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On Ekeland's Variational Principle for Set-Valued Mappings

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 141-148页

作者： Sheng-jie Li wen-yan Zhang College of Mathematics and Science Chongqing University Chongqing 400044 China

In this paper, we derive a general vector Ekeland variational principle for set-valued mappings, which has a dosed relation to εk^0 -efficient points of set-valued optimization problems. The main result presented in ... 详细信息

关键词： Vector Ekeland variational principle nonlinear scalarization function metric space set-valued mapping

The Prolongation Structure of a Coupled Kdv Equation

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Acta Mathematicae Applicatae Sinica 2018年第2期34卷 430-437页

作者： Yang-jie JIA wen-shan DUAN College of Physics and Electronic Engineering Northwest Normal University Lanzhou 730070 China Department of Mathematics Nationalities College of Qinghai Normal University Xining 810008 China

The new coupled KdV equation proposed by Ohta and Hirota, in which the phase shift depends on the mutual positions of solitons at the initial time, is investigated in the framework of prolongation structure theory. It... 详细信息

关键词： integrable equation prolongation structure lax pair

Role of the PTEN signaling pathway in autism spectrum disorder

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Neuroscience Bulletin 2013年第6期29卷 773-778页

作者： Jing-wen lv Tian-Lin Cheng Zi-Long Qiu wen-Hao Zhou Department of Neonatology Children's Hospital of Fudan University Institute of Neuroscience Shanghai Institute of Biological SciencesChinese Academy of Sciences

Autism is an etiologically heterogeneous group of neurodevelopmental disorders,diagnosed mostly by the clinical behavioral *** concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last *** this review,we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry,as well as genetic mouse models with Pten ***,accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.

关键词： PTEN TSC1/2 autism synapse neural stem cells

Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo

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Chinese Chemical Letters 2024年第5期35卷 290-295页

作者： Jiajia lv jie Gao Hongyu Li Zeli Yuan Nan Dong School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China School of Pharmacy Zunyi Medical UniversityZunyi 563003China Guizhou International Scientific and Technological Cooperation Base for Medical Photo-Theranostics Technology and Innovative Drug Development Zunyi 563003China

As key biomarkers,amyloid-β(Aβ)plaques are frequently used to diagnose Alzheimer’s disease(AD).Although fluorescence imaging has proven to be effective in detecting these plaques,the gold standard probe thioflavin T(ThT),used for Aβaggregates,cannot be applied in vivo owing to its invasive ***,the development of novel fluorescent probes capable of identifying Aβplaques in situ is *** on the ThT structure,twoπ-conjugated heterocyclic D-π-A probes were designed bearing the hydroxytricyanopyrrole acceptor and N,N-dimethylaminophenyl *** probes exhibited red to near-infrared fluorescence emission(λ_(max)=732 nm),large Stokes shifts(>100 nm),exceptional signal-to-noise ratio,rapid response(<30 s),and high binding affinity(NT-HTCP=33.32 nmol/L;NF-HTCP=53.35 nmol/L)for Aβ*** the best candidate,NT-HTCP was used for in situ imaging of Aβplaques in AD mouse ***,in vivo research demonstrated that NT-HTCP could cross the blood-brain barrier and continue imaging the Aβplaques with a good signal-to-noise ***,the outcomes of the docking computations helped guide the development of the Aβ*** study expands the family of N,N-dimethylaminophenyl-based Aβ-sensitive fluorophores,with NTHTCP emerging as a highly promising imaging agent.

关键词： Amyloid-β Fluorescent probe Hydroxytricyanopyrrole Fluorescence imaging Alzheimer’s disease

Geochemical,mineralogical,and petrological analyses for the interpretation of the sedimentary environment of the Middle-Late Ordovician Majiagou Formation(northern China)as a tool for more effective gas exploration

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Petroleum Science 2022年第6期19卷 2519-2532页

作者： jie Gao Da-Wei lv A.J.(Tom) van Loon Dun Wu Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and TechnologyQingdaoShandong266590China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyShandong266071China College of Earth Science and Engineering Shandong University of Science and TechnologyShandong266590China Exploration Research Institute Anhui Provincial Bureau of Coal GeologyHefeiAnhui230088China

Core samples from the deeply buried Ordovician Majiagou Formation below the Huainan Coalfield(E China) have been investigated for their carbonate types,major and trace elements(including rare earth elements) and C and O isotopes,The objective was to get a better insight into the possible occurrences of gas(and possibly oil) derived from Carboniferous *** was found that the carbonates are dolomites with strongly varying amounts of CaO and *** low concentrations of SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3)indicate deposition in a normal marine environment with little terrigenous input,The Na_(2)O/K_(2)O,Fe/Mn and Sr/Ba ratios,as well as the Ga values indicate mainly a marine salinity and a hot and humid *** slight depletion of Ce and Eu,the depletion of heavy rare earth elements(HREE) and the enrichment of light rare earth elements(LREE) indicate deposition in a reducing *** thus appears that the Majiagou Formation below the Huainan Coalfield closely resembles that in the eastern part of the Ordos Basin,where several gas reservoirs are present,so that the Majiagou Formation under the Huainan Coalfield represents a promising target for hydrocarbon exploration.

