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Dupilumab for treatment of severe atopic dermatitis accompanied by lichenoid amyloidosis in adults:Two case reports

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World Journal of Clinical Cases 2023年第10期11卷 2301-2307页

作者： Xue-Qi Zhao wen-jing zhu Yan Mou Meng Xu Jian-Xin Xia Department of Dermatology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND Lichenoid amyloidosis(LA)is a subtype of primary cutaneous amyloidosis characterized by persistent multiple groups of hyperkeratotic papules,usually on the lower leg,back,forearm,or *** may be associated with several skin diseases,including atopic dermatitis(AD).The treatment of LA is considered to be ***,as there is some overlap in the etiopathogenesis of LA and AD,AD treatment may also be effective for *** SUMMARY Case 1:A 70-year-old man was diagnosed with severe AD with LA based on large dark erythema and papules on the trunk and buttocks and dense hemispherical millet-shaped papules with pruritus on the extensor side of the lower *** had a long history of the disease(8 years),with repeated and polymorphic skin *** the poor efficacy of traditional treatments,this patient was recommended to receive dupilumab *** the initial stage,300 mg was injected subcutaneously every 2 *** 28 wk,the drug interval was extended to 1 mo due to the ***-up observations revealed that the patient reached an Eczema Area Severity Index of 90(skin lesions improved by 90%compared with the baseline)by the end of the ***,Investigator's Global Assessment score was 1,and scoring atopic dermatitis index and numeric rating scale improved by 97.7%and 87.5%compared with the baseline,respectively,with LA skin lesions having largely *** 2:A 30-year-old woman was diagnosed with severe AD with LA,due to dense and substantial papules on the dorsal hands similar to changes in cutaneous amyloidosis,and erythema and papules scattered on limbs and trunk with pruritus,present for 25 *** 16 wk of dupilumab treatment,she stopped,and skin lesions completely subsided,without recurrence since the last *** Dupilumab shows rational efficacy and safety in the treatment of severe AD with LA,in addition to benefits in the quality of life of the patients.

关键词： Atopic dermatitis Lichenoid amyloidosis Dupilumab Treatment Case report

Molecularly imprinted open porous membranes made from Pickering W/O HIPEs for selective adsorption and separation of methyl 4-hydroxybenzoate

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Chinese Chemical Letters 2015年第8期26卷 1036-1041页

作者： Hong-Yu Luo Min Zhang Nai-Chao Si Min-Jia Meng Li Yan wen-jing zhu Chun-Xiang Li School of Material Science and Engineering Jiangsu University School of Chemistry & Chemical Engineering Jiangsu University School of Chemistry Jilin Normal University

In this study, novel molecularly imprinted open porous membranes（MIOPMs） were prepared using the Pickering HIPEs template method and molecular imprinting technology for selective adsorption and separation of methyl 4-hydroxybenzoate（M4HB）. The template M4 HB, functional monomers,crosslinker and plastifier 2-ethylhexyl acrylate（2-EHA） were contained in the oil phase. Hydrophobic silica nanoparticles（HNP-SiO2） were employed as a stabilizer to establish stable W/O Pickering HIPEs with nonionic surfactant sorbitantrioleate（Span 85）. The results of SEM and FTIR indicated that the optimal MIOPMs were prepared successfully and possessed open and interconnecting pores. Then, the MIOPMs were used as sorbents for M4 HB. The correlation coefficient（R^2） values for the Langmuir–Freundlich isotherm model and pseudo-second-order kinetic model fitting to the adsorption equilibrium and kinetic data respectively were all higher than 0.95. The maximum adsorption capacity and the time of rapid adsorption for MIOPM4 were 4.146 mg g^-1 and 100 min, respectively. In addition, the permeability separation factor of MIOPMs for M4 HB compared to a structurally related analog methyl2-hydroxybenzoate（M2HB） could reach 3.122.

关键词： template porous surfactant silica ethylhexyl stabilizer fitting pores imprinting structurally

Selective Synthesis of Substituted Pyrrole from 2H-Azirines and 1,3-dicarbonyl compounds

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Selective Synthesis of Substituted Pyrrole from 2H-Azirines ...

Regulation of angiogenesis by microRNAs and long non-coding RNAs in endometriosis

河南省化学会2020年学术年会

作者： Fen Xu wen-jing zhu Department of Material and Chemical Engineering Zhengzhou University of Light Industry

Pyrroles are an important class of heterocycles,which represent a privileged structural motif extensively existing in medicinal chemistry,as exemplified by the antibacterial agents,inhibitors,as well as antagonists such as NMDA receptor antagonists,a nonsteroidal anti-inflammatory drug(NSAID),and potent antagonists of VLA-4 (Scheme 1).Specially,its structural unit,as a core feature,is also present in a large number of natural compounds,dyes,flavors,and advanced *** the past decade,several synthetic technologies of substituted pyrroles have been *** those systems,striking progress has been achieved on the ruthenium-catalyzed three-component coupling reaction of ketones with amines and vicinal diols, Ir orRucatalyzed dehydrogenative coupling ofβ-aminoalcohols with alcohols,rhodium-catalyzed transannulation of 1-sulfonyl-1,2,3-triazoles withβ-diketones, and the reaction ofα-imino rhodium carbene with enol ether orβ-diketone. Nevertheless,most of the existing methods to construct these frameworks either employed expensive transition metal catalyst or underwent hard reaction ***,the search for a straightforward process from readily available materials for access to substituted pyrroles and its derivatives under mild reaction conditions remains a great challenge.

关键词： Pyrroles Coupling reaction Heterocycles

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Reproductive and Developmental Medicine 2022年第3期6卷 133-137页

作者： Rui-Hui Lu jing-wen zhu Fang-Yuan Li Qing Xue Department of Obstetrics and Gynecology Peking University First HospitalBeijingChina

Endometriosis(EM)is a benign gynecological disease that affects the fertility and health of women of reproductive age;it is characterized by the presence of endometrial glands and stroma outside the uterine *** several hypotheses have been proposed to explain the underlying cause of EM,its pathogenesis remains ***,non-coding RNAs were reported to be involved in the occurrence and development of *** and long non-coding RNAs are the main members of the non-coding RNA family that contribute to EM progression in various aspects,such as cell proliferation,apoptosis,invasion,and *** plays a pivotal role in the initiation and development of EM and provides a substantial background for the invasion,proliferation,and long-term growth of endometriotic *** review aimed to investigate the role of microRNAs and long non-coding RNAs in regulating angiogenesis in EM and discuss how this mechanism can be used for diagnostic and therapeutic purposes in EM.

关键词： MicroRNAs Long non-coding RNAs Endometriosis Angiogenesis Pathogenesis

The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage

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Neural Regeneration Research 2021年第10期16卷 2071-2077页

作者： Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang wen-jing zhu Yuan-Yuan Gao Xing Feng Xin Ding Soochow Key Laboratory of Prevention and Treatment of Child Brain injury Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatrics Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’anJiangsu ProvinceChina Pediatrics Research Institute Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatrics The First Affiliated Hospital of Soochow University(Dushuhu Branch)SuzhouJiangsu ProvinceChina Cambridge-SU Genomic Resource Center Soochow UniversitySuzhouJiangsu ProvinceChina Clinical Laboratory Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely *** previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm *** better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in *** found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with ***,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of *** addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal *** established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 ***3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same ***,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and *** together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal *** clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,*** experiments were approved by An

关键词： brain injury circadian rhythm hypoxic-ischemic brain damage miRNA neonate pineal gland sleep transcription factor

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世界大豆出口格局变迁研究

上海经济研究 2017年第10期29卷 115-127页

作者：林大燕温珺朱晶南京理工大学经济管理学院江苏南京210094 江苏产业集群决策咨询研究基地江苏南京210094 南京理工大学国际经贸问题研究中心江苏南京210094 江苏粮食安全研究中心江苏南京210095

近几十年来,世界大豆出口格局变化显著,由美国绝对主导逐渐转变为美国、巴西、阿根廷"三国鼎立"的格局。该文从理论上和实证上分析了南北半球的季节差异对一国大豆比较优势及出口的影响,并据此解释世界大豆出口格局的变迁。研究发现,一... 详细信息

近几十年来,世界大豆出口格局变化显著,由美国绝对主导逐渐转变为美国、巴西、阿根廷"三国鼎立"的格局。该文从理论上和实证上分析了南北半球的季节差异对一国大豆比较优势及出口的影响,并据此解释世界大豆出口格局的变迁。研究发现,一国大豆出口数量在大豆收获季节后,将随着库存时间的延长显著下降。与非收获季节相比,处于收获季节的大豆更具比较优势。由于中国、欧盟等世界主要大豆进口国集中于北半球,在其大豆生产淡季、进口需求旺盛时,同位于北半球的美国也处于大豆生产淡季,大豆出口供给有限,而位于南半球的巴西和阿根廷则处于大豆生产旺季,大豆库存持有成本及出口成本较低,具有较强的比较优势,从而得以不断扩大大豆出口规模。在此激励下,南美利益相关者进一步通过改进技术、改善物流设施等途径大力发展本国大豆产业,助力本国土地及劳动力等资源优势,进一步协同两国大豆出口规模的提升,由此改变了世界大豆出口格局。

关键词：南北半球季节差异出口格局大豆世界

Association of Different Human Rhinovirus Species with Asthma in Children： A Preliminary Study

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Chinese Medical Journal 2016年第13期129卷 1513-1518页

作者： Min Zhao wen-jing zhu Yuan Qian Yu Sun Ru-Nan zhu Jie Deng Fang Wang Ya-Xin Ding Run Tian Chuan-He Liu Ling-Hui Meng Lin-Qing Zhao Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in Children Capital Institute of Pediatrics Beijing 100020 China Division of Respiratory Diseases Affiliated Children's Hospital Capital Institute of Pediatrics Beijing 100020 China Statistical Office Capital Institute of Pediatrics Beijing 100020 China

Background： Human rhinoviruses （HRVs） are divided into three genetic species： HRV-A, HRV-B, and HRV-C. The association of different HRV species with asthma in children in China has not yet been evaluated. This preliminary study aimed to assess the associations between different HRV species, particularly HRV-C, and asthma in young children in China. Methods： A total of 702 nasopharyngeal aspirates were obtained from 155 children with asthma （asthma group）, 461 children with acute respiratory infection （ARI） without asthma （nonasthma ARI group）, and 86 children from the control group. Semi-nested polymerase chain reaction （PCR） was used to detect HRVs, and PCR products were sequenced for species identification. Epidemiological characteristics of HRV-positive cases were analyzed. Results： HRVs were the most common pathogen （ 15.4%; 108/702） in the patients in this study. The prevalence of HRV was significantly different （F = 20.633, P = 0.000） between tile asthma （25.8%） and nonasthma ARI groups （11.1%）. Phylogenetic analysis indicated that in the 108 cases positive for HRVs, 41 were identified as HRV-A, 8 as HRV-B, and 56 as HRV-C, Comparing the asthma with the nonasthlna ARI group, Spearman＇s rank correlation analysis revealed an association between HRV-A （P 〈 0.05） and C （P 〈 0.01） and asthma, confirmed by regression analysis, with odds ratios of 2.2 （HRV-A） and 4.2 （HRV-C）. Conclusions： Our data revealed a high prevalence of HRVs in children in China, regardless of clinical status. HRV-C was the dominant species and may be one of the key factors in the association of HRVs with asthma.

关键词： Asthma Children China Human Rhinovirus

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水下单边带语音多通道增强技术

声学技术 2017年第5期36卷 473-478页

作者：曹文婧朱敏武岩波中国科学院声学研究所海洋声学技术中心北京100190 中国科学院大学北京100190 北京市海洋声学装备工程技术研究中心北京100190 中国科学院声学研究所声场声信息国家重点实验室北京100190

船舶噪声是影响水下语音通信质量的主要因素。为了提高单边带语音信号的信噪比和语音质量,采用多通道自适应增强算法对语音信号进行研究。该算法运用自适应信号增强技术,具有运算量小、易实时实现、消噪效果显著等优点,并且能够有效利... 详细信息

船舶噪声是影响水下语音通信质量的主要因素。为了提高单边带语音信号的信噪比和语音质量,采用多通道自适应增强算法对语音信号进行研究。该算法运用自适应信号增强技术,具有运算量小、易实时实现、消噪效果显著等优点,并且能够有效利用不同换能器接收到的信息。从理论上对该算法进行了分析,并结合海试数据进行验证。结果表明,低信噪比、非平稳噪声环境下,该算法有效抑制了接收信号中的尖锐噪声,并且当系统收敛时,使其趋于白化,明显提高了系统的输出信噪比,显著改善了语音质量,在性能上明显优于传统的信号相干叠加算法。

关键词：水下单边带语音信号多通道自适应增强噪声抑制信噪比

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移情设计在儿童牙科产品体验设计中的运用

包装工程 2015年第20期36卷 70-73页

作者：文菁竹张凌浩江南大学无锡214122

目的通过移情设计的介入,探索儿童牙科产品再设计的可能。细化用户的痛点和需求,为解决儿童牙科恐惧症提供更多视角。方法基于产品服务系统设计的理论,用移情设计中的多种工具,从用户研究到原型设计进行针对儿童牙科产品体验设计的探索... 详细信息

目的通过移情设计的介入,探索儿童牙科产品再设计的可能。细化用户的痛点和需求,为解决儿童牙科恐惧症提供更多视角。方法基于产品服务系统设计的理论,用移情设计中的多种工具,从用户研究到原型设计进行针对儿童牙科产品体验设计的探索。结论完善儿童的就医体验,通过对用户"说"、"做"、"想"的移情研究,增加产品设计的丰富度和科学性,以缓解儿童的牙科恐惧症。

关键词：移情设计儿童牙科医疗产品体验