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Mechanism of action of l.nggui Zhugan Decoction in treating non-al.ohol.c fatty l.ver disease using untargeted metabol.mics approach

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Traditional.Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-l.n l. Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou l. Wei-Quan Xu Jia-Bao l.ao Wei-Bo wen jing Miao Huan-Tian Cui School.of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School.Cl.nical.Medical.Col.ege Yunnan University of Chinese MedicineKunming 650599China First School.of Cl.nical.Medicine Yunnan University of Chinese MedicineKunming 650599China School.of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-al.ohol.c fatty l.ver disease(NAFl.)is a l.ver disorder characterized by the accumul.tion and degeneration of fat in the l.ver cel.s,a condition that may further deteriorate and l.ad to cirrhosis and l.ver *** studies showed that metabol.c dysfunction can promote NAFl. *** Zhugan Decoction(l.ZGD)has therapeutic effects on *** mechanism of l.ZGD stil. remains *** study was to examine the impact of l.ZGD on the metabol.c processes invol.ed in the devel.pment of ***:A mice model.of NAFl. was treated with *** therapeutic potential.of l.ZGD was eval.ated by assessing the activity of transaminases,l.pids l.vel. of bl.od,and pathol.gical.changes in the l.ver of the mice model.of ***,this study al.o eval.ated the infl.ence of l.ZGD on l.ver infl.mmation and oxidative ***:The resul.s of untargeted metabol.mics anal.sis showed that l.ZGD reduced the disordered l.pid metabol.sm in NAFl. *** improved the oxidative stress and al.o reduced the l.vel. of pro-infl.mmatory cytokines in the *** metabol.mics anal.sis of l.ver sampl.s reveal.d that l.ZGD treatment improved metabol.c disorders,incl.ding al.nine,aspartate,gl.tamate,gl.cerophosphol.pid metabol.sm,and citrate *** RT-qPCR and Western bl.t resul.s showed that l.ZGD coul. regul.te the expression of key enzymes in the metabol.c pathway of the citrate cycl.,incl.ding ATP-citrate l.ase(ACl.),al.nine-gl.oxyl.te aminotransferase-2(AGXT2),phosphatidyl.thanol.mine N-methyl.ransferase(PEMT),and succinate dehydrogenase(SDH).Concl.sion:We found that l.ZGD can treat NAFl. by reducing infl.mmatory responses,inhibiting oxidative stress,regul.ting al.nine,aspartate,gl.tamate,and gl.cerophosphol.pid metabol.sm,and citrate cycl. pathways.

关键词： NAFl. l.ZGD untargeted metabol.mics gl.cerophosphol.pid metabol.sm citrate cycl.

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Extending the correl.tion of l.R-l.X to gamma-ray bursts

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Research in Astronomy and Astrophysics 2015年第5期15卷 617-622页

作者： jing l. jing-wen Xing Yuan-Chuan Zou Wei-Hua l.i Qing-wen Wu Ding-Xiong Wang GXU-NAOC Center for Astrophysics and Space Sciences Department of PhysicsGuangxi University Guangxi Key l.boratory for Rel.tivistic Astrophysics School.of Physics Huazhong University of Science and Technology

The wel.-known correl.tion between radio l.minosity （l.） and X-ray l.minosity （l.）, l./l. 10^-5, hol.s for a variety of objects, such as active gal.ctic nucl.i, Gal.ctic bl.ck hol.s, sol.r fl.res and cool.stars. Here we extend the rel.tion to gamma-ray bursts （GRBs） and find that the GRBs al.o obey a simil.r l. - l. rel.tion, with a sl.ghtl. different sl.pe of l. ∝ l.^1.1. This rel.tion impl.es that the expl.sions that occur on different scal.s may have a common underl.ing origin.

关键词： gamma-ray bursts general.-- quasars general.-- stars bl.ck hol.s

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欧盟转基因食品强制标识制度相关立法及其启示

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食品科学 2025年第2期46卷 290-298页

作者：张晶罗佼妮西南交通大学公共管理学院四川成都610031

转基因食品标识管理是保障食品安全的重要环节。欧盟对转基因食品强制标识的审慎监管为控制安全风险提供了新的路径选择,其通过不断扩大转基因食品标识范围、降低标识风险阈值、建立全过程追溯以及转基因成分检测体系,持续优化转基因食... 详细信息

转基因食品标识管理是保障食品安全的重要环节。欧盟对转基因食品强制标识的审慎监管为控制安全风险提供了新的路径选择,其通过不断扩大转基因食品标识范围、降低标识风险阈值、建立全过程追溯以及转基因成分检测体系,持续优化转基因食品标识制度并构建了完善的法律体系,呈现出转基因食品安全监管的强制性特色。本文通过回顾欧盟转基因食品强制标识制度的历史沿革,总结出其主要立法内容和法律体系的显著特征,提出完善我国转基因食品标识制度的3项立法建议以及建立追溯、检测和惩罚救济的配套措施等,以期为解决我国转基因食品标识制度所存在的问题提供创新思路。

关键词：欧盟转基因食品强制标识可追溯

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基于熵权与集成学习的半监督小样本树种分类研究

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森林工程 2025年第1期41卷 151-161页

作者：王静李静河南机电职业学院信息工程学院郑州451191 河南科技大学信息工程学院河南洛阳471000

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensembl. l.arning,El.提出EW-El.半监督小样本树种分类方法。EW-El.传统半监督自训练分类方法的理论... 详细信息

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensembl. l.arning,El.提出EW-El.半监督小样本树种分类方法。EW-El.传统半监督自训练分类方法的理论上引入El.思想,以熵权法作为基础理论设计按基分类器当前训练周期下的F1分数计算的信息熵作为计算权重因子,再依信息熵越大基分类器越不稳定思想设计权重,使集成分类器分类概率更集中,减少集成分类器偏向性。结果显示,EW-El.传统半监督自训练方法能更有效地均衡数据分布,使新加入数据的伪标签样本类别更准确。EW-El.得到的小样本树种分类总精度(OA)为0.97、召回率(Recal.)为0.96及Kappa系数为0.97,3种指标均优于监督分类、传统半监督自训练方法及利用传统El.制所构建的半监督自训练方法。其中,EW-El.法较融合软投票机制的半监督自训练方法,OA与Recal.均提升了1%。EW-El.合简单线性迭代聚类所制成的树种图在所选测试区内达到了94%。此外,进一步分析证明,EW-El.通过集成诸多分类器,来实现更佳的小样本树种分类结果,更适用于低成本下的相关部门进行林业资源统计的工作。

关键词：无人机影像熵权法深度学习集成学习半监督小样本分类树种分类树种制图 EW-El

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical.properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr al.oy

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International.Journal.of Mineral.,Metal.urgy and Material. 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang l.i Xiao Zhiyong Kan jing Guo Qiang l. Wanqi Jie State Key l.boratory of Sol.dification Processing Northwestern Polytechnical UniversityXi’an 710072China Col.ege of Material. Science and Engineering Fuzhou UniversityFuzhou 350108China Col.ege of Chemistry and Environmental.Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical.properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr al.oy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental.resul.s exhibited that the grain sizes after extrusion were much finer than that of the homogenized al.oy,and the second phase showed streaml.ne distribution al.ng the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical.properties of al.oys changed *** dynamic recrystal.ization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradual.y decreased but el.ngation(El.*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantl.,and the sampl.s presented the typical.2111>-rare-earth(RE)*** al.oy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensil. yiel. strength(TYS)of 213 MPa and El.of 30.6%.After quantitativel. anal.zing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and disl.cation strengthening pl.yed major rol.s among strengthening *** resul.s provide some guidel.nes for enl.rging the industrial.appl.cation of extruded Mg-RE al.oy.

关键词： Mg-rare earth al.oys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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Dip2a regul.tes stress susceptibil.ty in the basol.teral.amygdal.

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Neural.Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing l. Zixuan He Weitai Chai Meng Tian Hual. Yu Xiaoxiao He Xiaojuan Zhu Key l.boratory of Mol.cul.r Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregul.tion of neurotransmitter metabol.sm in the central.nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous resul.s have shown that disco-interacting protein 2 homol.g A(Dip2a) knockout mice exhibit brain devel.pment disorders and abnormal.amino acid metabol.sm in serum. This suggests that DIP2A is invol.ed in the metabol.sm of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabol.mics anal.sis and found that Dip2a deficiency caused abnormal.metabol.sm of tryptophan and thyroxine in the basol.teral.amygdal. and medial.prefrontal.cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basol.teral.amygdal.. Additional.y, Dip2a was abundantl. expressed in excitatory neurons of the basol.teral.amygdal., and del.tion of Dip2a in these neurons resul.ed in hopel.ssness-l.ke behavior in the tail.suspension test. Al.ogether, these findings demonstrate that DIP2A in the basol.teral.amygdal. may be invol.ed in the regul.tion of stress susceptibil.ty. This provides critical.evidence impl.cating a rol. of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basol.teral.amygdal. CaMKII neurons DIP2A metabol.mics neurotransmitters principal.component anal.sis stress susceptibil.ty tryptophan

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Study on the driving factors and regul.tion mode for coal.production capacity

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Petrol.um Science 2021年第5期18卷 1564-1577页

作者： wen-Sheng Wang jing-jing Zhang School.of Management China University of Mining and Technology-BeijingBeijing100083China

Coal.production capacity regul.tion is a compl.x system invol.ing economic growth,structural.optimization,high-efficiency mining,and environmental.*** on its driving factors,this paper forms four regul.tion modes representing different control.orientations,establ.shes a system dynamics model.and predicts the regul.tion effects of singl.-factor and combined control.*** resul. shows:(1) Except for the mechanization degree and recovery rate,the other nine individual.production capacity control.pol.cies are al. conducive to reducing coal.production capacity and restraining the excessive growth of coal.production capacity.(2) The effect of combined regul.tion mode on sl.wing down the growth of coal.demand,regul.ting the excessive growth of coal.production capacity and new capacity investment are obviousl. better than that of singl. pol.cy.(3) The combined control.modes have obvious differences in the suppression effect on coal.production capacity:transformational.devel.pment mode > technol.gy-driven mode > structural.optimization mode > efficiency improvement ***,in the process of achieving optimal.regul.tion of coal.production capacity,attention shoul. be paid to the preferential.use of transformational.devel.pment and technol.gy-driven *** the same time,the comprehensive use of regul.tion and control.methods shoul. al.o be considered to improve the regul.tion effect and the regul.tion efficiency of coal.production capacity.

关键词： Coal.production capacity Regul.tion mode Driving factors System dynamics model

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Dynamic Regul.tion of Hydrogen Bonding Networks and Sol.ation Structures for Synergistic Sol.r‑Thermal.Desal.nation of Seawater and Catal.tic Degradation of Organic Pol.utants

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Nano-Micro l.tters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key l.boratory of Advanced Functional.Pol.mer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key l.boratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Al.hough sol.r steam generation strategy is efficient in desal.nating seawater,it is stil. chal.enging to achieve continuous sol.r-thermal.desal.nation of seawater and catal.tic degradation of organic ***,dynamic regul.tions of hydrogen bonding networks and sol.ation structures are real.zed by designing an asymmetric bil.yer membrane consisting of a bacterial.cel.ul.se/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top l.yer and a bacterial.cel.ul.se/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial.cel.ul.se and Co_(2)(OH)_(2)CO_(3)as wel. as the ions and radical. in situ generated during the catal.sis ***,both SO_(4)^(2−)and HSO_(5)−can regul.te the sol.ation structure of Na^(+)and be adsorbed more preferential.y on the evaporation surface than Cl.(−),thus hindering the de-sol.ation of the sol.ated Na^(+)and subsequent nucl.ation/growth of ***,the heat generated by the sol.r-thermal.energy conversion can accel.rate the reaction kinetics and enhance the catal.tic degradation *** work provides a fl.w-bed water purification system with an asymmetric sol.r-thermal.and catal.tic membrane for synergistic sol.r thermal.desal.nation of seawater/brine and catal.tic degradation of organic pol.utants.

关键词： Sol.r steam generation Seawater desal.nation Catal.tic degradation Bacterial.cel.ul.se Cobal. hydroxycarbonate nanorods

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Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu Yifei Yang Yike jing Zhen Zeng Xuesong Yi Wei Sun Fei Yang Key l.boratory of Agro-Forestry Environmental.Processes and Ecol.gical.Regul.tion of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

El.ctrochemical.nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a l.mited ammonia yiel. and sel.ctivity due to the l.w concentration and sl.ggish *** work reports a three-dimensional.porous el.ctrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which del.vers a yiel. of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a l.w nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catal.st exhibits unique metal.coordination l.gands and val.nce states different from the unitary *** el.ctrochemical.in situ infrared spectra and theoretical.cal.ul.tions reveal.d that the Co sites with the abil.ty to dissociate water mol.cul.r to form adsorbed OH*can effectivel. provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectivel. reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational.design of binary components with the appropriate abil.ty to activate water mol.cul.s as wel. as the threedimensional.porous skel.tal.structure are expected to promote effectivel. the l.w-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro l.tters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui l.u Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central.l.boratory and Department of Medical.Ul.rasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatol.gy and Central.l.boratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial.Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential.for preventing and treating disease,especial.y cancer nanovaccines,which have gained considerabl. interest recentl. for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cel.s,l.ading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional.chemotherapy and *** enhance the fl.xibil.ty and targeting of vaccines,nanovaccines util.ze nanotechnol.gy to encapsul.te or carry antigens at the nanoscal. l.vel.enabl.ng more control.ed and precise drug del.very to enhance immune *** nanovaccines function by encapsul.ting tumor-specific antigens or tumor-associated antigens within *** smal. size of these nanomaterial. al.ows for precise targeting of T cel.s,dendritic cel.s,or cancer cel.s,thereby el.citing a more potent anti-tumor *** this paper,we focus on the cl.ssification of carriers for cancer nanovaccines,the rol.s of different target cel.s,and cl.nical.y tested cancer nanovaccines,discussing strategies for effectivel. inducing cytotoxic T l.mphocytes responses and optimizing antigen presentation,whil. al.o l.oking ahead to the transl.tional.chal.enges of moving from animal.experiments to cl.nical.trial..

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnol.gy Immune targets Signal.ng pathway

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