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Epidemiology and evolution of Middle East respiratory syndrome coronavirus, 2012-2020

Infectious Diseases of Poverty 2021年第3期10卷 1-13页

作者： An-Ran Zhang wen-qiang shi Kun Liu Xin-Lou Li Ming-Jin Liu wen-Hui Zhang Guo-Ping Zhao Jin-Jin Chen Xiao-Ai Zhang Dong Miao Wei Ma Wei Liu Yang Yang Li-Qun Fang Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong University44 West Wenhua RoadJinanPeople's Republic of China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology20 Dong-Da StreetFengtai DistrictBeijing 100071People's Republic of China Department of Biostatistics College of Public Health and Health Professionsand Emerging Pathogens InstituteUniversity of FloridaGainesvilleFLUSA Department of Epidemiology Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational EnvironmentSchool of Public HealthAir Force Medical UniversityxranPeople's Republic of China Department of Medical Research Key Laboratory of Environmental Sense Organ Stress and Health of the Ministry of Environmental ProtectionPLA Stragetic Support Force Characteristic Medical CenterBeijingPeople's Republic of China Logistics College of Chinese People's Armed Police Forces TianjinPeople's Republic of China.

Background:The ongoing transmission of the Middle East respiratory syndrome coronavirus(MERS-CoV)in the Middle East and its expansion to other regions are raising concerns of a potential pandemic.An in-depth analysis about both population and molecular epidemiology of this pathogen is needed.Methods:MERS cases reported globally as of June 2020 were collected mainly from World Health Organization official reports,supplemented by other reliable sources.Determinants for case fatality and spatial diffusion of MERS were assessed with Logistic regressions and Cox proportional hazard models,respectively.Phylogenetic and phylogeographic analyses were performed to examine the evolution and migration history of MERS-CoV.Results:A total of 2562 confirmed MERS cases with 150 case clusters were reported with a case fatality rate of 32.7%(95%Cl:30.9-34.6%).Saudi Arabia accounted for 83.6%of the cases.Age of>65 years old,underlying conditions and>5 days delay in diagnosis were independent risk factors for death.However,a history of animal contact was associated with a higher risk(adjusted OR=297,95%Cl:1」0-7.98)among female cases65 years old.Diffusion of the disease was fastest from its origin in Saudi Arabia to the east,and was primarily driven by the transportation network.The most recent subclade C5.1(since 2013)was associated with non-synonymous mutations and a higher mortality rate.Phylogeographic analyses pointed to Riyadh of Saudi Arabia and Abu Dhabi of the United Arab Emirates as the hubs for both local and international spread of MERS-CoV.Conclusions:MERS-CoV remains primarily locally transmitted in the Middle East,with opportunistic exportation to other continents and a potential of causing transmission clusters of human cases.Animal contact is associated with a higher risk of death,but the association differs by age and sex.Transportation network is the leading driver for the spatial diffusion ofthe disease.These findings how this patho

关键词： Middle East respiratory syndrome MERS-CoV Case fatality rate Spatial diffusion Phylogeny Phylogeographic dynamic

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Ultrasound diagnosis of congenital Morgagni hernias: Ten years of experience at two Chinese centers

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World Journal of Clinical Cases 2024年第3期12卷 495-502页

作者： Hui-Qing shi wen-Juan Chen qiang Yin Xue-Hua Zhang Department of Ultrasound Fujian Children’s Hospital(Fujian Branch of Shanghai Children’s Medical Center)College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350011Fujian ProvinceChina Department of Ultrasound Hunan Children’s HospitalUniversity of South ChinaChangsha 410007Hunan ProvinceChina Department of Pediatric Surgery Hunan Children’s HospitalUniversity of South ChinaChangsha 410007Hunan ProvinceChina

BACKGROUND Morgagni hernias are rare anomalies that are easily misdiagnosed or missed.AIM To summarize the ultrasound(US)imaging characteristics of Morgagni hernias through a comparison of imaging and surgical results.METHODS The records of children with Morgagni hernias who were hospitalized at two hospitals between January 2013 and November 2023 were retrospectively re-viewed in terms of clinical findings,US features,and operative details.RESULTS Between 2013 and 2023,we observed nine(five male and four female)children with Morgagni hernias.Upper abdominal scanning revealed a widening of the prehepatic space,with an abnormal channel extending from the xiphoid process to the right or left side of the thoracic cavity.The channel had intestinal duct and intestinal gas echoes.Hernia contents were found in the transverse colon(n=6),the colon and small intestine(n=2),and the colon and stomach(n=1).Among the patients,seven had a right-sided lesion,two had a left-sided lesion,and all of them had hernial sacs.CONCLUSION US imaging can accurately determine the location,extent,and content of Morgagni hernias.For suspected Mor-gagni hernias,we recommend performing sonographic screening first.

