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Systematic identification and functional analysis of long noncoding RNAs involved in indoxacarb resistance in Spodoptera litura

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Insect Science 2022年第6期29卷 1721-1736页

作者： li Shi wen-lin li Hai-Xin Zeng Yao Shi Xiao-Lan liao Hunan Provincial Engineering and Technology Research Center for Bio-pesticide and Formulation Processing College of Plant ProtectionHunan Agricultural UniversityChangshaChina Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases andInsectPests ChangshaChina

Long noncoding RNAs(lncRNAs)are noncoding transcripts that are more than 200 nucleotides long.They play essential roles in regulating a variety of biological processes in many species,including insects,and some lncRNAs have been found to be associated with insecticide resistance.However,the characteristics and biological func-tions of lncRNAs involved in indoxacarb resistance are unknown in Spodoptera litura.We performed RNA sequencing in the SS,InRS,and FInRS of S.litura and identified 11978 lncRNAs,including 3136 intergenic lncRNAs,7393 intronic lncRNAs,and 1449 anti-sense lncRNAs.Compared with the SS,51 lncRNAs were upregulated and 134 lncRNAs were downregulated in the two resistant strains,and 908 differentially expressed mRNAs were predicted as the target genes of the 185 differentially expressed lncRNAs.Further analysis showed that 112 of differentially expressed lncRNAs may be associated with in-doxacarb resistance by regulating the expression of 14 P450s,seven CCEs,one GST,six UGTs,five ABC transporters,and 24 cuticle protein genes,and 79 of differentially ex-pressed lncRNAs may regulate the expression of 14 detoxification genes and 19 cuticle protein genes to participate in indoxacarb resistance by sponging 10 microRNAs.Interest-ingly,47 of differentially expressed lncRNAs may mediate indoxacarb resistance through both lncRNA-mRNA and lncRNA-miRNA-mRNA regulatory pathways.Furthermore,quantitative PCR,RNA interference,and indoxacarb bioassay analyses indicated that over-expressed LNC_004867 and LNC_006576 were involved in indoxacarb resistance.This study provides comprehensive information for lncRNAs of S.litura,and presents evidence that lncRNAs havekey roles in conferring insecticide resistance in S.litura.

关键词： indoxacarb resistance long noncoding RNAs regulatory pathways RNA sequencing Spodopteralitura

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Improved Results on Robust H_∞ Control of Uncertain Discrete-time Systems with Time-varying Delay

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International Journal of Automation and computing 2009年第1期6卷 103-108页

作者： Yong-Gang Chen wen-lin li Department of Mathematics Henan Institute of Science and Technology Xinxiang 453003 PRC College of Mathematics and Information Science Henan Normal University Xinxiang 453007 PRC

In this paper, the robust H∞ control problem for uncertain discrete-time systems with time-varying state delay is con- sidered. Based on the Lyapunov functional method, and by resorting to the new technique for estimating the upper bound of the difference of the Lyapunov functional, a new less conservative sufficient condition for the existence of a robust H∞ controller is obtained. Moreover, the cone complementary linearisation procedure is employed to solve the nonconvex feasibility problem. Finally, several numerical examples are presented to show the effectiveness and less conservativeness of the proposed method.

关键词： Robust H∞ control discrete-time systems time-varying delay linear matrix inequalities （LMIs）.

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Identification of key genes involved in post-traumatic stress disorder:Evidence from bioinformatics analysis

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World Journal of Psychiatry 2020年第12期10卷 286-298页

