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Development of a diagnostic nomogram for alpha-fetoproteinnegative hepatocellular carcinoma based on serological biomarkers

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2463-2475页

作者： Li He Cui Zhang Lan-Lan Liu Li-Ping Huang wen-jing lu Yuan-Yuan Zhang De-Yong Zou Yu-Fei Wang Qing Zhang Xiao-Li Yang School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine Jingyu County People’s HospitalBaishan 135200Jilin ProvinceChina School of Laboratory Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related death *** biomarkers play an important role in the early diagnosis and prognosis of *** a certain percentage of HCC patients are negative for alpha-fetoprotein(AFP),the diagnosis of AFP-negative HCC is essential to improve the detection rate of *** To establish an effective model for diagnosing AFP-negative HCC based on serum tumour *** A total of 180 HCC patients were enrolled in this *** expression levels of GP73,des-γ-carboxyprothrombin(DCP),CK18-M65,and CK18-M30 were detected by a fully automated chemiluminescence *** variables were selected by logistic regression *** models were constructed using stepwise backward logistic *** performance of the models was compared using the C statistic,integrated discrimination improvement,net reclassification improvement,and calibration *** clinical utility of the nomogram was assessed using decision curve analysis(DCA).RESULTS The results showed that the expression levels of GP73,DCP,CK18-M65,and CK18-M30 were significantly greater in AFP-negative HCC patients than in healthy controls(Pluded GP73 and CK18-M65 as the model variables,and the model had good discrimination ability(area under the curve=0.946)and good goodness of *** DCA curves indicated the good clinical utility of the *** Our study identified GP73 and CK18-M65 as serum biomarkers with certain application value in the diagnosis of AFP-negative *** diagnostic nomogram based on CK18-M65 combined with GP73 demonstrated good performance and effectively identified high-risk groups of patients with HCC.

关键词： Hepatocellular carcinoma Alpha-fetoprotein-negative Diagnostic Nomogram Biomarker

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Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第21期30卷 2763-2776页

作者： Li He Wan-Sheng Ji Hai-Long Jin wen-jing lu Yuan-Yuan Zhang Hua-Guang Wang Yu-Yu Liu Shuang Qiu Meng Xu Zi-Peng Lei Qian Zheng Xiao-Li Yang Qing Zhang Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Clinical Research Center The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Physiatry Department Naval Aviation UniversityYantai 100071Shandong ProvinceChina

BACKGROUND At present,liver transplantation(LT)is one of the best treatments for hepatocellular carcinoma(HCC).Accurately predicting the survival status after LT can significantly improve the survival rate after LT,and ensure the best way to make rational use of liver *** To develop a model for predicting prognosis after LT in patients with *** Clinical data and follow-up information of 160 patients with HCC who underwent LT were collected and *** expression levels of alphafetoprotein(AFP),des-gamma-carboxy prothrombin,Golgi protein 73,cytokeratin-18 epitopes M30 and M65 were measured using a fully automated chemiluminescence *** best cutoff value of biomarkers was determined using the Youden *** regression analysis was used to identify the independent risk factors.A forest model was constructed using the random forest *** evaluated the accuracy of the nomogram using the area under the curve,using the calibration curve to assess consistency.A decision curve analysis(DCA)was used to evaluate the clinical utility of the *** The total tumor diameter(TTD),vascular invasion(VI),AFP,and cytokeratin-18 epitopes M30(CK18-M30)were identified as important risk factors for outcome after *** nomogram had a higher predictive accuracy than the Milan,University of California,San Francisco,and Hangzhou *** calibration curve analyses indicated a good *** survival and recurrence-free survival(RFS)of high-risk groups were significantly lower than those of low-and middle-risk groups(P<0.001).The DCA shows that the model has better clinical *** The study developed a predictive nomogram based on TTD,VI,AFP,and CK18-M30 that could accurately predict overall survival and RFS after *** can screen for patients with better postoperative prognosis,and improve longterm survival for LT patients.

关键词： Hepatocellular carcinoma Liver transplantation Liver cancer Nomogram Prognosis

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Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

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Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng Chen Mao-Mao Zhang wen-jing Xiao Liang-Qiu lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Wuhan Institute of Photochemistry and Technology Wuhan 430082China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2]and van Maarseveen et al.[3]in 2008.

关键词： catalyzed asymmetric amines

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Energy beam-based direct and assisted polishing techniques for diamond:A review

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International Journal of Extreme Manufacturing 2024年第1期6卷 93-124页

作者： Zhuo Li Feng Jiang Zhengyi Jiang Zige Tian Tian Qiu Tao Zhang Qiuling wen Xizhao lu jing lu Hui Huang Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021People’s Republic of China School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021People’s Republic of China State Key Laboratory of High Performance Tools Huaqiao UniversityXiamen 361021People’s Republic of China

Diamond is a highly valuable material with diverse industrial applications,particularly in the fields of semiconductor,optics,and high-power ***,its high hardness and chemical stability make it difficult to realize high-efficiency and ultra-low damage machining of *** address these challenges,several polishing methods have been developed for both single crystal diamond(SCD)and polycrystalline diamond(PCD),including mechanical,chemical,laser,and ion beam processing *** this review,the characteristics and application scope of various polishing technologies for SCD and PCD are ***,various energy beam-based direct and assisted polishing technologies,such as laser polishing,ion beam polishing,plasma-assisted polishing,and laser-assisted polishing,are *** current research progress,material removal mechanism,and infuencing factors of each polishing technology are *** some of these methods can achieve high material removal rates or reduce surface roughness,no single method can meet all the ***,the future development prospects and application directions of different polishing technologies are presented.

关键词： single crystal diamond polycrystalline diamond energy beam polishing technology material removal mechanism influencing factors

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Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes

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Chinese Journal of Chemistry 2024年第9期42卷 990-996页

作者： Bin lu Feng-Shuo Bao Zi-Wei He wen-jing Xiao Jia-Rong Chen Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction College of ChemistryCentralChina Normal University152 Luoyu RoadWuhanHubei 430079China Wuhan Institute of Photochemistry and Technology 7North Bingang RoadWuhanHubei 430083China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhouJiangxi 341000China

Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl *** the significance of fluorine-containing groups,this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal ***,we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst.A wide range of alkenes and amines were well tolerated,providing the valuableβ-perfluoroalkylated amides with generally good yields and high chemoselectivity.

关键词： Visible light Photoredox catalysis Radical aminocarbonylation Multicomponent reaction Carbon monoxide Unactivated alkenes AmidesIReactionmechanisms

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KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease

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World Journal of Psychiatry 2024年第3期14卷 445-455页

作者： Qun-Shan lu Lin Ma wen-jing Jiang Xing-Bang Wang Mei lu Department of Geriatric Medicine Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Cardiovascular Proteomics of Shandong Province Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2D).Insulin resistance in the brain is a common feature in patients with T2D and ***7 is a histone acetyltransferase that participates in the modulation of various *** To determine the effects of KAT7 on insulin patients with *** APPswe/PS1-dE9 double-transgenic and db/db mice were used to mimic AD and diabetes,*** in vitro model of AD was established by Aβ*** resistance was induced by chronic stimulation with high insulin *** expression of microtubule-associated protein 2(MAP2)was assessed using *** protein levels of MAP2,Aβ,dual-specificity tyrosine phosphorylation-regulated kinase-1A(DYRK1A),IRS-1,p-AKT,total AKT,p-GSK3β,total GSK3β,DYRK1A,and KAT7 were measured via western *** of reactive oxygen species(ROS),malondialdehyde(MDA),and SOD activity was measured to determine cellular oxidative *** cytometry and CCK-8 assay were performed to evaluate neuronal cell death and proliferation,*** RNA levels of KAT7 and DYRK1A were examined using quantitative PCR.A chromatin immunoprecipitation assay was conducted to detect H3K14ac in *** KAT7 expression was suppressed in the AD *** of KAT7 decreased Aβaccumulation and MAP2 expression in AD ***7 overexpression decreased ROS and MDA levels,elevated SOD activity in brain tissues and neurons,and simultaneously suppressed neuronal ***7 upregulated levels of p-AKT and p-GSK3βto alleviate insulin resistance,along with elevated expression of ***7 depletion suppressed DYRK1A expression and impaired H3K14ac of ***1 overexpression recovered DYRK1A levels and reversed insulin resistance caused by KAT7 *** We determined that KAT7 overexpression recovered insulin sensitivity in AD by recruiting HMGN1 to enhance DYRK1A acetylati

关键词： Alzheimer's disease Diabetes Insulin resistance KAT7 Dual-specificity tyrosine phosphorylation-regulated kinase-1A HMGN1

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Synthesis of MnO2/N-doped ultramicroporous carbon nanospheres for high-performance supercapacitor electrodes

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Chinese Chemical Letters 2017年第6期28卷 1324-1329页

作者： wen-jing lu Shi-Ze Huang Ling Miao Ming-Xian Liu Da-Zhang Zhu Liang-Chun Li Hui Duan Zi-Jie Xu Li-Hua Gan Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University Shanghai 201804 China Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji University Shanghai 200092 China

We demonstrate a simple and highly efficient strategy to synthesize MnO2/nitrogen-doped ultramicroporous carbon nanospheres（MnO2/N-UCNs） for supercapacitor ***2/N-UCNs were fabricated via a template-free polymerization of resorcinol/formaldehyde on the surface of phloroglucinol/terephthalaldehyde colloids in the presence of hexamethylenetetramine,followed by carbonization and then a redox reaction between carbons and ***-prepared MnO2/N-UCNs exhibits regular ultramicropores,high surface area,nitrogen heteroatom,and high content of MnO2.A typical MnO2/N-UCNs with 57 wt.%MnO2 doping content（denoted as MnO2（57%）/N-UCNs） makes the most use of the synergistic effect between carbons and metal ***2（57%）/N-UCNs as a supercapacitor electrode exhibits excellent electrochemical performance such as a high specific capacitance（401 F/g at 1.0 A/g） and excellent charge/discharge stability（86.3%of the initial capacitance after 10,000 cycles at 2.0 A/g） in 1.0 mol/L Na2SO4 *** well-designed and high-performance MnO2/N-UCNs highlight the great potential for advanced supercapacitor applications.

