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Neuroscience Bulletin 2020年第2期36卷 165-173页

作者： Yu-Yu Xu wen-ping wan Sha Zhao Ze-Gang Ma Department of Physiology School of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and Disorders Qingdao UniversityQingdao 266071China

In the present study,we investigated the mechanisms underlying the mediation of iron transport by Ltype Ca^2+ channels(LTCCs)in primary cultured ventral mesencephalon(VM)neurons from *** found that cotreatment with 100 lmol/L FeSO4 and MPP^+(1-methyl-4-phenylpyridinium)significantly increased the production of intracellular reactive oxygen species,decreased the mitochondrial transmembrane potential and increased the caspase-3 activation compared to MPP^+ treatment ***-treatment with 500 lmol/L CaCl2 further aggravated the FeSO4-induced neurotoxicity in MPP^+-treated VM ***-treatment with 10 lmol/L isradipine,an LTCC blocker,alleviated the neurotoxicity induced by co-application of FeSO4 and FeSO4/*** studies indicated that MPP^+treatment accelerated the iron influx into VM *** addition,FeSO4 treatment significantly increased the intracellular Ca^2+ *** effects were blocked by *** results suggest that elevated extracellular Ca^2+ aggravates ironinduced *** mediate iron transport in dopaminergic neurons and this,in turn,results in elevated intracellular Ca^2+ and further aggravates iron-induced neurotoxicity.

关键词： L-type Ca^2+channels Iron overload Parkinson’s disease Isradipine Dopamine neuron

考虑换热能力和压降的永磁同步电机冷却流道设计

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华南理工大学学报（自然科学版） 2017年第7期45卷 25-32,40页

作者：万珍平温万昱吴柏禧付永清华南理工大学机械与汽车工程学院广东广州510640 华南理工大学设计学院广东广州510006

现有的对电动汽车驱动电机水冷系统的研究主要集中在水冷系统的换热能力方面,对压力损失考虑不够.针对这一问题,文中首先以常用的驱动电机——永磁同步电机为对象,通过理论计算分析了流道结构参数对换热能力和压力损失的影响,发现流道... 详细信息

现有的对电动汽车驱动电机水冷系统的研究主要集中在水冷系统的换热能力方面,对压力损失考虑不够.针对这一问题,文中首先以常用的驱动电机——永磁同步电机为对象,通过理论计算分析了流道结构参数对换热能力和压力损失的影响,发现流道螺旋圈数对换热和压力损失均有较大影响,而流道截面尺寸的变化对换热能力几乎没有影响,对压力损失影响较大,发现流道螺旋圈数对换热和压力损失均有较大影响,而流道截面尺寸的变化对换热能力几乎没有影响,对压力损失影响较大,提出了考虑换热能力和压力损失的流道设计方法,为高功率密度永磁同步电机水冷系统的设计提供了参考.

关键词：电动汽车永磁同步电机流道设计换热能力压力损失

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玻璃体手术后感染性眼内炎相关因素分析

中华医院感染学杂志 2016年第23期26卷 5471-5473页

作者：罗益文李娉万尚韬黄晓燕林明色中山大学中山眼科中心广东广州510060

目的探讨玻璃体视网膜疾病患者行玻璃体手术后发生感染性眼内炎的危险因素、病原菌分布及对抗菌药物敏感性,为临床防治措施提供依据。方法对2010年1月-2016年6月医院20 206例接受玻璃体手术患者的临床资料进行回顾性分析,分析其术后感... 详细信息

目的探讨玻璃体视网膜疾病患者行玻璃体手术后发生感染性眼内炎的危险因素、病原菌分布及对抗菌药物敏感性,为临床防治措施提供依据。方法对2010年1月-2016年6月医院20 206例接受玻璃体手术患者的临床资料进行回顾性分析,分析其术后感染相关因素,数据采用SPSS 19.0软件进行统计分析。结果术后发生感染性眼内炎14例,感染率为0.07%;共检出8株病原菌,以表皮葡萄球菌为主,其对万古霉素、利奈唑胺、头孢唑林、头孢呋辛、头孢他啶、庆大霉素、新霉素、利福平、莫西沙星敏感率均为100.00%;手术方式和玻璃体腔内佐剂的使用是玻璃体术后发生感染性眼内炎的危险因素(P<0.05)。结论玻璃体手术后发生感染性眼内炎的病原菌以葡萄球菌属为主,万古霉素、利奈唑胺、头孢唑林、头孢呋辛、头孢他啶对其有高度敏感性;应改进手术方式,减少玻璃体腔内佐剂的使用,以降低感染性眼内炎的发生率。

