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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin mai Xiang wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-mao Yuan jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang jun-Bang Feng Chuan-Ming Li wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

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锂电池中串扰行为的研究进展

聊城大学学报（自然科学版） 2025年第1期38卷 34-42页

作者：马君中国科学院青岛生物能源与过程研究所、青岛储能产业技术研究院山东青岛266101 山东能源研究院山东青岛266101 青岛新能源山东省实验室山东青岛266101

高安全和高能量密度的锂电池是加快能源转型的重要支撑技术。但是锂电池存在电、化、力和热失效行为,导致电池容量损失、寿命下降和安全性降低,严重阻碍了高能量密度和高安全锂电池的发展。本文从正极与负极协同作用的视角,阐述了锂电... 详细信息

高安全和高能量密度的锂电池是加快能源转型的重要支撑技术。但是锂电池存在电、化、力和热失效行为,导致电池容量损失、寿命下降和安全性降低,严重阻碍了高能量密度和高安全锂电池的发展。本文从正极与负极协同作用的视角,阐述了锂电池中电/化/力/热串扰行为的最新研究进展及相应的解决策略,对比分析了使用电解液的常规锂电池与使用固态电解质的全固态锂电池在电/化/力/热串扰失效行为方面的相似之处与不同之处,并且总结了电/化/力耦合串扰行为的新观点,展望了进一步深刻认识并解决锂电池电/化/力/热耦合串扰行为的重要研究方向。

关键词：锂电池全固态正极负极串扰

Bayesian inference of the crust–core transition density via the neutron-star radius and neutron-skin thickness data

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Nuclear Science and Techniques 2023年第6期34卷 125-133页

作者： wen-Jie Xie Zi-Wei ma jun-Hua Guo Department of Physics Yuncheng UniversityYuncheng044000China

In this work,we perform a Bayesian inference of the crust-core transition density ρ_(t) of neutron stars based on the neutron-star radius and neutron-skin thickness data using a thermodynamical *** and Gaussian distributions for the ρ_(t) prior were adopted in the Bayesian *** has a larger probability of having values higher than 0.1 fm^(−3) for ρ_(t) as the uniform prior and neutron-star radius data were *** was found to be controlled by the curvature K_(sym) of the nuclear symmetry *** phenomenon did not occur if K_(sym) was not extremely negative,namely,K_(sym)>−200 *** value ofρ_(t) obtained was 0.075_(−0.01)^(+0.005) fm^(−3) at a confidence level of 68%when both the neutron-star radius and neutron-skin thickness data were *** anti-correlations were observed between ρ_(t),slope L,and curvature of the nuclear symmetry *** dependence of the three L-K_(sym) correlations predicted in the literature on crust-core density and pressure was quantitatively *** most probable value of 0.08 fm^(−3) for ρ_(t) was obtained from the L-K_(sym) relationship proposed by Holt et *** larger values were preferred for the other two relationships.

关键词： Crust–core transition density of neutron stars Neutron-star radius Neutron-skin thickness Bayesian inference approach L–K_(sym)

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-jun Zhang wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Dense molecular gas tracers in high mass star formation regions

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Research in Astronomy and Astrophysics 2016年第2期16卷 33-44页

作者： Hong-jun ma Yu Gao Jing-wen Wu Purple Mountain Observatory/Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China

We report the FCRAO observations that mapped HCN （1-0）, CS （2-1）, HNC （1-0） and HCO＋（1-0） in ten high-mass star forming cores associated with water masers. We present velocity integrated intensity maps of the four lines for these dense cores, compare their line profiles, and derive physical properties of these cores. We find that these four tracers identify areas with similar properties in these massive dense cores, and in most cases, the emissions of HCN and HCO＋ are stronger than those of HNC and CS. We also use the line ratios of HCO＋/HCN, HNC/HCN and HNC/HCO＋ as the diagnostics to explore the environment of these high-mass star forming regions, and find that most of the cores agree with the model that photodominated regions dominate the radiation field, except for W44, for which the radiation field is similar to an X-ray dominated region.

关键词： ISM clouds -- ISM molecules -- stars formation

Resonancesρ(1450)^(+)andρ(1700)^(+)in B→DKK decays

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Chinese Physics C 2022年第5期46卷 38-43页

作者： Ai-jun ma wen-Fei Wang Department of mathematics and Physics Nanjing Institute of TechnologyNanjing 211167China Institute of Theoretical Physics Shanxi UniversityTaiyuan 030006China

The contributions for the kaon pair from the intermediate statesρ(1450)^(+) andρ(1700)^(+) in the decays B+→D¯^(0)K+K¯^(0),B^(0)→D−K+K¯^(0),and B^(0)_(s)→D−_(s)K+K¯^(0)are analyzed within the perturbative QCD factorization *** decay amplitudes for all concerned decays in this work are dominated by the factorizable Feynman diagrams with the emission of the kaon pair,and the chargedρmesons should be of great importance in the KK channel of the related three-body B ***,these quasi-two-body decays are CKM-favored,and the relevant branching ratios are predicted to be in the order of 10^(−5),which have the potential to be measured by *** is also shown that the contributions of the subprocessesρ(1450,1700)^(+)→KK for the three-body B meson decays are considerable according to the total three-body branching fractions presented by ***,the decays B+→D¯^(0)K+K¯^(0),B^(0)→D−K+K¯^(0),and B^(0)_(s)→D−_(s)K^(+)K¯^(0)can be employed to study the properties ofρ(1450)andρ(1700)in the LHCb and Belle-II experiments.

关键词： three-body B meson decays resonance contributions perturbative QCD factorization approach

Microstructure and mechanical properties of Ti-6Al-4V components fabricated by laser micro cladding deposition

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Rare Metals 2015年第7期34卷 445-451页

作者： Bo Yao Xu-Long ma Feng Lin wen-jun Ge Key Laboratory for Advanced materials Processing Technology Ministry of Education of China Key Laboratory for Biomanufacturing and Rapid Forming Technology Department of Mechanical Engineering Tsinghua University Department of Mechanical Engineering Army Aviation Institute of Chinese People’s Liberation Army

Laser micro cladding deposition manufacturing(Ll CDM) is a newly developed rapid manufacturing method for *** Ll CDM technology adopts a novel powder feeding method based on alternating friction and inertia force, and this powder feeding method can effectively improve the accuracy and orientation of the powder injection, resulting in a smaller molten pool size and a higher cooling rate of liquid ***, the components fabricated by Ll CDM could obtain the finer microstructures and the improved mechanical *** is found that the components fabricated by Ll CDM are fully dense free of cracks or pores and exhibit columnar prior b grains with a finer acicular a0 phase *** microhardness(HV0.2) of the thin-wall component is HV 400–HV 500 in the majority part of the cross section and can reach about HV 850 in the top *** ultimate tensile strength(UTS) and elongation show insignificant dependence on the testing directions of the *** UTS is between 1,002 and 1,100 MPa, and the elongation is between 10.0 % and 14.7 %.

关键词： Laser micro cladding deposition Ti-6Al-4V Microstr