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Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2023年第7期18卷 1512-1520页

作者： Miao Hu Jie Huang Lei Chen Xiao-Rong Sun Zi-Meng Yao Xu-Hui Tong wen-jing jin Yu-Xin Zhang Shu-Ying Dong Department of Pharmacology School of PharmacyBengbu Medical CollegeBengbuAnhui ProvinceChina Key Laboratory of Cardiovascular and Cerebrovascular Diseases Bengbu Medical CollegeBengbuAnhui ProvinceChina Anhui Engineering Technology Research Center of Biochemical Pharmaceutical BengbuAnhui ProvinceChina

CDGSH iron sulfur domain 2 can inhibit ferroptosis,which has been associated with cerebral ischemia/reperfusion,in individuals with head and neck ***,CDGSH iron sulfur domain 2 may be implicated in cerebral ischemia/reperfusion *** validate this hypothesis in the present study,we established mouse models of occlusion of the middle cerebral artery and HT22 cell models of oxygen-glucose deprivation and reoxygenation to mimic cerebral ischemia/reperfusion injury in vivo and in vitro,*** found remarkably decreased CDGSH iron sulfur domain 2 expression in the mouse brain tissue and HT22 *** we used adeno-associated virus and plasmid to up-regulate CDGSH iron sulfur domain 2 expression in the brain tissue and HT22 cell models separately,mouse neurological dysfunction was greatly improved;the cerebral infarct volume was reduced;the survival rate of HT22 cells was increased;HT22 cell injury was alleviated;the expression of ferroptosis-related glutathione peroxidase 4,cystine-glutamate antiporter,and glutathione was increased;the levels of malondialdehyde,iron ions,and the expression of transferrin receptor 1 were decreased;and the expression of nuclear-factor E2-related factor 2/heme oxygenase 1 was *** of CDGSH iron sulfur domain 2 upregulation via the nuclear-factor E2-related factor 2 inhibitor ML385 in oxygen-glucose deprived and reoxygenated HT22 cells blocked the neuroprotective effects of CDGSH iron sulfur domain 2 up-regulation and the activation of the nuclear-factor E2-related factor 2/heme oxygenase 1 *** data indicate that the up-regulation of CDGSH iron sulfur domain 2 can attenuate cerebral ischemia/reperfusion injury,thus providing theoretical support from the perspectives of cytology and experimental zoology for the use of this protein as a therapeutic target in patients with cerebral ischemia/reperfusion injury.

关键词： cerebral ischemia/reperfusion injury CDGSH iron sulfur domain 2 ferroptosis glutathione peroxidase 4 heme oxygenase 1 HT22 nuclear-factor E2-related factor 2 oxygen-glucose deprivation/reoxygenation injury stroke transferrin receptor 1

The"4+4"Medical Doctor(MD)Pilot Program at PUMC:Implementation,Performance,and Prospects

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Chinese Medical Sciences Journal 2024年第2期39卷 144-148页

作者： jing-jing Yi Wei-Wei Xu Chao Ma He Di jing jin Le Zeng wen-Ji Tu wen-wen Sun Qin Zhang Office of Educational Affairs Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730China

Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training policies to foster diverse and eager learners in *** the occasion of the graduation of the first class of the"4+4"MD pilot class at PUMC in 2023,we reviewed the teaching reform in the pilot program and carried out a systematic survey and interviews with students,faculties,and management staff of the pilot *** article reports on the measures taken by the pilot class at PUMC in enrollment and curriculum setting,and demonstrates the achievements of the pilot class in terms of student academic background structure,knowledge acquisition and skill learning,scientific research ability,and course *** results indicated that the pilot class had met the national demand for the"Medicine+X"talent training *** specifically,with a diverse academic backgrounds,the pilot class graduates had academic levels comparable to the eight-year medical education graduates,and their scientific research abilities were *** pilot program at PUMC will optimize the curriculum setting,strengthen the construction of faculty,learning resources,and teaching facilities,and reform the academic evaluation methods,thus deepening the reform of medical education and improving the"4+4"MD program as a novel medical education model.

