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A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction

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Asian Journal of Andrology 2017年第4期19卷 500-504页

作者： wen-jun Bai Hong-jun Li Jian-jun jin wen-Ping Xu Sorsaburu Sebastian Xiao-Feng Wang Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China Eli Lilly and Company Indianapolis Indiana 46285 USA

Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction （ED）. Recent study results indicate that men with ED in China who were naive to phosphodiesterase inhibitor type 5 （PDE5） therapy prefer tadalafil 20-mg （on-demand） versus sildenafil 100-mg （on-demand）. Differences in psychosocial outcomes may help to explain treatment preference in favor of tadalafih This open-label, randomized, crossover study compared psychosocial outcomes and drug attribute choices between tadalafil and sildenafil in Chinese men with ED na＇（ve to PDE5 inhibitor therapy. Eligible patients were randomized to sequential 20-mg tadalafU/lOO-mg sildenafil （n = 190） or 100-mg sildenafil/20-mg tadalafil （n = 193） for 8 weeks each and were asked which treatment they preferred to take for the 8-week extension phase. Psychosocial outcomes were assessed using the Psychological and Interpersonal Relationship Scale （PAIRS）, Drug Attributes Questionnaire （DRAQ）, and Sexual Life Quality Questionnaire （SLQQ）. When taking tadalafil versus sildenafil, men had a higher mean endpoint score on the PAIRS Spontaneity Domain （tadalafil = 2.86 vs sildenafil = 2.72; P 〈 0.001）, and a lower mean endpoint score on the Time Concerns Domain （tadalafil = 2.41 vs sildenafil = 2.55; P 〈 0.001）. A numerical increase in the Sexual Self-Confidence Domain was observed when taking tadalafil versus sildenafil （tadalafil -- 2.76 vs sildenafil = 2.72; P= 0.102）. The most frequently chosen drug attributes explaining treatment preference were able to get an erection long after having drug, and ability to get an erection every time. SLQQ results were comparable between treatment groups. These psychosocial outcomes may explain why more Chinese men preferred tadalafil versus sildenafil for the treatment of ED in this clinical trial.

关键词： drug attributes erectile dysfunction phosphodiesterase type 5 inhibitor psychological assessment of sexual dysfunction

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军队干部健康体检信息管理系统统计版设计

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华南国防医学杂志 2016年第12期30卷 801-804页

作者：郭雪清张伟谢峻陈文敏叶珺金红军黄正东解放军武汉总医院信息科湖北武汉430070 解放军武汉总医院保健办湖北武汉430070 解放军武汉总医院医务部湖北武汉430070

目的设计并开发适用于各大单位和总部卫生管理机关的统计版军队干部健康体检信息管理系统。方法采用JAVA开发语言、ORACLE数据库及TOMACT等信息技术,构建统计版军队干部健康体检信息系统应用服务支撑平台。结果通过参检单位及参检人员... 详细信息

目的设计并开发适用于各大单位和总部卫生管理机关的统计版军队干部健康体检信息管理系统。方法采用JAVA开发语言、ORACLE数据库及TOMACT等信息技术,构建统计版军队干部健康体检信息系统应用服务支撑平台。结果通过参检单位及参检人员基本信息、体检及患病情况等信息进行数据分析,可全面掌握军队干部体检信息及健康状态。结论统计版军队干部健康体检信息管理系统可为干部保健行政决策提供及时可靠的数据支持。

关键词：健康体检信息系统统计版方案设计

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A pilot-scale jet bubbling reactor for wet flue gas desulfurization with pyrolusite

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Journal of Environmental Sciences 2005年第5期17卷 827-831页

作者： SU Shi-jun ZHU Xiao-fan LIU Yong-jun JIANG wen-ju jin Yan National Engineering Research Center for Flue Gas Desulfurization Department of Environmental Science and Engineering Sichuan University Chengdu 610065 China

MnO2 in pyrolusite can react with SO2 in flue gas and obtain by-product MnSO4· H2O. A pilot scale jet bubbling reactor was applied in this work. Different factors affecting both SO2 absorption efficiency and Mn2^＋ extraction rate have been investigated, these factors include temperature of inlet gas flue, ration of liquid/solid mass flow rate（ L/S）, pyrolusite grade, and SO2 concentration in the inlet flue gas. In the meantime, the procedure of purification of absorption liquid was also discussed. Experiment results indicated that the increase of temperature from 30 to 70 K caused the increase of SO2 absorption efficiency from 81.4% to 91.2%. And when SO2 concentration in the inlet flue gas increased from 500 to 3000 ppm, SO2 absorption efficiency and Mn2^＋ extraction rate decreased from 98.1% to 82.2% and from 82.8% to 61.7%, respectively. The content of MnO2 in pyrolusite had a neglectable effect on SO2, absorption efficiency. Low L/S was good for both removal of SO2 and Mn2^＋ extraction. The absorption liquid was filtrated and purified to remove Si, Mg, Ca, Fe, Al and heavy metals, last product MnSO4· H2O was obtained which quality could reach China GB1622-86, the industry grade standards.

关键词： wet FGD jet bubbling reactor SO2 pyrolusite manganese sulfate

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Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe

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Chinese Chemical Letters 2001年第12期12卷 1089-1092页

作者： Wei LI wen YUAN Wei jun jin Chuan DONG Department of Chemistry Shanxi UniversityTaiyuan 030006 Department of Environment Science Shanxi UniversityTaiyuan 030006

Anticancer drug Mitomycin C (MMC) quenches remarkably phosphorescence and reduces lifetime of phosphorescence probe, Pd-meso-tetrakis-(4-trimethylaminophenyl)porphin (Pd-TAPP), in the presence of calf thymus DNA. These results may be attributed to the site competition of MMC with the probe and electron transfer between MMC and probe. MMC also increases polarization degree of the probe by covalent drug-DNA or DNA-drug-DNA crosslinking.

关键词： phosphorescence probe mitomycin C ct-DNA

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A Thermodynamic Model for square-well Chain Fluid:Theory and Monte Carlo Simulation

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Chemical Research in Chinese Universities 2001年第4期17卷 432-438页

作者： ZHANG Bing-jian LU Ying-hong HU wen-xuan jin Zhi-jun Department of Chemistry Zhejiang UniversityHangzhou 310027P.R.China Department of Earth Sciences Nanjing UniversityNanjing 210093P.R.China Basin and Reservoir Research Center China Petroleum UniversityBeijing 102200P.R.China

A thermodynamic model for the freely jointed square-well chain fluids was developed based on the thermodynamic perturbation theory of Barker-Henderson, Zhang and Wertheim. In this derivation Zhang’s expressions for square-well monomers improved from Barker-Henderson compressibility approximation were adopted as the reference fluid, and Wertheim’s polymerization method was used to obtain the free energy term due to the bond connectivity. An analytic expression for the Helmholtz free energy of the square-well chain fluids was obtained. The expression without adjustable parameters leads to the thermodynamic consistent predictions of the compressibility factors, residual internal energy and constant-volume heat capacity for dimer, 4-mer, 8-mer and 16-mer square-well fluids. The results are in good agreement with the Monte Carlo simulation. To obtain the MC data of residual internal energy and the constant-volume heat capacity needed, NVT MC simulations were performed for these square-well chain fluids.

关键词： Square-well chain Perturbation theory Compressibility factor Internal energy

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Water quality characteristics along the course of the Huangpu River (China)

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Journal of Environmental Sciences 2007年第10期19卷 1193-1198页

作者： YANG Hong-jun SHEN Zhe-min ZHANG jin-ping WANG wen-hua School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Xuhui District Environmental Protection Bureau Shanghai 200030 China Shanghai Environmental Monitoring Center Shanghai 200030 China

