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Multidisciplinary approaches in the management of advanced hepatocellular carcinoma:Exploring future directions

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4052-4054页

作者： Xin-Jin Liu Yi-Xiu Lin Liu-Xiang Chen wen-juan yang Bing Hu Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Recently,we read the article“Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of the literature”published in the World Journal of Gastrointestinal *** prognosis of advanced hepatocellular carcinoma(HCC)is poor,and multidisciplinary comprehensive treatment is currently the main research *** case report demonstrated the efficacy of the combination therapy of transcatheter arterial chemoembolization,hepatic arterial infusion chemotherapy,epclusa,lenvatinib and sintilimab for a patient with advanced HCC,and the report can serve as a reference for clinical *** would also like to share some of our views.

关键词： Hepatocellular carcinoma Multidisciplinary conversion therapy Pathological complete response Comment

Gastric epithelial histology and precancerous conditions

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 396-412页

作者： Hang yang wen-juan yang Bing Hu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

The most common histological type of gastric cancer(GC)is gastric adenocarcinoma arising from the gastric *** common variants include mesenchymal,lymphoproliferative and neuroendocrine *** Lauren scheme classifies GC into intestinal type,diffuse type and mixed *** WHO classification includes papillary,tubular,mucinous,poorly cohesive and mixed *** atrophic gastritis(CAG)and intestinal metaplasia are recommended as common precancerous *** definite precancerous condition of diffuse/poorly/undifferentiated type is *** superficial inflammation and hyperplasia of foveolar cells may be the ***,the management of early GC and precancerous conditions mainly relies on endoscopy including diagnosis,treatment and *** of precancerous conditions promotes the early detection and treatment of early GC,and even prevent the occurrence of *** the review,precancerous conditions including CAG,metaplasia,foveolar hyperplasia and gastric hyperplastic polyps derived from the gastric epithelium have been concluded,based on the overview of gastric epithelial histological organization and its renewal.

关键词： Gastric cancer Gastric precancerous conditions Gastric epithelium Diagnosis Histopathology

Immunomodulatory therapies for acute pancreatitis

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World Journal of Gastroenterology 2014年第45期20卷 16935-16947页

作者： Jing Li wen-juan yang Lu-Ming Huang Cheng-Wei Tang Department of Gastroenterology West China Hospital Sichuan University Division of Peptides Related with Human Diseases Key Laboratory of Biotherapy of Human Diseases Ministry of Education

It is currently difficult for conventional treatments of acute pancreatitis (AP), which primarily consist of anti-inflammatory therapies, to prevent the progression of AP or to improve its outcome. This may be because the occurrence and progression of AP, which involves various inflammatory cells and cytokines, includes a series of complex immune events. Considering the complex immune system alterations during the course of AP, it is necessary to monitor the indicators related to immune cells and inflammatory mediators and to develop more individualized interventions for AP patients using immunomodulatory therapy. This review discusses the recent advances in immunomodulatory therapies. It has been suggested that overactive inflammatory responses should be inhibited and excessive immunosuppression should be avoided in the early stages of AP. The optimal duration of anti-inflammatory therapy may be shorter than previously expected (< 24 h), and appropriate immunostimulatory therapies should be administered during the period from the 3rd d to the 14th d in the course of AP. A combination therapy of anti-inflammatory and immune-stimulating drugs would hopefully constitute an alternative to anti-inflammatory drug monotherapy. Additionally, the detection of the genotypes of critical inflammatory mediators may be useful for screening populations of AP patients at high risk of severe infections to enable the administration of early interventions to improve their prognosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Pancreatitis Immunomodulatory therapy Systemic inflammatory response syndrome Immunosuppression Immunostimulation

Comparative research on the catalytic activities of different molecular sieves for acetalization and ketalization

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Chinese Science Bulletin 2007年第13期52卷 1780-1784页

作者： LIANG XueZheng GAO Shan WANG wen juan CHENG wenPing yang JianGuo Shanghai Key Laboratory of Green Chemistry and Chemical Process East China Normal University Shanghai 200062 China

Molecular sieves with different acidities and pore-sizes have been applied to catalyze the acetalization and ketalization of carbonyl compounds with glycol. A comparative research on the catalytic activities of the catalysts for certain reactions has been carried out to figure out the relationship between the characters of the catalysts and the activities. The results show that the pore-size of the molecular sieves is one of the most important factors that determine the catalytic activity. Appropriate pore-size is needed for the certain *** acidity is another factor that affects the activities. They also have great effects on the recycled activities of the catalysts.