关键词：玻璃体手术眼内炎术后

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da wan Shuwei Tang Shulin Bai Xiaodong Li Peng Ai wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

Insights into the nitride-regulated processes at the electrolyte/electrode interface in quasi-solid-state lithium metal batteries

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Journal of Energy Chemistry 2022年第4期31卷 780-786页

作者： Jing wan wan-ping Chen Gui-Xian Liu Yang Shi Sen Xin Yu-Guo Guo Rui wen Li-Jun wan Key Laboratory of Molecular Nanostructure and Nanotechnology Beijing National Laboratory for Molecular SciencesCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Gel polymer electrolytes(GPEs)are one of the promising candidates for high-energy-density quasi-solid-state lithium metal batteries(QSSLMBs),for their high ionic conductivity and excellent interfacial *** comprehension of dynamic evolution and structure-reactivity correlation at the GPE/Li interface becomes ***,in situ electrochemical atomic force microscopy(EC-AFM)provides insights into the LiNO_(3)-regulated micromechanism of the Li plating/stripping processes upon cycles in GPE-based LMBs at *** additive LiNO_(3)induces the formation of amorphous nitride SEI film and facilitates Li^(+) ion *** stabilizes a compatible interface and regulates the Li nucleation/growth at steady *** deposited Li is in the shape of chunks and tightly *** Li dissolution shows favorable reversibility,which guarantees the cycling performance of *** situ AFM monitoring provides a deep understanding into the dynamic evolution of Li deposition/dissolution and the interphasial properties of tunable SEI film,regulating the rational design of electrolyte and optimizing interfacial establishment for GPE-based QSSLMBs.

关键词： In-situ electrochemical atomic force microscopy Gel polymer electrolyte Solid electrolyte interphase Lithium deposition/dissolution Quasi-solid-state lithium metal batteries

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo wan Tao wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Global identification of chemical constituents and rat metabolites of Si-Miao-wan by liquid chromatography-electrospray ionization/ quadrupole time-of-flight mass spectrometry

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Chinese Journal of Natural Medicines 2017年第7期15卷 550-560页

作者： LU Jin-Jin HU Xue-wen LI ping CHEN Jun State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China

Si-Miao-wan(SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-flight mass spectrometry(LC-Q-TOF/MS) method was established to identify the multiple constituents of SMW and its metabolites in rat biological samples after oral administration. A total of 48 compounds in SMW, including 21 alkaloids, 12 organic acids, 2 terpenes, 3 lactones, 2 phytosterols, and 8 other compounds, were tentatively characterized with the diagnostic-ion filtering strategy. Based on the diagnostic ions applied to identify compounds in SMW, 28 prototype compounds and 10 metabolic compounds were detected in the biological samples. This was the first comprehensive drug metabolism investigation of SMW in rats. The developed method could be a useful means for identifying the multi-components in SMW and the metabolic components. The results may help explore the possible metabolic processes and mechanism of action for SMW in vivo.

关键词： Si-Miao-wan LC-Q-TOF/MS Chemical constituents Metabolites

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Organic Photovoltaic Properties Based on Oligothiophenes

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Chinese Chemical Letters 2006年第7期17卷 903-906页

作者： ping LIU wan Zhang PAN Ming Sheng HUANG wen Ji DENG Research Institute of Materials Science South China University of Technology Guangzhou 510640 Department of Applied Physics South China University of Technology Guangzhou 510640

The ITO/5T/PCH/Al1 device has a short circuit current of 3.4 mA/cm^2, an open circuit voltage of 2.1 V, fill fact of 27.5 % and photoelectric conversion efficiency of 2.5 %.

关键词： Oligothiophene organic photovoltaic property device.

An Environmentally Benign Catalytic Method for Versatile Synthesis of 1,4-Dihydropyridines via Multicomponent Reactions

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Chinese Journal of Chemistry 2015年第5期33卷 568-572页

作者： Shuo Cao Shanshan Zhong Changfeng Hu Jie-ping wan Chengping wen Key Laboratory of Functional Small Organic Molecule Ministry of EducationCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchangJiangxi 330022China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

The synthesis of diverse 1,4-dihydropyridines have been achieved via the multicomponent reactions of aldehydes,enaminones and *** reactions have been smoothly performed in water to provide all products with moderate t... 详细信息

关键词： lactic acid catalysis multicomponent reactions 1 4-dihydropyridines green catalysis heterocycle