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Meta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease

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Chinese Medical Journal 2015年第10期128卷 1391-1398页

作者： Yong Zhang Hai-Qin Tang wen-jia peng Bing-Bing Zhang Ming Liu Department of Cardiovascular Disease First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China Department of Preventive Medicine Bengbu Medical College Bengbu Anhui 233030 China

Background：Coronary heart disease （CHD） is a multifactorial disease and is thought to have a polygenic *** E （APOE） gene is one such candidate with its common ε2/ε3/ε4 polymorphism in *** recent years,numerous case-control studies have investigated the relationship ofAPOE polymorphism with CHD ***,the results are ***：To clarify this point,we undertook a meta-analysis based on 14 published studies including 5746 CHD cases and 19,120 *** odds ratios （ORs） with 95% confidence intervals （CIs） were assessed for association using a random-effects or fixed-effects model using STATA version 10 （StataCorp LP,College Station,TX,USA）.Results：Overall,the analysis showed that carriers of APOE ε2 allele decreased risk for CHD （ε2 allele vs.ε3 allele：OR =0.82,95% CI：0.75-0.90,P 〈 0.001;ε2 carriers vs.ε3 carriers：OR =0.81,95% CI：0.73-0.89,P 〈 0.001）,compared with those carrying ε3 allele,especially in Caucasian ***,those with ε4 allele had a significant increased risk for CHD （ε4 allele vs.ε3 allele：OR =1.34,95% CI：1.15-1.57,P 〈 0.001）,especially in Mongoloid *** publication bias was observed in the genetic model of ε4 versus ε3,but the results might not be affected deeply by the publication *** we accounted for publication bias using the trim and fill method,the results were not materially alerted,suggesting the stability of our ***：Taken together,our meta-analysis supported a genetic association between APOE gene and CHD.ε4 increased the risk of CHD,whereas ε2 decreased the risk of CHD

关键词： Apolipoprotein E Coronary Heart Disease Meta-analysis Polymorphism

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新型直流系统绝缘在线监测方法

高电压技术 2011年第2期37卷 333-337页

作者：鲍谚姜久春张维戈王嘉悦温家鹏北京交通大学电气工程学院北京100044

针对传统直流系统绝缘监测方法的不足,提出了新型直流系统绝缘在线监测方法和检测装置。该方法采用监测主机与绝缘检测装置协调配合的模式,通过通信总线连接构成的监测系统可以同时完成多个直流系统的绝缘监测任务。同时,主机根据预设... 详细信息

针对传统直流系统绝缘监测方法的不足,提出了新型直流系统绝缘在线监测方法和检测装置。该方法采用监测主机与绝缘检测装置协调配合的模式,通过通信总线连接构成的监测系统可以同时完成多个直流系统的绝缘监测任务。同时,主机根据预设判据进行实时绝缘故障报警和绝缘故障预警,实现了绝缘监测的远程化、智能化,一定程度上避免了绝缘事故的发生。系统的绝缘电阻检测装置采用新型有源检测方法,通过注入直流电流提高了检测精度,避免了传统直流系统绝缘检测方法的缺陷。最后,通过实验运行验证了方法的有效性和准确性。

关键词：直流系统绝缘在线监测监测系统有源检测故障预警

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma jia Liu Xiang Xia Ning Xu wen Sun jianjun Du jiangli Fan Xiaojun peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

空心叶片激光快速成形过程的温度/应力场数值模拟

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中国激光 2007年第9期34卷 1308-1312页

作者：贾文鹏林鑫陈静杨海鸥钟诚文黄卫东西北工业大学凝固技术国家重点实验室陕西西安710072 西北工业大学高性能计算研究与发展中心陕西西安710072

针对航空发动机空心涡轮叶片激光快速成形(LRF),建立了温度场/应力场瞬态模型,采用有限单元生死技术模拟了熔覆层的沉积生长过程.采用随动强化及米塞斯屈服准则进行了热弹塑性分析,通过间接耦合模拟了TC4钛合金空心叶片激光快速成形的... 详细信息

针对航空发动机空心涡轮叶片激光快速成形(LRF),建立了温度场/应力场瞬态模型,采用有限单元生死技术模拟了熔覆层的沉积生长过程.采用随动强化及米塞斯屈服准则进行了热弹塑性分析,通过间接耦合模拟了TC4钛合金空心叶片激光快速成形的温度场/应力场演变过程.结果分析表明,在TC4钛合金空心叶片激光快速成形过程中,随着熔池的移动和成形高度的增加,温度场和应力场动态演化,其中由于基座的冷却及约束作用和熔池加热及应力释放作用,激光快速成形空心叶片温度和应力/应变场沿高度(z轴)方向呈梯度分布.温度场上高下低,散热方向从上至下,从熔池到基座;应力场下高上低,叶根等效应力最大.空心叶片激光快速成形结束冷却到室温,残余应力与熔覆过程应力分布规律基本相同,只是叶片顶部等效应力有所提高.

关键词：激光技术激光快速成形空心叶片温度/应力场

胸腰段脊柱骨折采取椎旁肌间隙入路椎弓根螺钉内固定治疗的临床效果

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临床医学研究与实践 2018年第14期3卷 54-55页

作者：贾文鹏富平县医院陕西渭南711700

目的探讨椎旁肌间隙入路椎弓根螺钉内固定治疗胸腰段脊柱骨折的临床疗效。方法选择本院收治的胸腰段脊柱骨折106例,以随机信封法分为常规组与治疗组,各53例,常规组采取传统入路椎弓根螺钉内固定治疗,治疗组采取椎旁肌间隙入路椎弓根螺... 详细信息

目的探讨椎旁肌间隙入路椎弓根螺钉内固定治疗胸腰段脊柱骨折的临床疗效。方法选择本院收治的胸腰段脊柱骨折106例,以随机信封法分为常规组与治疗组,各53例,常规组采取传统入路椎弓根螺钉内固定治疗,治疗组采取椎旁肌间隙入路椎弓根螺钉内固定治疗。比较两组手术时间、术中出血量、术后下床活动时间等。结果治疗组手术时间、术中出血量、术后下床活动时间均优于常规组(P<0.05);术后6个月,两组NRS评分、伤椎Cobb's角均明显降低,伤椎前缘高度比明显升高(P<0.05);术后6个月,治疗组NRS评分、伤椎Cobb's角均低于常规组(P<0.05)。结论椎旁肌间隙入路椎弓根螺钉内固定治疗胸腰段脊柱骨折的效果显著,值得临床应用。

关键词：胸腰段脊柱骨折椎旁肌间隙入路椎弓根螺钉内固定传统入路椎弓根螺钉内固定

髓内固定与髓外固定手术对股骨粗隆间骨折患者髋关节功能的影响

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临床医学研究与实践 2018年第12期3卷 75-76页

作者：贾文鹏富平县医院陕西渭南711700

目的比较髓内固定与髓外固定手术在股骨粗隆间骨折患者治疗中对临床指标、髋关节功能、并发症产生的影响。方法将我院收治的120例股骨粗隆间骨折患者随机分成甲组(60例,髓内固定手术治疗)与乙组(60例,髓外固定手术治疗)。对比两组的相... 详细信息

目的比较髓内固定与髓外固定手术在股骨粗隆间骨折患者治疗中对临床指标、髋关节功能、并发症产生的影响。方法将我院收治的120例股骨粗隆间骨折患者随机分成甲组(60例,髓内固定手术治疗)与乙组(60例,髓外固定手术治疗)。对比两组的相关临床指标、术后半年Harris评分及并发症发生情况。结果甲组的手术时间、住院时间、骨折愈合时间明显短于乙组,且术中出血量明显少于乙组(P<0.05);术后半年,甲组Harris评分明显高于乙组(P<0.05);甲组的并发症总发生率明显低于乙组(P<0.05)。结论相较于髓外固定手术,髓内固定方式治疗股骨粗隆间骨折可缩短手术时间、住院时间、骨折愈合时间,减少术中出血量,提升患者髋关节功能,减少并发症。

关键词：髓内固定髓外固定股骨粗隆间骨折髋关节功能

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水平筋与竖向筋位置关系的讨论

科技情报开发与经济 2007年第31期17卷 265-266页

作者：贾稳鹏长庆石油勘探局基建工程部陕西西安710021

通过对混凝土设计规范的各种计算公式的推导,分析了剪力墙双向网片纵向筋与竖向筋、暗梁纵向筋与剪力墙竖向筋以及挡土墙水平筋与竖直筋的位置关系。

关键词：水平筋竖向筋位置关系

Microstructure and fracture toughness of a TiAl-Nb composite consolidated by spark plasma sintering

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Transactions of Nonferrous Metals Society of China 2012年第11期22卷 2628-2632页

作者：杨鑫奚正平刘咏汤慧萍胡可贾文鹏中南大学粉末冶金国家重点实验室长沙410083 西北有色金属研究院金属多孔材料国家重点实验室西安710016 华南理工大学金属材料近净成形国家工程中心广州510641

A TiAl-Nb composite was prepared by spark plasma sintering （SPS） at 1250 °C and 50 MPa for 5 min from prealloyed TiAl powder and elemental Nb powder in a molar ratio of 9：1 for improving the fracture toughness of TiAl alloy at room temperature. The microstructure, phase constitute, fracture surface and fracture toughness were determined by X-ray diffractometry, electron probe micro-analysis, scanning and transmission electron microscopy and mechanical testing. The results show that the sintered samples mainly consist of γ phase, O phase, niobium solid solution （Nbss） phase and B2 phase. The fracture toughness is as high as 28.7 MPa？m1/2 at room temperature. The ductile Nbss phase plays an important role in absorbing the fracture energy in front of the cracks. Moreover, B2 phase can branch the propagation of the cracks. The microhardness of each phase of the composite was also tested.

关键词： TiAl-Nb composite fracture spark plasma sintering (SPS) powder metallurgy fracture toughness fracture energy crack propagation