检索结果-南通市图书馆

Behavior and controlling factors of methane adsorption in Jurassic continental shale,northeastern Sichuan Basin

Energy Geoscience 2023年第1期4卷 83-92页

作者： qian-wen li Zhong-bao liu Fei-Ran Chen Kun Zhang ling Tang Sinopec Petroleum Exploration and Production Research Institute Beijing102206China Sinopec Southern Company of Exploration ChengduSichuan 610041China School of Geoscience and Technology Southwest Petroleum UniversityChengduSichuan 610059China CNOOC Research Institute Ltd. Beijing100029China

The behavior and controlling factors of natural gas adsorption in the Jurassic continental shale in the northeastern Sichuan Basin are studied based on the organic geochemical features,mineral compositions and pore structure parameters through a series of experiments on samples from the *** show that the total gas content of the shale measured on-site is 0.1-5.3 cm^(3)/g,with an average of 0.7 cm^(3)/*** methane isothermal adsorption curves show a trend of increasing first and then decreasing,indicating an obvious excessive *** shale has a maximum adsorption capacity(V^(L))of 0.44-3.59 cm^(3)/g,with an average of 1.64 cm^(3)/g,lower than that of marine shale in the same *** organic matter content and pore structure characteristics are identified as the two main factors controlling the adsorption capacity of the *** in the shale are the main storage space for gas to be *** to well developed shell laminae and interlayers in the shale,calcite plays a more important role than clay minerals in affecting the adsorption of gas to the *** formation temperature and water content also significantly inhibit the gas adsorption to the *** with marine shale in the basin,the Jurassic continental shale is more heterogeneous and lower in TOC ***,with a more widely developed clayey shale lithofacies and shell limy shale lithofacies as well as relatively less developed organic pores and micropores,the continental shale is inferior to marine shale in terms of gas adsorption capacity.

关键词： Methane adsorption Controlling factors Continental shale Jurassic Sichuan basin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel MIP gene mutation causes autosomal-dominant congenital cataract

引用

International Journal of Ophthalmology(English edition) 2024年第3期17卷 454-465页

作者： Jing-Lan Ni Hua-Ming wen Xiao-Sheng Huang qian-wen li Jia-Min Cai Bao-Jian Fan Jun Zhao The Second Clinical Medical College Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Ophthalmology Dongguan Chang’an HospitalDongguan 523843Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Oral&Maxillofacial Surgery Shenzhen Stomatology Hospital Affiliated to Shenzhen UniversityShenzhen 518040Guangdong ProvinceChina Department of Neurosurgery Massachusetts General Hospital and Harvard Medical SchoolBoston 02114MassachusettsUSA Department of Ophthalmology Shenzhen People’s Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina

●AIM:To identify disease-causative mutations in families with congenital cataract.●METHODS:Two Chinese families with autosomaldominant congenital cataract(ADCC)were recruited and underwent comprehensive eye *** panel next-generation sequencing of common pathogenic genes of congenital cataract was performed in the proband of each *** sequencing was used to valid the candidate gene mutations and sequence the other family members for co-segregation *** effect of sequence changes on protein structure and function was predicted through bioinformatics *** intrinsic protein(MIP)-wildtype and MIP-G29R plasmids were constructed and microinjected into zebrafish single-cell stage *** embryonic lens phenotypes were screened using confocal microscopy.●RESULTS:A novel heterozygous mutation(c.85G>A;p.G29R)in the MIP gene was identified in the proband of one family.A known heterozygous mutation(c.97C>T;p.R33C;rs864309693)in MIP was found in the proband of another ***-silico prediction indicated that the novel mutation might affect the MIP protein *** embryonic lens was uniformly transparent in both wild-type PCS2+MIP and mutant PCS2+MIP.●CONCLUSION:Two missense mutations in the MIP gene in Chinese cataract families are identified,and one of which is *** findings expand the genetic spectrum of MIP mutations associated with *** functional studies suggest that the novel MIP mutation might not be a gain-of-function but a loss-of-function mutation.

关键词： congenital cataract major intrinsic protein missense mutation zebrafish model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical simulation on dynamic behaviors of bubbles flowing through bifurcate T-junction in microfluidic device

引用

Chinese Physics B 2019年第10期28卷 417-427页

作者： liang-Yu Wu ling-Bo liu Xiao-Tian Han qian-wen li Wei-Bo Yang School of Hydraulic Energyand Power EngineeringYangzhou UniversityYangzhou 225127China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Based on the volume of fluid(VOF) method, a numerical model of bubbles splitting in a microfluidic device with T-junction is developed and solved numerically. Various flow patterns are distinguished and the effects of bubble length,capillary number, and diameter ratio between the mother channel and branch are discussed. The break-up mechanism is explored in particular. The results indicate that the behaviors of the bubbles can be classified into two categories: break-up and non-break. Under the condition of slug flowing, the branches are obstructed by the bubbles that the pressure difference drives the bubbles into break-up state, while the bubbles that retain non-break state flow into an arbitrary branch under bubbling flow condition. The break-up of the short bubbles only occurs when the viscous force from the continuous phase overcomes the interfacial tension. The behavior of the bubbles transits from non-break to break-up with the increase of capillary number. In addition, the increasing of the diameter ratio is beneficial to the symmetrical break-up of the bubbles.