关键词：分子筛催化活度乙缩醛酮缩醇

Large Eddy Simulation of New Vortex Generator Enhancing Heat Exchange of Solar Energy

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湖南大学学报（自然科学版） 2009年第S1期36卷 186-192页

作者： wen juan,yang Li,QI Cheng-ying(Department of Thermal Power Engineering,Hebei University of Technology,Tianjin 300401,China) Department of Thermal Power Engineering Hebei University of Technology Tianjin 300401 China

This paper put forward a new-type vortex generator enhancing heat exchange of solar air-drier and air-heater on the gas side,and investigated the mechanism of heat transfer enhancement and drag reduction by the influence of vortex generators on the coherent structure of turbulent boundary *** flow and heat transfer characteristics of rectangle channel with bevel-cut half-elliptical column vortex generators were obtained using large eddy simulation(LES)and the hydromechanics software *** instantaneous properties of velocity,temperature and pressure in channel were *** coherent structure of turbulent boundary layer flow was showed,and the characteristic of vortex induced by inclined-cut semi-ellipse vortex generator and its influence on turbulent coherent structure were *** the effect mechanism of turbulent coherent structure on flow field,pressure field and temperature field was *** on the results,the heat transfer coefficient and drag reduction of the new vortex generator with different pitch angles were ***,the coherent effects of the increased wall heat transfer and the decreased skin friction do not satisfy the Reynolds *** turbulent coherent structure can be controlled through the geometry of the vortex generator,so the heat transfer and drag reduction can also be *** we can seek suitable form of vortex generator and structure parameters,in order to achieve the enhanced heat transfer and flow of drag reduction in the solar air-heater and solar air-drier.

关键词： large eddy simulation vortex generator bevel-cut half-elliptical column coherent structure heat transfer enhancement

Artificial intelligence technique in detection of early esophageal cancer

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World Journal of Gastroenterology 2020年第39期26卷 5959-5969页

作者： Lu-Ming Huang wen-juan yang Zhi-Yin Huang Cheng-Wei Tang Jing Li Department of Gastroenterology West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Due to the rapid progression and poor prognosis of esophageal cancer(EC),the early detection and diagnosis of early EC are of great value for the prognosis improvement of ***,the endoscopic detection of early EC,especially Barrett's dysplasia or squamous epithelial dysplasia,is ***,the requirement for more efficient methods of detection and characterization of early EC has led to intensive research in the field of artificial intelligence(AI).Deep learning(DL)has brought about breakthroughs in processing images,videos,and other aspects,whereas convolutional neural networks(CNNs)have shone lights on detection of endoscopic images and *** studies on CNNs in endoscopic analysis of early EC demonstrate excellent performance including sensitivity and specificity and progress gradually from in vitro image analysis for classification to real-time detection of early esophageal *** AI technique comes to the pathological diagnosis,borderline lesions that are difficult to determine may become easier than *** gene diagnosis,due to the lack of tissue specificity of gene diagnostic markers,they can only be used as supplementary measures at *** predicting the risk of cancer,there is still a lack of prospective clinical research to confirm the accuracy of the risk stratification model.

关键词： Artificial intelligence Early esophageal cancer Barrett's esophagus Esophageal squamous cell carcinoma Endoscopic diagnosis Pathological diagnosis

A multi-stream network for retrosynthesis prediction

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Frontiers of Computer Science 2024年第2期18卷 231-233页

作者： Qiang ZHANG juan LIU wen ZHANG Feng yang Zhihui yang Xiaolei ZHANG Institute of Artificial Intelligence School of Computer ScienceWuhan UniversityWuhan 430072China College of Informatics Huazhong Agricultural UniversityWuhan 430072China

1 Introduction Retrosynthesis aims to predict a set of reactants for producing given molecules[1],which plays a significant part in the biochemistry field,such as molecular pathway design and drug *** existing methods perform better in solving this problem,most of these methods[2,3]only describe the molecules from one kind of perspective,such as they use Simplified Molecular Input Line Entry System(SMILES)strings[4]to represent the atomic components and the relationship between atoms of molecules or leverage Extended Connectivity Fingerprints(ECFPs)represent the information of the molecular sub-structure composition via binary vectors[5].