关键词： Ultramicroporous carbon nanosphere Nitrogen-doping MnO2 Electrode Supercapacitor

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Upadacitinib for refractory ulcerative colitis with primary nonresponse to infliximab and vedolizumab:A case report

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World Journal of Clinical Cases 2024年第9期12卷 1685-1690页

作者： Xuan Xu jing-wen Jiang Bing-Yun lu Xia-Xi Li Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518100Guangdong ProvinceChina The First Clinical Medical School Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Many patients with ulcerative colitis(UC)do not respond well to,or tolerate conventional and biological *** is currently no consensus on the treatment of refractory *** have demonstrated that the selective Janus kinase 1 inhibitor upadacitinib,a small-molecule drug,is effective and safe for treating ***,no studies have revealed that upadacitinib is effective in treating refractory UC with primary nonresponse to infliximab and *** SUMMARY We report the case of a 44-year-old male patient with a chief complaint of bloody diarrhoea with mucus and pus,in addition to *** patient had recurrent disease after receiving mesalazine,prednisone,azathioprine,infliximab and vedolizumab over four *** on the endoscopic findings and pathological biopsy,the patient was diagnosed with refractory *** particular,the patient showed primary nonresponse to infliximab and *** on the patient’s history and recurrent disease,we decided to administer *** hospitalisation,the patient was received upadacitinib under our *** weeks after the initiation of upadacitinib treatment,the patient’s symptoms and endoscopic findings improved *** notable adverse reactions have been reported to *** Our case report suggests that upadacitinib may represent a valuable strategy for treating refractory UC with primary nonresponse.

关键词： Upadacitinib Refractory ulcerative colitis Primary nonresponse Infliximab Vedolizumab Case report

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Visible-light-driven photocatalysis degradation of antibiotic pollutants by La-doped CeO_(2) nanorods:synergy of La doping and oxygen vacancy

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Rare Metals 2024年第7期43卷 3134-3145页

作者： Shi-Hai Cao jing-Ru Qu Yu-Qi Zhao Yun-Tong Sun wen-Tong Gao Bing Han Yao lu College of Environmental Engineering Nanjing Institute of TechnologyNanjing 211167China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou215009China

Elemental doping is an effective strategy to enhance photocatalytic activity and extend the light absorption range of single-component *** this work,a series of La-doped CeO_(2) nanorods(La-CeO_(2)-x) with La content of 1 wt%-15 wt% are synthesized by a simple hydrothermal method and further used as photocatalyst for sulfamerazine(SMR) *** prepared La-CeO_(2)-x nanorods exhibit a great improvement in electron-hole pair migration and visible-light response due to the synergistic effect of abundant oxygen vacancies and heterogeneous elements(La).Consequently,La-CeO_(2)-x exhibited excellent visible-light photocatalytic performances and chemical stability for SMR degradation,the La-CeO_(2)-5 sample achieved the highest SMR degradation rate of 81%,which was 3.4 times higher than that of the original CeO_(2).Furthermore,three possible degradation pathways of SMR in La-CeO_(2) photocatalytic reactions were proposed by liquid chromatography-mass spectrometry ***,density functional theory calculations were carried out to provide an in-depth understanding of the structure-performance *** its excellent properties and better photocatalytic performance,this study demonstrates that La doping in CeO_(2) is an effective way to increase oxygen vacancy and improve the photochemical properties of photocatalysts.

关键词： CeO_(2)nanorod La-doped Photocatalysis Oxygen vacancy Sulfamerazine

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Early systemic anticoagulation reduces hospital readmission in acute necrotizing pancreatitis patients:A retrospective cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 77-82页

作者： wen-Jian Mao jing Zhou Guo-Fu Zhang Fa-Xi Chen jing-Zhu Zhang Bai-Qiang Li lu Ke Wei-Qin Li Department of Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjing 210002China Department of Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China National Institute of Healthcare Data Science Nanjing UniversityNanjing 210010China

Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been ***,whether it affects long-term outcomes is *** study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP ***:During January 2013 and December 2018,ANP patients admitted within 7 days from the onset of abdominal pain were *** primary outcome was 90-day readmission after *** proportional-hazards regression model and mediation analysis were used to define the relationship between early SAC and 90-day ***:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospitalization and 98 did *** who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95%CI:0.26-0.60,P<0.01]and lower 90-day readmission with an RR of 0.61(95%CI:0.41-0.91,P=0.02)than those who did *** the quality of life,patients who received early SAC had a significantly higher score in the subscale of vitality(P=0.03)while the other subscales were all comparable between the two *** Cox regression model showed that early SAC was an independent protective factor for 90-day readmission after adjusting for potential confounders with a hazard ratio of 0.57(95%CI:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0%of the early SAC-90-day readmission ***:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.

关键词： Anticoagulation Splanchnic venous thrombosis Acute necrotizing pancreatitis Readmission Long-term outcomes

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