检索结果-南通市图书馆

Inflammatory response in gastrointestinal cancers:Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第1期15卷 9-22页

作者： Ze-Xuan Fang wen-jia chen Zheng Wu Yan-Yu Hou Yang-Zheng Lan Hua-Tao Wu Jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Chronic inflammation is known to increase the risk of gastrointestinal cancers(GICs),the common solid tumors *** lesions,such as chronic atrophic inflammation and ulcers,are related to inflammatory responses in vivo and likely to occur in hyperplasia and ***,due to the lack of effective therapeutic targets,the prognosis of patients with GICs is still ***,it is found that six transmembrane epithelial antigens of the prostate(STEAPs),a group of metal reductases,are significantly associated with the progression of malignancies,playing a crucial role in systemic metabolic homeostasis and inflammatory *** structure and functions of STEAPs suggest that they are closely related to intracellular oxidative stress,responding to inflammatory *** the imbalance status of abnormal oxidative stress,STEAP members are involved in cell transformation and the development of GICs by inhibiting or activating inflammatory *** review focuses on STEAPs in GICs along with exploring their potential molecular regulatory mechanisms,with an aim to provide a theoretical basis for diagnosis and treatment strategies for patients suffering from these types of cancers.

关键词： Six transmembrane epithelial antigens of the prostate Gastrointestinal cancer Inflammation

Magnetic resonance imaging features of intrahepatic extramedullary hematopoiesis: Three case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第19期10卷 6626-6635页

作者： Ma Luo jia-wen chen Chuan-Miao Xie Department of Radiology Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina State Key Laboratory of Oncology in South China Guangzhou 510060Guangdong ProvinceChina Collaborative Innovation Center for Cancer Medicine Guangzhou 510060Guangdong ProvinceChina

BACKGROUND Extramedullary hematopoiesis rarely occurs within the liver alone,and is easily *** radiological literature on this disease is exclusively case *** is a paucity of literature on the role of magnetic resonance imaging(MRI).The most common imaging modalities used are computed tomography and *** report aims to provide more data on the appearance of extramedullary hematopoiesis using MRI to help radiologists establish the *** SUMMARY Three patients(one male and two females)were incidentally found to have a hepatic mass or nodule,without hepatomegaly or *** tests including liver function,serum hepatic tumor markers,and hepatitis serologic markers were *** MRI scans,all lesions showed lower signal intensity on in-phase images than on out-phase *** case showed changes in signal intensity on T2 weighted images(WI)and diffusion WI,which shifted from hyperintensity to hypointensity with size enlargement between two rounds of imaging *** lesions exhibited different enhancement patterns on dynamic contrast enhancement *** The MRI signal change and in-/out-phase image might provide useful information and help radiologists establish the diagnosis of intrahepatic extramedullary hematopoiesis.

关键词： Liver Extramedullary hematopoiesis Signal intensity Magnetic resonance imaging Case report

Recent advances in natural compounds inducing non-apoptotic cell death for anticancer drug resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2023年第4期6卷 729-747页

作者： jia-wen chen Sibao chen Guo-Qing chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100193China State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhen 518057GuangdongChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Research Centre for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China

The induction of cell death is recognized as a potent strategy for cancer *** is an extensively studied form of cell death,and multiple anticancer drugs exert their therapeutic effects by inducing ***,apoptosis evasion is a hallmark of cancer,rendering cancer cells resistant to chemotherapy ***,there is a growing interest in exploring novel non-apoptotic forms of cell death,such as ferroptosis,necroptosis,pyroptosis,and *** compounds with anticancer properties have garnered significant attention due to their advantages,including a reduced risk of drug *** the past two decades,numerous natural compounds have been discovered to exert anticancer and anti-resistance effects by triggering these four non-apoptotic cell death *** review primarily focuses on these four non-apoptotic cell death mechanisms and their recent advancements in overcoming drug resistance in cancer ***,it highlights the role of natural compounds in effectively addressing cancer drug resistance through the induction of these forms of non-apoptoticcell death.

