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Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan

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World Journal of Hepatology 2021年第11期13卷 1766-1776页

作者： Guan-Woei Tseng Mei-Chen Lin Shih-Wei Lai Cheng-Yuan Peng Po-Heng Chuang wen-pang su Jung-TaKao Hsueh-Chou Lai Department of Medicine China Medical UniversityTaichung 40402Taiwan Management Office for Health Data China Medical University HospitalTaichung 404Taiwan Department of Family Medicine China Medical University HospitalTaichung 404Taiwan Center for Digestive Disease Department of Internal Medicine China Medical University HospitalTaichung 404Taiwan School of Chinese Medicine China Medical UniversityTaichung 404Taiwan

BACKGROUND While primary liver cancer(PLC)is one of the most common cancers around the world,few large-scale population-based studies have been reported that evaluated the clinical survival outcomes among peripartum and postmenopausal women with *** To investigate whether peripartum and postmenopausal women with PLC have lower overall survival rates compared with women who were not peripartum and *** The Taiwan National Health Insurance claims data from 2000 to 2012 was used for this propensity-score-matched study.A cohort of 40 peripartum women with PLC and a reference cohort of 160 women without peripartum were *** the women with PLC with/without menopause study,a study cohort of 10752 menopausal females with PLC and a comparison cohort of 2688 women without menopause were *** Patients with peripartum PLC had a non-significant risk of death compared with the non-peripartum cohort[adjusted hazard ratios(aHR)=1.40,95%confidence intervals(CI):0.89-2.20,P=0.149].The survival rate at different follow-up durations between peripartum PLC patients and those in the non-peripartum cohort showed a non-significant *** who were diagnosed with PLC younger than 50 years old(without menopause)had a significant lower risk of death compared with patients diagnosed with PLC at or older than 50 years(postmenopausal)(aHR=0.64,95%CI:0.61-0.68,Psurvival rate of womensurvival rates compared with those patients without *** females with PLC have worse survival rates compared with those patients without menopause.

关键词： Primary liver cancer Peripartum and postmenopausal women Prognosis Nationwide cohort Peripartum women Postmenopausal women

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe sui Hong su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑Xia su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang su Ian N.Levasseur Kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

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基于指数滤波模型的青藏高原根系层土壤水分估算研究

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高原气象 2025年第1期44卷 134-149页

作者：宋雨曦苏建宾文军郑东海成都信息工程大学大气科学学院高原大气与环境四川省重点实验室四川成都610225 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室国家青藏高原科学数据中心北京100101

高精度、长时序的土壤水分数据对青藏高原陆-气相互作用研究十分重要。然而,当前青藏高原土壤水分研究大多聚焦表层土壤水分的卫星反演,根系层土壤水分的估算研究相对匮乏。基于青藏高原五个土壤水分观测网络(狮泉河、帕里、那曲、黑河... 详细信息

高精度、长时序的土壤水分数据对青藏高原陆-气相互作用研究十分重要。然而,当前青藏高原土壤水分研究大多聚焦表层土壤水分的卫星反演,根系层土壤水分的估算研究相对匮乏。基于青藏高原五个土壤水分观测网络(狮泉河、帕里、那曲、黑河上游、玛曲)数据,本文系统评估了指数滤波模型在青藏高原不同气候与下垫面区域估算根系层(10 cm/20 cm/40 cm)土壤水分的适用性,探讨了不同环境因素(土壤、气候、植被)对模型特征时长参数T值的影响,最后评估了利用三种方法(各观测网络或青藏高原站点最优T值(Topt)中位数、随机森林模型)获取的区域T值估算青藏高原根系层土壤水分的可靠性。研究发现:(1)随着土壤深度的增加,根系层与表层土壤水分的相关性降低,而其空间异质性增大,导致指数滤波模型的应用精度降低,而模型T值及其空间异质性增大;(2)空间上随着降水量和土壤含水量的增加,根系层与表层土壤水分的相关性增大,而其空间异质性降低,使得指数滤波模型的应用精度上升,而其在区域内不同站点应用精度的差异呈现降低趋势;(3)土壤性质尤其是砂土含量是控制青藏高原区域T值空间分布的主要因素;(4)T值的获取对指数滤波模型在青藏高原的应用精度影响较小,当前常用的区域Topt中位数和随机森林模型均能获取相对合理的区域T值和取得一致且相对准确的模拟结果。本研究的发现有望推动利用指数滤波模型基于卫星表层土壤水分资料准确获取青藏高原根系层土壤水分。

关键词：青藏高原指数滤波模型根系层土壤水分不同气候与下垫面区域

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Recent developments in novel silica-based optical fibers

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Frontiers of Information Technology & Electronic Engineering 2019年第4期20卷 481-489页

作者： Ting-yun WANG Fu-fei pang su-juan HUANG Jian-xiang wen Huan-huan LIU Li-bo YUAN Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication Shanghai Institute for Advanced Communication and Data ScienceShanghai University Photonics Research Center Guilin University of Electronic Technology

We have summarized our recent work in the area of novel silica-based optical fibers, which can be classified into two types: silica optical fiber doped with special elements including Bi, Al, and Ce, and micro-structured multi-core fibers. For element-doped optical fiber, the Bi/Al co-doped silica fibers could exhibit a fluorescence spectrum covering the wavelength range between 1000 and 1400 nm with a full width at half maximum(FWHM) of about 150 nm, which enables its use in fiber amplifiers and laser systems. The Ce-doped fiber's center wavelengths of excitation and emission are about 340 and 430 nm, respectively. The sapphire-derived fiber(SDF) with high alumina dopant concentration in the core can form mullite through heating and cooling with arc-discharge treatment. This SDF can be further developed for an intrinsic Fabry-Perot interferometric that can withstand 1200 ℃, which allows it to be used in high-temperature sensing applications. Owing to the strong evanescent field, microstructured multi-core fiber can be used in a wide range of applications in biological fiber optic sensing, chemical measurement, and interference-related devices. Coaxial-core optical fiber is another novel kind of silica-based optical fiber that has two coaxial waveguide cores and can be used for optical trapping and micro-particle manipulation by generating a highly focused conical optical field. The recent developments of these novel fibers are discussed.

关键词： Optical fiber Fiber optic device Silica-based special fiber

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Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng su Yanfang Huang Bingbing Liu Hu sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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