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Immune function, gastrointestinal hormone levels, and their clinical significance in patients with gastric ulcers complicated with depression

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World Journal of Psychiatry 2023年第9期13卷 665-674页

作者： Yun-Han Yang De-Jun Cui Zai-Li Yang wen-qiang yuan Bo Huang Department of Gastroenterology Guizhou Inflammatory Bowel Disease Research CenterNational Institution of Drug Clinical TrialGuizhou Provincial People’s HospitalMedical College of Guizhou UniversityGuiyang 550002Guizhou ProvinceChina

BACKGROUND Gastric ulcer(GU)is a common digestive tract disease,and medical records of GU combined with depression are increasingly ***,the risk factors and pathogenesis of GU complicated with depression remain *** immune function and gastrointestinal hormone levels may also be significant risk ***,this study explored the immune function and gastrointestinal hormone levels in patients with GU combined with *** To explore the immune function,gastrointestinal hormone level,and clinical significance of patients with GU combined with *** A retrospective analysis was conducted on 300 patients with GU combined with depression admitted to Guizhou Provincial People’s Hospital from January 2021 to June 2022 as the study *** to the Hamilton Depression Scale(HAMD)score,patients were divided into mild-to-moderate(n=210)and heavy(n=90)*** data,immune function indices[immunoglobulin A(IgA),IgM,IgG,serum CD4+and CD8+percentage,and CD4+/CD8+ratio],and gastrointestinal hormone indices[serum gastrin(GAS),cholecystokinin(CCK),and motilin(MTL)levels]were *** basic data of the two groups were compared,and the immune function and gastrointestinal hormone indices were *** logistic regression was used to analyze the factors influencing the severity of GU complicated with *** receiver operating characteristic(ROC)curve and area under the ROC curve(AUC)were used to analyze the value of the immune function index,gastrointestinal hormone index,and combined index in predicting the severity of GU complicated with *** There were no marked differences in sex,age,body mass index,abdominal distension,abdominal pain,belching,nausea,vomiting,or sleep disorders between the heavy and mild-to-moderate groups(P>0.05).There was a marked difference in the family history of depression between the heavy and mild-to-moderate groups(P<0.05).There were significant differences

关键词： Gastric ulcer combined with depression Immune function Gastrointestinal hormones

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基于声誉计算的可信O2O服务提供商推荐方法

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应用科学学报 2017年第5期35卷 585-601页

作者：朱文强钟元生江西财经大学软件与通信工程学院南昌330013

O2O电子商务近年来发展迅猛,然而部分O2O服务提供商存在不能诚信经营的问题.面对浩如烟海的O2O服务提供商,用户难以做出对自己有利的选择.针对这一问题,提出一种基于声誉计算的可信O2O服务提供商推荐方法.该方法根据用户服务评价矩阵计... 详细信息

O2O电子商务近年来发展迅猛,然而部分O2O服务提供商存在不能诚信经营的问题.面对浩如烟海的O2O服务提供商,用户难以做出对自己有利的选择.针对这一问题,提出一种基于声誉计算的可信O2O服务提供商推荐方法.该方法根据用户服务评价矩阵计算用户对服务的加权评价,产生用户对商家的综合评价,进而得到用户商家综合评价矩阵.结合商家声誉,计算用户之间的O2O服务提供商偏好相似性,然后进行推荐.与现有的推荐方法相比,所提出的推荐方法能更有效地对O2O服务提供商的服务质量和经营是否诚信等问题进行过滤,同时考虑用户的偏好属性,具有更高的推荐准确度和更强的抗欺诈能力.

关键词：推荐系统 O2O商务声誉服务推荐可信O2O服务商家协同过滤

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“三部”推拿法治疗椎动脉型颈椎病60例

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江苏中医药 2007年第12期39卷 49-50页

作者：姚冰温元强牟菁烟台市中医医院山东烟台264000 成都中医药大学四川成都610075

笔者自2004年11月至2006年11月．以头面、颈、肩三部推拿法治疗椎动脉型颈椎病60例．疗效满意，现报告如下。

关键词：椎动脉型颈椎病推拿疗法脑血流图

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao qiang yuan Liting Yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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Advances of studies on acupuncture and moxibustion for treatment of language disorder in children with cerebral palsy