关键词： Children Congenital diaphragmatic hernias Morgagni hernia Operation Ultrasound Gastrointestinal imaging

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Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

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Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU shi-hao shi Wei-qi LI Yu-hang LIU Ru-hui HU Da-yi ZHENG Li-qiang MA wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and QOL.Patients were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, P<0.01);57.52%(585/1,017) patients' depressive symptoms improved to sub-clinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, P<0.01) at F3. All aspects of QOL significantly improved at the end of treatment compared to those at baseline(all P<0.01) as assessed by SAQ: physical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

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Spontaneous Infection and Periodic Evolving of Domain in a Diffusive SIS Epidemic Model

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 164-191页

作者： qiang wen Guo-qiang Ren Bin Liu School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan430074China

In this paper, we consider a susceptible-infective-susceptible(SIS) reaction-diffusion epidemic model with spontaneous infection and logistic source in a periodically evolving domain. Using the iterative technique,the uniform boundedness of solution is established. In addition, the spatial-temporal risk index R0(ρ) depending on the domain evolution rate ρ(t) as well as its analytical properties are discussed. The monotonicity of R0(ρ)with respect to the diffusion coefficients of the infected dI, the spontaneous infection rate η(ρ(t)y) and interval length L is investigated under appropriate conditions. Further, the existence and asymptotic behavior of periodic endemic equilibria are explored by upper and lower solution method. Finally, some numerical simulations are presented to illustrate our analytical results. Our results provide valuable information for disease control and prevention.

关键词： diffusive SIS model spontaneous infection periodically evolving domain periodic endemic equilibrium

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Metallaphotoredox-Catalyzed Three-Component Couplings for Practical Synthesis of Ureas and Carbamates

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Chinese Journal of Chemistry 2024年第3期42卷 264-270页

作者： Ernest Koranteng Zhen-Cao Shu Yi-Yin Liu Qian Yang Bin shi qiang-Xian Wu Fen Tan Liang-Qiu Lu wen-Jing Xiao Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University152 Luoyu RoadWuhanHubei430079 China Wuhan Youji Industries Co. LtdNo.1 2nd Chemical Rd.WuhanHubei430082 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanHubei430205 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China Wuhan Institute of Photochemistry and Technology WuhanHubei430082 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen bonds.Therefore,it is of great scientific significance to develop efficient and green methods for the synthesis of urea compounds,especially unsymmetrical ureas.Here,we have disclosed novel and highly efficient three-component coupling reactions of organic halides,sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical ureas.The reaction features simple and safe operations,broad substrate scopes,and product diversities.It allows the facile synthesis of N-aryl/vinyl ureas from readily available,user-friendly feedstocks under mild conditions(27 examples,36%—98%yields).In addition,this method is further derived to alcohols as nucleophiles to synthesize a series of carbamates(15 examples,40%—95%yields).The mechanism experiment shows that the isocyanate produced by the coupling of halide and sodium cyanate may be the key intermediate in this reaction.

关键词： Cross-coupling Nickel Photoredox catalysis Three-component reaction Ureas Carbamates

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Emergent symmetry in quantum phase transition:From deconfined quantum critical point to gapless quantum spin liquid

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Science Bulletin 2024年第2期69卷 190-196页

作者： wen-Yuan Liu Shou-Shu Gong Wei-qiang Chen Zheng-Cheng Gu Department of Physics The Chinese University of Hong KongHong KongChina Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadena CA 91125USA School of Physical Sciences Great Bay UniversityDongguan 523000China Great Bay Institute for Advanced Study Dongguan 523000China Department of Physics and Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The emergence of exotic quantum phenomena in frustrated magnets is rapidly driving the development of quantum many-body physics,raising fundamental questions on the nature of quantum phase transitions.Here we unveil the behaviour of emergent symmetry involving two extraordinarily representative phenomena,i.e.,the deconfined quantum critical point(DQCP)and the quantum spin liquid(QSL)state.Via large-scale tensor network simulations,we study a spatially anisotropic spin-1/2 square-lattice frustrated antiferromagnetic(AFM)model,namely the J1x-J1y-J2 model,which contains anisotropic nearestneighbor couplings J1x,J1y and the next nearest neighbor coupling J2.For small J1y/J1x,by tuning J2,a direct continuous transition between the AFM and valence bond solid phase is observed.With growing J1y/J1x,a gapless QSL phase gradually emerges between the AFM and VBS phases.We observe an emergent O(4)symmetry along the AFM–VBS transition line,which is consistent with the prediction of DQCP theory.Most surprisingly,we find that such an emergent O(4)symmetry holds for the whole QSL–VBS transition line as well.These findings reveal the intrinsic relationship between the QSL and DQCP from categorical symmetry point of view,and strongly constrain the quantum field theory description of the QSL phase.The phase diagram and critical exponents presented in this paper are of direct relevance to future experiments on frustrated magnets and cold atom systems.

