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Quantitative image analysis for evaluation of tumor response in clinical oncology

Chronic Diseases and Translational Medicine 2018年第1期4卷 18-28页

作者： wen-li cai Guo-Bin Hong Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Radiology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhaiGuangdong 519000China

The objective, accurate, and standardized evaluation of tumor response to treatment is an indispensable procedure in clinical oncology. Compared to manual measurement, computer-assisted linear measurement can significantly improve the accuracy and reproducibility of tumor burden quantification. For irregular-shaped and infiltrating or diffuse tumors, which are difficult to quantify by linear measurement, computer-assisted volumetric measurement may provide a more objective and sensitive quantification to evaluate tumor response to treatment than linear measurement does. In the evaluation of tumor response to novel oncologic treatments such as targeted therapy, changes in overall tumor size do not necessarily reflect tumor response to therapy due to the presence of internal necrosis or hemorrhages. This leads to a new generation of imaging biomarkers to evaluate tumor response by using texture analysis methods, also called radiomics. Computer-assisted texture analysis technology offers a more comprehensive and in-depth imaging biomarker to evaluate tumor response. The application of computer-assisted quantitative imaging analysis techniques not only reduces the inaccuracy and improves the reliability in tumor burden quantification, but facilitates the devel-opment of more comprehensive and intelligent approaches to evaluate treatment response, and hence promotes precision imaging in the evaluation of tumor response in clinical oncology. This article summarizes the state-of-the-art technical developments and clinical applications of quantitative imaging analysis in evaluation of tumor response in clinical oncology.

关键词： Quantitative image analysis Tumor imaging biomarker Response evaluation

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马克思主义社会形态理论的正本清源——基于马列著作的文本学考察

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河北学刊 2024年第2期44卷 58-67页

作者：李文才潘静扬州大学社会发展学院

中国学术界在马克思主义社会形态理论的认识上,长期存在“三种社会形态论”和“五种社会形态论”(或作“五种生产方式论”)两种主要观点及其争论,其中后者则为中国史学界的主导性理论。改革开放以来,包括历史学界在内的中国学术界对马... 详细信息

中国学术界在马克思主义社会形态理论的认识上,长期存在“三种社会形态论”和“五种社会形态论”(或作“五种生产方式论”)两种主要观点及其争论,其中后者则为中国史学界的主导性理论。改革开放以来,包括历史学界在内的中国学术界对马克思社会形态理论进行了较为深刻的省思,也提出了一些新的认识或阐释。但争论依然激烈,分歧继续存在,甚至对于马克思是否提出过社会形态理论这样的问题也未能形成一致性看法。造成这种状况的重要原因是一些学者狃于寻章摘句以论证预设观点的研究方法,其结果既相悖于真正的学术探讨,也背离了马列著作的原义。立足于文本学考察,可知马克思在人类社会发展形态的问题上,从未明确提出过“三种社会形态”或“五种社会形态”的理论,而只是对人类社会发展过程中的某些“社会形态”及其特征作过一些描述或设想,认为马克思在《德意志意识形态》一书明确阐述“三种社会形态”或“五种社会形态”的说法,并不符合事实。长期支配中国学术界的“五种社会形态(生产方式)论”,实为列宁和斯大林总结出来的“理论”,特别是后者将其教条化和神圣化,因而并非马克思主义的基本原理。

关键词：马克思主义社会形态理论 “三种社会形态论” “五种社会形态论” 《德意志意识形态》列宁斯大林

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Gear walk instability caused by brake-disc friction characteristics

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Chinese Journal of Aeronautics 2024年第2期37卷 343-359页

作者： Xiaoqiong DU Bin li wen cai linyin LUO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of MichiganAnn Arbor 48109USA AVIC General Huanan Aircraft Industry Co.Ltd. Zhuhai 519040China

A multi-body dynamic rigid-flexible coupling model of landing gear is established to study the gear walk instability caused by the friction characteristics of the brake disc.After validating the model with the experimental results,the influence of the landing gear structure and braking system parameters on gear walk is further investigated.Among the above factors,the slope of the graph for the friction coefficient of the brake disc and the relative velocity of brake stators and rotors is the most influential factor on gear walk instability.Phase trajectory analysis verifies that gear walk occurs when the coupling of multiple factors causes the system to exhibit an equivalent negative damping trend.To consider a more realistic braking case,a back propagation neural network method is employed to describe the nonlinear behavior of the friction coefficient of the brake disc.With the realistic nonlinear model of the friction coefficient,the maximum error in predicting the braking torque is less than 10%and the effect of the brake disc temperature on gear walk is performed.The results reveal that a more negative friction slope may contribute to a more severe unstable gear walk,and reducing the braking pressure is an effective approach to avoid gear walk,which provides help for future braking system design.

关键词： Gear walk Friction characteristics of brake disc Brake-induced vibration Negative damping Rigid-flexible coupling Negative slope of braking torque

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Spin-based magnetic random-access memory for high-performance computing

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National Science Review 2024年第3期11卷 20-23页

作者： Kaiming cai Tianli Jin wen Siang Lew School of Physics Huazhong University of Science and Technology Interuniversity Microelectronics Centre(IMEC) School of Physical and Mathematical Sciences Nanyang Technological University

Memory serves as a critical component in today's electronic systems for data storage and processing. In traditional computer architectures, the logic and memory units are physically separated, due to the performance gap in operational speed and capacity among memories, resulting in the fundamental limitation of the von Neumann computers.

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Landslide Displacement Prediction Based on Time Series and PSO-BP Model in Three Georges Reservoir, China

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Journal of Earth Science 2024年第3期35卷 1079-1082页

作者： Dexiang Gao Kou li Yuncheng cai Tao wen School of Geosciences Yangtze UniversityWuhan 430100China School of Science Yunnan Agricultural UniversityKunming 650201China

0 INTRODUCTION Landslides are one of the most frequent geological disasters in the world(wen et al.,2020;Froude and Petley,2018),which have occurred frequently and widely distributed in China for a long time.The landslides are essentially a complex multidimensional nonlinear dynamic system affected by its own geological conditions and external factors(Ma et al.,2021;Wang et al.,2019),including geotechnical characteristics,hydrogeology,geomorphologic conditions,climate,and weathering(Ma et al.,2020).The interaction of these factors makes the change of landslide displacement random,fuzzy and variable(Park and Michalowski,2017),and also brings great difficulties to the landslide displacement prediction(Ma et al.,2018).

关键词： landslide Landslide weathering

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Oscillation properties of eigenfunctions for Sturm-liouville problems with interface conditions via Prufer transformation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 191-200页

作者： li Zhi-yu li Kun cai Jin-ming QIN Jian-fang ZHENG Zhao-wen School of Mathematical Sciences Qufu Normal UniversityQufu 273165China College of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China

A class of Sturm-liouville problems with discontinuity is studied in this paper.The oscillation properties of eigenfunctions for Sturm-liouville problems with interface conditions are obtained.The main method used in this paper is based on Prufer transformation,which is different from the classical ones.Moreover,we give two examples to verify our main results.

关键词： Sturm-liouville problem interface condition oscillatory solution

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Two-Staged Method for Ice Channel Identification Based on Image Segmentation and Corner Point Regression

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China Ocean Engineering 2024年第2期38卷 313-325页

作者： DONG wen-bo ZHOU li DING Shi-feng WANG Ai-ming cai Jin-yan School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ice class often navigate in channels opened up by icebreakers.Navigation in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large extent.The ship may get stuck if steered into ice fields off the channel.Under this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable method.In this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point regression.The first stage employs the image segmentation method to extract channel regions.In the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression network.The training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel dataset.The evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.