Huangpu River is about 114.5 km from upriver Dianfeng to downriver Wusong, near the estuary of the Yangtze River. It plays a key role in supplying water for production, life, shipment and irrigation. With the industrial development, the pollution of the Huangpu River has become serious recently. The biological oxygen demand （BOD）, total nitrogen （TN）, total phosphorus （TP）, oil, phenol and suspended solids （SS） were lower in the upstream sites than in the downstream sites, indicating pollutants being input along its course. Water quality was the worst in the Yangpu site, near the center of Shanghai City. Dissolved oxygen （DO） content was less than 2 mg/L in the site of Yangpu in July. Among relations between thirteen characteristics, relations between BOD, DO, TN, TP, NH4^＋ -N, NO3^- -N and the count of total bacteria or Escherichia coli were significant and interdependent. Inner relationships between these main characteristics in the Huangpu River were studied. High nutrient concentration led to growth of microorganisms, including E. coli. Degradation of organic matters and respiration of bacteria made oxygen concentration decreased in the water body, and DO was a key factor for nitrification-denitrification process of nitrogen. In the Yangpu site, DO was decreased to less than 3.0 mg/L with BOD higher than 7.5 mg/L in May and July. Low DO concentration will decrease nitrification rate. Nitrification need at higher DO value than other organic substrate oxidation. Consequently, river water contains low NO3^- -N values with high amounts of TN and NH4^＋ -N there. This will block the self-purification of surface water, by decreasing the rate of nitrification-denitrification transformation process in the water body.

关键词： water quality ecological assessment Huangpu River nitrification

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Epidemiology and region-specific risk factors for low Apgar scores in China:a nationwide study

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World Journal of Pediatrics 2022年第2期18卷 135-141页

作者： Yi-wen Wang Yan Chen Yan-Hong Ming jin-wen Zhang Kun Sun jun Zhang Yong-jun Zhang Department of Neonatology Xinhua HospitalShanghai Jiao Tong University School of Medicine1665 Kongjiang RoadShanghai 200092China Department of Obstetrics and Gynecology Hospital of Obstetrics and GynecologyFudan UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases The International Peace Maternity&Child Health HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pediatrics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Ministry of Educaticn-Shanghai Key Laboratory of Children's Env ironmental Health Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Background Neonatal asphyxia is a serious public health *** study aimed to determine the epidemiology and region-specific risk factors for low Apgar scores,an important proxy for neonatal asphyxia,in China from 2015 to *** The China Labor and Delivery Survey was a multicenter cross-sectional study including 96 hospitals distributed in 24(out of 34)*** regression analysis was performed to examine the risk factors for a low Apgar score(<7).Correspondence analyses were performed among neonates with low Apgar scores to explore the relationship between risk factors and geographical *** population attributable risk percentage(PAR%)was calculated for each region-specific risk *** A total of 72,073 live births,including 320 births with low Apgar scores,were used for the analysis,giving a weighted rate of 3.9/1000 live *** was a substantial difference in the incidence of low Apgar scores by geographic region,from 2.3/1000 live births in East China to 10.9/1000 live births in Northeast *** and obstetric factors are the major region-specific risk *** Southwest China,hypertensive disorders in pregnancy were more important contributors,with PAR% being 74.47%;in North and Northwest China,pre-pregnancy underweight was a more significant factor,with PAR% of 62.92%;in East China,infants born between 0:00 *** 7:59 *** a key factor,with PAR% of 80.44%.Conclusion Strategies based on region-specific risk factors should be considered to reduce the burden of low Apgar scores in China.

关键词： Apgar score China Epidemiology Risk factor

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基于三矩形谐振腔非通MIM波导的四重法诺传感

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原子与分子物理学报 2025年第3期42卷 116-123页

作者：王叶壮沈宏君陈俊坤王雅雯宁夏大学物理学院银川750000

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共... 详细信息

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共振.采用了有限时域差分方法计算了此结构的传输特性与Z方向的归一化磁场,并详细分析了其法诺共振的产生机理.通过计算结构几何参数调节后的透射光谱,从而得出了四处法诺共振峰透射率和共振位置可以通过改变结构几何参数而获得独立调节.此外还发现在结构中添加不同浓度的葡萄糖溶液可以实现高折射率传感灵敏度(S),获得最高灵敏度2736.98nm/RIU,可以看出此结构对于折射率变化有很高的灵敏度,这为设计和优化纳米级别的折射率传感器提供了新的思路,还可以应用于电路构建前进行性能测试.

