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Chinese Chemical Letters 2023年第1期34卷 378-381页

作者： Zheng-Hua Zhang You-Ming Zhang wen-juan qu Bingbing Shi Hong Yao Tai-Bao Wei Key Laboratory of Eco-environmental Polymer Materials of Gansu Province College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Gansu Natural Energy Research Institute Lanzhou 730046China

Supramolecular chemistry has received considerable attention in host-guest *** structureresponse relationship of host-guest recognition system is a meaningful ***,a series of tripodal nitrogen mustard derivatives(TMs)have been developed in this *** rationally design the intramolecular alkyl chain lengths of host,the host-guest binding model have been successfully tuned,which underwent a transformation fromπ-πto multiple hydrogen *** process enhances the host-guest binding force and recognition efficiency.

关键词： Host-guest recognition Supramolecular interactions Fluorescent Intramolecular alkyl chain Aggregation induced emission

A Pd_(2)L_(4) Metallacage-Cored Supramolecular Amphiphile and Its Application in Dual-Responsive Controllable Release

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Chinese Journal of Chemistry 2022年第20期40卷 2421-2427页

作者： Yongping Chai Peng Qin Xupeng Li Tai-Bao Wei Qi Lin You-Ming Zhang Hong Yao wen-juan qu Bingbing Shi Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhouGansu730070 China Gansu Natural Energy Research Institute LanzhouGansu730046 China

The construction of multi-responsive supramolecular systems for drug delivery is a challenging *** this work,a Pd_(2)L_(4) metallacage 1·([BF_(4)]^(−))_(4) with four pyrene units was first designed and synthesized through coordination-driven *** the introduction ofγ-CD,a supramolecular amphiphile 1–γ-CD was successfully constructed based on the host–guest molecular recognition betweenγ-CD and the pyrene unit of 1·([BF_(4)]^(−))_(4),which further self-assembled into dual-responsive supramolecular vesicles in aqueous ***·HCl was used as a model molecule to study the drug encapsulation and release behavior of the supramolecular *** adjusting the pH of the solution to acidic condition or adding a certain amount ofα-amylase,the vesicle structure was destroyed to achieve rapid and effective release of the drug *** study provides an example for the rational design of efficient dual-responsive supramolecular nanocarriers,which have potential application value in the field of controlled drug delivery.

关键词： Self-assembly Molecular recognition Metallacages Host-Guest systems Controllable release

A supramolecular oligo[2]rotaxane constructed by orthogonal platinum(Ⅱ) metallacycle and pillar[5]arene-based host–guest interactions

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Chinese Chemical Letters 2024年第10期35卷 201-204页

作者： Bingbing Shi Yuchun Wang Yi Zhou Xing-Xing Zhao Yizhou Li Nuoqian Yan wen-juan qu Qi Lin Tai-Bao Wei Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070.China

Oligo[n]rotaxanes are one of the most extensively studied categories of mechanically bonded *** this study,a supramolecular oligo[2]rotaxane is successfully constructed driven by platinum(Ⅱ)metallacycle and pillar[5]arene-based host–guest interactions in an orthogonal *** supramolecular oligo[2]rotaxane is further applied in fabricating a light harvesting system.

关键词： Pillararene Metallacycles Host-guest interactions Light-harvesting system Mechanically interlocked molecules

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling Zhang juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Pquires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： wen-Jin Yuan Yi-juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor

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World Journal of Gastroenterology 2023年第26期29卷 4200-4213页

作者： wen-Zhi qu Luan Wang juan-juan Chen Yang Wang Department of General Surgery The 4^(th)Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina Department of Emergency Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Medical Service Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal *** kinase inhibitors,such as imatinib,have been used as first-line therapy for the treatment of *** these drugs have achieved considerable efficacy in some patients,reports of resistance and recurrence have *** signal-regulated kinase 1/2(ERK1/2)protein,as a member of the mitogen-activated protein kinase(MAPK)family,is a core molecule of this signaling ***,research reports on the important clinical and prognostic value of phosphorylated-ERK(P-ERK)and phosphorylated-MAPK/ERK kinase(P-MEK)proteins closely related to raf kinase inhibitor protein(RKIP)have gradually emerged in digestive tract tumors such as gastric cancer,colon cancer,and pancreatic ***,literature on the expression of these downstream proteins combined with RKIP in GIST is *** study will focus on this aspect and search for answers to the *** To detect the expression of RKIP,P-ERK,and P-MEK protein in GIST and to analyze their relationship with clinicopathological characteristics and prognosis of this *** to establish a new prognosis evaluation model using RKIP and PERK in combination with analysis and its prognosis evaluation *** The research object of our experiment was 66 pathologically diagnosed GIST patients with complete clinical and follow-up *** patients received surgical treatment at China Medical University Affiliated Hospital from January 2015 to January *** method was used to detect the expression of RKIP,PERK,and P-MEK proteins in GIST tissue samples from these ***-Meier method was used to calculate the survival rate of 63 patients with complete follow-up data.A Nomogram was used to represent the new prognostic evaluation *** Cox multivariate regression analysis was conducted separately for each set of risk evaluation factors,bas

关键词： Raf kinase inhibitory protein Phosphorylated extracellular-signal-regulated kinase Gastrointestinal stromal tumors Immunohistochemistry Survival analysis Risk grade model

FAST MULTIPOLE SINGULAR BOUNDARY METHOD FOR LARGE-SCALE PLANE ELASTICITY PROBLEMS

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Acta Mechanica Solida Sinica 2015年第6期28卷 626-638页

