检索结果-南通市图书馆

long-term outcomes and failure patterns after laparoscopic intersphincteric resection in ultralow rectal cancers

World Journal of Gastrointestinal Surgery 2023年第6期15卷 1104-1115页

作者： wen-long qiu Xiao-Lin Wang Jun-Guang Liu Gang Hu Shi-wen Mei Jian-Qiang Tang Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery The Second Hospital of YulinYulin 100021Shaanxi ProvinceChina Department of General Surgery Peking University First HospitalBeijing 100021China

BACKGROUND Intersphincteric resection(ISR),the ultimate anus-preserving technique for ultralow rectal cancers,is an alternative to abdominoperineal resection(APR).The failure patterns and risk factors for local recurrence and distant metastasis remain controversial and require further *** To investigate the long-term outcomes and failure patterns after laparoscopic ISR in ultralow rectal *** Patients who underwent laparoscopic ISR(LsISR)at Peking University First Hospital between January 2012 and December 2020 were retrospectively *** analysis was performed using the Chi-square or Pearson's correlation *** factors for overall survival(OS),local recurrence-free survival(LRFS),and distant metastasis-free survival(DMFS)were analyzed using Cox *** We enrolled 368 patients with a median follow-up of 42 *** recurrence and distant metastasis occurred in 13(3.5%)and 42(11.4%)cases,*** 3-year OS,LRFS,and DMFS rates were 91.3%,97.1%,and 90.1%,respectively Multivariate analyses revealed that LRFS was associated with positive lymph node status[hazard ratio(HR)=5.411,95%confidence interval(CI)=1.413-20.722,P=0.014]and poor differentiation(HR=3.739,95%CI:1.171-11.937,P=0.026),whereas the independent prognostic factors for DMFS were positive lymph node status(HR=2.445,95%CI:1.272-4.698,P=0.007)and(y)pT3 stage(HR=2.741,95%CI:1.225-6.137,P=0.014).CONCLUSION This study confirmed the oncological safety of LsISR for ultralow rectal *** differentiation,(y)pT3 stage,and lymph node metastasis are independent risk factors for treatment failure after LsISR,and thus patients with these factors should be carefully managed with optimal neoadjuvant therapy,and for patients with a high risk of local recurrence(N+or poor differentiation),extended radical resection(such as APR instead of ISR)may be more effective.

关键词： Rectal cancer Intersphincteric resection Laparoscopic surgery Recurrence Risk factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

引用

Rare Metals 2024年第3期43卷 1309-1315页

作者： long-Hua Ding Ya-wen Wang qiu-wen Li Li-Li Zhang Ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Colorimetric Detection of Acid Phosphatase and Malathion Using NiCo_(2)O_(4)Nanosheets as Peroxidase-Mimicking Activity

引用

Journal of Analysis and Testing 2024年第2期8卷 170-179页

作者： Jia Chen Zerong long Yan Li Hongdeng qiu Xinjiang Uygur Autonomous Product Quality Supervision and Inspection Institute Urumqi830000China CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

The establishment of a low-cost and facile approach for the assay of acid phosphatase(ACP)and its inhibitor is a research *** this paper,we successfully synthesized NiCo_(2)O_(4)nanosheets with peroxidase-mimicking activity in alkaline deep eutectic solvents(DESs)composed of NaOH and PEG-200,which can catalyze 3,3',5,5'-tetramethylbenzidine(TMB)to the oxidation state TMB(ox-TMB)in the presence of *** to L-ascorbic acid-2-phosphate can be hydrolyzed into ascorbic acid by ACP,the peroxidase-like activity of NiCo_(2)O_(4)nanosheets is ***,the addition of malathion,an inhibitor of ACP,can inhibit the activity of ACP and thus limit the production of ascorbic acid(AA).Therefore,a colorimetric approach can be established for highly sensitive and selective detection of ACP and malathion with detection limits of 0.032 U/L and 0.65 nmol/L,*** importantly,this method can be successfully applied to malathion detection in environmental samples tap water and food cucumber juice,indicating that it has potential application prospects in environmental and agricultural fields.

关键词： NiCo_(2)O_(4)nanosheets Acid phosphatase Malathion Peroxidase-mimicking activity Colorimetric

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Short- and long-term results of open vs laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments

引用

世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 1969-1977页

作者： Ji-Chuan Quan Xin-Jun Zhou Shi-wen Mei Jun-Guang Liu wen-long qiu Jin-Zhu Zhang Bo Li Yue-Gang Li Xi-Shan Wang Hu Chang Jian-Qiang Tang Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Colorectal Anorectal Surgery Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina Department of General Surgery Peking University First HospitalBeijing 100034China Department of Hospital Administration Office National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND It remains unclear whether laparoscopic multisegmental resection and ana-stomosis(LMRA)is safe and advantageous over traditional open multisegmental resection and anastomosis(OMRA)for treating synchronous colorectal cancer(SCRC)located in separate *** To compare the short-term efficacy and long-term prognosis of OMRA as well as LMRA for SCRC located in separate *** Patients with SCRC who underwent surgery between January 2010 and December 2021 at the Cancer Hospital,Chinese Academy of Medical Sciences and the Peking University First Hospital were retrospectively *** accordance with the RESULTS LMRA patients showed markedly less intraoperative blood loss than OMRA patients(100 vs 200 mL,P=0.006).Compared to OMRA patients,LMRA patients exhibited markedly shorter postoperative first exhaust time(2 vs 3 d,P=0.001),postoperative first fluid intake time(3 vs 4 d,P=0.012),and postoperative hospital stay(9 vs 12 d,P=0.002).The incidence of total postoperative complications(Clavien-Dindo grade:≥II)was 2.9%and 17.1%(P=0.025)in the LMRA and OMRA groups,respectively,while the incidence of anastomotic leakage was 2.9%and 7.3%(P=0.558)in the LMRA and OMRA groups,***,the LMRA group had a higher mean number of lymph nodes dissected than the OMRA group(45.2 vs 37.3,P=0.020).The 5-year overall survival(OS)and disease-free survival(DFS)rates in OMRA patients were 82.9%and 78.3%,respectively,while these rates in LMRA patients were 78.2%and 72.8%,*** prognostic analysis revealed that N stage[OS:HR hazard ratio(HR)=10.161,P=0.026;DFS:HR=13.017,P=0.013],but not the surgical method(LMRA/OMRA)(OS:HR=0.834,P=0.749;DFS:HR=0.812,P=0.712),was the independent influencing factor in the OS and DFS of patients with *** LMRA is safe and feasible for patients with SCRC located in separate *** to OMRA,the LMRA approach has more advantages related to short-term efficacy.

