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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： LIU Xiao-rong LI Shuo-fu MEI wen-ya LIU Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG Yi LI Xin-yue LIANG Tian-jun DING bao-zhu MA Ke-xin REN wen-xuan LIANG wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

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可溶盐对兰州非饱和重塑黄土抗剪强度的影响

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岩土力学 2017年第10期38卷 2881-2887页

作者：闫亚景文宝萍黄志全华北水利水电大学资源与环境学院郑州河南450045 中国地质大学(北京)水资源与环境学院北京100083

岩土体抗剪强度是分析评价斜坡稳定性的关键指标。为了弄清可溶盐在黄土抗剪特性中的作用程度及控制机制,以兰州重塑黄土为对象,基于直剪试验,研究了黄土抗剪强度及其参数在不同溶滤次数下的变化特征。结果显示,可溶盐对非饱和黄土抗剪... 详细信息

岩土体抗剪强度是分析评价斜坡稳定性的关键指标。为了弄清可溶盐在黄土抗剪特性中的作用程度及控制机制,以兰州重塑黄土为对象,基于直剪试验,研究了黄土抗剪强度及其参数在不同溶滤次数下的变化特征。结果显示,可溶盐对非饱和黄土抗剪强度及黏聚力具有明显非线性弱化作用,而对内摩擦角的影响则相对微弱。其中,抗剪强度与黏聚力随可溶盐的变化规律存在临界分段现象,其降低幅度在溶滤1次时达到最大值,在溶滤5次后近似于0;而降低速率以易溶盐含量2 620 mg/100 g干土为分界值,呈先快后慢的变化特征。上述关系的内在机制是,在溶滤初始阶段,黄土抗剪特性弱化主要源于易溶盐与部分难溶盐分解;随溶滤次数增加,则更多依赖于易溶盐分解与基质吸力减弱。

关键词：非饱和黄土抗剪强度溶滤可溶盐

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Interfacial engineering for high-performance garnet-based solid-state lithium batteries

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SusMat 2024年第1期4卷 72-105页

作者： Lingchen Wang Jiaxin Wu Chengshuai bao Zichang You Yan Lu Zhaoyin wen State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina

Solid-state batteries represent the future of energy storage technology,offering improved safety and energy ***-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO)solidstate electrolytes-based solid-state lithium batteries(SSLBs)stand out for their appealingmaterial properties and chemical ***,their successful deployment depends on conquering interfacial *** review article primarily focuses on the advancement of interfacial engineering for LLZO-based *** commence with a concise introduction to solid-state electrolytes and a discussion of the challenges tied to interfacial properties in LLZO-based *** deeply explore the correlations between structure and properties and the design principles vital for achieving an ideal electrode/electrolyte ***,we delve into the latest advancements and strategies dedicated to overcoming these challenges,with designated sections on cathode and anode interface *** the end,we share our insights into the advancements and opportunities for interface design in realizing the full potential of LLZO-based SSLBs,ultimately contributing to the development of safe and high-performance energy storage solutions.

关键词： anode interfaces cathode interfaces garnet-based electrolytes interfacial modifications solidstate lithium batteries

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High performance 2T0C DRAM cells based on atomic-layer-deposited InAlZnO FETs

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Science China(Information Sciences) 2024年第09期67卷 344-345页

作者： wen XIONG Binbin LUO Wei MENG bao ZHU Xiaohan WU Shi-Jin DING School of Microelectronics Fudan University

Recently, the oxide semiconductor-based 2T0C dynamic random-access memory(DRAM) has shown great potential in monolithic three-dimensional(M3D)-integrated memory,owing to some unique advantages of oxide semiconductors,such as high electron mobility, wide band gap, and compatibility with back-end-of-line(BEOL) processes [1, 2].

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Risk assessment of oil and gas investment environment in countries along the Belt and Road Initiative

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Petroleum Science 2024年第2期21卷 1429-1443页

作者： bao-Jun Tang Chang-jing Ji Yu-Xian Zheng Kang-Ning Liu Yi-Fei Ma Jun-Yu Chen Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing100081China School of Management and Economics Beijing Institute of TechnologyBeijing100081China Collaborative Innovation Center of Electric Vehicles in Beijing BeijingChina Sustainable Development Research Institute for Economy and Society of Beijing BeijingChina Institute of Carbon Neutrality ShanghaiTech UniversityShanghai201210China