关键词： Drug resistance cancer therapy natural compound non-apoptotic cell death

Potential of six-transmembrane epithelial antigen of the prostate 4 as a prognostic marker for colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第9期14卷 1675-1688页

作者： Ze-Xuan Fang Chun-Lan Li wen-jia chen Hua-Tao Wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Immune cells play a role in the regulation of tumor cell behavior, and accumulating evidence supports their significance in predicting outcomes and therapeutic efficacy in colorectal cancers(CRC). Human six-transmembrane epithelial antigen of the prostate(STEAP) proteins have been recognized and utilized as promising targets for cell-and antibody-based immunotherapy. One STEAP family member, STEAP4, is expected to be an attractive biomarker for the immunotherapy of prostate and breast cancer. However, the immunotherapeutic role of STEAP4 for colorectal carcinomas has not been *** To explore the expression pattern of STEAPs in CRC and their relationship with immune infiltration, and investigate the potential utilization of STEAPs as novel prognostic indicators in colorectal *** The expression level of STEAPs in CRC was evaluated using various openresource databases and online tools to explore the expression characteristics and prognostic significance of STEAPs, as well as their correlation with immunerelated biomarkers, such as immune infiltration. Immunohistochemical(IHC) experiments were subsequently performed to verify the database *** The levels of STEAPs in CRC were inconsistent. The expression of STEAPs 1-3 in CRC was not significantly different from that in normal tissues. However,STEAP4 mRNA levels were significantly lower in CRC than in normal tissue and were positively correlated with immune-related biomarkers, such as immune cell infiltration, immune stimulation, major histocompatibility complex levels, and chemokines. Interestingly, the expression of STEAP4 in microsatellite instability-high CRC subtype was higher than that in microsatellite stability subtype. IHC staining was performed on colon cancer tissue samples and showed that high expression of STEAP4 in adjacent tissues positively correlated with immune-related biomarkers, including MLH1, MLH6, and PMS2, but negatively correlated with programm

关键词： Six-transmembrane epithelial antigen of the prostate Colorectal cancer Immunotherapy Target Survival

Diverse roles of FOXO family members in gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第10期13卷 1367-1382页

作者： Yu-Han chen Chun-Lan Li wen-jia chen Jing Liu Hua-Tao Wu Department of Clinical Medicine Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Changjiang Scholar's LaboratoryDepartment of PhysiologyShantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Gastric cancer(GC)is the fifth most diagnosed cancer and the third leading causeof cancer-related death *** progress has been made in diagnosis,surgical resection,systemic chemotherapy,and immunotherapy,patientswith GC still have a poor *** overall 5-year survival rate in patientswith advanced GC is less than 5%.The FOXO subfamily,of the forkhead boxfamily of transcription factors,consists of four members,FOXO1,FOXO3,FOXO4,and *** subfamily plays an important role in many cellular processes,such as cell cycle,cell growth,apoptosis,autophagy,stress resistance,protectionfrom aggregate toxicity,DNA repair,tumor suppression,and metabolism,in bothnormal tissue and malignant *** studies support a role for FOXOs astumor suppressors based on their ability to inhibit angiogenesis and metastasis,and promote apoptosis,yet several other studies have shown that FOXOs mightalso promote tumor progression in certain *** elucidate the diverseroles of FOXOs in GC,this article systematically reviews the cellular functions ofFOXOs in GC to determine potential therapeutic targets and treatment strategiesfor patients with GC.