作者： Yao-Yao Bian li-li Yang Bin Zhang wen li Zheng-Jun li wen-lin li li Zeng School of Nursing Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of First Clinical Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Jingwen library Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Digestive Department Ningbo Hospital of Traditional Chinese MedicineNingbo 315200Zhejiang ProvinceChina School of Preclinical Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Management School University of St AndrewsSt Andrews KY169AJUnited Kingdom College of Health Economics Management Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Post-traumatic stress disorder(PTSD)is a serious stress-related disorder.AIM To identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics methods.METHODS Gene expression profiles were obtained from the Gene Expression Omnibus database.The differentially expressed genes(DEGs)were identified by using GEO2R.Gene functional annotation and pathway enrichment were then conducted.The gene-pathway network was constructed with Cytoscape software.Quantitative real-time polymerase chain reaction(qRT-PCR)analysis was applied for validation,and text mining by Coremine Medical was used to confirm the connections among genes and pathways.RESULTS We identified 973 DEGs including 358 upregulated genes and 615 downregulated genes in PTSD.A group of centrality hub genes and significantly enriched pathways(MAPK,Ras,and ErbB signaling pathways)were identified by using gene functional assignment and enrichment analyses.Six genes(KRAS,EGFR,NFKB1,FGF12,PRKCA,and RAF1)were selected to validate using qRT-PCR.The results of text mining further confirmed the correlation among hub genes and the enriched pathways.It indicated that these altered genes displayed functional roles in PTSD via these pathways,which might serve as key signatures in the pathogenesis of PTSD.CONCLUSION The current study identified a panel of candidate genes and important pathways,which might help us deepen our understanding of the underlying mechanism of PTSD at the molecular level.However,further studies are warranted to discover the critical regulatory mechanism of these genes via relevant pathways in PTSD.

关键词： Post-traumatic stress disorder Differentially expressed genes Key pathway Gene-pathway co-expression Bioinformatics analysis Microarray

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Analysis of risk factors for retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2011年第6期4卷 631-633页

作者： wen-lin li li He Xi-Hua liu Yu-Mei Wang and Jian-Qing liu Department of Ophthalmology Shenzhen Children's Hospital Shenzhen 518026 Guangdong Province China

AIM: To analyze the incidence and risk factors for retinopathy of prematurity (ROP). METHODS: A retrospective analysis was conducted on 568 premature infants from September 2005 to December 2010 with birth weight (BW) equal to or less than 2 500g or a gestational age (GA) at birth of 34 weeks or less. All of the members were examined by indirect binocular ophthalmoscopy. RESULTS: ROP occurred with an incidence rate of 10.7% among 568 premature infants, and stages 3 and above ROP occurred with an incidence rate of 2.5%. This study showed the infants were more prone to develop ROP with short geststional age, low BW, long time of oxygen inhalation, and severe infants diseases. Twins had a significantly higher rate of ROP (18.3%) than singleton babies (9.8%), ROP were severer in twins than singleton babies. CONCLUSION: Short GA, low BW, long time of oxygen inhalation, severe infants diseases, and non-singleton babies were the most significant risk factors associated with ROP.

关键词： retinopathy of prematurity ROP epidemiology ROP incidence

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Effect of tool plunge depth on the microstructure and fracture behavior of refill friction stir spot welded AZ91 magnesium alloy joints

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 699-709页

作者： Hai-feng Zhang li Zhou wen-lin li Gao-hui li Yi-tang Tang Ning Guo Ji-cai Feng Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology at WeihaiWeihai 264209China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

We used refill friction stir spot welding(RFSSW)to join 2-mm-thick AZ91D-H24 magnesium alloy sheets,and we investigated in detail the effect of tool plunge depth on the microstructure and fracture behavior of the joints.A sound joint surface can be obtained using plunge depths of 2.0 and 2.5 mm.Plunge depth was found to significantly affect the height of the hook,with greater plunge depths corresponding to more severe upward bending of the hook,which compromised the tensile-shear properties of the joints.The hardness reached a minimum at the thermo-mechanically affected zone due to the precipitation phases of this zone as it dissolved into theα-matrix during the welding process.The fracture modes of RFSSW joints can be divided into three types:shear fracture,plug fracture,and shear–plug fracture.Of these,the joint with a shear–plug fracture exhibited the best tensile-shear load of 6400 N.

关键词： refill friction stir spot welding AZ91 magnesium alloy microstructure fracture behavior

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Chemical approach to generating long-term self-renewing pMN progenitors from human embryonic stem cells

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Journal of Molecular Cell Biology 2022年第1期14卷 1-10页

作者： Guan-Yu Zhang Zhu-Man Lv Hao-Xin Ma Yu Chen Yuan Yuan Ping-Xin Sun Yu-Qi Feng Ya-wen li wen-Jie Lu Yu-Dong Yang Cheng Yang Xin-Lu Yu Chao Wang Shu-Long liang Ming-liang Zhang Hui-liang li wen-lin li Department of Cell Biology Second Military Medical UniversityShanghai 200433China Changhai Hospital Second Military Medical UniversityShanghai 200433China Department of Histoembryology Genetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China Wolfson Institute for Biomedical Research University College LondonGower StreetLondon WC1E 6BTUK Shanghai Key Laboratory of Cell Engineering Second Military Medical UniversityShanghai 200433China

Spinal cord impairment involving motor neuron degeneration and demyelination can cause lifelong disabilities,but effective clinical interventions for restoring neurological functions have yet to be developed.In early spinal cord development,neural progenitors of the motor neuron(pMN)domain,defined by the expression of oligodendrocyte transcription factor 2(OliG2),in the ventral spinal cord first generate motor neurons and then switch the fate to produce myelin-forming oligodendrocytes.Given their differentiation potential,pMN progenitors could be a valuable cell source for cell therapy in relevant neurological conditions such as spinal cord injury.However,fast generation and expansion of pMN progenitors in vitro while conserving their differentiation potential has so far been technically challenging.In this study,based on chemical screening,we have developed a new recipe for efficient induction of pMN progenitors from human embryonic stem cells.More importantly,these OliG2+pMN progenitors can be stably maintained for multiple passages without losing their ability to produce spinal motor neurons and oligodendrocytes rapidly.Our results suggest that these self-renewing pMN progenitors could potentially be useful as a renewable source of cell transplants for spinal cord injury and demyelinating disorders.

关键词： human embryonic stem cells neural differentiation chemical approach self-renewing progenitors of motor neurons oligodendrocytes

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Identification of candidate biomarkers correlated with pathogenesis of postoperative peritoneal adhesion by using microarray analysis

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 54-65页

作者： Yao-Yao Bian li-li Yang Yan Yan Min Zhao Yan-Qi Chen Ya-Qi Zhou Zi-Xin Wang wen-lin li li Zeng School of Nursing Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of First Clinical Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Jingwen library Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Guang′anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Postoperative peritoneal adhesion(PPA),characterized by abdominal pain,female infertility,and even bowel obstruction after surgery,has always been a major concern.The occurrence and formation of adhesion are from complex biological processes.However,the molecular mechanisms underlying the basis of microarray data profile,followed by peritoneal adhesion formation,are largely unknown.AIM To reveal the underlying pathogenesis of PPA at the molecular level.METHODS The gene expression profile was retrieved from the Gene Expression Omnibus database for our analysis.We identified a panel of key genes and related pathways involved in adhesion formation using bioinformatics analysis methods.We performed quantitative PCR and western blotting in vivo to validate the results preliminarily.RESULTS In total,446 expressed genes were altered in peritoneal adhesion.We found that several hub genes(e.g.,tumor necrosis factor,interleukin 1 beta,interleukin 6,CX-C motif chemokine ligand 1,C-X-C motif chemokine ligand 2)were marked as significant biomarkers.Functional analysis suggested that these genes were enriched in the Toll-like receptor signaling pathway.According to the Kyoto Encyclopedia of Genes and Genomes pathway and published studies,TLR4,myeloid differentiation primary response protein 88(MyD88),and nuclear factor kappa B(NF-κB)played essential roles in Toll-like signaling transduction.Here,we obtained a regulatory evidence chain of TLR4/MyD88/NF-κB/inflammatory cytokines/peritoneal adhesion involved in the pathogenesis of postoperative adhesion.The results of the microarray analysis were verified by the animal experiments.These findings may extend our understanding of the molecular mechanisms of PPA.CONCLUSION The regulatory evidence chain of TLR4/MyD88/NF-κB/inflammatory cytokines/peritoneal adhesion may play key roles in the pathogenesis of PPA.Future studies are required to validate our findings.

关键词： Postoperative peritoneal adhesion Candidate biomarkers Molecular pathogenesis Bioinformatics analysis

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Prostate lymphoma with renal obstruction;reflections on diagnosis and treatment:Two case reports

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World Journal of Clinical Cases 2023年第7期11卷 1627-1633页

作者： Tao-Fen Chen wen-li lin wen-Ya liu Chi-Ming Gu Department of Urology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Prostate lymphoma has no characteristic clinical symptomatology,is often misdiagnosed,and currently,clinical case reports of this disease are relatively rare.The disease develops rapidly and is not sensitive to conventional treatment.A delay in the treatment of hydronephrosis may lead to renal function injury,often causing physical discomfort and rapid deterioration with the disease.This paper presents two patients with lymphoma of prostate origin,followed by a summary of the literature concerning the identification and treatment of such patients.CASE SUMMARY This paper reports on the cases of two patients with prostate lymphoma admitted to the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,one of whom died of the disease 2 mo after diagnosis,while the other was treated promptly,and his tumor was significantly reduced at the 6-mo follow-up.CONCLUSION The literature shows that prostate lymphoma is often seen as a benign prostate disease during its pathogenesis,even though primary prostate lymphoma enlarges rapidly and diffusely with the invasion of surrounding tissues and organs.In addition,prostate-specific antigen levels are not elevated and are not specific.There are no significant features in single imaging either,but during dynamic observation of imaging,it can be found that the lymphoma is diffusely enlarged locally and that systemic symptoms metastasize rapidly.The two cases of rare prostate lymphoma reported herein provide a reference for clinical decision making,and the authors conclude that early nephrostomy to relieve the obstruction plus chemotherapy is the most convenient and effective treatment option for the patient.

关键词： Lymphoma Prostate Cancer Prognosis Case report

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Advancements in the modification of magnesium-based hydrogen storage materials

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Progress in Natural Science:Materials International 2024年第3期34卷 540-554页

作者： lin Yang wen Zeng Yanqiong li College of Materials Science and Engineering Chongqing University School of Electronic Information & Electrical Engineering Chongqing University of Arts and Sciences

Magnesium-based hydrogen storage materials represent a hydrogen storage technology with broad application prospects. As the global energy crisis and environmental pollution issues become increasingly severe, hydrogen,as a clean and efficient energy source, has garnered growing attention. Magnesium-based hydrogen storage,serving as a crucial means for storing and transporting hydrogen, is gaining prominence due to its abundant resources, low cost, low density, and high hydrogen storage density. However, challenges in terms of absorption/desorption rates, temperature, activation energy, and enthalpy during hydrogen application impede its development. To address these challenges, this paper systematically reviews current research on magnesium-based hydrogen storage materials, encompasses their types, characteristics, and hydrogen absorption mechanisms.Furthermore, it delves into the impacts of nanoscale dimensions, alloying, doping, and catalysis on the performance of magnesium-based materials. The aim is to provide valuable insights for research in related fields.

关键词： For hydrogen storage Magnesium-based materials Research on modifying

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Selective photosynthesis of imines from biomass-derived aldehydes over Ni/TiO_(2)

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Rare Metals 2024年第3期43卷 1116-1124页

作者： Wu-lin li Qing-Qing Zhang lin Dong wen-Jun Zhang li-li lin Zu-Peng Chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing210037China Institute of Industrial Catalysis State Key Laboratory of Green Chemistry Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

Photocatalytic reductive amination of biomass-derived aldehydes is a desirable way to selectively upgrade biomass into value-added nitrogen-containing chemicals under mild conditions.However,it is challenging to produce imines in high selectivity because of the undesirable side reactions caused by the activity of functional groups.Here,we demonstrate the highly reactive and selective production of imines from biomass derived aldehydes via the photocatalytic reductive amination,using a defective TiO_(2)supported nickel catalyst.The employment of methanol as the hydrogen donor and ammonia solution as the nitrogen source avoids the use of high-pressure H_(2)and expensive amines,rendering the current catalytic process safe,economical,and environmentally friendly.In depth investigations attribute the improved separation and transfer of photogenerated charge carriers to the presence of oxygen vacancies and decorated Ni nanoparticles,thereby accelerating the production of imines from benzaldehyde amination(conversion,95.8%;seleetivity,95.2%).Furthermore,the developed system could be easily translated to the photocatalytic conversions of various biomass derived aldehydes,which provided an example of a cost-effective and sustainable approach for the valorization of biomass derived feedstocks.

关键词： Photocatalysis Biomass derivatives Imines Reduction amination Heterogeneous catalyst

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