With the implementation of the Belt and Road Initiative, China is deepening its cooperation in oil and gas resources with countries along the Initiative. In order to better mitigate risks and enhance the safety of investments, it is of significant importance to research the oil and gas investment environment in these countries for China's overseas investment macro-layout. This paper proposes an indicator system including 27 indicators from 6 dimensions. On this basis, game theory models combined with global entropy method and analytic hierarchy process are applied to determine the combined weights, and the TOPSIS-GRA model is utilized to assess the risks of oil and gas investment in 76 countries along the Initiative from 2014 to 2021. Finally, the GM(1,1) model is employed to predict risk values for 2022-2025. In conclusion, oil and gas resources and political factors have the greatest impact on investment environment risk, and 12 countries with greater investment potential are selected through cluster analysis in conjunction with the predicted results. The research findings may provide scientific decisionmaking recommendations for the Chinese government and oil enterprises to strengthen oil and gas investment cooperation with countries along the Belt and Road Initiative.

关键词： Belt and Road Initiative Oil and Gas Investment Risk assessment

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Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： Feng-Xia Wu Feng-Hua Li Xia-Li Lv Qi-Xian Zhang Guo-bao Xu wen-Xin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic ***,significant advance has been made in synthesizing metal nanocrystals with intrinsic ***,the majority reports are limited to ***,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was *** heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell *** employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were *** optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and L-dihydroxyphenylalanine(L-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of L-DOPA,which enables the determination of the enantiomeric excess(EE,%)of ***,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer Electrochemical sensors Chiral recognition Chiroplasmonics

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A tectono-thermal perspective on the petroleum generation,accumulation and preservation in the southern Ordos Basin, North China

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Petroleum Science 2024年第3期21卷 1459-1473页

作者： Peng Yang Zhan-Li Ren Jin-Hua Fu Hong-Ping bao Hui Xiao Zheng Shi Kun Wang Yuan-Yuan Zhang wen-Hui Liu wen-Hou Li State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069ShanxiChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an710018ShaanxiChina Shaanxi Key Lab of Petroleum Accumulation Geology School of Earth Science and EngineeringXi'an Shiyou UniversityXian710065ShaanxiChina Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxi214126JiangsuChina

The southern Ordos Basin has excellent petroleum exploration ***,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are *** this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution *** the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern *** paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source *** vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation *** Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation *** southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and *** event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and *** southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic *** southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the *** str

关键词： Fission-track dating Vitrinitereflectance Geothermal field Tectono-thermal evolution Petroleum geology Ordos Basin

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Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

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Rare Metals 2024年第7期43卷 3055-3065页

作者： Yu-Shi Feng Yu Shen Fang Wang Chuan Tian Qin-Yi Hu Qian Duan jing-Wei Li Di bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects

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Permanent lining castable with low bulk density and thermal conductivity:bauxite castable for tundish obtained by adding pearlescent sand

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Journal of Iron and Steel Research International 2024年第3期31卷 634-646页

作者： Yi Wang Jian Yang bao Wang Hai-jun Zhang Juan Han Pei-yan Pei wen-long Lv Jian-an Zhou The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Research Institute of Metallurgical Construction MCCWuhan 430081HubeiChina

The low thermal conductivity and light mass of castables for tundish permanent linings are crucial for minimizing the heat loss of molten *** consideration of the low bulk density and thermal conductivity of pearlescent sand,the thermal insulation performance of castables was attempted to be improved by adding pearlescent *** sand was modified to prevent the strength of its porous structure from *** modification mechanism of pearlescent sand and the effect of pearlescent sand on the performance of bauxite castables were *** results suggested that the addition of the modified pearlescent sand significantly raised the apparent porosity and decreased the bulk density of bauxite *** 1000℃,the bulk density of more than 60%of the modified pearlescent sand-bauxite castable was only 2.03 g/cm^(3).The mechanical properties and thermal shock resistance of the modified pearlescent sand-bauxite castable were inferior to those of conventional bauxite castable but were adequate to meet the use conditions of casta-bles for tundish permanent *** high temperatures of 200-800℃,the thermal conductivity of more than 60%of the modified pearlescent sand-bauxite castable was smaller than that of conventional bauxite *** addition of the modified pearlescent sand can greatly reduce the thermal conductivity and bulk density of bauxite castable.

关键词： Pearlescent sand-Hydrophobic modification Bauxite castable Thermal insulation performance Mechanical property

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