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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang li wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo li Xingwei Lei liuyang Tang Daochen wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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痔消栓的HPLC含量测定

中国实验方剂学杂志 2009年第7期15卷 25-27页

作者：张荣邓秀霞卫罡李润美李文周陈军广州中医药大学广东广州510405 广东轻工职业技术学院广东广州510300

目的:建立痔消栓的HPLC含量测定方法。方法:采用HPLC法,以Kromasil C18(4.6 mm×250 mm,5μm)色谱柱为固定相,以乙腈-0.2%磷酸水溶液为流动相,梯度洗脱,流速1.0 ***-1,柱温23℃,检测波长为203 nm。结果:三七皂苷R1、人参皂苷Rg1、人参皂... 详细信息

目的:建立痔消栓的HPLC含量测定方法。方法:采用HPLC法,以Kromasil C18(4.6 mm×250 mm,5μm)色谱柱为固定相,以乙腈-0.2%磷酸水溶液为流动相,梯度洗脱,流速1.0 ***-1,柱温23℃,检测波长为203 nm。结果:三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1分别在0.368～2.76μg,0.676～5.07μg,0.812～6.09μg范围内线性关系良好,相关系数分别为0.999 9,0.999 9,0.999 8,平均加样回收率分别为98.53%,99.20%,99.35%,RSD分别为2.11%,1.88%,2.38%。结论:样品分离效果好,测定结果准确、可靠,重复性好,可用于痔消栓的质量控制。

关键词：痔消栓三七皂苷R1 人参皂苷Rg1 人参皂苷Rb1 高效液相色谱法

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湿热环境力竭运动后的脑电活动变化

北京体育大学学报 2016年第12期39卷 50-55,73页

作者：陈相可郑晨周越张宇纯邹辈辈封文平李显周涛北京体育大学运动人体科学学院北京100084 国家体育总局体育科学研究所北京100061

目的：探究湿热环境力竭运动后的脑电活动变化特点及导致其变化的可能机制。方法：17名非体育专业男性大学生在温度36.0℃、相对湿度60.0%的环境下以60%VO2max强度运动至力竭。运动中监测受试者的心率（HR）、核心温度（Tc）和额温（T... 详细信息

目的：探究湿热环境力竭运动后的脑电活动变化特点及导致其变化的可能机制。方法：17名非体育专业男性大学生在温度36.0℃、相对湿度60.0%的环境下以60%VO2max强度运动至力竭。运动中监测受试者的心率（HR）、核心温度（Tc）和额温（Tf）,运动前后测量受试者的体重与脑电（EEG）。结果：受试者运动（29.88±4.06）min后力竭,力竭时刻的HR达（200.94±9.76）次/min,Tc和Tf分别上升至（39.14±0.32）℃和（39.64±0.71）℃,体重丢失（623.53±536.81）g。运动后脑电波功率谱能量（SP）与运动前相比总体升高,右侧脑区升高区域多于左侧。α与β波频段内的α2与β2波的SP显著升高的脑区多于α1与β1波。唤醒水平（α/β）主要在左侧脑区显著下降（P〈0.05）。α波相对能量α/（α＋β）在F3、F7、T3区显著下降（P〈0.05）。相关分析发现躯体指标与脑电活动在多个脑区呈中度相关（r为0.48-0.74）。结论：湿热环境力竭运动后机体脑电活动整体升高,右侧脑区α2与β2波是潜在的运动性疲劳和运动热疾病的预测指标,机体疲劳是脑电活动与躯体指标相互作用的共同结果。

关键词：湿热环境力竭运动脑电活动中枢疲劳核心温度

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji li Tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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聚丙烯纤维改性橡胶高强混凝土高温性能研究

混凝土 2008年第3期 51-54页

作者：朱江李丽娟文周礼谢伟锋陈智泽陈应钦广东工业大学广东广州510006 广东省建筑材料研究院广东广州510160

对研配的试件进行了高温试验,利用外表面观察法和残余强度法对比研究了高强混凝土、橡胶粉高强混凝土及聚丙烯纤维改性橡胶粉高强混凝土高温作用后的性能变化。研究结果表明,聚丙烯纤维的加入有效地改善了高强混凝土和橡胶粉高强混凝土... 详细信息

对研配的试件进行了高温试验,利用外表面观察法和残余强度法对比研究了高强混凝土、橡胶粉高强混凝土及聚丙烯纤维改性橡胶粉高强混凝土高温作用后的性能变化。研究结果表明,聚丙烯纤维的加入有效地改善了高强混凝土和橡胶粉高强混凝土的高温抗爆裂性能,聚丙烯纤维与适量的橡胶粉混杂有利于提高橡胶粉高强混凝土的剩余抗压强度。

关键词：聚丙烯纤维橡胶粉高强混凝土高温爆裂

右美托咪定复合罗哌卡因Ⅱ型胸神经阻滞在乳腺癌改良根治术中的应用

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中国新药与临床杂志 2021年第4期40卷 287-291页

作者：李文舟章云飞罗艳芳卢锡华郑州大学附属肿瘤医院麻醉科河南郑州450008

目的探讨右美托咪定复合罗哌卡因Ⅱ型胸神经阻滞(PECSⅡ)对乳腺癌改良根治术后疼痛和炎症反应的影响。方法将拟行乳腺癌改良根治术的72例女性患者随机分为单用罗哌卡因组(R组)和右美托咪定复合罗哌卡因组(RD组),每组36例。2组麻醉诱导... 详细信息

目的探讨右美托咪定复合罗哌卡因Ⅱ型胸神经阻滞(PECSⅡ)对乳腺癌改良根治术后疼痛和炎症反应的影响。方法将拟行乳腺癌改良根治术的72例女性患者随机分为单用罗哌卡因组(R组)和右美托咪定复合罗哌卡因组(RD组),每组36例。2组麻醉诱导和维持方案相同。2组镇痛方法选择麻醉诱导前超声引导下PECSⅡ联合术后镇痛泵患者自控静脉镇痛(PCIA),R组PECSⅡ单用0.25%罗哌卡因30 mL,RD组PECSⅡ采用右美托咪定0.5μg·kg^(-1)复合0.25%罗哌卡因30 mL,2组术后镇痛泵配方相同,药液中含舒芬太尼100μg,均无持续给药剂量。以PECSⅡ起效至患者第一次按压镇痛泵给药键的时间为PECSⅡ有效镇痛时间,记录术中丙泊酚、瑞芬太尼以及术后48 h内舒芬太尼用量,术后6 h(T_(1))、12 h(T_(2))、24 h(T_(3))、48 h(T_(4))时静息状态下疼痛视觉模拟量表(VAS)评分。酶联免疫吸附(EliSA)法测定术前1 h(T_(0))、T_(1)、T_(2)、T_(3)、T_(4)时血清白细胞介素(IL)-6和前列腺素E2(PGE2)浓度,并观察不良反应发生情况。结果与R组相比,RD组PECSⅡ有效镇痛时间延长(P0.05)。结论将右美托咪定0.5μg·kg^(-1)作为罗哌卡因的佐剂行PECSⅡ,可以延长PECSⅡ镇痛时间,减少术中、术后麻醉药的用量,还具有抗炎作用。

关键词：右美托咪定罗哌卡因神经传导阻滞乳腺癌改良根治术镇痛炎症反应

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng zhou Yang Dai Guoyao Yue Yiman Zhang Lulu li Zhong-Zhen Yu Peng Min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

Hydrogen-bonded organic framework-ionic liquid composite quasisolid electrolyte for high-performance lithium battery

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Nano Research 2025年第1期18卷 332-340页

作者： Junmei Zhang Yatao Wu Chenye Wang Yong liu Zhirong Yang Shiyue zhou wenpeng li wenjia Wu Jingtao Wang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China

Ionic liquids(ILs)hold great promise as highperformance electrolyte material due to their unique advantages including nonvolatility,high thermal stability and high ionic ***,the IL-based electrolytes always suffer from serious ion aggregation and high viscosity at low temperatures,leading to significantly decline in ionic ***,hydrogen-bonded organic framework-ionic liquid composite quasi-solid electrolyte(high temperature treatment(HT)-HOF-IL CQSE)was prepared through confining the IL electrolytes(ILEs)into the pore of HOF lamellar *** weak hydrogen bonding interactions within HOF nanosheets,together with the generated interactions between ILE and HOF,enable uniform and continuous distribution of ILE in HOF lamellar *** effectively inhibits the ion migration of ILE,which meanwhile serves as li+transfer sites,affording high ionic conductivity of 5.7×10^(-5)S·cm-1 at-60 ℃,with high lithium-ion transference number of 0.69,whereas ILEs usually lose ionic conduction ability at such low *** assembled li symmetrical cell can stably cycle at 0.2 mA·cm^(-2)and^(-2)0 ℃ for more than 1500 *** liFePO_(4)|HT-HOF-IL CQSE|li cell shows excellent cycling performance at 0.5 C at a wide temperature range of^(-2)0 to 60 ℃.This work may pave a new avenue for the development of high-performance IL-based composite electrolytes.

关键词： ionic liquid hydrogen-bonded organic framework low-temperature ionic conductivity lithium-ion transference number quasi-solid electrolyte