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SPECTRUM OF FUNCTIONING ISLET CELL TUMOR ON MULTISLICE COMPUTED TOMOGRAPHY:EXPERIENCE ON 70 PATIENTS

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Chinese Medical Sciences Journal 2008年第1期23卷 1-9页

作者： Hua-dan Xue Wei Liu Hao Sun Reto Merges Xuan Wang Xiao-na Zhang Yun Wang wen-min zhao Jiu-hong Chen Zheng-yu Jin Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Medical Solutions Siemens Ltd. Beijing 100102

Objective To review experience in preoperative detection of islet cell tumors using multislice computed tomography （MSCT） and summarize various imaging features of functioning islet cell tumors on enhanced MSCT. Methods Seventy patients with clinical or pathological diagnosis of functioning pancreatic islet cell tumor between October 2003 and February 2007 were included in this retrospective study. Seventy-four enhanced MSCT scans in these patients were identified. All MSCT scans were interpreted by two experienced radiologists by consensus interpretation. Surgery and pathology reports were used to confirm the diagnosis, localization, and size of tumors. Results Totally, 73 functioning islet cell tumors including 65 benign insulinomas, 2 benign glucagonomas, 3 malignant insulinomas, and 3 malignant glucagonomas were pathologically diagnosed. Tumors in only two cases were not found by MSCT. In 67 benign lesions, 32 showed typical enhancement style, 21 showed prolonged enhancement in portal venous phase, 4 showed delayed enhancement, 4 had iso-dense enhancement with normal pancreatic parenchyma, 2 had no enhancement at all in arterial phase and portal venous phase, and 4 had inhomogeneous enhancement with necrosis or cyst-formation. Patchy or spotty calcifications were found in 3 of the 67 tumors. In 6 malignant islet cell tumors, vessel invasion （2/6） and bowel invasion （1/6） were seen. Different enhancement patterns were shown. All hepatic metastases showed hyper-enhancement during their arterial phase. Conelttsions Pancreatic islet cell tumor may display a wide spectrum of presentations in MSCT. Tumors with unusual appearances often present as diagnostic challenges. Non-contrast and post-contrast multiphase scans are recommended for the localization of functioning islet cell tumors.

关键词： islet cell tumor pancreas multislice computed tomography

CORONARY ANGIOGRAPHY WITH DUAL SOURCE COMPUTED TOMOGRAPHY:INITIAL EXPERIENCE

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Chinese Medical Sciences Journal 2007年第4期22卷 205-210页

作者： Zhu-hua Zhang Zheng-yu Jin Shu-yang Zhang Song-bai Lin Dong-jing Li Ling-yan Kong Yi-ning Wang Lan Song Yun Wang wen-min zhao wen-bin Mou Li-ren Zhang wen-ling Zhu Qi Miao Qi Fang Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Special Medical Care Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Cardiac Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To explore the scan technique and image quality of coronary angiography with dual source computed tomography(CT) without oral metoprolol *** Plain and enhanced dual source CT coronary angiography without oral metoprolol preparation was prospectively performed in 600 *** scoring with plain scan images as well as multi-planar reconstruction(MPR),maximum intensity projection(MIP),and volume rendering technique(VRT) reconstruction with enhanced scan images were performed in all *** scan technique and post-reconstruction experience was *** image quality was classified as 1 to 4 points,and coronary segments classified according to the American Heart Association standards were *** The average calcium score of the 600 cases was 213.6±298.7(0-3 216.5).The average heart rate of the enhanced scan was 82.1±16.2(47-139) *** post-reconstruction methods with which coronary segments could be shown as best as possible consisted of single phase reconstruction method,two or more phases supplemented method,and electrocardiogram editing *** 8 457 coronary segments were evaluated,among which 97.2% were evaluated as point 1,1.7% point 2,0.5% point 3,and 0.6% point *** coronary segments in 261 cases were completely normal,while 360 segments were diagnosed with <50% stenosis and 625 segments with ≥50% *** Excellent coronary artery image can be obtained with dual source CT in patients with any heart rate without oral metoprolol *** rate is not a major source of the artifact,coronary segments can be well shown with single or multiple-phase reconstruction method.

关键词： computed tomography coronary angiography coronary heart disease

Correlation of matrix metalloproteinase suppressor genes RECK,VEGF,and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2007年第45期13卷 6076-6081页

作者： Sheng-Lei Li, Zhi-Hua zhao, Dong-Ling Gao, Zong-wen Liu, Qiu-min zhao, Jin-Xia Yu, Kui-Sheng Chen, Yun-Han Zhang, Department of Pathology, The First Affiliated Hospital Zhengzhou University He’nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, He’nan Province, China Department of Pathology The First Affiliated Hospital Zhengzhou University Henan Key Laboratory of Tumor Pathology Zhengzhou 450052 He'nan Province China.