关键词： Majiagou Formation Middle Ordovician Major-element analysis REE analysis Trace-element analysis Hydrocarbon exploration

Analysis of a Nutrient-phytoplankton Model in the Presence of Viral Infection

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 113-128页

作者： Jian-jun LI wen-jie GAO College of science Liaoning Technical University Institute of Mathematics Jilin University

In this paper,a system of reaction-diffusion equations arising in a nutrient-phytoplankton populations is *** equations model a situation in which phytoplankton population is divided into two groups,namely susceptible phytoplankton and infected phytoplankton.A number of existence and non-existence results about the non-constant steady states of a reaction diffusion system are *** the diffusion coefficient of the infected phytoplankton is treated as bifurcation parameter,non-constant positive steady-state solutions may bifurcate from the constant steady-state solution under some conditions.

关键词： coexistence bifurcations non-constant positive steady solution

The Unconventional Influence of a Nearby Molecule onto Transport of Single C60 Molecule Transistor

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Chinese Physics Letters 2019年第12期36卷 62-66页

作者： Xiao Guo wen-jie Liang Beijing National Center for Condensed Matter Physics Bejjing Key Laboratory for Nanomaterials and NanodevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190 CAS Center of Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190 Songshan Lake Materials Laboratory Dongguan 523808

We study the transport property of single C60 molecular transistors with special focus on the situation that other molecules are in *** devices are prepared using electromigration and thermal deposition *** single C60 molecule transistors show typical coulomb blockade behavior at low *** we increase the coverage of molecules slightly by extending the deposition time,the transport spectrum of devices displays a switching behavior in the general coulomb blockade *** attribute this unconventional phenomenon to the influence from a nearby C60 *** analyzing this transport behavior quantitatively based on the parallel-double-quantum-dot model,the interaction from the nearby molecule is proved to be of capacity and tunneling *** stimulation is also applied to the device to investigate the effect of local charging environment variation on intermolecular interaction.

关键词： transport behavior tunneling

Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARγsignaling pathway

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Journal of Genetics and Genomics 2023年第1期50卷 20-26页

作者： jie wen Jiangming Deng Ting Xiao Yu Liu wen Meng Department of Nephrology Hunan Key Laboratory of Kidney Disease and Blood PurificationThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Metabolic Syndrome Research Center The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China

Dysregulation of microRNAs(miRNAs)in adipocytes plays a critical role in the pathogenesis of ***,the signaling mechanisms regulating miRNAs production in adipose tissue remain largely ***,we show that adipose tissue-specific knockout of Ras homolog enriched in brain(Rheb),a direct upstream activator of mTOR,increases miR-182-5p level in mouse subcutaneous white adipose ***,the inhibition of mTOR signaling by rapamycin has no effect on miR-182-5p level in primary subcutaneous white adipocytes,suggesting the presence of a mTOR-independent mechanism regulating Rheb-mediated miR-182-5p *** with this view,Rheb-ablation activates the cAMP/PPARγsignaling *** addition,treatment of white adipocytes with pioglitazone,a PPARγagonist,dramatically upregulates miR-182-5p *** study reveals a unique mechanism by which Rheb regulates miR-182-5p in *** that increasing miR-182-5p in adipose tissue promotes beige fat development,our study also suggests a unique mechanism by which Rheb promotes thermogenesis and energy expenditure.

关键词： Rheb miR-182-5p White adipocytes cAMP/PPARγpathway Adipose tissue

Global stabilization control of stochastic quantum systems

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Science China(Information Sciences) 2016年第11期59卷 208-219页

作者： Shuang CONG jie wen Sen KUANG Fangfang MENG School of Information and Science Technology University of Science and Technology of China Department of Electronic Information and Electrical Engineering Hefei University

The global stabilization control of arbitrary eigenstates for finite dimensional stochastic quantum systems with non-diagonal free Hamiltonian and non-regular measurement operator is studied in this *** propose a switching feedback control law, in which a constant control is used to steer the system state to a convergence domain, and another control law designed based on Lyapunov stability theorem, is used to attract the states in the convergence domain to the desired target state. The convergence to an arbitrary target eigenstate from any initial state is strictly proved. Moreover, numerical simulation experiments on a three-dimensional stochastic quantum system are implemented to demonstrate the effectiveness of the proposed control.

关键词： eigenstate stochastic quantum systems global stabilization switching control Lyapunov stability theorem