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Journal of Systematics and Evolution 2009年第3期47卷 220-225页

作者： Qin-wen lin Zhi-Xiang zhang (College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China) (College of Biological Sciences and Biotechnology Beijing Forestry University Beijing 100083 China)

Microtropis macrocarpa C.Y. Cheng & T.C. Kao has been treated as a synonym of Microtropis macrophylla Merr. & Freeman in most taxonomic reports in China. According to our study, M. macrocarpa is an independent species endemic to Yunnan, China. Microtropis macrophylla and Microtropis pachyphylla Merr. & Freeman should be treated as synonyms of Microtropis longifolia Wall. ex Kurz. M. macrocarpa is also identified as a critically endangered species, CR B1ab (i,ii,iii,v), based on the IUCN Red List Categories and Criteria. The foliar surface, anther and pollen structures were also observed with a scanning electron microscope.

关键词： Celastraceae foliar epidermis IUCN Red List Microtropis pollen.

Biological distribution of ^(131)I-labeled anti-nucleus antigen monoclonal antibody chTNT in patients with pulmonary metastases from differentiated thyroid carcinoma

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Nuclear Science and Techniques 2008年第4期19卷 230-235页

作者： MA Qingjie GAO Shi ZHAO Jie wen Qiang BAI lin zhang Haoran ZHAO Guoqing China-Japan Union Hospital Jilin University Changchun 130033 China

This work is to study the in vivo biological distribution of 131I-labeled mouse/human chimeric monoclonal antibody (131I-chTNT) in patients with pulmonary metastases from differentiated thyroid carcinoma. Ten patients with differentiated thyroid carcinoma were injected intravenously with a single dose of 131I-chTNT (5 MBq·kg-1 body weight). Radioactivity of blood and urine samples was measured at different time points. The in vivo stability and the metabolic status of 131I-chTNT were detected with supersaturated trichloroacetic acid. Continuous imaging was performed to outline the region of interest (ROI) and estimate the intake level on the whole body,major organs and tumor lesions at different time points. The serum time-radioactivity curve of 131I-chTNT accorded with the two-compartment model after a single intravenous injection: T1/2(h)=65.28±14.83,AUC0-t(MBq·h·mL-1)=8.93±1.32,AUC0-∞(MBq·h·mL-1)=10.58±2.19,and CL(mL·min-1·kg-1)=1635±359. The time-radioactivity percentage curve of 131I-chTNT urine excretion accorded with the one-compartment model after a single intravenous injection: T1/2(h)=99±10,and accumulative (31±9) % radioactivity of the injected dose was excreted in urine in one week. The percentages of serum 131I-chTNT in radioactive components at 24,48 and 72 h were over 95% and it was still (88±7) % at 168 h. As for chemical composition of radioactive substances in urine,radioactivity in urine samples originated from free 131I by 100%. Radioactivity of 131I-chTNT after intravenous administration was mainly concentrated in the lung and liver,least in the brain. Radioactivity of tumor tissues reached the maximum at 24 h and the tumor/normal tissue (T/N) ratio reached the maximum (1.28～3.83) during 3～7 d. The characteristics of in vivo biological distribution of 131I-chTNT in patients with pulmonary metastases from differentiated thyroid carcinoma are favorable for its therapeutic application for the metastasis tumors.

关键词：放射性同位素生物学肺部疾病肿瘤转移

Formula Revision of Natural Ventilation Driven by Hot Pressure in Single Large Window Opening

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湖南大学学报（自然科学版） 2009年第S1期36卷 26-29页

作者： lin wen,zhang Quan,HOU Xi-kuai,LI Ping,ZHOU Jun-li,zhang Guo-qiang(Key Laboratory of Building Safety and Energy Efficiency(MOE),College of Civil Engineering,Hunan University,Changsha,Hunan 410082,China) Key Laboratory of Building Safety and Energy Efficiency College of Civil Engineering Hunan University Changsha 410082 China

This paper investigated the natural ventilation driven by hot pressure on a typical office building with single window *** actual result indicates that the ventilation rate of natural ventilation driven by hot pressure in the actual single window opening construction is very different from that obtained by the theoretical formula,since the ventilation conditions between actual environment and ventilation driven by hot pressure in the single window opening are ***,the theoretical formula is amended,and it becomes more consistent with the actual ventilation rate of natural ventilation driven by hot pressure under conditions that the construction is in the form of single window opening.

关键词： single opening natural ventilation theoretical formula

Inhibition of ATP-induced calcium influx in HT4 cells by glucocorticoids:involvement of protein kinase A

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Acta Pharmacologica Sinica 2005年第2期26卷 199-204页

作者： Jian-zhong HAN,wen lin~2,Yi-zhang CHEN~3Neuroscience Research Institute and Department of Neurobiology,~2Department of Pharmacology,College of Pharmacy,Second Military MedicalUniversity,Shanghai 200433,China Neuroscience Research Institute and Department of Neurobiology College of Pharmacy Second Military Medical University Shanghai China Department of Pharmacology College of Pharmacy Second Military Medical University Shanghai China

Aim:In our previous observations,adenosine triphosphate(ATP)was found toevoke immediate elevations in intracellular free calcium concentration([Ca2+]i)in HT4 neuroblastoma cells of *** tried to see if a brief pretreatment ofglucocorticoids could inhibit the Ca2+response and reveal the underlying signal-ing ***:Measurement of[Ca2+]iwas carried out using thedual-wavelength fluorescence method with Fura-2 as the ***:Pre-incubation of HT4 cells for 5 min with corticosterone(B)or bovine serum albu-min conjugated corticosterone(B-BSA)inhibited the peak[Ca2+]iincrements in aconcentration-dependent *** and dexamethasone had a similar action,while deoxycorticosterone and cholesterol were *** extracellularCa2+influx and intemal Ca2+release contributed to ATP-induced[Ca2+]*** brief treatment with only B attenuated Ca2+***,the[Ca2+]ielevation induced by the P2X receptor agonist adenosine 5’-(β,γ-methylene)triph-osphate(β,γ-meATP)was also *** rapid inhibitory effect of B canbe reproduced by forskolin 1 mmol/L and blocked by H89 20 mmol/*** glucocorticoid receptor antagonist mifepristone nor protein kinase C in-hibitors influenced the rapid action of ***:Our results suggest thatglucocorticoids modulate P2X receptor-medicated Ca2+influx through a mem-brane-initiated,non-genomic and PKA-dependent pathway in HT4 cells.

关键词： calcium glucocorticoids adenosine triphosphate protein kinase C protein kinase A

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一种三轮转向机构的设计

机械科学与技术 2001年第3期20卷 403-403,412页

作者：何宇廷林文章空军工程大学工程学院西安710038

针对常用的三轮运动机构 ,应用两组平行四边形机构协调工作的原理 ,设计了一套新型三轮转向机构控制其运动方向。

关键词：三轮运动机构转向机构设计

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing zhang Chun-lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

TGF-β1参与全反式维甲酸对大鼠肾脏系膜细胞MMP-2表达的调节

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复旦学报（医学版） 2001年第4期28卷 287-291,295页

作者：张农刘琛林文生张颂文顾建新郭慕依复旦大学基础医学院病理学教研室上海200032

目的　研究全反式维甲酸 (ATRA)对于大鼠肾脏系膜细胞表达MMP 2的影响以及转化生长因子 β1在这一过程中的作用。方法　采用Northernblot、Westernblot和Zymography法检测ATRA对培养大鼠肾脏系膜细胞MMP 2mRNA、蛋白分泌及酶活性表达变... 详细信息

目的　研究全反式维甲酸 (ATRA)对于大鼠肾脏系膜细胞表达MMP 2的影响以及转化生长因子 β1在这一过程中的作用。方法　采用Northernblot、Westernblot和Zymography法检测ATRA对培养大鼠肾脏系膜细胞MMP 2mRNA、蛋白分泌及酶活性表达变化 ;ATRA对系膜细胞表达TGF β1的作用 ,以及TGF β1对A TRA调节MMP 2表达的影响。结果　证实ATRA可增加培养大鼠肾脏系膜细胞的MMP 2mRNA表达、MMP 2蛋白分泌和增强MMP 2酶活性。ATRA也可引起TGF β1多肽呈剂量依赖型增加。反义TGF β1几乎可以完全阻断活性TGF - β1的分泌。经反义TGF β1转染的系膜细胞在 10 -6mol/LATRA作用下 ,其表达MMP 2mRNA的水平不发生变化 ,但是加入抗TGF β1抗体时 ,在 10 -6mol/LATRA作用下系膜细胞表达MMP 2呈剂量依赖型下降。结论　ATRA可上调培养大鼠系膜细胞的MMP 2mRNA、蛋白分泌和MMP 2酶活性的表达 ;TGF β1参与ATRA对MMP 2表达的调节 ,并为ATRA调节MMP

关键词：转化生长因子-β1 全反式维甲酸基质金属蛋白酶-2 肾脏系膜细胞 ATRA MMP-2

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-ling zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

TGF-β1对大鼠系膜细胞增殖和纤溶酶原激活物及其抑制剂表达的影响

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复旦学报（医学版） 2001年第3期28卷 213-215页

作者：林文生张农张颂文顾建新郭慕依复旦大学基础医学院病理学教研室上海200032 复旦大学基础医学院基因研究中心上海200032

目的　通过对大鼠系膜细胞转染TGF β1基因和反义TGF β1基因 ,观察该细胞增殖和纤溶酶原激活物及其抑制剂表达的影响。方法　采用MTT、细胞计数和流式细胞仪检测细胞增殖 ;Northernblot和Westernblot法检测其纤溶酶原激活物抑制剂 1(PA... 详细信息

目的　通过对大鼠系膜细胞转染TGF β1基因和反义TGF β1基因 ,观察该细胞增殖和纤溶酶原激活物及其抑制剂表达的影响。方法　采用MTT、细胞计数和流式细胞仪检测细胞增殖 ;Northernblot和Westernblot法检测其纤溶酶原激活物抑制剂 1(PAI 1)的表达 ;酶谱分析法检测其纤溶酶原激活物 (tPA)活性。结果　过表达TGF β1的系膜细胞生长受抑制 ,其PAI 1mRNA和蛋白表达增强 ,而tPA酶活性则降低 ;而低表达TGF β1的系膜细胞增殖加速 ,其PAI 1mRNA和蛋白表达降低 ,tPA酶活性增强。结论　TGF β1可通过对大鼠系膜细胞增殖、纤溶酶原激活物及其抑制因子表达的影响。

关键词：肾小球系膜细胞转化生长因子-β1 细胞增殖纤溶酶原激活物抑制剂-1 纤溶酶原激活性大鼠