AIM: To explore the expression of reversion inducing cysteine-rich protein with Kazal motifs (RECK), vascular endothelial growth factor (VEGF) and endoglin (CD105) protein and its correlation with occurrence, development, invasion and metastasis in esophageal squamous cell carcinoma (ESCC). METHODS: Streptavidin-peroxidase (SP) immunohisto- chemistry was used to detect expression of RECK and VEGF in 62 cases of ESCC, 31 cases of adjacent atypical hyperplastic epithelium and 62 cases of normal esophageal epithelium. CD105 Mb was used to assess microvessel density (MVD). RESULTS: The expression of RECK was closely correlated with histological grade, infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK decreased during cancer development: normal esophageal epithelium (85.5%, 53/62), adjacent atypical hyperplastic epithelium (71.0%, 22/31), and carcinoma (59.7%, 37/62). There was a significant difference among the groups (P < 0.05). The expression of VEGF protein was closely correlated with infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of VEGF protein increased during cancer development: normal esophageal epithelium (29.0%, 18/62), adjacent atypical hyperplastic epithelium (54.8%, 17/31), and carcinoma (67.7%, 42/62). There was a significant difference among the groups (P < 0.05). MVDCD105 increased in accordance with histological grade, butthere was no significant difference (grade Ⅰ, 36.92 ± 10.85; grade Ⅱ, 37.65 ± 9.50; and grade Ⅲ, 38.06 ± 12.19). The MVDCD105 was closely correlated with infiltration and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK was inversely correlated with the expression of VEGF and CD105. CONCLUSION: RECK, VEGF and CD105 play important roles in the infiltration, metastasis and carcinogenesis in esophageal carcinoma. Angiogenesis in ESCC may be promoted by over-expression of CD105.

关键词： Reversion inducing cysteine rich proteinwith Kazal motifs Vascular endothelial growthfactor CD105 Esophageal squamous cell carcinoma Immunohistochemistry Microvessel density

Fabrication of RGO/Cu composites based on electrostatic adsorption

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Transactions of Nonferrous Metals Society of China 2020年第4期30卷 982-991页

作者： wen-min zhao Rui BAO Jian-hong YI Xiang-hui HOU Dong FANG Chun-xuan LIU Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Advanced Materials of Yunnan Province Kunming 650093China Faculty of Engineering University of NottinghamUniversity ParkNottingham NG72RDUK Hunan Xiangtou Goldsky Technology Group Co. Ltd.Changsha 410012China

To address the issues of reduced graphene oxide(RGO) dispersion in copper(Cu) matrix and interface bonding between RGO and Cu, an electrostatic adsorption method with interface transition phase design was employed to prepare the RGO/Cu based composites. Cu-Ti alloy powder was employed to improve the combination by forming carbides at the RGO-Cu interface. It was noted that the mechanical property of 0.3 wt.%RGO/Cu-Ti composite was increased by 60% compared with that of the matrix. Strengthening mechanism analysis suggested that the enhancement of the mechanical property was ascribed to the load transfer and second phase strengthening which were from the improved dispersion of RGO and the in-situ formed titanium carbide phase.

关键词： graphene oxide(GO) electrostatic adsorption Cu?Ti in-situ TixCy mechanical property

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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多空隙组合介质隧道渗透物理模型试验

中国农村水利水电 2017年第3期 112-116,120页

作者：夏伟符文熹赵敏四川大学水力学与山区河流保护国家重点实验室成都610065 四川大学水利水电学院成都610065 核工业西南勘察设计研究院有限公司成都610066

跃龙门隧道工程施工期出现严重的涌突水问题,不仅制约隧道开挖安全,而且会因地下水位降低而触发该区植被生态健康问题。结合该隧道的水文地质条件,并基于相似模型原理,选用普通砖钻孔填砂模拟具有多空隙组合特征的岩体,设计研制了隧道... 详细信息

跃龙门隧道工程施工期出现严重的涌突水问题,不仅制约隧道开挖安全,而且会因地下水位降低而触发该区植被生态健康问题。结合该隧道的水文地质条件,并基于相似模型原理,选用普通砖钻孔填砂模拟具有多空隙组合特征的岩体,设计研制了隧道渗透物理模型。物理模型考虑了岩体主要裂隙倾角分别为0°和60°两种情况。对两个倾角8种工况进行了渗透试验,测试分析表明:(1)主要裂隙方向会对渗流产生较大的影响,当倾角与水流方向夹角较小时涌水现象较为突出;(2)隧道正上方的地下水位下降最快,离隧道轴线越远的水位下降越慢,稳定渗流时的水位也越高,连接相同高程测点在同一时刻的水位形成的水面线均呈现降落漏斗形状;(3)试验获得的稳定渗流时间与原型观测结果一致;(4)模型影响范围与数值计算隧道开挖影响范围较为接近。

关键词：隧道开挖渗流物理模型涌水量降落漏斗

逆向工程中基于共轴立体视觉的曲面边界测量（英文）

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光子学报 2017年第2期46卷 164-180页

作者：卢科青王文张敏赵春峰杭州电子科技大学机械工程学院机械电子工程研究所杭州310018

针对逆向工程中引导性曲面边界信息的快速获取问题,系统地研究了共轴立体视觉测量方法,建立该方法的数学模型,详细分析了摄像机焦距、基线距等系统结构参数及被测点空间位置对测量精度的影响,通过数学分析确定摄像机基线距的最佳取值范... 详细信息

针对逆向工程中引导性曲面边界信息的快速获取问题,系统地研究了共轴立体视觉测量方法,建立该方法的数学模型,详细分析了摄像机焦距、基线距等系统结构参数及被测点空间位置对测量精度的影响,通过数学分析确定摄像机基线距的最佳取值范围,研究共轴立体视觉测量系统特殊的极线几何关系.提出基于共轴立体视觉的曲面边界快速测量方法,利用三坐标测量机的精密机械系统及精确的空间定位能力,用单个摄像机以两次共轴定位摄取图像的方式实现共轴立体视觉测量功能,然后利用共轴立体视觉外极线相互平行且通过各自像平面主点的特殊极线几何关系简化同源像点匹配过程,从而快速获取被测曲面的边界信息.实验结果表明:用基于三坐标测量机的单摄像机共轴立体视觉测量方法获取的曲面边界平均误差为0.268mm,基本满足逆向工程中对引导性曲面边界的测量精度要求.

关键词：立体视觉逆向工程边界提取图像处理图像匹配

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di zhao Lemei Zhu Zheyu Zhang min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis