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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao Fang Qiuxia peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Lignicolous freshwater fungi in China

Lignicolous freshwater fungi in China

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中国菌物学会2024年学术年会

作者： Zong-Long Luo Dan-Feng Bao Hong-Wei Shen wen-peng wang College of Agriculture and Biological Science Dali University Engineering and Research Center for Southwest Biopharmaceutical Resource of National Education Ministry of China Guizhou University

Lignicolous freshwater fungi are a special ecological group which adapted to lignocellulose as substrate,and rich in species *** play an important role in nutrient and carbon cycling of freshwater *** species diversity,distribution pattern and driven factors of lignicolous freshwater fungi in rivers,streams and lakes of China are not *** the last ten years,we are focused on the species diversity of lignicolous freshwater fungi in the southwestern *** than 5000 samples of submerged decaying wood were collected from different freshwater habitats,including rivers,streams,plateau lakes and ponds in southwest of *** were deposited in the herbarium of Kunming Institute of Botany,Chinese Academy of Sciences(KUN-HKAS),Kunming,*** cultures were deposited with the China General Microbiological Culture Collection Center(CGMCC),and Kunming Institute of Botany Culture Collection(KUNCC).Images were photographed by a Nikon ECLIPSE Ni-U compound microscope fitted with a Nikon DS-Ri2 digital *** on the morphological characters and multi-gene phylogenetic analysis,one new order,three new families,ten new genera and 205 new species of lignicolous freshwater fungi were introduced in 85 SCI *** studies enriched the knowledges of biodiversity and community structure of lignicolous freshwater fungi in ***,there is still a significant knowledge gap in our understanding of lignicolous freshwater fungi in lentic freshwater habitats(such as:lakes and ponds) comparing to the lotic freshwater *** studies focusing on the lignicolous freshwater fungi in lentic habitats are needed.

关键词： Ascomycota Freshwater fungi Species diversity Morphology Phylogeny

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A Major QTL, Ghd8, Plays Pleiotropic Roles in Regulating Grain Productivity, Plant Height, and Heading Date in Rice

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Molecular Plant 2011年第2期4卷 319-330页

作者： wen-Hao Yan peng wang Hua-Xia Chen Hong-Ju Zhou Qiu-Ping Li Chong-Rong wang Ze-Hong Ding Yu-Shan Zhang Si-Bin Yu Yong-Zhong Xing Qi-Fa Zhang National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan430070 China

Rice yield and heading date are two distinct traits controlled by quantitative trait loci （QTLs）. The dissection of molecular mechanisms underlying rice yield traits is important for developing high-yielding rice varieties. Here, we report the cloning and characterization of Ghd8, a major QTL with pleiotropic effects on grain yield, heading date, and plant height. Two sets of near isogenic line populations were developed for the cloning of GhdS. Ghd8 was narrowed down to a 20-kb region containing two putative genes, of which one encodes the OsHAP3 subunit of a CCAAT-box binding protein （HAP complex）; this gene was regarded as the Ghd8 candidate. A complementary test confirmed the identity and pleiotropic effects of the gene; interestingly, the genetic effect of Ghd8 was dependent on its genetic background. By regulating Ehdl, RFT1, and Hd3a, Ghd8 delayed flowering under long-day conditions, but promoted flowering under short-day conditions. Ghd8 up-regulated MOC1, a key gene controlling tillering and branching; this increased the number of tillers, primary and secondary branches, thus producing 50% more grains per plant. The ectopic expression of Ghd8 in Arabidopsis caused early flowering by 10 d-a situation similar to the one observed by its homolog AtHAP3b, when compared to wild-type under long-day conditions; these findings indicate the conserved function of Ghd8 and AtHAP3b in flowering in Arabidopsis. Our results demonstrated the important roles of Ghd8 in rice yield formation and flowering, as well as its opposite functions in flowering between rice and Arabidopsis under long-day conditions.

关键词： Near isogenic lines CCAAT-box binding protein ectopic expression flowering pathway yield formation

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Lignicolous freshwater fungi from karst landscapes in Yunnan Province,China

Lignicolous freshwater fungi from karst landscapes in Yunnan...

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中国菌物学会2024年学术年会

作者： wen-peng wang Dan-Feng Bao Hong-Wei Shen Yong-Zhong Lu Zong-Long Luo College of Agriculture and Biological Science Dali University Engineering and Research Center for Southwest Biopharmaceutical Resource of National Education Ministry of China Guizhou University School of Food and Pharmaceutical Engineering Guizhou Institute of Technology

Lignicolous freshwater fungi represent an important ecological group that can participate in the material cycle and energy flow of freshwater ecosystems by breaking down lignocellulose and softening submerged decaying wood,and mycelium provides food for aquatic *** study explores the diversity of lignicolous freshwater fungi in the karst landscapes of Yunnan Province,focusing on Bamei Town,wenshan Zhuang and Miao Autonomous *** both morphological examination and multi-gene phylogenetic analysis,this research identifies a new genus Pseudosavoryella,fifteen new species,alongside introducing six new combinations and a new name for existing species,which also provides the sexual morphological characteristics corresponding to ***,the study reports eight new geographical records for China and identifies three species encountered in freshwater habitats for the first *** investigation contributes to the taxonomy and biodiversity of lignicolous freshwater fungi and emphasizes their ecological significance in freshwater *** detailed descriptions and illustrations of each species,we provide understandings into the microfungal diversity of the karst regions,thereby facilitating further research and conservation efforts in these unique *** work highlights the importance of integrating detailed morphological and DNA analyses to reveal new species and enriches the global fungal diversity records,and emphasizes the need for ongoing research and conservation efforts in these ecologically significant but often overlooked ecosystems.