关键词： microfluidic T-junction bubble break-up numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First-line atezolizumab plus chemotherapy in treatment of extensive small cell lung cancer:a cost-effectiveness analysis from China

引用

Chinese Medical Journal 2019年第23期132卷 2790-2794页

作者： ling-Yu li Hong Wang Xiao Chen wen-qian li Jiu-Wei Cui The Cancer Center of the First Hospital of Jilin University ChangchunJilin 130021China

Background:IMpower 133 trial first confirmed the efficacy and safety of adding atezolizumab or placebo to first-line treatment with chemotherapy in patients with extensive-stage small-cell lung cancer(SCLC).While,overprice limited its broad use in *** aim of this study was to evaluate the cost-effectiveness of atezolizumab plus chemotherapy in treatment of extensive SCLC as first line in ***:A Markov model was established by extracting data from the IMpower 133 trial with untreated extensive SCLC *** values were obtained from published studies,and the costs were acquired from real world and ***,sensitivity analyses based on a willingness-to-pay(WTP)threshold were performed to identify the uncertain parameters of Markov ***:Total costs of atezolizumab group were$48,129,while cost of chemotherapy alone was just$12,920 in placebo *** quality-adjusted life-years(QALYs)in atezolizumab group was just 0.072 higher than that in placebo group(0.858 QALYs vs.0.786 QALYs).The cost-effectiveness ratio between atezolizumab combination with chemotherapy and chemotherapy alone was$489,013/QALY in *** net benefit of placebo group was significantly higher than atezolizumab ***-way sensitivity analyses highlighted that utilities of the progression-free survival(PFS)and progression disease state in placebo group were the most influential ***:Atezolizumab combination therapy was not more cost-effective than chemotherapy alone at a WTP threshold of$25,929/QALY in China.

关键词： Cost-effectiveness Immunotherapy Chemotherapy Small cell lung cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cost-effectiveness of programmed cell death ligand 1 testing and tumor mutational burden testing of immune checkpoint inhibitors for advanced non-small cell lung cancer

引用

Chinese Medical Journal 2020年第21期133卷 2630-2632页

作者： wen-qian li ling-Yu li Ri-Lan Bai Lei qian Nai-Fei Chen Jiu-Wei Cui Department of Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

To the Editor:Worldwide,lung cancer,particularly non-small cell lung cancer(NSCLC),is the leading cause of tumor-related ***-effectiveness analysis show no economic benefits for advanced NSCLC patients over chemotherapy.[1]Furthermore,tests such as programmed cell death ligand 1(PD-L1)and tumor mutational burden(TMB)tests,evaluated via immunohistochemical methods and next-generation sequencing,respectively,are widely used for screening potential beneficiaries of immune checkpoint inhibitors(ICIs).However,these two methods have different predictive values,making their comprehensive evaluation the focus of the current controversy.

关键词： lung cancer NSCLC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis

引用

Chinese Medical Journal 2015年第13期128卷 1787-1792页

作者： Xiao-Long Du ling-Shang Kong Qing-You Meng Aimin qian wen-Dong li Hong Chen Xiao-qiang li Cheng-Long li Department of Vascular Surgery The Second Affiliated Hospital of Soochow University Suzhou 215000 Jiangsu China

Background： Catheter-directed thrombolysis （CDT） has been a mainstay in treating deep venous thrombosis （DVT）. However, the optimal dosage ofa thrombolytic agent is still controversial. The goal of this study was to evaluate the safety and efficacy of low dosage urokinase with CDT for DVT. Methods： A retrospective analysis was perfornaed using data from a total of 427 patients with DVT treated with CDT in our single center between July 2009 and December 2012. Early efficacy of thrombolysis was assessed with a thrombus score based on daily venography. The therapeutic safety was evahmted by adverse events. A venography or duplex ultrasound was performed to assess the outcome at 6 months, 1 year and 2 years postoperatively. Results： The mean total dose of 3.34 （standard deviation [SD] 1.38） million units of urokinase was administered during a mean of 5.18 （SD 2.28） days. Prior to discharge, Grade Ⅲ （complete lysis） was achieved in 154 （36%） patients; Grade II （50-99% lysis） in 222 （52%）： and Grade I （50%~ lysis） in 51 （12%）. The major complications included one intracranial hemorrhage, one henaatochezia, five gross hematuria, and one pulmonary embolism. Moreover, no death occurred in the study. Conclusions： Treatment of low-dose catheter-directed thrombosis is an efficacious and safe therapeutic approach in patients with DVT offering good long-term outcomes and minimal complications.