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World Journal of Acupuncture-Moxibustion 2010年第4期20卷 54-59页

作者：温元强董小丽成都市中西医结合医院儿童康复中心

The literatures about the therapeutic effect of acupuncture and moxibustion on language disorder in children with cerebral palsy were reviewed. The symptoms of language disorder in children with cerebral palsy and the procedures of rehabilitation treatments were analyzed. The acupuncture intervention on language disorder in children with cerebral palsy was investigated. It showed that the acupuncture intervention may markedly improve the condition of language disorder in children with cerebral palsy. However, the effectiveness is compared between comprehensive therapy and single therapy in the current literatures on acupuncture intervention. Therefore, the comparison between comprehensive therapies was lacked, and the advantage of acupuncture intervention combined with other therapies was not demonstrated. In the future, the studies should focus on the combination of various therapies and the different effectiveness of different therapies. Furthermore, the studies should focus on the mechanism of acupuncture. Therefore, it may contribute to build a comprehensive treatment system in which acupuncture is dominant for cerebral palsy in children.

关键词： Acupuncture-Moxibustion Cerebral Palsy Language Disorder

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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推拿治疗心脾两虚型颈性失眠的疗效观察

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中医药导报 2015年第17期21卷 56-58页

作者：温元强陈立温伯平成都军区机关医院四川成都610017

目的:观察不同理论指导的推拿疗法治疗心脾两虚型颈性失眠的临床疗效。方法:124例心脾两虚型颈性失眠患者随机分为推拿Ⅰ组(40例)、推拿Ⅱ组(42例)和推拿Ⅲ组(42例),分别进行推拿治疗,记录治疗后PSQI评分改变情况,并进行统计学分析。结... 详细信息

目的:观察不同理论指导的推拿疗法治疗心脾两虚型颈性失眠的临床疗效。方法:124例心脾两虚型颈性失眠患者随机分为推拿Ⅰ组(40例)、推拿Ⅱ组(42例)和推拿Ⅲ组(42例),分别进行推拿治疗,记录治疗后PSQI评分改变情况,并进行统计学分析。结果:治疗后3组PSQI评分均较治疗前有所下降(P0.05)。推拿Ⅰ组愈显率为42.5%,推拿Ⅱ组47.6%,推拿Ⅲ组69.1%,3组之间差异有统计学意义(P<0.05)。结论:推拿是治疗心脾两虚型颈性失眠的有效方法,且综合理论指导的推拿方法疗效优于单一理论指导的推拿方法。

关键词：颈性失眠心脾两虚推拿

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中药蜡疗治疗脑瘫上肢痉挛30例疗效观察

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辽宁中医杂志 2008年第8期35卷 1191-1192页

作者：孔勉董晓丽温元强余亚平成都市中西医结合医院儿童康复中心四川成都610017

目的:观察中药蜡疗配合作业疗法对脑瘫上肢痉挛的治疗效果。方法:将60例有上肢痉挛的脑瘫患儿随机分为治疗组和对照组,每组30例,两组均进行常规作业疗法,对照组于作业治疗前进行45m in普通蜡疗;治疗组于作业治疗前进行45m in中药蜡疗,... 详细信息

目的:观察中药蜡疗配合作业疗法对脑瘫上肢痉挛的治疗效果。方法:将60例有上肢痉挛的脑瘫患儿随机分为治疗组和对照组,每组30例,两组均进行常规作业疗法,对照组于作业治疗前进行45m in普通蜡疗;治疗组于作业治疗前进行45m in中药蜡疗,治疗均为每日1次,3个月后进行疗效评价。结果:两组患儿经过3个月治疗后,各项指标与治疗前相比有所改善,差异均有统计学意义(P<0.01),且治疗组较对照组效果明显。结论:中药蜡疗加作业疗法组与普通蜡疗加作业疗法对脑瘫的上肢痉挛、上肢运动功能及日常生活能力均有改善作用,但中药蜡疗加作业疗法较普通蜡疗加作业疗法对脑瘫的上肢痉挛及运动功能、日常生活能力的改善作用更明显。

关键词：中药蜡疗作业疗法脑瘫上肢痉挛

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao yuan Lingqi Yu Xudong Zhuang Dongjing wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang wen-Chao Cheng De-Zhi yuan wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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