关键词： Synchronous colorectal cancer Separate segments Laparoscopic surgery Multisegmental resection Short-term efficacy Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Emergence of Functional Ultrasound for Noninvasive Brain-Computer Interface

引用

Research 2024年第2期6卷 301-317页

作者： Hairong Zheng Lili Niu Weibao qiu Dong Liang Xiaojing long Guanglin Li Zhiyuan Liu long Meng Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen Institute of Advanced Integration Technology Chinese Academy of Sciences and The Chinese University of Hong KongShenzhen518055China

A noninvasive brain-computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science *** implanted brain-computer interfaces are cranial and invasive,which considerably limits their *** development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain-computer ***,we review the theory and development of the ultrasound brain functional imaging and its ***,we introduce latest advancements in ultrasound brain modulation and its applications in rodents,primates,and human;its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also ***,high-frequency acoustic noninvasive brain-computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

关键词： breakthrough computer Computer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy

引用

Chinese Journal of Chemical Engineering 2024年第8期72卷 19-25页

作者： Yao Pei Ran Wang Xiang Rong Xiang Xia Hexiang Wang Zongwei Zhang Tian qiu Saran long Jianjun Du Jiangli Fan wen Sun Xiaojun Peng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

The key factor in photothermal therapy lies in the selection of photothermal *** photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion ***,we have designed and synthesized an isoindigo(IID)*** used isoindigo as the molecular center and introduced common triphenylamine and methoxy groups as *** order to improve the photothermal stability and tumor targeting ability,we encapsulated IID into *** a result,the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency(67%)upon 635 nm laser ***,the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.

关键词： Photothermal therapy Isoindigo Nanoparticles Photoacoustic imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Algorithms and statistical analysis for linear structured weighted total least squares problem

引用

Geodesy and Geodynamics 2024年第2期15卷 177-188页

作者： Jian Xie Tianwei qiu Cui Zhou Dongfang Lin Sichun long School of Earth Science and Spatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China College of Science Central South University of Forestry and TechnologyChangsha 410018China National-Local Joint Engineering Laboratory of Geo-spatial Information Technology Hunan University of Science and TechnologyXiangtan 411201China

Weighted total least squares(WTLS)have been regarded as the standard tool for the errors-in-variables(EIV)model in which all the elements in the observation vector and the coefficient matrix are contaminated with random ***,in many geodetic applications,some elements are error-free and some random observations appear repeatedly in different positions in the augmented coefficient *** is called the linear structured EIV(LSEIV)*** kinds of methods are proposed for the LSEIV model from functional and stochastic *** the one hand,the functional part of the LSEIV model is modified into the errors-in-observations(EIO)*** the other hand,the stochastic model is modified by applying the Moore-Penrose inverse of the cofactor *** algorithms are derived through the Lagrange multipliers method and linear *** estimation principles and iterative formula of the parameters are proven to be *** first-order approximate variance-covariance matrix(VCM)of the parameters is also derived.A numerical example is given to compare the performances of our proposed three algorithms with the STLS ***,the least squares(LS),total least squares(TLS)and linear structured weighted total least squares(LSWTLS)solutions are compared and the accuracy evaluation formula is proven to be feasible and ***,the LSWTLS is applied to the field of deformation analysis,which yields a better result than the traditional LS and TLS estimations.

关键词： Linear structured weighted total least squares Errors-in-variables Errors-in-observations Functional modelmodification Stochastic model modification Accuracyevaluation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

引用

Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi Cai long qiu Zhenying Diao Lintao Cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

引用

Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling CHEN Ken HUANG Yun-ke ZHAO qiu-long HUANG wen-ya HUANG Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implicit Function Based Open-loop Analysis Method for Detecting the SSR Using Identified System Parameters

引用

CSEE Journal of Power and Energy Systems 2024年第5期10卷 2016-2026页

作者： Luonan qiu Tianhao wen Yang Liu Q.H.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China

This paper proposes an implicit function based open-loop analysis method to detect the subsynchronous resonance(SSR),including asymmetric subsynchronous modal attraction(ASSMA)and asymmetric subsynchronous modal repulsion(ASSMR),of doubly-fed induction generator based wind farms(DFIG-WFs)penetrated power *** some important parameters of DFIG-WF are difficult to obtain,reinforcement learning and least squares method are applied to identify those important *** predicting the location of closed-loop subsynchronous oscillation(SSO)modes based on the calculation of partial differentials of characteristic equation,both ASSMA and ASSMR can be *** proposed method in this paper can select SSO modes which move to the right half complex planes as control parameters ***,the proposed open-loop analysis method is adaptive to parameter *** studies are carried out on the 4-machine 11-bus power system to verify properties of the proposed method.

关键词： Open-loop modal analysis reinforcement learning based parameter identification subsynchronous resonance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：