关键词： Catheter-based Interventions Deep Vein Thrombosis Endovascular Treatment Thrombolysis: Venous Disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hyperthermia inhibits hypoxia-induced epithelial-mesenchymal transition in HepG2 hepatocellular carcinoma cells

引用

World Journal of Gastroenterology 2012年第34期18卷 4781-4786页

作者： Guang-Jin Yuan qian-wen li Shun-lin Shan Wu-Ming Wang Sen Jiang Xi-Ming Xu Cancer Center the 82nd Hospital of the Chi- nese People's Liberation Army Huai'an 223001 Jiangsu Prov- ince China Cancer Center Renmin Hospital of Wuhan Uni-versity Wuhan 430060 Hubei Province China

AIM:To investigate the effect of hyperthermia on hy-poxia-induced epithelial-mesenchymal transition (EMT) in HepG2 hepatocellular carcinoma (HCC) cells, and its mechanism. METHODS:Cells were treated with hyperthermia at 43 ℃ for 0.5 h, followed by incubation under hypoxic or normoxic conditions for 72 h. Cell morphology was observed. Expressions of E-cadherin and vimentin were determined by immunofluorescence assay or Western blot. The protein and mRNA expressions of Snail were also determined by Western blot and reverse transcrip-tion-polymerase chain reaction. Cell migratory capacity was evaluated. RESULTS:Hypoxia induced EMT in HepG2 cells, which was evidenced by morphological, molecular and func-tional changes, including the formation of a spindle shape and the loss of cell contact. The expression of E-cadherin was decreased but the expression of vimentin was increased; also, the migratory capability was increased by 2.2 ± 0.20-fold as compared with normoxia. However, those effects were inhibited by hyperthermia pretreatment. Furthermore, protein synthesis and mRNA expression of Snail in the cells were enhanced by hy-poxia as compared with normoxia, and also significantly inhibited by hyperthermia pretreatment. CONCLUSION:Hyperthermia may inhibit hypoxia-induced EMT in HepG2 HCC cells, and the mechanism may involve inhibition of induced expression of Snail.

关键词： Hyperthermia Hypoxia Epithelial-mesen-chymal transition Hepatocellular carcinoma Snail

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Low Complexity VCS Method for PAPR Reduction in Multicarrier Code Division Multiple Access

引用

Journal of Electronic Science and Technology of China 2007年第2期5卷 102-106页

作者： Si-Si liu Yue Xiao Qing-Song wen Shao-qian li National Key Lab of Communications University of Electronic Science and Technology of China （UESTC） Chengdu 610054 China

This paper investigates a peak to average power ratio （PAPR） reduction method in multicarrier code division multiple access （MC-CDMA） system. Variable code sets （VCS）, a spreading codes selection scheme, can improve the PAPR property of the MC-CDMA signals, but this technique requires an exhaustive search over the combinations of spreading code sets. It is observed that when the number of active users increases, the search complexity will increase exponentially. Based on this fact, we propose a low complexity VCS （LC-VCS） method to reduce the computational complexity. The basic idea of LC-VCS is to derive new signals using the relationship between candidature signals. Simulation results show that the proposed approach can reduce PAPR with lower comtational pucomplexity. In addition, it can be blindly received without any side information.

关键词： Low complexity variable code sets,multicarrier code division multiple access (MC-CDMA),peak to average power ratio variable code sets.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sacro-anterior haemangiopericytoma: a case report

引用

Cancer Biology & Medicine 2014年第2期11卷 139-143页

作者： Xiu-Hong Ge Shuai-Shuai liu Hu-Sheng Shan Zhi-Min Wang qian-wen li Department of Graduate Bengbu Medical College Cancer Center No. 82 Hospital of People's Liberation Army Subsidiary

Haemangiopericytoma(HPC) is a rare vascular tumor with borderline malignancy, considerable histological variability, and unpredictable clinical and biological behavior. HPC can present a diagnostic challenge because of its indeterminate clinical, radiological, and pathological features. HPC generally presents in adulthood and is equally frequent in both sexes. HPC can arise in any site in the body as a slowly growing and painless mass. The precise cell type origin of HPC is uncertain. One third of HPCs occur in the head and neck areas. Exceptional cases of hemangioblastoma arising outside the head and neck areas have been reported, but little is known about their clinicopathologic and immunohistochemical features. This study reports on a case of a large sacro-anterior HPC in a 65-year-old male.

关键词： Sacro-anterior haemangiopericytoma(HPC) soft tissue tumor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

引用

World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： wen-Chong Zhen Jing Sun Xue-Ting Bai qian Zhang Zi-Han li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-wen Pu Xiao-Feng li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,Pline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：