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Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 523-528页

作者： Li Zhou Jian Li Yu-Pei Zhao Jun-Chao Guo Quan-Cai Cui Wei-Xun Zhou Tai-Ping Zhang wen-ming wu Lei You Hong Shu Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College

BACKGROUND： Recent studies have shown the clinical significance of epidermal growth factor-like domain 7（EGFL7）in a variety of cancers. However, the relationship between EGFL7 and the prognosis of pancreatic cancer（PC） remains unclear. The present study was undertaken to investigate the role of EGFL7 in the prognosis of ***： The expression of EGFL7 in nine PC cell lines was first determined by Western blotting analysis. Tissue microarray-based immunohistochemical staining was performed in paired formalin-fixed paraffin-embedded tumor and non-tumor samples from 83 patients with PC. Finally,correlations between EGFL7 expression and clinicopathological variables as well as overall survival were ***： EGFL7 was widely expressed in all PC cell lines ***7 expression in tumor tissues was significantly higher than that in non-tumor tissues（P0.040）. In addition, univariate analysis revealed that high EGFL7 expression in tumor tissues was significantly associated with poor overall survival,accompanied by several conventional clinicopathological variables, such as gender, histological grade and lymph node metastasis. In a multivariate Cox regression test, EGFL7 expression was identified as an independent marker for longterm outcome of ***： Our data showed that EGFL7 is extensively expressed in PC and that EGFL7 is associated with poor prognosis.

关键词： epidermal growth factor-like domain 7 pancreatic cancer prognosis Western blotting immunohistochemistry tissue microarray

Laparoscopic Partial Splenectomy for Splenic Hemangioma： Experience of a Single Center in Six Cases

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Chinese Medical Journal 2015年第5期128卷 694-697页

作者： Xian-Lin Han Yu-Pei Zhao Ge Chen wen-ming wu Meng-Hua Dai Department of General Surgery Peking Union Medical College Hospital Beijing 100730 China

INTRODUCTION Despite a higher incidence of postoperative complications, splenectomy is a commonly performed procedure for splenic space-occupying lesions. A retrospective analysis of 2796 splenectomy patients showed t... 详细信息

关键词： Laparoscopic Partial Splenectomy Splenic Function Splenic Hemangioma

AN EFFICIENT SYNTHESIS OF PROPARGYLIC PHOSPHONIUM SALTS

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Chinese Chemical Letters 1991年第3期2卷 209-212页

作者： wen Fang HUANG wen Jing XIAO,ming wu DIKG,Jun ZHU and Xiao Ru CHENG Institute of Organic Synthesis,Central China Normal University,wuhan 430070

Alkylated propargyl bromides react with phosphiaes in acidic tetrahydrofuran solution to give propargylic phosphonium salts in good yield.

关键词： AN EFFICIENT SYNTHESIS OF PROPARGYLIC PHOSPHONIUM SALTS THF

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

基于X射线塔尔博特效应的纳米光栅制作模拟研究

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物理学报 2015年第11期64卷 103-110页

作者：闻铭武杨笑微王占山同济大学物理科学与工程学院精密光学工程技术研究所先进微结构材料教育部重点实验室上海200092

沿纳米多层膜生长方向切割可制成周期只有几纳米而厚度几十微米的切片多层膜光栅.基于该切片多层膜光栅塔尔博特自成像效应的X射线光刻是一种新型的纳米图样制作方法.已有学者用该方法完成了百纳米结构光栅的制作.采用严格耦合波方法,... 详细信息

沿纳米多层膜生长方向切割可制成周期只有几纳米而厚度几十微米的切片多层膜光栅.基于该切片多层膜光栅塔尔博特自成像效应的X射线光刻是一种新型的纳米图样制作方法.已有学者用该方法完成了百纳米结构光栅的制作.采用严格耦合波方法,本文模拟计算了切片多层膜光栅在满足塔尔博特自成像条件下的后表面光场分布,详细讨论三个影响光栅后表面成像质量的重要参数:光栅厚度、材料厚度所占比例和多层膜周期.模拟结果表明,光栅厚度不仅影响X射线透射率,还会改变像面条纹衬比度.材料厚度比的大小直接决定像面是否存在清晰条纹,选取合适的材料厚度比,得到了前人实验中近场反常成像现象.计算还表明,在一定条件下,采用周期更小的多层膜光栅有望获得更高分辨率的纳米图形,这说明使用塔尔博特效应制作更加精细的纳米结构图形具有可行性.

关键词： X射线塔尔博特效应光栅严格耦合波理论

Clinical characteristics, treatments, and prognosis of patients with multiple primary carcinoma of head and neck

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Chinese Medical Journal 2020年第3期133卷 377-378页

作者： Kun Liu Xin-Xin Zhang Nan-Xiang Chen wen-ming wu Jia-Ling Wang De-Liang Huang Jian-Dong Zhao Shi-ming Yang Lin Ma Department of Otorhinolaryngology Head and Neck SurgeryChinese People's Liberation Army General HospitalMedical School of Chinese People's Liberation ArmyBeijing 100853China Department of Radiotherapy Chinese People's Liberation Army General HospitalMedical School of Chinese People's Liberation ArmyBeijing 100853China.

To the Editor: Multiple primary carcinoma (MPC) or secondary primary carcinoma refers to two or more malignant tumors occurring in the same organ or different organs of a patient. MPC is classified into synchronous MPC (time between diagnoses ≤6 months) and metachronous MPC (time between diagnoses >6 months).[1] Clinically, MPC was easily misdiagnosed as the recurrence and metastasis of malignant tumor. In head and neck MPC patients, the correct diagnosis and active treatments are important.

关键词： organs diagnosis treatment metastasis head

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冯．诺依曼代数交叉积的一点注记

数学学报（中文版） 2008年第4期51卷 803-808页

作者：吴文明袁巍清华大学数学科学系中国科学院数学与系统科学研究院北京100080

设α是可数离散群G和H的半直积G■_σH在冯·诺依曼代数M上的作用,则β_h=α_((e,h))AdU_h定义了群H在冯·诺依曼代数交叉积M■_αG上的作用β.本文证明了交叉积冯·诺依曼代数M■_α(G■_σH)与(M■_αG)■_βH是*-同构的,因此在一... 详细信息

设α是可数离散群G和H的半直积G■_σH在冯·诺依曼代数M上的作用,则β_h=α_((e,h))AdU_h定义了群H在冯·诺依曼代数交叉积M■_αG上的作用β.本文证明了交叉积冯·诺依曼代数M■_α(G■_σH)与(M■_αG)■_βH是*-同构的,因此在一定条件下,冯·诺依曼代数的交叉积满足结合律.

关键词：半直积可数离散群交叉积冯.诺依曼代数

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： wen Jin LIU Zhanzhi wu Zhengwei PAN Yu ZHANG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods