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Effectiveness of Tenofovir Alafenamide in Chronic Hepatitis B Patients with Normal Alanine Aminotransferase and Positive Hepatitis B Virus DNA

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 112-119页

作者： wen-kang gao Yan-Yun Shu Yue Chen Yan Ai Xiao-Qian Yang Fan Du Jin Ye Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background and Aims:With an increasing understanding of hepatitis B,the antiviral indications have been broadening *** evaluate the effectiveness of tenofovir alafena-mide(TAF)in chronic hepatitis B(CHB)patients with normal alanine aminotransferase(ALT)and detectable hepatitis B virus(HBV)DNA,those who are ineligible for broader anti-viral criteria from the Chinese CHB prevention guide(2019).Methods:A total of 117 patients were recruited and their data were collected from paper or electronic medical *** DNA and liver function were measured at baseline and throughout the 24-week *** effectiveness end-point was complete virological *** safety endpoint was the first occurrence of any clinical adverse event during the ***:Among the 117 patients,45 had normal ALT as well as detectable HBV DNA and they were not recommended for antiviral therapy according to Chinese Guidelines(2019).After TAF antiviral therapy,the rates of patients who achieved HBV DNA<20 IU/mL at 4,12 and 24 weeks were 77.1%,96.7%and 96.8%*** them,the undetectable rates of HBV DNA in patients with low baseline viral load at 4,12 and 24 weeks were 92.3%,100%and 100%,while the rates of those with high baseline viral load were 68.2%,94.1%and 94.4%.Compared with 71.4%,94.4%and 94.7%in the high baseline group,the undetectable rates of HBV DNA at 4,12 and 24 weeks in the low baseline liver stiffness group were 85.7%,100%and 100%.There was no statistical significance among the above ***:CHB patients who had normal ALT and detectable HBV DNA and did not meet“CHB prevention guide(2019)”,could achieve complete virological response in 24 weeks after antiviral treatment by TAF.

关键词： Chronic hepatitis B virus Tenofovir alafenamide Effectiveness Observational study

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang Xuan Cheng Hui gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi Song Sujuan Qin Qiaoyan wen Fei gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao wen Zhao Yudan gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Bulging Performance and Quality Control of Aluminum Alloy Tailor-welded Overlapping Sheets Based on Interface Friction

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 258-264页

作者： gao Tiejun gao Bowen LI Weijie ZHANG Jiabin College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Shenyang Aerospace Xinguang Group Co.L td. Shenyang 110043China

In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping *** the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded *** this work,the bulging process of the tailor-welded overlapping sheets was taken as the research *** alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental *** results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming *** increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.

关键词： tailor-welded sheets overlapping sheet bulging interface friction weld seam stress

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慢性HBV感染不确定期患者的临床治疗现状及展望

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世界华人消化杂志 2022年第10期30卷 436-443页

作者：陈阅高文康舒艳芸叶进华中科技大学同济医学院附属协和医院消化内科湖北省武汉市430022

慢性乙型肝炎病毒(chronic hepatitis B virus,HBV)感染的自然病程通常分为4个阶段:免疫耐受期、乙肝e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎(chronic Hepatitis B,CHB)(即免疫清除期)、免疫控制期、HBeAg阴性CHB(即再活动期).根据HBeAg、乙肝病毒脱氧核糖核酸(HBV deoxyribonucleic acid,HBV DNA)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)和肝脏组织学表现,将不适合上述任何一个阶段的不确定期患者分为以下四组:(1)免疫耐受期相关不确定期:其余指标符合免疫耐受期,但HBV DNA2×10^(3)IU/mL或有显著炎症和纤维化;(4)再活动期相关不确定期:其余指标符合再活动期,但HBV DNA<2×10^(3)IU/mL或ALT 1-2 ULN.据统计我国约有7000万人感染了慢性HBV,其中约有2000-3000万是CHB患者.此外我国肝硬化和肝细胞癌(hepatocellular carcinoma,HCC)患者中,由HBV感染引起的比例分别为77%和84%.慢性HBV感染严重威胁着人民的生命健康并给国家医疗卫生体系带来沉重的经济负担.虽然现有指南建议动态监测这部分不确定期患者血清ALT和HBV DNA水平并评估肝脏组织学,但是否对这部分患者进行抗病毒治疗仍存有争议.本文主要介绍了CHB免疫控制期及与其相关不确定期患者的临床治疗现状,和对这部分患者进行抗病毒治疗的展望.

关键词：慢性乙型肝炎免疫控制期不确定期抗病毒治疗

Construction Concept and Innovative Practices of Virtual Power Plants in Megacities Under Electricity Market Environment

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Dianwang Jishu/Power System Technology 2025年第1期49卷 103-112页

作者： Tang, Jun gao, Hongchao Yu, Tao kang, Chongqing State Grid Shanghai Municipal Electric Power Company Pudong New Area Shanghai 200122 China National Key Laboratory of New Power System Operation and Control [Tsinghua University Haidian District Beijing 100084 China

With the accelerated construction of new power systems, the Virtual Power Plant (VPP), a key component of the new energy framework, provides critical support for safe supply, energy conservation, and emission reduction for power systems. However, the increasingly diverse technological forms and application scenarios of VPPs present challenges for standardization in large-scale development. A timely summary and generalization of VPP development principles, construction pathways, and technical practices can promote technical synergy and drive industry growth. This paper takes the VPP in a megacity as a typical use case. It thoroughly discusses the top-level design of the VPP by reviewing and analyzing four perspectives of form, policy, market, and standards. Secondly, this paper examines a multi-spatiotemporal regulation technology system for VPPs from three dimensions precise response, regional coordination, and fast regulation, which supports the normalized operation of Shanghai’s VPP. Then, this paper introduces the large-scale demonstration outcomes of Shanghai’s VPP, offering a valuable reference for development constructions and innovative practices of VPPs at the megacity scale. Finally, by analyzing the construction and operational outlook of Shanghai's VPP, this paper distills a clear pathway for its future development. © 2025 Power System Technology Press. All rights reserved.

关键词： Virtual Power Plants

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生物节律与肝脏能量代谢

世界华人消化杂志 2020年第20期28卷 1025-1035页

作者：高文康舒艳芸叶进潘晓莉华中科技大学同济医学院附属协和医院消化内科湖北省武汉市430022

生物节律起源于生物钟,是机体为适应外界环境的昼夜变化而进化成的一种内在变化节律.在其影响下,哺乳动物具有了明显的进食和禁食周期,产生了营养物质供需的节律性变化.近年来,大量研究表明生物节律与机体代谢有着紧密联系,而肝脏作为... 详细信息

生物节律起源于生物钟,是机体为适应外界环境的昼夜变化而进化成的一种内在变化节律.在其影响下,哺乳动物具有了明显的进食和禁食周期,产生了营养物质供需的节律性变化.近年来,大量研究表明生物节律与机体代谢有着紧密联系,而肝脏作为机体的代谢中枢,其功能必然受到昼夜节律的影响.随着现代社会节奏的加快,熬夜、轮班、快餐等生活方式打乱了机体原本节律,导致肝脏相关的代谢性疾病发病率大大增加, 而昼夜节律的紊乱又可促进这些疾病的发生、发展, 并影响其预后和转归. 本文就肝脏生物钟基因的功能与糖、脂质、胆汁酸、蛋白质等代谢物质间的关系展开综述.

关键词：昼夜节律生物钟基因肝脏能量代谢代谢障碍

Pronounced impact of size and shape effects on creep rupture life of a K439B superalloy combustion chamber casting simulator

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China Foundry 2025年

作者： wen-tong Liu Yi-dong Wu Lei gao Jing-yang Chen Cheng-bo Xiao Xi-dong Hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The size and shape effect(SSE) of components has become a critical issue for mechanical properties, application reliability, and processing. In this study, the creep rupture life(CRL) of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated. The intrinsic mechanisms of the SSE were explored from the dendrite structure, volume fraction and size of the γ' phase, and element segregation, etc. It is shown that this casting exhibits a strong SSE of creep rupture life, characterized by a significant difference in the CRL values up to 60% with the variation of wall thickness and position in the casing. In terms of casting technology, the influence of SSE on CRL is actually determined by the cooling rate. The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing), volume fraction size of the γ' phase in the dendrite trunk, and elements segregation rate. This work may have implications for the design and application of engineering components with large sizes and complex structures.

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