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Investigation of spatial structure and sympathetic cooling in the^(9)Be^(+)–^(40)Ca^(+)bi-component Coulomb crystals

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Chinese Physics B 2023年第3期32卷 378-383页

作者：李敏张勇张乾煜白文丽何胜国彭文翠童昕 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

We study the spatial structure and sympathetic cooling of the bi-component Coulomb crystal(CC),which consists of approximate 450^(9)Be^(+)ions and 450^(40)Ca^(+)ions with a mass ratio of 0.225 in a segmented linear ion *** twodimensional imaging of the bi-component CC,the^(9)Be^(+)ions are found to be surrounded by the^(40)Ca^(+)ions in the radial direction with a separation ratio of~2.0,and the axial length of the^(9)Be^(+)ions occupied area is much larger than that of the^(40)Ca^(+)ions occupied *** with the previous experimental results,the structure of the^(9)Be^(+)–^(40)Ca^(+)CC shows the larger the difference in the mass–charge ratio,the larger the separation between the two *** comparison of the fluorescence spectra of the^(9)Be^(+)ions in the bi-component CC and the pure CC indicates that the^(9)Be^(+)ions can be sympathetically cooled and stably localized by the laser-cooled^(40)Ca^(+)ions during the recording of the fluorescence spectrum.

关键词： Coulomb crystals sympathetic cooling fluorescence spectrum

Comparison of clinical features and outcomes in peritoneal dialysisassociated peritonitis patients with and without diabetes:A multicenter retrospective cohort study

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World Journal of Diabetes 2020年第10期11卷 435-446页

作者： Ling-Fei Meng Li-Ming Yang Xue-Yan Zhu Xiao-Xuan Zhang Xin-Yang Li Jing Zhao Shi-Chen Liu Xiao-Hua Zhuang Ping Luo wen-peng cui Department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Nephrology The First Hospital of Jilin University-the Eastern DivisionChangchun 130041Jilin ProvinceChina Department of Nephrology Jilin Central HospitalJilin 132011Jilin ProvinceChina Department of Nephrology Jilin FAW General HospitalChangchun 130041Jilin ProvinceChina

BACKGROUND The number of end-stage renal disease patients with diabetes mellitus(DM)who are undergoing peritoneal dialysis is *** dialysis-associated peritonitis(PDAP)is a serious complication of peritoneal dialysis leading to technical failure and increased mortality in patients undergoing peritoneal *** profile of clinical symptoms,distribution of pathogenic organisms,and response of PDAP to medical management in the subset of end-stage renal disease patients with DM have not been reported *** results have been found in long-term prognostic outcomes of PDAP in patients with *** inferred that DM is associated with bad outcomes in PDAP *** To compare the clinical features and outcomes of PDAP between patients with DM and those *** In this multicenter retrospective cohort study,we enrolled patients who had at least one episode of PDAP during the study *** patients were followed for a median of 31.1 *** were divided into a DM group and a non-DM *** features,therapeutic outcomes,and long-term prognostic outcomes were compared between the two *** factors associated with therapeutic outcomes of PDAP were analyzed using multivariable logistic regression.A Cox proportional hazards model was constructed to examine the influence of DM on patient survival and incidence of technical *** Overall,373 episodes occurred in the DM group(n=214)and 692 episodes occurred in the non-DM group(n=395).The rates of abdominal pain and fever were similar in the two groups(P>0.05).The DM group had more infections with coagulase-negative Staphylococcus and less infections with Escherichia coli(***)as compared to the non-DM group(P0.05).Patients in the DM group were older and had a higher burden o

关键词： Diabetes mellitus Mortality Peritoneal dialysis Peritoneal dialysis-associated peritonitis Technical failure

Risk factors for mortality within 6 mo in patients with diabetes undergoing urgent-start peritoneal dialysis:A multicenter retrospective cohort study

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World Journal of Diabetes 2022年第4期13卷 376-386页

作者： Si-Yu Cheng Li-Ming Yang Zhan-Shan Sun Xiao-Xuan Zhang Xue-Yan Zhu Ling-Fei Meng Shi-Zheng Guo Xiao-Hua Zhuang Ping Luo wen-peng cui Department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Nephrology The First Hospital of Jilin University-the Eastern DivisionChangchun 130041Jilin ProvinceChina Department of Nephrology Xing’anmeng People’s HospitalUlan Hot 137400Inner Mongolia Autonomous Region China Department of Nephrology Jilin FAW General HospitalChangchun 130041Jilin ProvinceChina Department of Nephrology Jilin Central HospitalJilin 132011Jilin ProvinceChina

BACKGROUND The risk of early mortality of patients who start dialysis urgently is high;however,in patients with diabetes undergoing urgent-start peritoneal dialysis(USPD),the risk of,and risk factors for,early mortality are *** To identify risk factors for mortality during high-risk periods in patients with diabetes undergoing *** This retrospective cohort study enrolled 568 patients with diabetes,aged≥18 years,who underwent USPD at one of five Chinese centers between 2013 and *** divided the follow-up period into two survival phases:The first 6 mo of USPD therapy and the months *** compared demographic and baseline clinical data of living and deceased patients during each ***-Meier survival curves were generated for all-cause mortality according to the New York Heart Association(NYHA)classification.A multivariate Cox proportional hazard regression model was used to identify risk factors for mortality within the first 6 mo and after 6 mo of *** Forty-one patients died within the first 6 mo,accounting for the highest proportion of mortalities(26.62%)during the entire follow-up *** disease was the leading cause of mortality within 6 mo(26.83%)and after 6 mo(31.86%).The risk of mortality not only within the first 6 mo but also after the first 6 mo was higher for patients with obvious baseline heart failure symptoms than for those with mild or no heart failure *** risk factors for mortality within the first 6 mo were advanced age hazard ratio(HR:1.908;95%CI:1.400-2.600;P<0.001),lower baseline serum creatinine level(HR:0.727;95%CI:0.614-0.860;P<0.001),higher baseline serum phosphorus level(HR:3.162;95%CI:1.848-5.409;P<0.001),and baseline NYHA class III-IV(HR:2.148;95%CI:1.063-4.340;P=0.033).Independent risk factors for mortality after 6 mo were advanced age(HR:1.246;95%CI:1.033-1.504;P=0.022)and baseline NYHA class III-IV(HR:2.015;95%CI:1.298-3.130;P=0.002).CONCLUSION To reduce the risk

关键词： Peritoneal dialysis Urgent start Diabetes mellitus,Mortality within the first 6 mo Risk factor End-stage renal disease

基于冷分子离子HD^(+)振转光谱的精密测量

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物理学报 2024年第20期73卷 67-82页

作者：张乾煜白文丽敖致远丁彦皓彭文翠何胜国童昕中国科学院精密测量科学与技术创新研究院波谱与原子分子物理国家重点实验室武汉430071 中国科学院大学北京100049 武汉量子技术研究院武汉430074

由一个质子、一个氘核和一个电子组成的氢分子离子“HD^(+)”是最简单的异核双原子分子,其有着丰富的、可精确计算和测量的振转跃迁谱线.通过HD^(+)振转光谱实验测量和理论计算的对比,可实现物理常数的精确确定,量子电动力学理论的检验... 详细信息

由一个质子、一个氘核和一个电子组成的氢分子离子“HD^(+)”是最简单的异核双原子分子,其有着丰富的、可精确计算和测量的振转跃迁谱线.通过HD^(+)振转光谱实验测量和理论计算的对比,可实现物理常数的精确确定,量子电动力学理论的检验,并开启了超越标准模型新物理的探寻.目前,HD^(+)的振转跃迁频率确定的相对精度已经进入了10^(-12)量级,并由此获得了当前最高精度的质子电子质量比,相对精度达到20 ppt(1 ppt=10^(-12)).本文全面介绍了目前HD^(+)振转光谱的研究现状与理论背景,阐述了基于Be^(+)离子协同冷却HD^(+)分子离子的高精度振转光谱测量方法,包括Be^(+)离子和HD^(+)分子离子的产生与囚禁,HD^(+)外态冷却与内态制备,双组分库仑晶体中HD^(+)数目的确定,以及HD^(+)振转跃迁的探测.最后,文章展望了进一步提高频率测量精度的光谱前沿技术,及同位素氢分子离子的振转光谱在未来研究中的发展前景.

关键词：振转光谱 HD^(+)分子离子协同冷却

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ENSO与长江流域中游地区雨季极端降水的关系

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山地学报 2011年第3期29卷 299-305页

作者：汶林科崔鹏杨红娟邹强向灵芝中国科学院水利部成都山地灾害与环境研究所

湖北、湖南和江西沿长江地区的极端降水在长江中游的洪水灾害中发挥着重要的作用。选取可以表征极端降水的7种指数进行降水趋势分析,发现除连续最大降水日数外,1951—2009年间的5—9月>25 mm和>50mm降水日数、>95%与>90%降水量百分位数... 详细信息

湖北、湖南和江西沿长江地区的极端降水在长江中游的洪水灾害中发挥着重要的作用。选取可以表征极端降水的7种指数进行降水趋势分析,发现除连续最大降水日数外,1951—2009年间的5—9月>25 mm和>50mm降水日数、>95%与>90%降水量百分位数值的日数以及1 d最大降水量、连续5 d最大降水量都没有明显的变化趋势。相关分析显示雨季的各种极端降水指数与前年9月至当年2月Nino3区海温有较好的正相关关系。

关键词：极端降水 Nino3区海温趋势长江中游

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long Jiajia Liu Yu Wang Haidong Guo Guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao cui Yueru Shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish