检索结果-南通市图书馆

Exploring the Nanomechanical Properties of a Coordination-bond Based Supramolecular Polymer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第12期40卷 1613-1622,I0008页

作者： Rui-Xiang Yao Jun-Juan Shi ke-Huan Li Xin Liu Hou-Yu zhang Ming Wang wen-ke zhang State key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Institute of Theoretical Chemistry College of ChemistryJilin UniversityChangchun 130012China

Due to their dynamic nature and strength tunability,metallo-supramolecular polymers have been introduced into various *** mechanical strength of the metallo-supramolecular polymers in the system directly influences the mechanical properties(e.g.,the toughness)of the ***,it is necessary to explore the mechanical behavior of the metallo-supramolecular ***,we present a single-molecule method to systematically explore the chain structure and mechanical properties of metallo-supramolecular polymer by using a loop protected ***,we found that the mechanical stability of the individual chain,which is determined by the strength of terpyridine-Fe^(2+) -terpyridine(tpy-Fe^(2+)-tpy)bonds,was about 0.6–1.0 nN,depending on the pulling *** value is around three times higher than those measured using old *** addition,the unique loop protected structure further reduces the interference of non-specific polymer-AFM tip(or polymer-substrate)interactions on the quantification of the actual strength and kinetic parameter of noncovalent interactions in supramolecular ***,the single chain flexibility of the metallo-supramolecular polymer was investigated and found to be comparable to the corresponding covalent *** findings provide a new way to explore the force response of supramolecular polymers composed of metal-ligand interactions and will be useful for the design of metallo-supramolecular polymer-based functional materials with tailored mechanical properties.

关键词： Supramolecular polymer Single-molecule force spectroscopy Coordination chemistry Polymer mechanochemistry

在线全文

学校读者我要写书评

暂无评论

聚氧乙烯单晶介观力学性质研究

高分子学报 2018年第6期28卷 748-754页

作者：吕秀娟宋宇张文科超分子结构与材料国家重点实验室吉林大学化学学院理论化学研究所长春130012

以固定于平整硅基底上的聚氧乙烯单晶为模型体系,利用原子力显微镜的成像功能定位单晶后,用探针压穿聚氧乙烯单晶层,测量单晶层的介观力学性质.结果显示,原子力显微镜探针压穿单晶层所需要的力值为50~200 n N,随着探针曲率半径、下压速... 详细信息

以固定于平整硅基底上的聚氧乙烯单晶为模型体系,利用原子力显微镜的成像功能定位单晶后,用探针压穿聚氧乙烯单晶层,测量单晶层的介观力学性质.结果显示,原子力显微镜探针压穿单晶层所需要的力值为50~200 n N,随着探针曲率半径、下压速率和聚氧乙烯与溶剂界面能的增加,压穿单晶层所需要的力值也随之增加.结合分子模型证明在压穿过程中聚氧乙烯分子被原子力显微镜探针挤压到单晶外部.另外,发现在相同的下压速率和拉伸速率下,将相同数目的聚氧乙烯分子链挤压出晶体的能量与拉伸出晶体所需要的能量接近,继而从能量角度建立了聚氧乙烯晶体微观力学性质与介观力学性质的联系.

关键词：聚氧乙烯单晶原子力显微镜介观力学性质

在线全文

学校读者我要写书评

暂无评论

斜视手术后屈光状态的变化

国际眼科杂志 2018年第10期18卷 1819-1821页

作者：周文轲张黎重庆医科大学附属第一医院眼科眼科学重庆市重点实验室重庆市眼科研究所中国重庆市400016

斜视是指任何一眼视轴偏离的临床现象,可因双眼单视异常或控制眼球运动的神经肌肉异常或各类机械性限制引起。手术治疗是斜视矫正的重要方法,最初人们的关注点只在眼位,但随着对手术患者逐渐深入地观察及随访,有研究发现斜视手术可能改... 详细信息

斜视是指任何一眼视轴偏离的临床现象,可因双眼单视异常或控制眼球运动的神经肌肉异常或各类机械性限制引起。手术治疗是斜视矫正的重要方法,最初人们的关注点只在眼位,但随着对手术患者逐渐深入地观察及随访,有研究发现斜视手术可能改变眼球原本的屈光状态。本文从斜视手术后受术者屈光状态、眼球参数的改变、其可能的发生机制以及影响因素等作一综述,希望能对斜视手术有更为全面的认识,同时为确定术后验光配镜的理想时间提供依据。

关键词：斜视手术屈光散光

基于原子力显微镜的单分子力谱技术在高分子表征中的应用

在线全文

学校读者我要写书评

暂无评论

高分子学报 2021年第11期52卷 1523-1546页

作者：张薇侯矍李楠张文科吉林大学超分子结构与材料国家重点实验室长春130012

基于原子力显微镜(atomic force microscopy,AFM)的单分子力谱技术以其操作简便、适用面广等优势,成为了单分子领域应用最为广泛的技术之一.本文阐述了该技术的基础原理与实验技巧,包括仪器构造、工作原理、探针与基底的选择、样品固定... 详细信息

基于原子力显微镜(atomic force microscopy,AFM)的单分子力谱技术以其操作简便、适用面广等优势,成为了单分子领域应用最为广泛的技术之一.本文阐述了该技术的基础原理与实验技巧,包括仪器构造、工作原理、探针与基底的选择、样品固定、实验操作、单分子信号的获得以及数据处理.介绍了基于AFM的单分子力谱技术在合成高分子及生物大分子表征中的典型应用及前沿进展.AFM单分子力谱技术将有助于建立合成高分子的链结构、链组成与单链弹性以及链间相互作用与其宏观力学性能间的关联,帮助理解生物大分子的结构、相互作用与其生物功能之间的联系.

关键词： AFM单分子力谱合成高分子生物大分子

Correction to:Research on manufacture technology of spherical fuel elements by dry-bag isostatic pressing

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2022年第11期33卷 21-21页

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于水射流的轮胎粉碎效率的试验研究

机械设计 2016年第9期33卷 70-74页

作者：刘萍杨巧文张轲安徽理工大学机械工程学院安徽淮南232001

用传统方法粉碎废旧轮胎制得胶粉时会出现高能耗、易污染、设备复杂等问题，为避免上述问题，基于高压水射流技术，设计了一套子午线轮胎回收试验装置，并安排了L25（5）3正交试验。试验得出了影响胶粉粉碎效率的主次因素，得到了最优... 详细信息

用传统方法粉碎废旧轮胎制得胶粉时会出现高能耗、易污染、设备复杂等问题，为避免上述问题，基于高压水射流技术，设计了一套子午线轮胎回收试验装置，并安排了L25（5）3正交试验。试验得出了影响胶粉粉碎效率的主次因素，得到了最优射流工作参数为A4B4C4，还对高压水射流作用在轮胎橡胶层上的粉碎机理进行了分析，试验证明：用正交试验法所决定的最优射流工作参数是可行的，冲击粉碎和水楔粉碎是橡胶层粉碎的最重要机理。

关键词：正交试验粉碎效率子午线轮胎高压水射流粉碎机理

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

聚轮烷互锁结构的单分子力化学研究

高分子学报 2022年第10期53卷 1279-1286页

作者：李占东鞠华强黄飞鹤张文科吉林大学超分子结构与材料国家重点实验室化学学院长春130012 化学工程国家重点实验室浙江大学化学系杭州310027

基于冠醚和二级铵盐的轮烷体系是一类重要的超分子机器.理解外力作用下该轮烷体系的解离及结合机制,将有助于开发基于轮烷体系的力学响应材料.基于原子力显微镜(AFM)的单分子力谱(SMFS)是研究这种超分子弱相互作用的有效方法.为了提升... 详细信息

基于冠醚和二级铵盐的轮烷体系是一类重要的超分子机器.理解外力作用下该轮烷体系的解离及结合机制,将有助于开发基于轮烷体系的力学响应材料.基于原子力显微镜(AFM)的单分子力谱(SMFS)是研究这种超分子弱相互作用的有效方法.为了提升实验效率并降低界面非特异性相互作用对单分子力谱实验的干扰,通过合理的分子设计和聚合方法,将单体轮烷结构单元聚合,形成轮/轴首尾相连的聚互锁结构.通过将该聚合物桥联于AFM针尖与固体基片之间,并对该聚合物进行恒速拉伸操纵,实现了聚轮烷互锁结构的动态打开与形成过程的原位观测.实验结果显示,外力作用下聚轮烷结构中的重复单元依次打开,产生了具有锯齿状平台的力学信号,该锯齿状信号的力值体现出对拉伸过程中力加载速率的依赖性,随着力加载速率从600 pN/s升高至90000 pN/s,其力值从~84 pN升高至142 pN.往复拉伸实验结果显示,该聚轮烷结构的形成是一个自发、可逆的过程,且结合力值随着松弛速率的增加而降低.通过结合动态力学谱及相关动力学模型,得到该轮烷体系的结合速率常数为1.3×10^(4)s^(-1),解离速率常数为0.26 s^(-1),平衡态自由能为-34.6 kJ/mol,并绘制出其解离与结合的能量路径.本研究深化了对基于冠醚和二级铵盐的轮烷体系力学稳定性及结合与解离机制的认识,为基于轮烷的材料体系力学性质调控及理性设计提供了重要参考.

关键词：聚轮烷超分子材料单分子力谱力化学