关键词： ice channel ship navigation identification image segmentation corner point regression

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One-step construction of strongly coupled Co_(3)V_(2)O_(8)/Co_(3)O_(4)/MXene heterostructure via in-situ Co-F bonds for high performance all-solid-state asymmetric supercapacitors

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Rare Metals 2024年第2期43卷 682-691页

作者： Ji Zhou Bin-Bin liu Hu Zheng wen-Qing Ma Qian li cai-Xia Xu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China

Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) composite was easily synthesized via one-step succinct-operated hydrothermal process.The interconnected Co_(3)V_(2)O_(8)/Co_(3)O_(4) nanowires network can in-situ grow and anchor on the surface of Ti_(3)C_(2)T_(x) via the strong Co-F bonds and contribute tremendously to depress Ti_(3)C_(2)T_(x) self-restacking.Profiting from the synergistically interplayed effect among the multiple interfaces and high conductivity of Ti_(3)C_(2)T_(x) as well as outstanding stability of the as-designed nanostructure,the optimum Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x)electrode reaches a commendable specific capacitance(up to 3800 mF·cm^(−2)),great rate capability(80%capacitance retention after 20-times current increasing),and preeminent cycling stability(95.4%/85.5%retention at 7000th/20,000th cycle).Moreover,the all-solid-state asymmetric supercapacitor based on Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) and active carbon can deliver a high energy density of 84.0μWh·cm^(−2) at the power energy of 3.2 mW·cm^(−2),and excellent cycling durability with 87.0%of initial capacitance retention upon 20,000 loops.This work provides a practicable pathway to tailor MXene-based composites for high-performance supercapacitor.

关键词： Ti_(3)C_(2)T_(x) Co_(3)V_(2)O_(8)/Co_(3)O_(4) Heterostructure Cathode Supercapacitor

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Preface to the special topic on metals and their compounds for lithium ion/metal batteries

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Tungsten 2024年第1期6卷 162-163页

作者： Ying-Ze Song wen-Long cai Gao-Ran li State Key Laboratory of Environment-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

The fast development of electronics and electric devices has inspired the practical application of lithium ion/metal batteries.Along this line,the metals and their compounds as electrode materials as well as the corresponding mechanism for energy storage have gained extensive international attention.The as-organized special topic focuses on W,Mo,Co,Zr,Hf,Re,Ta,Nb,V-based metals and their compounds for lithium ion/metal batteries.This special topic involves four reviews and four research papers totally,providing the latest advances of transition metals and their related compounds for rechargeable lithium ion/metal batteries.

关键词： lithium metals gained

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Novel MIP gene mutation causes autosomal-dominant congenital cataract

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 454-465页

作者： Jing-Lan Ni Hua-Ming wen Xiao-Sheng Huang Qian-wen li Jia-Min cai Bao-Jian Fan Jun Zhao The Second Clinical Medical College Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Ophthalmology Dongguan Chang’an HospitalDongguan 523843Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Oral&Maxillofacial Surgery Shenzhen Stomatology Hospital Affiliated to Shenzhen UniversityShenzhen 518040Guangdong ProvinceChina Department of Neurosurgery Massachusetts General Hospital and Harvard Medical SchoolBoston 02114MassachusettsUSA Department of Ophthalmology Shenzhen People’s Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina

●AIM:To identify disease-causative mutations in families with congenital cataract.●METHODS:Two Chinese families with autosomaldominant congenital cataract(ADCC)were recruited and underwent comprehensive eye examinations.Gene panel next-generation sequencing of common pathogenic genes of congenital cataract was performed in the proband of each family.Sanger sequencing was used to valid the candidate gene mutations and sequence the other family members for co-segregation analysis.The effect of sequence changes on protein structure and function was predicted through bioinformatics analysis.Major intrinsic protein(MIP)-wildtype and MIP-G29R plasmids were constructed and microinjected into zebrafish single-cell stage embryos.Zebrafish embryonic lens phenotypes were screened using confocal microscopy.●RESULTS:A novel heterozygous mutation(c.85G>A;p.G29R)in the MIP gene was identified in the proband of one family.A known heterozygous mutation(c.97C>T;p.R33C;rs864309693)in MIP was found in the proband of another family.In-silico prediction indicated that the novel mutation might affect the MIP protein function.Zebrafish embryonic lens was uniformly transparent in both wild-type PCS2+MIP and mutant PCS2+MIP.●CONCLUSION:Two missense mutations in the MIP gene in Chinese cataract families are identified,and one of which is novel.These findings expand the genetic spectrum of MIP mutations associated with cataracts.The functional studies suggest that the novel MIP mutation might not be a gain-of-function but a loss-of-function mutation.

关键词： congenital cataract major intrinsic protein missense mutation zebrafish model

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