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基于XSite的钻孔起裂水力裂缝三维扩展研究

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岩土工程学报 2021年第8期43卷 1483-1491,I0007,I0008,F0003页

作者：赵凯凯张镇李文洲王小华伊康孙卓越中煤科工开采研究院有限公司北京100013 Engineering Geology and Resource Geotechnics Group Simon Fraser UniversityBurnabyBCCanada V5A 1S6 煤炭资源高效开采与洁净利用国家重点实验室北京100013 中国煤炭科工集团有限公司北京100013 同济大学岩土与地下工程教育部重点实验室上海200092 同济大学土木工程学院地下建筑与工程系上海200092

为了认识近井筒水力裂缝三维扩展特征,采用基于离散格点理论和合成岩体方法研发的数值模拟软件XSite,分析了井筒方位和地应力对水力裂缝三维扩展的影响。研究结果表明:裸眼井筒起裂条件下,井筒方位变化导致裂缝三维形态产生差异,但整体... 详细信息

为了认识近井筒水力裂缝三维扩展特征,采用基于离散格点理论和合成岩体方法研发的数值模拟软件XSite,分析了井筒方位和地应力对水力裂缝三维扩展的影响。研究结果表明:裸眼井筒起裂条件下,井筒方位变化导致裂缝三维形态产生差异,但整体上裂缝趋向沿垂直于最小主应力的平面扩展。中间主应力的增加抑制了垂直于本方向的裂缝扩展,裂缝在中间主应力方向的扩展轨迹变得更加平直。低应力比(最大主应力与最小主应力之比)条件下,井筒上产生多条裂缝分支,趋向于形成空间缝网。随应力比增加,裂缝分支扩展受到抑制,主裂缝趋于沿最大主应力方向扩展。对于预制切槽压裂情况,裂缝沿切槽方向扩展后会逐渐偏转至垂直于最小主应力的平面,裂缝并未产生多条分支。水力裂缝最终扩展方向不受起裂方式的控制,而是由地应力主导。研究结果可为优化水力压裂设计和施工提供参考。

关键词：水力压裂扩展形态钻孔起裂地应力格点法

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用物理摆测重力加速度的实验介绍

物理实验 2017年第7期37卷 32-34,42页

作者：高文莉周进南京大学物理实验教学中心江苏南京210093

介绍了用物理摆测量重力加速度的实验方法.根据物理摆的简谐运动周期与摆锤到转轴之间的距离的关系,找到合适的摆锤位置,使物理摆正挂与倒挂时的振动周期值相等,从而得到比较精确的重力加速度值.

关键词：重力加速度物理摆简谐运动周期

作物育种学领域新的革命:高通量的表型组学时代

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植物科学学报 2016年第6期34卷 962-971页

作者：穆金虎陈玉泽冯慧李文建周利斌中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 甘肃农业大学兰州730070

传统的表型组学研究已严重滞后于高速发展的基因组、转录组及蛋白质组学,这也制约了作物育种学、功能基因组学等领域研究的深入开展。为突破这一瓶颈,国内外科研工作者经不懈的努力开发出了各类具有自动化、高精度、高通量特点的表型组... 详细信息

传统的表型组学研究已严重滞后于高速发展的基因组、转录组及蛋白质组学,这也制约了作物育种学、功能基因组学等领域研究的深入开展。为突破这一瓶颈,国内外科研工作者经不懈的努力开发出了各类具有自动化、高精度、高通量特点的表型组学分析平台,并将该平台与各类"组学"研究相结合,这将是作物育种学领域的一次新的技术革命。本文对植物表型组学的概念和研究意义进行了介绍和分析,并对高通量表型组学分析平台进行了详细介绍,同时对未来表型组学的发展和各类组学及生物大数据的综合利用进行了展望。

关键词：基因型表型表型组学高通量

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang li Xingping Quan Jinfen Chen Yan Han li Yang Manfei zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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基于化学成分相互作用的槐花-地榆配伍

中国实验方剂学杂志 2015年第15期21卷 74-78页

作者：曾浩涛赵淼陈地灵李文周深圳市龙岗中心医院耳鼻咽喉科医院广东深圳518116 广东省微生物研究所广州510070

目的:基于化学成分相互作用,探讨地榆-槐花的配伍作用。方法:设计地榆-槐花药材不同配伍比例,经过提取后,采用紫外分光光度法,分别测定不同比例提取液中总黄酮和鞣质含量;采用体外法测定各提取液清除DPPH自由基能力,并分析DPPH清除能力... 详细信息

目的:基于化学成分相互作用,探讨地榆-槐花的配伍作用。方法:设计地榆-槐花药材不同配伍比例,经过提取后,采用紫外分光光度法,分别测定不同比例提取液中总黄酮和鞣质含量;采用体外法测定各提取液清除DPPH自由基能力,并分析DPPH清除能力与各提取液中总黄酮和鞣质含量的关系;同时制备各提取液HPLC指纹图谱,运用统计学方法分析比较配伍后指纹图谱的变化,优选地榆-槐花配伍比。结果:地榆-槐花不同配伍比其总黄酮和鞣质含量,以及DPPH清除率均有差异,其中地榆-槐花在2∶1,1∶1比例下,DPPH清除率较大,总黄酮和总鞣质含量综合得分最高,提示DPPH清除率与黄酮和鞣质含量正相关;不同配伍比,提取液HPLC指纹图谱均有差异,提示配伍对化学成分有一定的影响。结论:地榆-槐花在配伍比例2∶1或1∶1下,其总黄酮、鞣质含量较高,DPPH清除率较大。本实验结果可为地榆-槐花在临床上配伍使用提供依据。

关键词：槐花地榆化学成分配伍

Research on TA as lidar receiver

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Research on TA as Lidar receiver

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

2006 7th International Symposium on Antennas, Propagation and EM Theory

作者： wen Chuanhua li Yiquan, zhou li ( Institute of Communications Engineering, PIA Univ of Sci.&Tech, Nanjing, 210007 Institute of Communications, PIA Univ. of Sci&Tech, Chongqing, 400035 Wuhan commanding communication academy information campaign lab, 430010)

This paper compared the performances of lidar system using telescope with TA (telescope array). The different performances including antenna gain and pattern of telescope and TA are given in this paper. The analyses results show that TA is better than telescope in lidar system. Adaptive receive telescope array technique is described in this paper.

关键词： lidar, TA (telescope array), adaptive receive telescope array

来源： cnki会议评论

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui Ren Woon Genevieve Saw li Zeng Eng King Tan Zhi Dong zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue li Ziliang Xie wenjiao zhou Huan Tong Dawen Yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle