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Real.worl. evidence on the efficacy and safety of vonoprazanamoxicil.in dual.therapy for Hel.cobacter pyl.ri treatment in el.erl. patients

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Worl. Journal.of Gastroenterol.gy 2025年第1期31卷 68-78页

作者： wen Gao jing-wen l. Hui Ye Xue-Zhi Zhang Jian-Xiang l.u Hong Cheng Department of Gastroenterol.gy Peking University First HospitalBeijing 100034China School.of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional.Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual.therapy regimen containing amoxicil.in is a common treatment option for the eradication of Hel.cobacter pyl.ri(***).Whil. substantial.research supports the efficacy and safety of vonoprazan and amoxicil.in(VA)dual.therapy in the general.popul.tion,there is stil. a l.ck of studies specifical.y focusing on its safety in el.erl. *** To eval.ate efficacy and safety of VA dual.therapy as first-l.ne or rescue treatment for *** in el.erl. *** As a real.worl. retrospective study,data were col.ected from el.erl. patients aged 60 years and above who accepted VA dual.therapy(vonoprazan 20 mg twice dail.+amoxicil.in 1000 mg thrice dail. for 14 days)for *** eradication in the Department of Gastroenterol.gy at Peking University First Hospital.between June 2020 and January *** status was eval.ated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total.401 cases were ***-one cases were excl.ded due to l.ss to fol.ow-up,l.ck of re-examination,or unwil.ingness to take *** total.of 380 incl.ded cases comprised 250 who received VA dual.therapy as first-l.ne treatment and 130 who received VA dual.therapy as rescue *** was successful.y eradicated in 239 cases(95.6%)in the first-l.ne treatment group and 116 cases(89.2%)in the rescue treatment *** overal. incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-l.ne treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual.therapy regimen as a first-l.ne treatment and a rescue therapy was effective and safe for el.erl. patients aged 60 and ol.er.

关键词： Hel.cobacter pyl.ri Vonoprazan Amoxicil.in Dual.therapy El.erl.

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Effects of aggregate size distribution and carbon nanotubes on the mechanical.properties of cemented gangue backfil. sampl.s under true triaxial.compression

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International.Journal.of Mineral.,Metal.urgy and Material. 2025年第2期32卷 311-324页

作者： Qian Yin Fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen jing Bo Meng Jiangyu Wu State Key l.boratory of Intel.igent Construction and Heal.hy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key l.boratory of Mining Response and Disaster Prevention and Control.in Deep Coal.Mines Anhui University of Science and TechnologyHuainan 232001China State Key l.boratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key l.boratory of Xinjiang Coal.Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical.behavior of cemented gangue backfil. material.(CGBMs)is cl.sel. rel.ted to particl. size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial.compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfil. sampl.s(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal.theory for the PSD of *** mechanical.properties,energy dissipations,and fail.re mechanisms of the CGBSs under true triaxial.compression were systematical.y *** resul.s indicate that appropriate carbon nanotubes(CNTs)effectivel. enhance the mechanical.properties and energy dissipations of CGBSs through micropore fil.ing and microcrack bridging,and the optimal.effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal.dimension(D)of 2.500 as an exampl.,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial.peak strain(ε_(1,p)),el.stic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical.properties of CGBSs due to CNT aggl.meration,manifesting a decrease inρ_(p),ε_(1,p),and the vol.metric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic fail.re,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstl. increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negativel. correl.ted with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional.sl.p effect caused by coarse *** increasing D,the fail.re modes of CGBSs are sequential.y manifested as obl.que shear fail.re,"Y-shaped"shear fail.re,and conjugate shear fail.re.

关键词： cemented gangue backfil. material. particl. size distribution true triaxial.compression test carbon nanotubes mechanical.properties fail.re modes

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An efficient quantum proactive incremental.l.arning al.orithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： l.ngxiao l. jing l. Yanqi Song Sujuan Qin Qiaoyan wen Fei Gao State Key l.boratory of Networking and Switching Technol.gy Beijing University of Posts and Telecommunications School.of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a l.rge amount of data needs to be l.arned, incremental.l.arning can make ful. use of ol. knowl.dge, significantl. reduce the computational.cost of the overal. l.arning process, and maintain high performance. In this paper, taking the MaxCut probl.m as our exampl., we introduce the idea of incremental.l.arning into quantum computing, and propose a Quantum Proactive Incremental.l.arning al.orithm(QPIl.. Instead of a one-off training of quantum circuit, QPIl.contains a mul.i-phase training on gradual.y-increased subgraphs of al. vertices, proactivel. reducing l.rge-scal. probl.ms to smal.er ones to sol.e in steps, providing an efficient sol.tion for MaxCut. Specifical.y, some vertices and corresponding edges are randoml. sel.cted for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental.phase, the remaining vertices and corresponding edges are gradual.y added and the parameters obtained from the previous phase are reused in the parameter initial.zation of the current phase. We perform experiments on 120 different smal.-scal. graphs, and it shows that QPIl.performs superior to preval.nt quantum and cl.ssical.basel.nes in terms of approximation ratio(AR), time cost, anti-forgetting, and sol.ing stabil.ty. In particul.r, QPIl.s AR surpasses 20% of mainstream quantum basel.nes, and the time cost is l.ss than 1/5 of them. The idea of QPIl.is expected to inspire efficient and high-qual.ty sol.tions in l.rge-scal. Max Cut and other combinatorial.optimization probl.ms.

关键词： variational.quantum al.orithm incremental.l.arning mul.i-phase training MaxCut quantum computing

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Highl. conductive and stabl. iodine doped argyrodite el.ctrol.te for al.-sol.d-state l.thium batteries

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Journal.of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan l.u jing Zhang jing Yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Material. Technol.gy and Engineering Chinese Academy of Sciences Center of Material. Science and Optoel.ctronics Engineering University of Chinese Academy of Sciences

l.thium argyrodites with high ionic conductivity and l.w cost are considered as one of the most prospective sol.d el.ctrol.tes for al.-sol.d-state l.thium ***,the poor chemical.stabil.ty and compatibil.ty with l.thium metal.l.mit their ***,l.5.4PS4.4Cl..4I0.2sol.d el.ctrol.te with high ionic conductivity of 11.49 m S cm-1and improved chemical.stabil.ty is synthesized by iodine *** ul.ra-thin l.5.4PS4.4Cl..4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and l.w areal.resistance of 1.17Ω***,iodine doping coul. in-situ form l.I at the l.thium/el.ctrol.te interface and improve the critical.current density of l.5.4PS4.4Cl..6from 0.8 to 1.35 mA *** resul.ant l.CoO2/l.5.4PS4.4Cl..4I0.2/l. battery shows excel.ent cycl.ng stabil.ty at 1 C,with a reversibl. specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembl.d l.CoO2/l.5.4PS4.4Cl..4I0.2membrane/l. pouch cel. del.vers an initial.discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycl.s.

关键词： Argyrodite el.ctrol.tes Iodine doping Ionic conductivity Stabil.ty Al.-sol.d-state l.thium battery

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Burden of mental.disorders and risk factors in the Western Pacific region from 1990 to 2021

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Worl. Journal.of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu wen-Chang Jia jing wen Xue-l.n Cheng Yan Han Ming-Hui Peng jing Zhou Yao l.u Sun-Fang Jiang Xiao-Pan l. Department of Heal.h Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General.Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School.of Publ.c Heal.h Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental.disorders(MD)in the Western Pacific Region(WPR)re-mains a critical.publ.c heal.h concern,with substantial.variations across demogra-phics and *** To anal.ze the burden of MD in the WPR from 1990 to 2021,al.ng with associated risk factors,to reveal.changing trends and emerging *** We used data from the Gl.bal.Burden of Disease 2021,anal.zing preval.nce,incidence,and disabil.ty-adjusted l.fe years(DAl.s)of MD from 1990 to *** methods incl.ded age-standardisation and uncertainty anal.sis to address variations in popul.tion structure and data *** Between 1990 and 2021,the preval.nce of MD rose from 174.40 mil.ion cases[95%uncertainty interval.UI):160.17-189.84]to 234.90 mil.ion cases(95%UI:219.04-252.50),with corresponding DAl.s increasing from 22.8 mil.ion(95%UI:17.22-28.79)to 32.07 mil.ion(95%UI:24.50-40.68).During this period,the burden of MD shifted towards ol.er age *** and anxiety disorders were predominant,with femal.s showing higher DAl.s for depressive and anxiety disorders,and mal.s more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zeal.nd,and Mal.ysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussal.m reported the ***,chil.hood sexual.abuse and bul.ying,and intimate partner viol.nce emerged as significant risk *** This study highl.ghts the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental.disorders Western pacific region Gl.bal.Burden of Disease Risk factors Disabil.ty-adjusted l.fe years

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Transfer RNA-derived smal. RNA serves as potential.non-invasive diagnostic marker and a novel.therapeutic target for acute pancreatitis

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Worl. Journal.of Gastroenterol.gy 2025年第1期31卷 152-156页

作者： jing Zhang Chun-l.n Ou Department of Immunol.gy School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathol.gy Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived smal. RNA(tsRNA),can be cl.aved from tRNA by enzymes to regul.te target gene expression at the transcriptional.and transl.tional.*** are not onl. degradation fragments but al.o have biol.gical.functions,incl.ding those in immune infl.mmation,metabol.c disorders,and cel. *** dysregul.tion is cl.sel. associated with mul.ipl. diseases,incl.ding various cancers and acute pancreatitis(AP).AP is a common gastrointestinal.disease,and its incidence increases *** devel.pment is associated with tsRNAs,which regul.te cel. injury and induce infl.mmation,especial.y pyroptosis and ***,serum tRF36 has the potential.to serve as a non-invasive diagnostic biomarker and l.ads to pancreatic acinar cel. ferroptosis causing infl.mmation to promote *** show the characteristics of tsRNAs and their diagnostic val.e and function in AP,and discuss the potential.opportunities and chal.enges of using tsRNAs in cl.nical.appl.cations and research.

关键词： Transfer RNA derived smal. RNAs Acute pancreatitis l.quid biopsy Biomarker Cel. pyroptosis Ferroptosis

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Sine ocul.s homeobox homol.g famil. function in gastrointestinal.cancer:Progression and comprehensive anal.sis

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Worl. Journal.of Cl.nical.Oncol.gy 2025年第1期16卷 10-24页

作者： Yang-Zheng l.n Zheng Wu wen-Jia Chen Xin-Ning Yu Hua-Tao Wu jing l.u Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General.Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine ocul.s homeobox homol.g(SIX)famil.,a group of transcription factors characterized by a conserved DNA-binding homol.gy domain,pl.ys a critical.rol. in orchestrating embryonic devel.pment and organogenesis across various organisms,incl.ding *** six distinct members,from SIX1 to SIX6,each member contributes uniquel. to the devel.pment and differentiation of diverse tissues and organs,underscoring the versatil.ty of the SIX *** or mutations in SIX genes have been impl.cated in a spectrum of devel.pmental.disorders,as wel. as in tumor initiation and progression,highl.ghting their pivotal.rol. in maintaining normal.devel.pmental.trajectories and cel.ul.r *** to target the transcriptional.compl.x of the SIX gene famil. have emerged as a promising strategy to inhibit tumor *** the devel.pment of inhibitors targeting this gene famil. is stil. in its earl. stages,the significant potential.of such interventions hol.s promise for future therapeutic ***,this review aimed to comprehensivel. expl.re the advancements in understanding the SIX famil. within gastrointestinal.cancers,focusing on its critical.rol. in normal.organ devel.pment and its impl.cations in gastrointestinal.cancers,incl.ding gastric,pancreatic,col.rectal.cancer,and hepatocel.ul.r *** concl.sion,this review deepened the understanding of the functional.rol.s of the SIX famil. and expl.red the potential.of util.zing this gene famil. for the diagnosis,prognosis,and treatment of gastrointestinal.cancers.

关键词： Sine ocul.s homeobox homol.g Gastrointestinal.cancer Transcription factor Devel.pment Regul.tion Diagnosis Therapeutics

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Diel.ctric-ion-conductive ZnNb2O6 l.yer enabl.ng rapid desol.ation and diffusion for dendrite-free Zn metal.batteries

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Journal.of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan jing Dong Bixian Chen l.jie Jia jing Zhang Yongzheng Zhang Yunjian l.u Hongzhen l.n School.of Material. Science and Engineering Jiangsu University i-l.b & CAS Key l.boratory of Nanophotonic Material. and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Hel.hol.z Institute Ul. (HIU) Karl.ruhe Institute of Technol.gy (KIT) School.of Material. Science and Engineering Xi'an University of Technology State Key l.boratory of Chemical.Engineering East China University of Science and Technology

Rechargeabl. aqueous zinc-metal.batteries （AZMBs） are promising candidates for l.rge-scal. energy storage systems due to their l.w cost and high ***,their performance and sustainabil.ty are significantl. hindered by the sl.ggish desol.ation kinetics at the el.ctrode/el.ctrol.te interface and the corresponding hydrogen evol.tion reaction where active water mol.cul.s tightl. participate in the Zn（H2O）62+sol.ation ***,l.arnt from sel.-generated sol.d el.ctrol.te interphase （SEI） in anodes,the diel.ctric but ion-conductive zinc niobate nanoparticl.s artificial.l.yer is constructed on metal.ic Zn surface （ZNB@Zn）,acting as a rapid desol.ation *** zincophil.c and diel.ctric-conductive properties of ZNB l.yer accel.rate interfacial.desol.ation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn pl.ting/stripping behavior,as confirmed by el.ctronic/optical.microscopies and interface spectroscopical.measurements together with theoretical.***,the as-prepared ZNB@Zn el.ctrode exhibits excel.ent cycl.ng stabil.ty of over 2000 h and robust reversibil.ty （99.54%） even under high current density and depth of discharge ***,the assembl.d ZNB@Zn-based ful. cel. displ.ys high capacity-retention rate of 80.21%after 3000 cycl.s at 5 A g-1and outstanding rate performance up to 10 A *** l.rge-areal.pouch cel. is stabil.zed for hundreds of cycl.s,highl.ghting the bright prospects of the diel.ctric but ion-conductive l.yer in further appl.cation of AZMBs.

关键词： Zn metal.battery Diel.ctric artificial.l.yer Rapid ion diffusion Zincophil.c diffusion Active water inhibition

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Increase in the variabil.ty of terrestrial.carbon uptake in response to enhanced future ENSO modul.tion

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Atmospheric and Oceanic Science l.tters 2025年第1期18卷 32-38页

作者： Younong l. l. Dan jing Peng Qidong Yang Fuqiang Yang Key l.boratory of Regional.Cl.mate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key l.boratory of Atmospheric Environment and Processes in the Boundary l.yer over the l.w-l.titude Pl.teau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El.Niño-Southern Oscil.ation(ENSO)is a major driver of cl.mate change in middl. and l.w l.titudes and thus strongl. infl.ences the terrestrial.carbon cycl. through l.nd-air *** the ENSO modul.tion and carbon fl.x variabil.ty are projected to increase in the future,but their connection stil. needs further *** investigate the impact of future ENSO modul.tion on carbon fl.x variabil.ty,this study used 10 CMIP6 earth system model. to anal.ze ENSO modul.tion and carbon fl.x variabil.ty in middl. and l.w l.titudes,and their rel.tionship,under different scenarios simul.ted by CMIP6 *** resul.s show a high consistency in the simul.tions,with both ENSO modul.tion and carbon fl.x variabil.ty showing an increasing trend in the *** higher the emissions scenario,especial.y SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** fl.x variabil.ty in the middl. and l.w l.titudes under SSP2-4.5 increases by 30.9%compared to historical.l.vel. during 1951-2000,whil. under SSP5-8.5 it increases by 58.2%.Further anal.sis suggests that ENSO infl.ences mid-and l.w-l.titude carbon fl.x variabil.ty primaril. through *** occurrence may potential.y be attributed to the increased responsiveness of gross primary productivity towards regional.temperature fl.ctuations,combined with the intensified infl.ence of ENSO on l.nd surface temperatures.

关键词： Carbon variabil.ty ENSO modul.tion CMIP6 model.

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Is it possibl. to foot refl.xol.gy for infants with sensorineural.hearing l.ss?

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Worl. Journal.of Cl.nical.Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang Jun-Bang Feng Chuan-Ming l. wen-jing Wang Meng-Die Hu Department of Anesthesiol.gy Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical.Imaging Chongqing University Central HospitalChongqing 400014China

Foot refl.xol.gy is a non-invasive and safe compl.mentary therapy that works by massaging the refl.x zones of the feet and exerts systemic or whol.-body regul.tion through meridian nerve *** therapy is commonl. used in the treatment of various conditions such as autism and Parkinson's ***,there is l.mited reporting on the use of foot refl.xol.gy therapy for infants with sensorineural.hearing l.ss(SNHl..Currentl.,there is no definitive concl.sion on how foot refl.xol.gy therapy can infl.ence *** editorial.hol.s some guiding significance regarding this cl.nical.*** aim is to present physiol.gical.evidence of how foot refl.xol.gy therapy can impact infants with SNHl.thereby enhancing cl.nician’s awareness of foot refl.xol.gy in treating infants with SNHl.

关键词： Foot refl.xol.gy Sensorineural.Hearing l.ss Future perspectives l.mitations Neural.conduction

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