关键词： Tensor network Quantum phase transition Emergent symmetry Quantum spin liquid Deconfined quantum critical point Anisotropic

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Lithospheric strength of the Anatolian plateau and implications for strong earthquake activity in Turkey

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Geodesy and Geodynamics 2024年第3期15卷 209-218页

作者： Yuhang Pan shi Chen wen shi Institute of Geophysics China Earthquake AdministrationBeijing 100081China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 100095China

On February 6, 2023, the doublet earthquake including two main shocks with magnitudes M_(W)7.8 and M_(W)7.5, occurred near the western side of the East Anatolian Fault at the southeast boundary of the Anatolian Plateau in Turkey. Based on the WGM2012 Bouguer gravity anomaly data and the Etopo1topography data, this study first introduced a joint inversion of admittance and coherence functions and used the Bayesian optimal parameter estimation method to obtain the effective elastic thickness Teand loading ratio F of the lithosphere for various tectonic units in the Anatolian Plateau. Secondly, we discussed the characteristics and influencing factors of the lithospheric mechanical strength and analyzed its relationship with seismic activity. The lithospheric mechanical strength of the Anatolian Plateau showed clear lateral heterogeneity and a "weak-strong-weak" spatial pattern from east to west,reflecting various tectonic processes. At last, the strong seismic activity was found where the lithospheric strength was low in the Anatolian Plate. We also incorporated GPS strain rate and other results to investigate the tectonic background and primary causes of the M_(W)7.8 and M_(W)7.5 doublet earthquakes in Turkey. The results have a good insight into urban safety design in the Turkish region, including postdisaster rehabilitation, earthquake hazard assessment, and loss reduction.

关键词： Effective elastic thickness Anatolian plateau Turkey doublet earthquakes Bayesian optimization

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A bilateral heterogeneous graph model for interpretable job recommendation considering both reciprocity and competition

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Frontiers of Engineering Management 2024年第1期11卷 128-142页

作者： Xiaowei shi qiang WEI Guoqing CHEN School of Economics and Management Tsinghua UniversityBeijing 100084China

Amidst the inefficiencies of traditional job-seeking approaches in the recruitment ecosystem, the importance of automated job recommendation systems has been magnified. However, existing models optimized to maximize user clicks for general product recommendations prove inept in addressing the unique challenges of job recommendation, namely reciprocity and competition. Moreover, sparse data on online recruitment platforms can further negatively impact the performance of existing job recommendation algorithms. To counteract these limitations, we propose a bilateral heterogeneous graph-based competition iteration model. This model comprises three integral components: 1) two bilateral heterogeneous graphs for capturing multi-source information from people and jobs and alleviating data sparsity, 2) fusion strategies for synthesizing attributes and preferences to produce mutually beneficial job matches, and 3) a competition-enhancing strategy for dispersing competition realized through a two-stage optimization algorithm. Augmented by granular attention mechanisms for enhanced interpretability, the model’s efficacy, competition dispersion, and interpretability are validated through rigorous empirical evaluations on a real-world recruitment platform.

关键词： job recommendation competition reciprocity interpretability

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Quantitative characterization of fusion state of virgin and aged asphalt using nano-ferrous ferric oxide tracer

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 467-480页

作者： qiang Li Song Liu Huameng wen Zhou Zhou College of Civil Engineering Nanjing Forestry University School of Transportation Southeast University

The exact evaluation of the fusion rate of virgin and aged asphalt is essential to optimize the performance of the recycled asphalt mixture. The fusion rate index was developed by tracing the distribution of tracer asphalt, which contains nano-ferrous ferric oxide（nano-Fe3O4） tracer. Laboratory fusion simulation tests were performed on three types of asphalt to obtain different fusion states, and fatigue tests were performed to evaluate the influence of the fusion rate on the fatigue life of the recycled asphalt. It was found that the tracer asphalt containing 4% nano-Fe3O4shows the optimal trace effect, and the developed fusion rate index can quantitatively characterize the influence of different factors on the fusion state of the recycled asphalt. The fusion state is closely related to the fatigue performance of recycled asphalt, and the fusion rate index can fairly evaluate its fatigue performance.The relationship between the fusion rate and the fatigue life of recycled asphalt depends on the factors that cause the fusion rate variation. Under the influence of the amount of rejuvenator, the fatigue life of recycled asphalt grows exponentially with increasing fusion rate due to enhancement of molecular motion as well as a supplement of lightweight components. Under the influence of heat preservation treatment, fatigue life increases linearly with increasing fusion rate. The proposed fusion rate index can be utilized to quantitatively characterize the fusion state of virgin and aged asphalt, thus providing a simple way to guide the practical application of recycled asphalt.

关键词： Recycled asphalt Rejuvenator Tracing technique Fusion rate Fatigue

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Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第10期30卷 1393-1404页

作者： Ming-Hui Zeng Qi-Yu shi Liang Xu Yu-qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Gastroenterology Cangzhou People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Tianjin Research Institute of Liver Diseases Tianjin 300192China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic burden.To date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of treatment.Identifying patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very important.AIM To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle interventions.METHODS The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently evaluated.Demographic and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 months.The efficacy of the EDAS was evaluated in the initial cohort.Subsequently,the efficacy of the EDAS was internally verified in a validation cohort.RESULTS The EDAS consisted of 33 items in six dimensions,with a total of 165 points.Total EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(P500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,and<97 points were indicative of good,average,and poor adherence,respectively,to diet and exercise recommendations.CONCLUSION The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

关键词： Fatty liver Lifestyle intervention Behavioral change Patient adherence Compliance

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