关键词： Ascomycota Sixteen new taxa Freshwater fungi Morphology Phylogeny

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构建医院内中药饮片质量控制体系的必要性与探索研究

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中草药 2017年第20期48卷 4361-4366页

作者：原文鹏王洁马双成魏锋深圳市人民医院暨南大学第二临床医学院广东深圳518020 中国食品药品检定研究院北京100050

中药饮片是中医临床防治疾病的处方药,医院作为应用中药饮片的主体之一,医院内中药饮片质量的优劣直接影响着中药临床疗效,关系到患者切身健康。但是目前中药饮片市场较为混乱,中药材种植或养殖、生产加工、贮藏管理、流通经营等方面均... 详细信息

中药饮片是中医临床防治疾病的处方药,医院作为应用中药饮片的主体之一,医院内中药饮片质量的优劣直接影响着中药临床疗效,关系到患者切身健康。但是目前中药饮片市场较为混乱,中药材种植或养殖、生产加工、贮藏管理、流通经营等方面均有不规范的问题出现。同时,中药饮片供应方式隔绝了医院对所用中药饮片来源和生产过程的知情权,医院受制于中药饮片供应企业,被动接受供应企业提供的中药饮片产品,这对医院购进的中药饮片质量的可控形成了很大障碍。为解决以上问题,应从中药饮片进入医院的源头和医院的质量管理两方面出发,探索构建以中药饮片采购管理、入库验收、储存养护、人员能力提升等措施为内容的中药饮片质量控制体系。同时,应积极发挥中药临方炮制的重要作用、中药产品全过程追溯体系与中药材市场监管体系的保障作用,加强医院在中药饮片质量控制体系中的主导地位。

关键词：中医药中药饮片质量控制体系临床疗效全过程追溯体系

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Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： Yun-peng Guo Ling-Xue Bao Yu-Yang wang Quan wen Gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： peng Li Meifeng Cai Shengjun Miao Yuan Li Yu wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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Rethinking the diagnosis and treatment of renal anastomotic hemangioma after partial nephrectomy

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World Journal of Clinical Cases 2025年第5期13卷 58-60页

作者： Yun-peng Guo Gaurab Pokhrel Yu-Yang wang Quan wen Gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina First Affiliated Hospital of Zhengzhou University Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Urinary Surgery Tongliao City HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

Renal anastomotic hemangioma(AH)is a rare,benign vascular tumor with unique histopathological features,a disease that is clinically rare,and existing clinical cases offer different treatment *** reported in the text,this is a very unusual case of renal AH with AH secondary to residual renal tissue after renal clear cell carcinoma,describing a rare renal AH and a history of renal clear cell carcinoma,including ultrasound,computed tomography and magnetic re-sonance ***,the available imaging data and the literature do not provide an effective basis for the diagnosis of the disease,raising the lack of un-derstanding and misdiagnosis,where the patient eventually underwent neph-rectomy,but the author is not the most appropriate surgical *** po-stoperative pathological results of the patient are benign lesions,and it is unde-niable that nephrectomy is suspected to be *** reading the literature,we provide different insights into the treatment of the patient,and we hope that this paper can provide some help for the future clinical diagnosis and treatment.

关键词： Anastomotic hemangioma Renal Ultrasound Computed tomography Case report

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Molecular Mechanism for Jasmonate-Induction of Anthocyanin Accumulation in Arabidopsis

Molecular Mechanism for Jasmonate-Induction of Anthocyanin A...

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2009整合植物生物学研讨会

作者： Xiaoyi Shan~*,Yongsheng Zhang~*,wen peng,Zhilong wang and Daoxin Xie~(**) Department of Biological Sciences and Biotechnology,Tsinghua University,Beijing 100084,China.

Anthocyanins are important plant pigments that fulfill many physiological and ecological *** biosynthesis is controlled by numerous regulatory factors at transcriptional ***(JAs)has been shown to induce anthocyanin accumulation in several plant species,however,the molecular mechanism for JA-regulated anthocyanin accumulation remains *** this studv,we used genetic,molecular and

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Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期 651-651页

作者： Lin Lu, wen-hui peng, Wei wang, Ling-jie wang, Qiu-jing Chen, Wei-feng Shen

Objective:Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE). This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat kidney. Methods:Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks). Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple methods. Renal AGEs, RAGE, endogenous secretory RAGE (es-RAGE), and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting. Results:Mesangial expansion and microalbuminuria were aggravated in diabetic rats, and improved with atorvastatin treatment. Serum sRAGE levels were lower in diabetic than in normal rats. After atorvastatin treatment, serum and renal sRAGE levels were up-regulated, while renal RAGE expression was decreased in diabetic rats, associated with a reduction in accumulation of AGEs, though renal esRAGE mRNA expression was not significantly increased. Conclusions:Atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation, down-regulating RAGE expression and up-regulating sRAGE in the kidney.

关键词： RAGE Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats AGEs

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