关键词：金属-绝缘体-金属传感器谐振腔法诺共振灵敏度

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Dynamic lithium-compensation mechanism for densification of garnet-type Li_(7)La_(3)Zr_(2)O_(12)electrolyte by Li_(2)O atmosphere buffer pair

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Nano Research 2024年第7期17卷 6184-6191页

作者： Chujun Zheng Ya Chen Haoxin Dong Yan Lu jun jin Zhaoyin wen CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of CeramicsChinese Academy of ScienceShanghai 200050China State Key Lab High Performance Ceram and Superfine Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Solid-state lithium metal batteries are one of the most promising options for next-generation batteries pursuing high-energy density and ***,the inevitable volatilization of lithium compounds during sintering leads to low relative density and low ionic conductivity of solid-state ***,the dynamic lithium-compensation mechanism is proposed to facilitate the densification of Ta-substituted garnet-type electrolyte(Li_(6.5)La_(3)Zr_(1.5)Ta_(0.5)O_(12)(LLZT))through the reversible manipulating of Li_(2)O ***_(2)ZrO_(3)is used as mother powder additive,which reacts with Li_(2)O in sintering atmosphere and forms Li_(6)Zr_(2)O_(7).Li_(2)ZrO_(3)/Li_(6)Zr_(2)O_(7)buffer pair manipulates the sintering Li_(2)O atmosphere,which is vital for LLZT,within the Li_(2)O partial pressure range corresponding to Li_(2)ZrO_(3)and Li_(6)Zr_(2)O_(7).Furthermore,the reversibility mechanism of buffer pair for Li_(2)O absorption and release is *** obtained LLZT exhibits a relative density of over 96%and an ionic conductivity exceeding 7×10^(−4)S·cm^(−1)with no abnormal grain *** symmetric cell demonstrates an excellent lithium dendrite suppressing ability(stable cycling at a current density of 0.3 mA·cm^(−2)for over 1000 h).Such dynamic lithium-compensation strategy has been successfully applied in atmosphere manipulation of LLZT sintering process,which reduces the dependence of LLZT on the Li_(2)O atmosphere,making it conducive to large-scale preparation of electrolyte ceramics.

关键词： solid-state batteries garnet-type electrolyte high-density electrolyte dynamic lithium-compensation buffer pair

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Association of neonatal blood levels of brain-derived neurotrophic factor with development of autism spectrum disorder:a systematic review and meta-analysis

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World Journal of Pediatrics 2021年第2期17卷 164-170页

作者： Ya-Kun Liu Hua Gao Shao-Bin jin wen-jun Tu Ya-jun Chen Department of General Surgery Beijing Children’s HospitalCapital Medical UniversityNo.56 Nanlishi St.Beijing 100045China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityNo.107 West Wenhua StJinan 250000China Institute of Radiation Medicine Chinese Academy of Medical SciencePeking Union Medical CollegeNo.238 Baidi StTianjin 300192China Key Lab of Cerebral Microcirculation in Universities of Shandong Shandong First Medical UniversityShandong Academy of Medical SciencesNo.619 Changcheng St.Taian 271000China

Background Our goal was to evaluate the association between neonatal blood brain-derived neurotrophic factor(BDNF)level and autism spectrum disorder(ASD)diagnosis later in *** MEDLINE and Web of Science databases were searched from inception until September 16,*** lists of all relevant articles also were *** blood BDNF concentrations,standard deviations,sample sizes,and other data needed for calculation of effect sizes were extracted by two independent *** quality of the included studies was appraised using the Newcastle-Ottawa Scale for case-control *** were pooled using the random-effects *** Five case-control studies involving 1341 cases and 3395 controls were included in the *** meta-analysis of all included studies showed no significant difference in blood BDNF levels between neonates diagnosed with ASD later in life and healthy controls[standardized mean difference(SMD)=0.261;95%confidence interval(CI)-0.052 to 0.573;P=0.102],with high level of heterogeneity(Q=64.346;I2=93.784;P<0.001).A subgroup analysis by assay type showed decreased blood BDNF levels in ASDs compared to controls(SMD=—0.070;95%CI-0.114 to-0.026;P=0.002),with high level of homogeneity(Q=0.894;I2=0.000;P=0.827).No evidence of publication bias was *** Neonates diagnosed with ASD later in life have decreased blood levels of BDNF measured by double-antibody *** studies are warranted to facilitate a more robust conclusion.

关键词： Autism spectrum disorder Autistic disorder Brain-derived neurotrophic factor Neonates Neurotrophins

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