作者： wenzhen qu wen Chen State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Center for Numerical Simulation Software in Engineering and SciencesCollege of Mechanics and MaterialsHohai University Department of Mathematics University of North Carolina

The singular boundary method （SBM） is a recent meshless boundary collocation method that remedies the perplexing drawback of fictitious boundary in the method of fundamental solutions （MFS）. The basic idea is to use the origin intensity factor to eliminate singularity of the fundamental solution at source. The method has so far been applied successfully to the potential and elasticity problems. However, the SBM solution for large-scale problems has been hindered by the operation count of O（N^3） with direct solvers or O（N^2） with iterative solvers, as well as the memory requirement of O（N^2）. In this study, the first attempt was made to combine the fast multipole method （FMM） and the SBM to significantly reduce CPU time and memory requirement by one degree of magnitude, namely, O（N）. Based on the complex variable represen- tation of fundamental solutions, the FMM-SBM formulations for both displacement and traction were presented. Numerical examples with up to hundreds of thousands of unknowns have successfully been tested on a desktop computer. These results clearly illustrated that the proposed FMM-SBM was very efficient and promising in solving large-scale plane elasticity problems.

关键词： fast multipole method singular boundary method meshless boundary collocation method elasticity problems

Nonlinear magneto-electric response of a giant magnetostrictive/piezoelectric composite cylinder

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Acta Mechanica Sinica 2012年第2期28卷 385-392页

作者： Yuan-wen Gao juan-juan Zhang Key Laboratory of Mechanics on Western Disaster and Environment Ministry of Education and College of Civil Engineering and MechanicsLanzhou University730000 LanzhouChina

In this study, we investigate the nonlinear cou- pling magneto-electric （ME） effect of a giant magnetostric- tive/piezoelectric composite cylinder. The nonlinear consti- tutive relations of the ME material are taken into account, and the influences of the nonlinear material properties on the ME effect are investigated for the static and dynamic cases, respectively. The influences of different constraint conditions on the ME effect are discussed. In the dynamic case considering nonlinear material properties, the double frequency ME response （The response frequency is twice the applied magnetic frequency） is obtained and discussed, which can be used to explain the experiment phenomenon in which the input signal with frequency f is converted to the output signal with 2f in ME laminated structures. Some calculations on nonlinear ME effect are conducted. The obtained results indicate that the nonlinear material properties affect not only the magnitude of the ME effect in the static case but also the ME response frequency in the dynamic case

关键词： Nonlinear coupling ME effect Layered com- posite cylinder. Double frequency ME response

Decomposition characteristics of organic materials and their effects on labile and recalcitrant organic carbon fractions in a semi-arid soil under plastic mulch and drip irrigation

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Journal of Arid Land 2018年第1期10卷 115-128页

作者： hu juan wu jinggui qu xiaojing college of resource and environmental science jilin agricultural universityChangchun 130118China

Labile organic carbon （LC） and recalcitrant organic carbon （RC） are two major fractions of soil organic carbon （SOC） and play a critical role in organic carbon turnover and sequestration. The aims of this study were to evaluate the variations of LC and RC in a semi-arid soil （Inner Mongolia, China） under plastic mulch and drip irrigation after the application of organic materials （OMs）, and to explore the effects of OMs from various sources on LC and RC by probing the decomposition characteristics of OMs using in-situ nylon mesh bags burying method. The field experiment included seven treatments, i.e., chicken manure （CM）, sheep manure （SM）, mushroom residue （MR）, maize straw （MS）, fodder grass （FG）, tree leaves （TL） and no OMs as a control （CK）. Soil LC and RC were separated by Huygens D＇s method （particle size-density）, and the average soil mass recovery rate and carbon recovery rate were above 95%, which indicated this method was suitable for carbon pools size analysis. The LC and RC contents significantly （P〈0.01） increased after the application of OMs. Moreover, LC and RC contents were 3.2%-8.6% and 5.0%-9.4% higher in 2016 than in 2015. The applications of CM and SM significantly increased （P〈0,01） LC content and LC/SOC ratio, whereas they were the lowest after the application of TL. However, SOC and RC contents were significantly higher （P〈0.01） after the applications of TL and MS. The correlation analysis indicated the decomposition rate of OMs was positively related with LC content and LC/SOC ratio. In addition, lignin, polyphenol, WOM （total water-soluble organic matter）, WHA （water-soluble humic acid）, HSL （humicdike substance） and HAL （humic acid-like） contents in initial OMs played important roles in SOC and RC. In-situ nylon mesh bags burying experiment indicated the decomposition rates of CM, SM and MS were significantly higher than those of MR, FG, and TL. Furthermore, MS could result in more lignin derivatives, WHA, and HAL polymers in shorter time

关键词： organic materials labile organic carbon recalcitrant organic carbon decomposition characteristics plasticmulch drip irrigation Inner Mongolia

Optimization of the transmission mechanism for wireless TCP

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The Journal of China Universities of Posts and Telecommunications 2008年第1期15卷 38-42页

作者： qu Zhao-wei ZHANG juan Beijing University of Posts and Telecommunications Beijing 100876 China

A novel method which can detect the possible handoffs for mobile nodes is proposed in this article. The method can be deployed on mobile nodes. So when a possible handoff occurs, mobile nodes can detect and take some necessary actions in time. In this study, the method is also used to optimize the transmission mechanism of Q-TCP. Moreover, the simulation results show that Q-TCP can provide better quality of service （QoS） for mobile nodes when they are moving among different agents.

关键词： wireless TCP data stream handoff QoS