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Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease

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Neuroscience Bulletin 2020年第11期36卷 1299-1314页

作者： Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro Lucas Bonfim Marques Qing Ye wen-jing ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich Department of Biochemistry Institute of ChemistryUniversity of Sao PauloAv.Prof.Lineu Prestes 74&Sao PauloSP 05508-000Brazil Key Laboratory of Sichuan Province for Acupuncture and Chronobiology Chengdu 610075China Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Sechenov First Moscow State Medical University Moscow 119992Russia Rudolf-Boehm-Institut ftir Pharmakologie und Toxikologie Universitat LeipzigLeipzig 04107Germany International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China

Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,*** review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative *** adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor ***,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor *** interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal ***,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD.

关键词： Purinergic receptor Central nervous system Huntington’s disease Parkinson’s disease 6-hydroxydopamine

Statistical analysis on the validity of the cold plasma approximation for chorus waves based on Van Allen Probe observations and their effects on radiation belt electrons

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Earth and Planetary Physics 2025年第1期9卷 159-170页

作者： AoJun ren Jiang Yu jing Wang ZuZheng Chen XiaoMan Liu Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai Guangdong 519000China

Theoretical analysis has demonstrated that the dispersion relation of chorus waves plays an essential role in the resonant interaction and energy transformation between the waves and magnetospheric *** quantitative analyses often simplified the chorus dispersion relation by using the cold plasma ***,the applicability of the cold plasma assumption is doubtful,especially during geomagnetic *** here present a systematic statistical analysis on the validity of the cold plasma dispersion relation of chorus waves based on observations from the Van Allen Probes over the period from 2012 to *** statistical results show that the observed magnetic field intensities deviate substantially from those calculated from the cold plasma dispersion relation and that they become more pronounced with an increase in geomagnetic activity or a decrease in background plasma *** region with large deviations is mainly concentrated in the nightside and expands in both the radial and azimuthal directions as the geomagnetic activity increases or the background plasma density *** addition,the bounce-averaged electron scattering rates are computed by using the observed and cold plasma dispersion relation of chorus *** with usage of the cold plasma dispersion relation,usage of the observed dispersion relation considerably lowers the minimum resonant energy of electrons and lowers the scattering rates of electrons above tens of kiloelectronvolts but enhances those ***,these differences are more pronounced with the enhancement of geomagnetic activity or the decrease in background plasma density.

关键词： chorus waves cold plasma approximation dispersion relations scattering rates

基于不同奖惩机制项目支付进度优化:双重视角

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运筹与管理 2017年第7期26卷 10-20页

作者：李兰英何正文刘人境西安交通大学管理学院陕西西安710049 过程控制与效率工程教育部重点实验室陕西西安710049

奖惩机制会对合同双方的收益产生重大影响,本文基于承包商和业主的双重视角,对不同奖惩机制下项目支付进度优化问题进行了研究。首先对所研究问题进行界定,并分别基于承包商和业主视角构建了不同奖惩机制下的优化模型;基于模型的属性设... 详细信息

奖惩机制会对合同双方的收益产生重大影响,本文基于承包商和业主的双重视角,对不同奖惩机制下项目支付进度优化问题进行了研究。首先对所研究问题进行界定,并分别基于承包商和业主视角构建了不同奖惩机制下的优化模型;基于模型的属性设计了模拟退火启发式算法;最后通过一个实例对比了承包商和业主在四种不同奖惩机制下收益的优化结果,并对其中的关键参数进行了敏感性分析。结果显示:不同的奖惩机制对承包商和业主的收益有较大影响;不同的奖惩强度也会影响承包商和业主的收益。通过对奖惩机制类型及强度的分析,可以为项目中奖惩机制的设置提供定量化决策支持。

关键词：项目支付进度优化模型模拟退火启发式算法奖惩机制多模式

精细乳房模型及其在乳腺X射线摄影剂量评估中的应用

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原子能科学技术 2016年第11期50卷 2085-2091页

作者：王文静邱睿任丽李君利李春艳武祯清华大学工程物理系北京100084 粒子技术与辐射成像教育部重点实验室北京100084 同方威视技术股份有限公司北京100084

乳腺是对辐射致癌最敏感的组织之一,而辐射致癌风险与受照剂量密切相关。为更准确地评估电离辐射所致乳腺受照剂量,本文建立了一个具有皮肤、皮下脂肪、乳房后侧脂肪、悬吊韧带、纤维腺体区脂肪、输乳管、小叶、输乳窦和乳头等精细结构... 详细信息

乳腺是对辐射致癌最敏感的组织之一,而辐射致癌风险与受照剂量密切相关。为更准确地评估电离辐射所致乳腺受照剂量,本文建立了一个具有皮肤、皮下脂肪、乳房后侧脂肪、悬吊韧带、纤维腺体区脂肪、输乳管、小叶、输乳窦和乳头等精细结构的乳房数学模型,并将其体素化为体素模型。考虑到在乳腺X射线摄影中的应用,对乳房体素模型进行头尾位(CC位)压迫,建立压迫乳房模型,并与中国成年女性参考人体素体模(CRAF)相拼接。采用Geant4对乳腺X射线摄影进行蒙特卡罗模拟,计算了一系列平均腺体剂量转换因子。根据计算结果,采用精细乳房模型计算的平均腺体剂量转换因子低于我国现行国家标准的取值,但与美国放射学会(ACR)标准的取值差别不大。

关键词：乳房体素体模乳腺X射线摄影蒙特卡罗模拟剂量转换因子

合同双方基于合作博弈的Max-npv项目调度优化

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工业工程与管理 2016年第5期21卷 42-48,91页

作者：李兰英何正文刘人境西安交通大学管理学院陕西西安710049 过程控制与效率工程教育部重点实验室陕西西安710049

从合同双方的双重视角出发,研究了合同双方基于合作博弈的多模式Max-npv项目调度优化问题。在合作博弈中,承包商和业主基于合作的态度对项目调度进行优化,以降低项目成本,增加合同双方的共同利益。作者首先对所研究问题进行了界定,在此... 详细信息

从合同双方的双重视角出发,研究了合同双方基于合作博弈的多模式Max-npv项目调度优化问题。在合作博弈中,承包商和业主基于合作的态度对项目调度进行优化,以降低项目成本,增加合同双方的共同利益。作者首先对所研究问题进行了界定,在此基础上建立了基于合作博弈的合同双方共同受益最大化子模型和共同收益分割子模型。鉴于问题的属性,设计了模拟退火启发式算法。最后,用一个实际案例对研究进行验证说明,并与不合作情况下的结果进行对比,得到如下结论:与不合作情况相比,合作情况下承包商和业主的项目收益均有显著提升。可为承包商和业主对于项目支付和进度安排提供决策支持,有助于合同双方协调彼此的合作关系,取得一个双赢的结果。

关键词：合同双方 Max-npv项目调度合作博弈优化模型模拟退火算法

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang jing ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo wen jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

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本质与价值:数字时代广告本体的再认识

武汉大学学报（哲学社会科学版） 2025年第1期78卷 125-132页

作者：姚曦任文姣武汉大学新闻与传播学院湖北武汉430072 武汉大学媒体发展研究中心

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值... 详细信息

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值需深耕数字广告实践,用创意提升广告的社会吸引力,建构多主体参与的沟通网络。彰显广告价值还需要在理论层面,以本体观为支点,立足于本土广告实践,重新组织数字广告研究范畴,使用大数据技术与混合研究法探究新问题,为广告学知识体系的建构提供框架与方向。

关键词：广告广告本质广告价值广告本体

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