关键词： synthesis reactant hough

Effect of early stepwise cardiopulmonary rehabilitation on function and quality of life in sepsis patients

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World Journal of Clinical Cases 2024年第4期12卷 729-736页

作者： Ming-Hui Zheng wen-Jun Liu juan yang Division of Cardiovascular First Ward Departments of Internal Medicine Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Respiratory Medicine PuRen Hospital Affiliated to Wuhan University of Science and Technology/Respiratory MedicineWuhan 430000Hubei ProvinceChina Department of Cardiology Huanggang Central HospitalHuanggang 438000Hubei ProvinceChina

BACKGROUND Sepsis,as a non-limiting host infection disease,can be accompanied by serious complications such as organ failure,which seriously threatens patient quality of *** To investigate the effect of early stepwise cardiopulmonary rehabilitation on cardiopulmonary function and quality of life in patients evacuated from mechanical ventilation with *** A total of 80 patients with sepsis who were hospitalized in our hospital from January 2021 to January 2022 were selected and divided into the observation group(n=40)and the control group(n=40)according to the random number table *** observation group was treated with early stepwise cardiopulmonary rehabilitation,and the control group was treated with a conventional treatment *** function indexes(central venous pressure,cardiac troponin I,B-type brain natriuretic peptide),lung function indicators(diaphragmatic mobility,changes in central venous oxygen saturation,oxygenation index),and quality of life(Quality of Life Evaluation Scale)were compared between the two groups after *** After treatment,the central venous pressure,diaphragm mobility,central venous oxygen saturation,oxygenation index,and Quality of Life Evaluation Scale scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The observation group was less than that of the control group for other parameters,and the differences were statistically significant(P<0.05).CONCLUSION Early stepwise cardiopulmonary rehabilitation can effectively enhance cardiac and pulmonary function and improve the quality of life in patients evacuated from mechanical ventilation with sepsis.

关键词： Stepwise cardiopulmonary rehabilitation Sepsis Evacuation of mechanical ventilation Cardiopulmonary function Quality of life

Updates on global epidemiology,risk and prognostic factors of gastric cancer

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World Journal of Gastroenterology 2023年第16期29卷 2452-2468页

作者： wen-juan yang He-Ping Zhao Yan Yu Ji-Han Wang Lei Guo Jun-Ye Liu Jie Pu Jing Lv Department of Clinical Laboratory Honghui HospitalXi'an Jiaotong UniversityXi'an 710054Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi'an 710072Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an 710054Shaanxi ProvinceChina Department of Cardiology Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina

Gastric cancer(GC)is defined as the primary epithelial malignancy derived from the stomach,and it is a complicated and heterogeneous disease with multiple risk *** its overall declining trend of incidence and mortality in various countries over the past few decades,GC remains the fifth most common malignancy and the fourth leading cause of cancer-related death *** the global burden of GC has shown a significant downward trend,it remains severe in certain areas,such as *** ranks third in incidence and mortality among all cancer types in China,and it accounts for nearly 44.0%and 48.6%of new GC cases and GC-related deaths in the world,*** regional differences in GC incidence and mortality are obvious,and annual new cases and deaths are increasing rapidly in some developing ***,early preventive and screening strategies for GC are urgently *** clinical efficacies of conventional treatments for GC are limited,and the developing understanding of GC pathogenesis has increased the demand for new therapeutic regimens,including immune checkpoint inhibitors,cell immunotherapy and cancer *** present review describes the epidemiology of GC worldwide,especially in China,summarizes its risk and prognostic factors,and focuses on novel immunotherapies to develop therapeutic strategies for the management of GC patients.

关键词： Gastric cancer Epidemiology Risk factors Prognosis Treatment Immunotherapy