characteristics of particle settlement and entrainment motion,was used to simulate the erosion process of the sand gravels;(3)Based on the bending moment balance method,a failure equation of the concrete face slab under dead weight and water load was *** proposed model was verified through a case study on the failure of the Gouhou *** results showed that the proposed model could well simulate the erosion mode of the special vortex flow of the CFSGD scouring the support body of the concrete face slab inward and reflect the mutual coupling relationship between the dam-break flow,sand gravels,and concrete face *** with the measured values,the relative errors of the peak discharge,final breach average width,dam breaching duration,and maximum failure length of the face slab calculated using the proposed model were all less than 12%,thus verifying the rationality of the *** proposed model was demonstrated to perform better and provide more detailed results than three selected parametric models and three simplified mathematical *** study results can aid in establishing the risk level and devising early warning strategies for CFSGDs.

关键词： Concrete-face sand-gravel dam Overtopping Dam-break flow Concrete face slab failure Refined mathematical model

Analysis of the penalty version of the Arlequin framework for the prediction of structural responses with large deformations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第7期12卷 552-560页

作者： Hua qiao Wei-qiu CHEN Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China

The Arlequin framework proposed by Ben Dhia in 1998 is a flexible and robust method for conducting global/local analysis of structures and materials.A penalty version of the Arlequin framework for the study of structural problems involving large deformation is considered *** implementation of the penalty-based Arlequin framework into ABAQUS is then explored and the corresponding Arlequin user element subroutine is *** nonlinear simulations of a cantilever beam and a shallow arch are conducted and the choice of the coupling operator with an appropriate penalty parameter is *** numerical results justify the feasibility of the proposed method,ensuring its further application to more complicated problems involving geometric or material nonlinearities.

关键词： Global/Local analysis Geometric nonlinear analysis Penalty-based Arlequin method User defined element

Exploring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies

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World Journal of Gastroenterology 2025年第2期31卷 147-156页

作者： Tong qiao Xian-Hui wen Department of Clinical Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Life Science and Technology Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Extensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental ***,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of *** paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and exploring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic *** fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut *** characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD ***,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary *** elucidating the complex interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关键词： Crohn’s disease Gut microbiome Dysbiosis Creeping fat Fecal microbiota transplantation

Nitrogen-doped graphene/carbon nanohorns composite as a high-performance supercapacitor electrode

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Journal of Materials Science & Technology 2017年第11期33卷 1339-1345页

作者： Xiao-Qiang Lin wen-Dong Wang qiu-Feng Lu Yan-qiao Jin Qilang Lin Rui Liu College of Materials Science and Engineering Fuzhou University Fuzhou 350116 China Key Laboratory of Eco-materials Advanced Technology Fuzhou University Fuzhou 350116 China Ministry of Education Key Laboratory of Advanced Civil Engineering Material School of Materials Science and Engineering and Institute for AdvancedStudy Tongji University Shanghai 201804 China

Nitrogen-doped graphene/carbon nanohorns composite（NGLC） was prepared by one-step co-pyrolysis of graphene oxide, carbon nanohorns（CNHs）, urea, and lignosulfonate. CNHs as spacers were inserted into graphene nanosheets. The introduction of CNHs and the loosened nano-structure of NGLC make it achieve a high specific capacitance of 363 Fg^（-1） at a discharge current density of 1 A g^（-1）, and NGLC exhibits an ultrahigh stability of 93.5% capacitance retention ratio after 5000 cycles. The outstanding comprehensive electrochemical performance of NGLC could meet the need of the future acted as an efficient supercapacitor electrode material.

关键词： Nitrogen-doped graphene Carbon nanohorns Spacer Supercapacitor High-performance

Design,Synthesis and Electrochromic Properties of Anthraquinone Imide-based Donor-acceptor Type of Near Infrared Chromophores

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Chemical Research in Chinese Universities 2012年第2期28卷 239-241页

作者： qiao wen-qiang Key Laboratory of Materials Behaviors and Evaluation Technology in Space Environments Harbin Institute of TechnologyHarbin 150001P.R.China

A new series of near infrared（NIR） electrochromic anthraquinone imides containing a triphenylamine moiety as an electron donor was synthesized and their electrochemical and spectroelectrochemical behavior were *** results show that the new anthraquinone imides are redox active which can be reduced electrochemically from the neutral state to the radical anion form that absorbs in a range of 700―1200 nm.

关键词： Anthraquinone imide Triphenylamine moiety Near infrared electrochromism

Preparation and Characterization of Nano-silver Loaded Montmorillonite with Strong Antibacterial Activity and Slow Release Property

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Journal of Materials Science & Technology 2011年第8期27卷 685-690页

作者： Guangnian Xu Xueliang qiao Xiaolin qiu Jianguo Chen Anhui Provincial Laboratory of Biomimetic Sensing and Detection Technology West Anhui University Liuan 237012 China State Key Laboratory of Material Processing and Die & Mould Technology Huazhong University of Science and Technology Wuhan 430074 China Nanomaterials Research Center Nanchang Institute of Technology Nanchang 330013 China

Nano-silver loaded montmorillonite （Ag-MMT） was prepared by ion-exchange and then a UV-photoreduction two-step approach was applied. The silver content in Ag-MMT determined by Volhard method was about 6.4 wt%. The morphology and structure of as-synthesized Ag-MMT were characterized by scanning electron microscopy （SEM） and X-ray diffraction （XRD）. The results showed that the Ag nanoparticles were spherical and their diameters were about 15-20 nm. Moreover, the structure of MMT did not change. The minimum inhibition concentration （MIC） of Ag-MMT was 100×10-6 and the sterilizing efficiency （SE） of Ag-MMT was approximately 100% against Escherichia coli ATCC 11229 （E. coli. In addition, the slow release property of silver in Ag-MMT was also demonstrated.

关键词： Silver loaded montmorillonite Photoreduction Antibacterial activity Slow release property