关键词： "4+4"MD pilot program teaching reform medical education

Ni-Cu bimetallic alloy anchored on nitrogen-doped carbon nanotubes for CO_(2)-to-CH_(4) electrochemical conversion

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Nano Research 2024年第8期17卷 6922-6930页

作者： jing Li Chuanyong jing jin Wang School of Environment Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality SafeguardBeijing Jiaotong UniversityBeijing 100044China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Tangshan Research Institute Beijing Jiaotong UniversityTangshan 063000China

Electrocatalytic CO_(2) reduction to CH_(4) remains challenging due to multi-electron transfer and intermediates ***,we synthesized electrocatalysts by growing Ni-Cu alloy structure on nitrogen-doped carbon nanotubes(NixCuy-NCNT)for electrocatalytic CO_(2) reduction reaction(CO_(2)RR)via hydrothermal method followed by *** optimized Ni_(1)Cu_(1)-NCNT demonstrated a superior CO_(2)RR performance,achieving 99.7%FECH_(4)(FE=Faradaic efficiency)and 11.54 mA·cm^(−2) current density at−1.2 V *** hydrogen electrode(RHE),which outperformed single metal *** outstanding performance was due to the electrons transferred from Cu to Ni and Ni-Cu alloy shifted the d-band center toward the Fermi level,which was more conducive to the intermediate *** situ electrochemical attenuated total reflection(EC-ATR)and density functional theory(DFT)calculations revealed the appearance of *CHO intermediate and the pathway during the CO_(2)RR *** design of the bimetallic electrocatalyst in this study provides a new perspective for the highly selective reduction of CO_(2).

关键词： electrocatalytic CO_(2) reduction Ni-Cu alloy nitrogen-doped carbon nanotube(NCNT) electrochemical attenuated total reflection(EC-ATR) density functional theory(DFT)calculations

Two-dimensional conjugated coordination polymer monolayer as anode material for lithium-ion batteries:A DFT study

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Chinese Chemical Letters 2024年第6期35卷 180-184页

作者： Xin-Tong Zhao jin-Zhi Guo wen-Liang Li jing-Ping Zhang Xing-Long Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

Nowadays,lithium-ion batteries(LIBs)play a crucial role in modern society in the aspect of portable electronic devices and large-scale smart ***,the current performance of lithium-ion batteries has been unable to meet the growing expectations of society and scientific ***,we have synthetically investigated availability of 2D Ni-TABQ monolayer as anode based on DFT for LIBs *** findings have demonstrated that 2D Ni-TABQ monolayer is a semiconductor with a small band gap of 0.2 eV,which suggest that the electronic property of 2D Ni-TABQ monolayer would take place an evident shift from semiconductor property to metallic property after Li ***,we checked the stability of 2D Ni-TABQ monolayer and investigated the viability of exfoliation from bulk multilayer Ni-TABQ to form 2D Ni-TABQ monolayer in the light of exfoliation energy and binding *** continuously studied electrochemical properties of 2D Ni-TABQ monolayer with respect of theoretical specific capacity,Li-ion diffusion barriers and open-circuit *** the charging process,2D Ni-TABQ monolayer can achieve a high specific capacity of 722 m Ah/g with an open-circuit voltage range from 1.12 V to 0.22 *** aforementioned results make the 2D Ni-TABQ monolayer a promising anode for LIBs.

关键词： The first principles Density functional theory Lithium-ion battery Anode material Two-dimensional material

Spin-based magnetic random-access memory for high-performance computing

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National Science Review 2024年第3期11卷 20-23页

作者： Kaiming Cai Tianli jin wen Siang Lew School of Physics Huazhong University of Science and Technology Interuniversity Microelectronics Centre(IMEC) School of Physical and Mathematical Sciences Nanyang Technological University

Memory serves as a critical component in today's electronic systems for data storage and processing. In traditional computer architectures, the logic and memory units are physically separated, due to the performance gap in operational speed and capacity among memories, resulting in the fundamental limitation of the von Neumann computers.

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In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： Wei-Jian Guo Ao Zhou wen-wen Cai jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry (Ministry of Education) School of Chemistry and Chemical EngineeringShandong University

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO2) into high-value chemicals, thereby presenting a promising avenue toward achieve carbon neutrality. However, addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting task. In this study, the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ pyrolysis. The porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer, thus enhancing their electrocatalytic activity and stability. Additionally, nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions, thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical calculation. Consequently, Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential windows. Notably, its faradaic efficiency(FE) of formate reaches 92.7% in H-cell and94.9% in flow cell, respectively, with good electrocatalytic stability. The in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Carbon dioxide reduction Electron delocalization N-doping Porous carbon nanofiber

Observation of gapless corner modes of photonic crystal slabs in synthetic translation dimensions

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Photonics Research 2024年第3期12卷 444-455页

作者： wen-jin ZHANG HAO-CHANG MO wen-JIE CHEN XIAO-DONG CHEN JIAN-wen DONG School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Second-order topological photonic crystals support localized corner modes that deviate from the conventional bulk-edge ***,the frequency shift of corner modes spanning the photonic band gap has not been experimentally ***,we observe the gapless corner modes of photonic crystal slabs within a parameter space by considering translation as an additional synthetic *** corner modes,protected by topological pumping in synthetic translation dimensions,are found to exist independently of the specific corner *** gapless corner modes are experimentally imaged via the near-field scanning measurement and validated numerically by full-wave *** propose a topological rainbow with gradient translation,demonstrating the ability to extract and separate specific frequency components of light into different spatial *** work contributes to the advancement of topological photonics and provides valuable insights into the exploration of gapless corner modes in synthetic dimensions.

关键词： translation dimensions corner

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

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mLife 2024年第1期3卷 74-86页

作者： Ya-wen He Zi-jing jin Ying Cui Kai Song Bo Chen Lian Zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Zhiyuan Innovative Research Centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and *** is also an opportunistic pathogen in plants,insects,animals,and *** response to increasing cell density,*** uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-C12-HSL]and Nbutanoyl-homoserine lactone[C4-HsL]),which regulate the expression of hundreds of ***,how the biosynthesis of these two QS signals is coordinated remains *** studied the regulation of these two QS signals in the rhizosphere strain ***1201 sequentially produced 3-oxo-C12-HSL and C4-HSL at the early and late growth stages,*** highest 3-oxo-C12-HSL-dependent elastase activity was observed at the early stage,while the highest C4-HSL-dependent rhamnolipid production was observed at the late *** atypical regulator RsaL played a pivotal role in coordinating 3-oxo-C12-HSL and C4-HSL biosynthesis and QS-associated *** repressed las/transcription by binding the-10 and-35 boxes of the lasl *** contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll ***,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL ***,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in ***,C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling ***,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

Assessment of soil total phosphorus storage in a complex topography along China's southeast coast based on multiple mapping scales

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Pedosphere 2024年第1期34卷 236-251页

作者： Zhongxing CHEN jing LI Kai HUANG Miaomiao wen Qianlai ZHUANG Licheng LIU Peng ZHU Zhenong jin Shihe XING Liming ZHANG Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Guangxi Zhuang Autonomous Region Plant Protection Station Nanjing 530022China Department of Earth Atmosphericand Planetary SciencesPurdue UniversityWest Lafayette IN47907US Department of Bioproducts and Biosystems Engineering University of Minnesota-Twin CitiesSaint Paul MN 55108USA Department of Geography The University of Hong KongHong Kong 999077China

Soil phosphorus (P) plays a vital role in both ecological and agricultural ecosystems, where total P (TP) in soil serves as a crucial indicator of soil fertility and quality. Most of the studies covered in the literature employ a single or narrow range of soil databases, which largely overlooks the impact of utilizing multiple mapping scales in estimating soil TP, especially in hilly topographies. In this study, Fujian Province, a subtropical hilly region along China’s southeast coast covered by a complex topographic environment, was taken as a case study. The influence of the mapping scale on soil TP storage (TPS)estimation was analyzed using six digital soil databases that were derived from 3 082 unique soil profiles at different mapping scales, i.e., 1:50 000 (S5),1:200 000 (S20), 1:500 000 (S50), 1:1 000 000 (S100), 1:4 000 000 (S400), and 1:10 000 000 (S1000). The regional TPS in the surface soil (0–20 cm) based on the S5, S20, S50, S100, S400, and S1000 soil maps was 20.72, 22.17, 23.06, 23.05, 22.04, and 23.48 Tg, respectively, and the corresponding TPS at0–100 cm soil depth was 80.98, 80.71, 85.00, 84.03, 82.96, and 86.72 Tg, respectively. By comparing soil TPS in the S20 to S1000 maps to that in the S5map, the relative deviations were 6.37%–13.32%for 0–20 cm and 0.33%–7.09%for 0–100 cm. Moreover, since the S20 map had the lowest relative deviation among different mapping scales as compared to S5, it could provide additional soil information and a richer soil environment than other smaller mapping scales. Our results also revealed that many uncertainties in soil TPS estimation originated from the lack of detailed soil information, i.e., representation and spatial variations among different soil types. From the time and labor perspectives, our work provides useful guidelines to identify the appropriate mapping scale for estimating regional soil TPS in areas like Fujian Province in subtropical China or other places with similar complex topographies. Moreover,

关键词： agricultural management appropriate mapping scale digitized conventional soil map estimation uncertainty subtropical hilly region