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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2047-2053页

作者： Cheng-Ming Zhou Jun cao Shao-Ke Chen Tuerhongjiang Tuxun Shadike Apaer Jing Wu Jin-Ming Zhao Hao wen Department of Liver and Laparoscopic Surgery Digestive and Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Operation Management The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of General Surgery The First Teaching CollegeXinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND The optimal approach for managing hepatic hemangioma is *** To evaluate a clinical grading system for management of hepatic hemangioma based on our 17-year of single institution *** A clinical grading system was retrospectively applied to 1171 patients with hepatic hemangioma from January 2002 to December *** were classified into four groups based on the clinical grading system and treatment:(1)Observation group with score0.05;χ^(2)=1.68,P>0.05).CONCLUSION This clinical grading system appeared as a practical tool for hepatic *** can be suggested for patients with a score≥*** those with<4,follow-up should be proposed.

关键词： Hepatic hemangioma Clinical grading system Surgical indication Outcome Postoperative complications

Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism

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Zoological Research 2024年第5期45卷 1048-1060页

作者： Xiao-Xiao Li Dan-Chen Zhang Yan Wang Jian wen Xing-Ju Wang Yu-Lu cao Ru Jiang Jia-Rui Li Yi-Nuo Li He-He Liu wen-Hai Xie Zheng-Feng Xu Ping Hu Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Stem Cell Research and Translation Center Nanjing Agricultural UniversityNanjingJiangsu 210095China School of Life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Department of Prenatal Diagnosis Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Extracellular membrane proteins are crucial for mediating cell attachment,recognition,and signal transduction in the testicular microenvironment,particularly germline stem *** 18(CDH18),a type II classical cadherin,is primarily expressed in the nervous and reproductive ***,we investigated the expression of CDH18 in neonatal porcine prospermatogonia(ProSGs)and murine spermatogonial stem cells(SSCs).Disruption of CDH18 expression did not adversely affect cell morphology,proliferation,self-renewal,or differentiation in cultured porcine ProSGs,but enhanced cell adhesion and prolonged cell *** analysis indicated that the down-regulation of CDH18 in ProSGs significantly up-regulated genes and signaling pathways associated with cell *** further elucidate the function of CDH18 in germ cells,Cdh18 knockout mice were generated,which exhibited normal testicular morphology,histology,and *** analysis showed increased expression of genes associated with adhesion,consistent with the observations in porcine *** interaction of CDH18 withβ-catenin and JAK2 in both porcine ProSGs and murine SSCs suggested an inhibitory effect on the canonical Wnt and JAK-STAT signaling pathways during CDH18 ***,these findings highlight the crucial role of CDH18 in regulating cell adhesion in porcine ProSGs and mouse *** this regulatory mechanism provides significant insights into the testicular niche.

关键词： Extracellular signal Fertility Quiescency Wnt signaling pathway

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu Geng-Ting Dong Yi Li Qing Luo Liu cao Xi-Min Wang Qi-wen Wang Yi-Ting Wang Zhe Zhang Xi-wen Zhong Wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

Novel method for extraction of ship target with overlaps in SAR image via EM algorithm

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Journal of Systems Engineering and Electronics 2024年第4期35卷 874-887页

作者： cao Rui WANG Yong School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China

The quality of synthetic aperture radar(SAR)image degrades in the case of multiple imaging projection planes(IPPs)and multiple overlapping ship targets,and then the performance of target classification and recognition can be *** addressing this issue,a method for extracting ship targets with overlaps via the expectation maximization(EM)algorithm is ***,the scatterers of ship targets are obtained via the target detection ***,the EM algorithm is applied to extract the scatterers of a single ship target with a single ***,a novel image amplitude estimation approach is pro-posed,with which the radar image of a single target with a sin-gle IPP can be *** proposed method can accom-plish IPP selection and targets separation in the image domain,which can improve the image quality and reserve the target information most *** of simulated and real mea-sured data demonstrate the effectiveness of the proposed method.

关键词： expectation maximization(EM)algorithm image processing imaging projection plane(IPP) overlapping ship tar-get synthetic aperture radar(SAR)

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清末地缘政治和国际经济竞争中的海参崴

清史研究 2024年第3期 133-147页

作者：曹雯中国人民大学清史研究所北京100872

1903年,随着海参崴与其他地域间海上航线的开通,以及西伯利亚大铁道各区段线路的开通,它不仅可以通过海上,还可以仅凭借陆路铁道即可到达俄国的欧洲部分。由此,海参崴获得了成为东西方欧亚贸易中转枢纽港口的发展契机。就中国进出口贸... 详细信息

1903年,随着海参崴与其他地域间海上航线的开通,以及西伯利亚大铁道各区段线路的开通,它不仅可以通过海上,还可以仅凭借陆路铁道即可到达俄国的欧洲部分。由此,海参崴获得了成为东西方欧亚贸易中转枢纽港口的发展契机。就中国进出口贸易额而言,1894年为2.23亿美元,至1911年增长到5.52亿美元。然而,明显呈上升趋势的东西方贸易货运仍主要依靠开发了东西方航线的西方轮船公司,位于西伯利亚大铁道东端的海参崴并未如预期般发展成为一个具有全球性地位的国际贸易港口。造成这一局面的原因有三:一是俄国为贪图更大的地缘政治和经济利益,不惜建设了与海参崴贸易利益相冲突的新商港大连;二是无法容忍俄国去撼动既定国际经济关系乃至地缘政治格局的英、日两国结为同盟,以阻挠俄国的这一发展进程;三是俄方人为设定的种种限制政策,束缚了外国人在海参崴的发展。

关键词：海参崴地缘政治国际经济竞争

Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure

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World Journal of Clinical Cases 2024年第27期12卷 6045-6056页

作者： Yong Lin Geng-Jie Yan Mei-Yan Liu Yin cao Kan Zhang Na Wang Fu-Li long De-wen Mao Graduate School Guangxi University of Chinese MedicineNanning 530200Guangxi Zhuang Autonomous RegionChina Guangxi School of Chinese Medicine Guangxi University of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina Department of Hepatology The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina Department of Administration The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality *** immune status is an important factor affecting LF ***(Ils)are a type of cytokine that act and interact with multiple cells,including immune *** signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory *** date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of *** article reviews the potential use of Ils as the prognostic biomarkers of ***,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to *** biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient ***,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.

关键词： Interleukin-21 Interleukin-22 Interleukin-31 Liver failure Biological markers Potential value

Silicon photonic spectrometer with multiple customized wavelength bands

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Photonics Research 2024年第5期12卷 1016-1023页

作者： long ZHANG XIAOLIN YI DAJIAN LIU SHIHAN HONG GAOPENG WANG HENGZHEN cao YAOCHENG SHI DAOXIN DAI State Key Laboratory for Modern Optical Instrumentation Center for Optical&Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityZjingang CampusHangzhou 310058China Intelligent Optics and Photonics Research Center Jiaxing Research InstituteZhejiang UniversityJiaxing 314000China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

A silicon photonic spectrometer with multiple customized wavelength bands is developed by introducing multiple channels of wideband optical filters based on multimode waveguide gratings(MWGs)for pre-filtering and the corresponding thermally tunable narrowband filter for high *** these multiple customized wavelength bands,the central wavelengths,bandwidths,and resolutions are designed flexibly as desired,so that the system is simplified and the footprint is minimized for several practical applications(e.g.,gas sensing).A customized silicon photonic spectrometer is designed and demonstrated experimentally with four wavelength bands centered around1310 nm,1560 nm,1570 nm,and 1930 nm,which is,to the best of our knowledge,the first on-chip spectrometer available for sensing multiple gas components like HF,CO,H_(2)S,and CO_(2).The spectral resolutions of the four wavelength bands are 0.11 nm,0.08 nm,0.08 nm,and 0.37 nm,*** a customized silicon photonic spectrometer shows great potential for various applications,including gas monitors,wearable biosensors,and portable spectral-domain optical coherence tomography.

关键词： waveguide bands multiple

Distributed Heterogeneous Multi-Agent Optimization with Stochastic Sub-Gradient

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Journal of Systems Science & Complexity 2024年第4期37卷 1470-1487页

作者： HU Haokun MO Lipo cao Xianbing School of Mathematics and Statistics Central South UniversityChangsha 410083China School of Mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048China Research Centre for Agri-Product Quality Traceability Beijing Technology and Business UniversityBeijing 100048China School of Computer and Artificial Intelligence Beijing Technology and Business UniversityBeijing 100048China China Food Flavor and Nutrition Health Innovation Center Beijing Technology and Business UniversityBeijing 100048China

This paper studies the optimization problem of heterogeneous networks under a timevarying *** agent only accesses to one local objective function,which is *** improved algorithm with noisy measurement of local objective functions' sub-gradients and additive noises among information exchanging between each pair of agents is designed to minimize the sum of objective functions of all *** weaken the effect of these noises,two step sizes are introduced in the control *** graph theory,stochastic analysis and martingale convergence theory,it is proved that if the sub-gradients are uniformly bounded,the sequence of digraphs is balanced and the union graph of all digraphs is joint strongly connected,then the designed control protocol can force all agents to find the global optimal point almost *** last,the authors give some numerical examples to verify the effectiveness of the stochastic sub-gradient algorithms.

关键词： Communication noises distributed stochastic optimization heterogeneous networks subgradient measurement noises

Effect of TiO_(2) addition on microstructures and properties of Mgo-cao refractory aggregates

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Journal of Iron and Steel Research International 2024年第6期31卷 1547-1554页

作者： Shuai Zhang Jing-ran Wang Yuan-gao Li Feng-you Li wen Yan Hui-ying Shi The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Joint International Research Laboratory of Refractories and Metallurgy Wuhan 430081HubeiChina Shanxi Luweibao Taigang Refractory Co. Ltd.Taiyuan 030003ShanxiChina

MgO-cao(40 wt.%cao)refractory aggregates were prepared using the calcined dolomite and light-burned magnesia fine powder as raw materials and TiO_(2) as *** effect of TiO_(2) on their phase composition,microstructures and properties was investigated by X-ray diffraction and scanning electron *** properties such as bulk density,apparent porosity,relative aggregate tube strength and hydration resistance were also *** results showed that the CaTiO_(3) generated by the reaction between cao and TiO_(2) was distributed around the cao grain boundaries and intermittently distributed with MgO,which formed an isolation layer around cao and greatly improved the hydration ***,the introduction of TiO_(2) promoted sintering and increased the grain size,further improving the strengths and hydration resistance of the *** addition,the most significant enhancement in the hydration resistance and strengths of the samples was achieved when 1.0-2.0 wt.%TiO_(2) was *** this case,the relative strength of aggregate increased from 33.3% to 37.3%-43.1%,and the mass gain after the hydration test decreased from 3.13% to 1.26%-1.45%.

关键词： MgO-cao refractory aggregate TiO_(2)addition Phase composition Microstructure Hydration resistance

Fatigue-resistant Hydrogels

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Chemical Research in Chinese Universities 2024年第1期40卷 64-77页

作者： LI Luofei LEI Hai cao Yi Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureDepartment of PhysicsNanjing UniversityNanjing 210093P.R.China Department of Physics Zhejiang UniversityHangzhou 310027P.R.China

Hydrogels have been extensively studied for applications in various fields, such as tissue engineering and soft robotics, as determined by their mechanical properties. The mechanical design of hydrogels typically focuses on the modulus, toughness, and deformability. These characteristics play important roles and make great achievements for hydrogel use. In recent years, a growing body of research has concentrated on the fatigue property of hydrogels, which determines their resistance to crack propagation in the networks during cyclic mechanical loads for applications. However, knowledge of hydrogel fatigue behavior remains notably deficient. Here, we present a brief overview of the fatigue behavior of hydrogels, encompassing the general experimental methods to measure the fatigue property and fundamental theoretical calculation models. Then, we highlight multiple strategies to enhance the fatigue resistance of hydrogels. Finally, we present our perspectives on fatigue-resistant hydrogels, outstanding challenges and potential directions for future research.

关键词： Hydrogel Fatigue-resistant Fracture