关键词： FOXO Gastric cancer Regulation Therapy Expression

The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu cheng Zhi-Hui Wang Mou Peng Zhi-Chao Huang Lu Yi Yi-jian Li Lei Yi wen-Zhi Luo jia-wen chen Yin-Huai Wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China T.H.Chan School of Public Health Harvard UniversityBostonMA 02115USA

The first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRT)with or without androgen deprivation therapy(ADT)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRT in patients with high-risk *** summary hazard ratios(HRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCT])of low risk of bias were selected and up to 9504 patients were *** comparing EBRT-based treatment with RP-based treatment,the pooled HRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRT-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRT-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

Extending Structures for Gel'fand-Dorfman Bialgebras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第2期40卷 619-638页

作者： jia jia wen Yan Yong HONG School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

Gel'fand-Dorfman bialgebra,which is both a Lie algebra and a Novikov algebra with some compatibility condition,appeared in the study of Hamiltonian pairs in completely integrable *** also emerged in the description of a class special Lie conformal algebras called quadratic Lie conformal *** this paper,we investigate the extending structures problem for Gel'fand-Dorfman bialgebras,which is equivalent to some extending structures problem of quadratic Lie conformal ***,given a Gel'fand-Dorfman bialgebra(A,o,[.,.]),this problem is how to describe and classify all Gel'fand-Dorfman bialgebra structures on a vector space E(A⊂E)such that(A,o,[.,.])is a subalgebra of E up to an isomorphism whose restriction on A is the identity *** by the theories of extending structures for Lie algebras and Novikov algebras,we construct an object gH2(V,A)to answer the extending structures problem by introducing the notion of a unified product for Gel'fand-Dorfman bialgebras,where V is a complement of A in *** particular,we investigate the special case when dim(V)=1 in detail.

关键词： Gel'fand-Dorfman bialgebra Lie conformal algebra Extending structures problem Novikovalgebra

Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 657-666页

作者： wen-jie FAN jia-qi ZHANG jia-qi ZHAN Li HU Li-li chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Deep insight of unique phase transition behaviors and mechanism in Zr_(2)Co-H isotope system with ultra-low equilibrium pressure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 212-224页

作者： Yang Liu Pan-Pan Zhou Xue-Zhang Xiao jia-cheng Qi jia-Peng Bi Tiao Ying Xing-wen Feng Yan Shi wen-Hua Luo Li-Xin chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China

Efficient capture,safe storage and release of tritium from the international thermonuclear experimental reactor(ITER) reaction exhaust gas is a perplexing problem,and the development of an efficient tritium-getter material with ultra-low hydrogenation equilibrium pressure is considered as a reliable *** this work,Zr_(2)Co alloy was selected as a tritium-getter material and prepared through induction levitation *** performance test results show that Zr_(2)Co exhibits an ultra-low hydrogenation equilibrium pressure of 3.22 × 10^(-6) Pa at 25℃ and excellent hydriding kinetics under a low hydrogen pressure of 0.005 ***,unique phase transition behaviors were presented in Zr_(2)Co-H ***,Zr_(2)CoH_(5) formed by Zr_(2)Co hydrogenated at room temperature is initially decomposed into ZrH_(2) and ZrCoH_(3) at200 ℃.With the temperature increasing to 350 ℃,ZrCoH_(3)is dehydrogenated to ZrCo,and then ZrCo further reacts with ZrH_(2) at 650 ℃ to reform Zr_(2)Co and *** the staged phase transition pathways during dehydrogenation,the decomposition of Zr_(2)CoH_(5) occurs preferentially,which is well accordance with both the smallest reaction energy barrier and the maximum reaction spontaneity that are determined respectively from kinetics activation energy and thermodynamics Gibbs free ***,first principles calculation results indicate that the stronger binding of hydrogen in interstitial environments of ZrCoH_(3)and ZrH_(2) triggers the hydrogen-stabilized phase transformation of Zr_(2)CoH_(5).The unique phase transition mechanisms in Zr_(2)Co-H system can shed light on the further exploration and regulation of analogous staged phase transition of hydrogen storage materials.

关键词： Zr_(2)Co alloy Tritium-getter materials Ultralow equilibrium hydrogen pressure Phase transition mechanism